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segment is present in one member of a chromosome pair. In that case, a crossover event will result in one chromosome with two centromeres and an acentric fragment. The acentric fragment will be lost as explained above, and chromosomes with two centromeres will break unevenly during mitosis, resulting
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Lack of the acentric fragment in one of the daughter cells may have deleterious consequences, depending on the function of the DNA in this region of the chromosome. In the case of a
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found in the homologous chromosome. Developmental geneticists look for cells and cell lineages lacking
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segments produced this way as a means of identifying essential genes for specific functions.
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organism, the daughter cell lacking the acentric fragment will show expression of any
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Acentric
Fragment, In: Sydney Brenner and Jeffrey H. Miller, Editor(s)-in-Chief,
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Acentric fragments are commonly generated by chromosome-breaking events, such as
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Because the centromere is the point of attachment for the
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253:Introduction to Genetic Analysis (Looseleaf)
234:, Academic Press, New York, 2001, Page 2,
187:in one daughter lacking essential genes.
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118:Chromosome segment without a centromere
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44:adding citations to reliable sources
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31:needs additional citations for
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242:, 10.1006/rwgn.2001.1750.
232:Encyclopedia of Genetics
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255:. Macmillan. 2008.
173:unpaired chromosome
55:"Acentric fragment"
286:Classical genetics
144:in cell division (
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138:mitotic apparatus
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38:Please help
33:verification
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212:Telocentric
207:Acrocentric
197:Metacentric
180:irradiation
218:References
131:centromere
127:chromosome
96:April 2019
66:newspapers
280:Category
191:See also
184:inverted
165:diploid
157:haploid
150:meiosis
146:mitosis
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161:gamete
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