1340:...and then we have in October of 1991 an 11th meeting of that committee, the Advisory Committee on the Virological Safety of Blood considering recommendations in relation to HCV testing and the results of the first HCV test trials and the possibility of look-back study although no decision then taken....
1622:
Recommendations to proceed with the introduction of the anti-Hep C testing were made by the relevant UK Committee, the ACVSB, in July and
November 1990, subject to the holding of various trials. Ministerial approval was given on 21 January 1991 and a programme of implementation was then commenced for
420:
of 13 May 2019, there were 17 volumes of papers generated by the advisory committee during the course of its operation. The investigation by the
Department's internal auditors conducted in April 2000 found that of the 17 volumes, 14 had been destroyed and only volumes 1-3 survived. A court disclosure
520:
Prior to the formation of SaBTO advice was provided at UK Government level by the
Committee for the Microbiological Safety of Blood, Tissues and Organs (MSBTO) and its predecessor, the Committee for the Microbiological Safety of Blood and Tissues (MSBT) (1993 -2007). Prior to that we understand that
184:
After the inaugural meeting of 4 April 1989, the advisory committee met a further 13 times, with the fourteenth meeting being held on 29 September 1992. The files and minutes of the committee do not continue beyond
February 1993 by which time the ACVSB was considered defunct. Following a memorandum
433:
A significant decision made by the committee in
November 1990 was to recommend to Ministers that routine anti-HCV screening of blood be introduced. However, the ACVSB decision was not implemented until September 1991 which came under criticism in the Final Report of the Penrose Inquiry for having
411:
It came to light in 2004 that documentation that fell within the scope of NHS contaminated blood products had gone missing from within the
Department of Health and was thought to have been destroyed in the early 1990s. It was claimed by the (then) Minister of State, Lord Warner, that the files in
135:
on the safety of blood with respect to viral infections. The scope of the ACVSB concerned areas of significant policy for the whole of the United
Kingdom and operated under the terms of reference: "To advise the Health Departments of the UK on measures to ensure the virological safety of blood,
452:, or deed of undertaking, aimed at ensuring that the claimants would not be able to litigate against the government if they were found to have contracted any further viruses. It was recorded in Hansard in 2007 that a number of these deeds of undertaking from 1989 were inadvertently destroyed.
1401:"Dry heat treatment of 8O°C for 72 hours reduced but did not always eliminate detectable B19 from factor VIII concentrates, consistent with recent observations that current methods of viral inactivation during blood product manufacture are insufficient to entirely eliminate B19 infectivity.
354:
Hepatitis C, screening of non UK plasma in blood products, results of first HCV testing trials, ALT testing, use of plasma from anti-HBc positive donors with a history of jaundice, re-admittance of donors not confirmed HIV antibody positive, HTLV-I BTS study, possible look-back study.
1563:
Penrose ruled that, overall, little could have been done differently by the authorities to prevent the contamination, but that mistakes were made. He criticised a 10-month delay in 1990 by the advisory committee on the virological safety of blood to recommend that screening
727:, 11 (EWCH 2001) ("...and reported back to the two high powered committees on which he sat, the UK Advisory Committee on Virological Safety of Blood ('ACVSB'), and the UK Advisory Committee on Transfusion Transmitted Diseases ('ACTTD')...").
1324:
136:
whilst maintaining adequate supplies of appropriate quality for both immediate use and for plasma processing." Of particular emphasis to the remit was the testing of blood donors using surrogate markers for Non-A Non-B hepatitis (NANBH) and later on,
412:
question had been identified by the
Department of Health as minutes and background papers of the ACVSB spanning May 1989 to February 1992 and that they were "unfortunately destroyed" having not been properly archived. In May 2006, it was recorded in
323:
meeting on
Hepatitis C, protocol for HCV Screening and supplementary testing, EC directive on viral safety, EC directive on blood products, hepatitis C: Community transmission, anti-HBc testing of blood donors, hepatitis BsAg confirmatory testing,
143:
The first meeting took place on 4 April 1989 and was chaired by the (then) Deputy Chief
Medical Officer (DCMO), Dr E L Harris. From August 1989, Dr J Metters, also DCMO, sat as chair. The advice to be given by the committee extended to
1683:
It is also believed that the committee was responsible for suggesting that those who had been infected with HIV and wanted compensation should sign a waiver agreeing not to sue if they were later found to have contracted other
1592:
The Inquiry has endeavoured to assess why there was a delay of almost 10 months between the decision by the ACVSB on 21 November 1990 to recommend the introduction of screening as soon as practicable and 1 September
1741:
861:
1481:
500:
1517:
1623:
all RTCs. The tests (by now second generation tests, and with a supplementary test available for confirmatory purposes in place) were introduced throughout England and Wales on 1 September 1991.
