45:
229:
183:, a clinical condition with acanthocytic red blood cells, neurologic problems and steatorrhea. This particular cause of acanthocytosis (also known as abetalipoproteinemia, apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive condition due to the inability to fully digest dietary fats in the intestines as a result of various mutations of the
196:
247:
Acanthocytosis secondary to malnourishment, such as anorexia nervosa and cystic fibrosis, remits with resolution of the nutritional deficiency. Acanthocyte-like cells may be found in hypothyroidism, after splenectomy, and in myelodysplasia.
267:
due to elevated pH, blood storage, ATP depletion, calcium accumulation, and contact with glass. Acanthocytes should also be distinguished from keratocytes, also called 'horn cells' which have a few very large protuberances.
255:, which are also called 'burr cells', which although crenated are dissimilar in that they have multiple, small, projecting spiculations at regular intervals on the cell membrane. Burr cells usually imply
295:
1028:
217:
deficient lipoprotein accumulates in plasma causing increased cholesterol in RBCs. This causes abnormalities of membrane of RBC causing remodeling in spleen and formation of acanthocytes.
179:
can refer generally to the presence of this type of crenated red blood cell, such as may be found in severe cirrhosis or pancreatitis, but can refer specifically to
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259:, but are seen in many conditions, including mild hemolysis in hypomagnesemia and hypophosphatemia, hemolytic anemia in long-distance runners, and
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Acanthocytes arise from either alterations in membrane lipids or structural proteins. Alterations in membrane lipids are seen in
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Acanthocytes, from peripheral blood, under light microscopy. Note the irregularly shaped, non-circular cells in the image.
915:
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31:
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and liver dysfunction. Alteration in membrane structural proteins are seen in neuroacanthocytosis and McLeod syndrome.
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to acanthocytes, or may refer in some sources to a specific subset of 'extreme acanthocytes' that have undergone
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Mentzer WC. Spiculated cells (echinocytes and acanthocytes) and target cells. UpToDate (release: 20.12- C21.4)
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The diagnosis of acanthocytosis should be differentiated from: acute or chronic anemia, hepatitis A, B, and C,
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874:
220:
In abetalipoproteinemia, there is deficiency of lipids and vitamin E causing abnormal morphology of RBCs.
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987:
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Rampoldi L, Danek A, Monaco AP (2002). "Clinical features and molecular bases of neuroacanthocytosis".
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513:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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Hoffman, R; Benz, EJ; Silberstein, LE; Heslop, H; Weitz J; Anastasi, J. (2012).
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Longo, D; Fauci, AS; Kasper, DL; Hauser, SL; Jameson, JL; Loscalzo J. (2012).
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173:('spheroacanthocyte'), as seen in some patients with severe liver disease.
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327:"Decreased fluidity of red cell membrane lipids in abetalipoproteinemia"
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526:"Acanthocytosis: Practice Essentials, Pathophysiology, Epidemiology"
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99:
43:
110:, and several inherited neurological and other disorders such as
623:
244:, hypopituitarism, malabsorption syndromes, and malnutrition.
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Acanthocytes have coarse, irregularly spaced, variably sized
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Hillman, RS; Ault, KA; Leporrier, M; Rinder, HM. (2011).
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loss has blunted the spicules and the cells have become
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Abnormal red blood cell with a spiked cell membrane
1029:Abnormal clinical and laboratory findings for RBCs
90:, resembling many-pointed stars. They are seen on
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567:
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505:Haldeman-Englert, C; Zieve, D. (August 4, 2011).
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325:Cooper RA, Durocher JR, Leslie MH (July 1977).
71:, due to thorny projections. A similar term is
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8:
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482:Harrison's Principles of Internal Medicine
251:Acanthocytes should be distinguished from
612:at the U.S. National Library of Medicine
606:: Presented by the University of Virginia
578:Hematology: Basic Principles and Practice
350:
232:Acanthocytes compared to other forms of
185:microsomal triglyceride transfer protein
288:
464:
462:
7:
59:, meaning 'thorn'), in biology and
524:Alarcon, Pedro A de (2024-01-17).
75:. Often they may be confused with
25:
199:Acanthocytosis in a patient with
165:modification whereby additional
63:, refers to an abnormal form of
443:Hematology in Clinical Practice
313:Wrongdiagnosis / Acanthocytosis
554:de Alarcon PA (Nov 30, 2011).