320:
308:
Hepatitis C testing, counselling of HCV positive donors, anti-HBc testing, reinstatement of donors found to be reactive in previously-used HIV screening tests, HCV in the community.
1666:
416:
that officials became aware of the destruction of the files as early as April 2000, at which point the Department of Health undertook an internal audit. According to a report in
370:, non HCV-tested plasma, EC directive on blood products, ALT testing of blood and plasma, HTLV-I testing of blood donations, non-viral infections of blood transfusions including
718:
435:
422:
461:
1653:
The ACVSB had advised ministers to require victims to sign a waiver agreeing not to pursue the Government over hepatitis infections when applying for compensation.
260:
Human Growth Hormone, EC directive on blood products, HTLV-I screening, Non A Non B hepatitis, report on UKBTS survey of surrogate testing and Chiron screening.
1731:
1234:
1488:
438:
in that ministerial approval had been given on 21 January 1991, yet the second generation tests were not introduced in England and Wales until 1 September 1991
820:
The ACVSB advised the UK government, among other things, on surrogate testing of blood donors for NANB Hepatitis and screening of donors for Hepatitis C.
185:
from NHS Management Executive dated 8 February 1993, the ACVSB was replaced by the committee on the Microbiological Safety of Blood and Tissues (MSBT).
685:
466:
1547:
425:
dated 9 May 2000 also confirms that ACVSB volumes 4-17 of file series "GEB1" were destroyed at various stages between July 1994 and March 1998.
237:
EC directive on blood products, HGH, HTLV-I, Non A Non B hepatitis, action in response to reports of blood/blood product infectivity, effect of
132:
585:
1736:
1697:
1440:
366:
Funding anti-HCV screening, chronology of HCV testing, preliminary analysis of HCV testing, evaluation of in-vitro diagnostics by
833:
385:
Anti-HTLV testing/screening, virus inactivated plasma (VIP), initial screening and alternatives to PCR/RIPA confirmatory tests.
271:
Human Growth Hormone, EC directive on blood products, HTLV-I screening, Non A Non B hepatitis, combined HIV 1 and HIV2 testing.
1636:
173:
521:
advice was provided on a national level by a body called the Advisory Committee on the Virological Safety of Blood (ACVSB).
161:
1461:
544:, 100 (EWHC 2001) ("The Department confirmed to Dr Gunson on 8 March 1989, when it set up the ACVSB...").
1708:
A number of signed waivers, going back to 1989, were inadvertently destroyed with the files in which they were held.
846:
Surrogate testing of blood donations in relation to Non A Non B hepatitis formed an important part of its business.
471:
445:
939:
Each group met in May 1989: the ACTTD had its second meeting on 19 May and the ACVSB its second meeting on 22 May.
705:
I have also been Chairman of the Advisory Committee of the Virological Society of Blood (ACVSB) since August 1989.
367:
325:
1414:
1576:
807:
554:
128:
1726:
1061:
Below is the agenda for the 4th meeting of the ACVSB, to be held at 1030hrs Monday 6 November 1989...
741:"Note of Meeting of the Advisory Committee on the Virological Safety of Blood held at Hannibal House"
1041:
1009:
919:
776:
740:
620:
1140:
567:
Dr Gunson had recommended to the DHSS that a group should be established and this had been agreed.
980:
891:"Advisory Committee on the Microbiological Safety of Blood and Tissue for Transplantation (MSBT)"
343:
Protocol for hepatitis C screening and supplementary testing, anti-HCV tests on blood donations.
1606:"A & Ors v National Blood Authority & Ors [2001] EWHC QB 446 (26th March, 2001)"
1172:
1108:
137:
1356:"Minutes of the Twelfth Meeting of the Advisory Committee on the Virological Safety of Blood"
434:
been delayed by 10 months. In 2001, the role of the ACVSB was referred to in the judgment of
226:, EC directive on blood products, overview on hepatitis, hepatitis B, Non A Non B hepatitis.
1577:"Final Report: Chapter 31 - The Introduction of Screening of Donated Blood for Hepatitis C"
792:
He explained that the Committee had been set up to give advice to the UK Health Ministers.
604:
The committee produced 17 volumes of documents and the files were closed in February 1993.
476:
165:
157:
153:
1605:
724:
541:
81:
Blood safety, maintaining adequate blood supplies, testing and screening of blood donors
1204:
951:
397:
223:
149:
124:
1294:
652:
293:
Hepatitis C testing, anti-HCV ELISA tests, chimpanzee study of Anti-HCV tested source
1720:
145:
282:
EC directive on blood products, HIV 1 and 2 testing, Hepatitis C, anti HCV testing.
1262:
1076:
294:
169:
1439:
Lord Warner, The Minister of State, Department of Health (27 February 2006).
1355:
890:
246:
211:
Creutzfeldt-Jakob Disease, the EC directive on blood products, HTLV-I testing.
1384:
1548:"Cameron apologises to those infected with hepatitis C and HIV 30 years ago"
1263:"Tenth Meeting of the Advisory Committee on the Virological Safety of Blood"
590:
417:
238:
120:
867:(Report). Infected Blood Inquiry. 19 October 2021. p. 218. WITN0672006
1141:"Seventh Meeting of the Advisory Committee on Virological Safety of Blood"
152:
as well as blood, and the viral agents to be considered by the group were
371:
1696:
Caroline Flint, Minister of State for Public Health (14 May 2007).
1460:
Caroline Flint, Minister of State for Public Health (23 May 2006).
1415:
HIV and Hepatitis C infection from contaminated blood and blood products
997:
The report was given to the third meeting of the ACVSB on 3 July 1989...
777:
Minutes of the First Meeting on 4 April 1989 at the Department of Health
1702:
1466:
1445:
1325:"Professor Bloom and Cardiff Haemophilia Centre - Inquiry Presentation"
834:
Follow Up Submission by the Scottish National Blood Transfusion Service
413:
775:
Advisory Committee on the Virological Safety of Blood (4 April 1989).
1487:(Report). Department of Health. April 2000. p. 6. Archived from
449:
1077:"Fifth Meeting of Advisory Committee on Virological Safety of Blood"
329:
1385:"ACVSB Minutes - Parvovirus B19 Contamination of Factor Products"
653:"Advisory Committee on the Virological Safety of Blood - Members"
1504:...although volumes 14-17 were destroyed, volumes 1-3 survive...
55:
686:"Dr Jeremy Metters (scheduled to give evidence 14th July 1998)"
242:
1667:"Bereaved families fear blood scandal cover-up by officials"
586:"Bereaved families fear blood scandal cover‑up by officials"
1742:
Defunct departments of the Government of the United Kingdom
1420:(Report). House of Commons Library. p. 22. SN/SC/5698
760:
The task of the Advisory Committee was to devise policy...
1637:"Shred of Evidence; Fury at HIV blood scandal 'cover-up'"
1295:"Minutes of the Eleventh Meeting Held on 29 October 1991"
374:, hepatitis A, virally inactivated fresh frozen plasma.
619:
Advisory Committee on the Virological Safety of Blood.
1546:
Carrell, Severin; Perraudin, Frances (25 March 2015).