484:(18th ed.). McGraw-Hill.
278:List of hematologic conditions
1:
445:(5th ed.). McGraw-Hill.
315:Retrieved on October 12, 2009
144:chronic granulomatous disease
301:Dorland's Medical Dictionary
263:. Burr cells can also arise
55:(from the Greek word ἄκανθα
32:Acanthocyte (disambiguation)
507:"Bassen-Kornzweig syndrome"
1050:
580:(6th ed.). Elsevier.
261:pyruvate kinase deficiency
36:
29:
941:Hypersegmented neutrophil
848:Hemoglobin precipitation
778:Hereditary stomatocytosis
724:Hereditary elliptocytosis
388:10.1007/s00109-002-0349-z
973:Critical green inclusion
764:Sickle cell/drepanocyte
736:Hereditary spherocytosis
614:Medical Subject Headings
37:Not to be confused with
705:Membrane abnormalities
875:Red cell agglutination
237:
224:Differential diagnoses
213:In liver dysfunction,
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126:, idiopathic neonatal
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231:
198:
104:chorea acanthocytosis
47:
978:Alder–Reilly anomaly
832:Basophilic stippling
242:hepatorenal syndrome
208:abetalipoproteinemia
201:abetalipoproteinemia
181:abetalipoproteinemia
96:abetalipoproteinemia
30:For other uses, see
953:Pelger–Huët anomaly
911:Reactive lymphocyte
837:Pappenheimer bodies
768:Sickle cell disease
215:apolipoprotein A-II
112:neuroacanthocytosis
801:Hypochromic anemia
530:Medscape Reference
238:
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67:that has a spiked
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1016:
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968:Toxic vacuolation
963:Toxic granulation
894:White blood cells
888:
887:
827:Howell–Jolly body
587:978-1-4377-2928-3
452:978-0-07-162699-6
343:10.1172/JCI108747
16:(Redirected from
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983:Jordans' anomaly
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816:Inclusion bodies
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556:"Acanthocytosis"
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491:978-0-07174889-6
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418:"Acanthocytosis"
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191:Pathophysiology
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108:McLeod syndrome
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1034:Histopathology
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234:poikilocytosis
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177:Acanthocytosis
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140:Zieve syndrome
124:hypothyroidism
65:red blood cell
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337:(1): 115–21.
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296:"acanthocyte"
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167:cell membrane
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134:, congestive
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69:cell membrane
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958:Döhle bodies
946:Arneth count
933:Granulocytes
796:Anisochromia
774:Stomatocyte
708:
685:Microcytosis
680:Macrocytosis
675:Anisocytosis
610:Acanthocytes
577:
533:. Retrieved
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421:. Retrieved
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176:
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159:synonymously
154:
153:
136:splenomegaly
120:pyknocytosis
118:, infantile
85:
81:schistocytes
72:
56:
52:
51:
18:Acanthocytes
916:Smudge cell
903:Lymphocytes
842:Cabot rings
755:Schistocyte
719:Elliptocyte
709:Acanthocyte
604:Acanthocyte
423:18 November
253:echinocytes
171:spherocytic
92:blood films
77:echinocytes
53:Acanthocyte
1023:Categories
988:Left shift
870:Haemoconia
852:Heinz body
750:Echinocyte
731:Spherocyte
651:Blood film
535:2024-06-26
284:References
157:may refer
155:Spur cells
132:alcoholism
88:crenations
73:spur cells
39:Acanthosis
760:Degmacyte
745:Dacrocyte
376:J Mol Med
128:hepatitis
102:disease,
1004:Auer rod
880:Rouleaux
714:Codocyte
653:findings
404:21615621
396:12185448
272:See also
265:in vitro
61:medicine
163:splenic
57:acantha
789:Colour
616:(MeSH)
584:
488:
449:
402:
394:
361:874076
359:
352:372349
349:
257:uremia
142:, and
997:Other
863:Other
694:Shape
400:S2CID
150:Usage
100:liver
668:Size
582:ISBN
486:ISBN
447:ISBN
425:2012
392:PMID
357:PMID
384:doi
347:PMC
339:doi
298:at
94:in
79:or
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380:80
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335:60
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643:e
636:t
629:v
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538:.
494:.
455:.
427:.
406:.
386::
363:.
341::
236:.
41:.
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