1205:"Minutes of the 9th Meeting held on 25 February 1991"
1173:"Minutes of the 8th Meeting held on 21 November 1990"
117:
Advisory Committee on the Virological Safety of Blood
22:
Advisory Committee on the Virological Safety of Blood
810:. Preliminary Report (Report). Penrose Inquiry. 2010
1240:(Report). BSE Inquiry. YB 91/1.2/2.7 (BSE21/1 0074)
952:"Minutes of the Second Meeting Held on 22 May 1989"
101:
85:
77:
69:
61:
50:
42:
34:
26:
1109:"Minutes of the 6th meeting held on 24 April 1990"
981:"A & Ors v National Blood Authority & Ors"
38:Microbiological Safety of Blood and Tissues (MSBT)
1527:. Infected Blood Inquiry. p. 26. WITN4505389
1365:. Penrose Inquiry. 21 February 1992. SNB.001.9204
1214:. Penrose Inquiry. 25 February 1991. SNB.001.8934
1182:. Penrose Inquiry. 21 November 1990. SNB.001.1777
1304:. Penrose Inquiry. 29 October 1991. SNB.001.9148
1086:. Penrose Inquiry. 17 January 1990. SNF.001.1491
1051:. Penrose Inquiry. 30 October 1989. SNF.001.1383
719:A & Ors v National Blood Authority & Ors
537:A & Ors v National Blood Authority & Ors
462:Contaminated blood scandal in the United Kingdom
1518:"Third Written Statement of Charles Lister OBE"
1118:. Penrose Inquiry. 24 April 1990. SNB.001.9761
735:
733:
770:
768:
16:Defunct UK advisory committee on blood safety
8:
1665:Burgess, Kaya; Halle, Martyn (13 May 2019).
1272:. Penrose Inquiry. 21 May 1991. SNB.001.9107
1150:. Penrose Inquiry. 2 July 1990. SNF.001.1706
1019:. Penrose Inquiry. 3 July 1989. SNB.001.9513
961:. Penrose Inquiry. 22 May 1989. SNB.001.9416
584:Burgess, Kaya; Halle, Martyn (13 May 2019).
21:
1010:"Minutes of the 3rd Meeting of 3 July 1989"
862:Written Statement of Dr Gail Miflin (NHSBT)
836:(Report). Scottish Parliament. SP Paper 398
1470:. House of Commons. col. 1742W–1743W.
1350:
1348:
1289:
1287:
1257:
1255:
1199:
1197:
1167:
1165:
1135:
1133:
1103:
1101:
1071:
1069:
1042:"Department of Health and Social Security"
1036:
1034:
802:
800:
557:(Report). Penrose Inquiry. 2010. para 9.34
20:
1706:. House of Commons. col. 571W–573W.
856:
854:
679:
677:
614:
612:
531:
529:
647:
645:
579:
577:
575:
187:
782:(Report). Penrose Inquiry. SNF.001.1219
494:
492:
488:
467:Contaminated haemophilia blood products
436:A and Others v National Blood Authority
1462:"Destroyed Documents (Blood Products)"
1449:. House of Lords. col. WA26–WA27.
328:(ME) and blood transfusion, CJD agent/
1482:Hepatitis C Litigation - Final Report
510:. Infected Blood Inquiry. WITN3530007
448:, the ACVSB recommended the use of a
109:Dr J Metters (chair from August 1989)
7:
1732:Blood donation in the United Kingdom
1330:. Infected Blood Inquiry. p. 79
1248:– via nationalarchives.gov.uk.
877:The ACVSB first met on 4 April 1989.
119:, often abbreviated to ACVSB, was a
1441:"NHS: Contaminated Blood Products"
1413:Dr Gavin Colthart (13 July 2011).
501:"Written Statement of Marc Turner"
14:
1635:Selby, Alan (27 September 2020).
1323:Ms Richards (24 September 2020).
684:Metters, Jeremy (14 July 1998).
319:Hepatitis C: UKBTS pilot study,
1703:Parliamentary Debates (Hansard)
1516:Lister, Charles (19 May 2022).
1467:Parliamentary Debates (Hansard)
1446:Parliamentary Debates (Hansard)
1235:ACVSB paper: Prions & Blood
1233:Dr H Pickles (2 January 1991).
929:. Penrose Inquiry. SNF.017.2159
900:. Penrose Inquiry. SGH.003.1137
889:Tucker, G W (8 February 1993).
662:. Penrose Inquiry. SNB.001.9364
630:. Penrose Inquiry. SNB.001.9366
499:Turner, Marc (7 October 2021).
222:HTLV-I, Non A Non B hepatitis,
920:"A38112 Schedule of Questions"
1:
1502:– via Squarespace.com.
140:-screening of blood donors.
808:"9 - Hepatitis 1986 to date"
243:Human Immunodeficiency Virus
127:to devise policy and advise
123:formed in March 1989 in the
1671:The Times (London, England)
1525:infectedbloodinquiry.org.uk
508:infectedbloodinquiry.org.uk
1758:
472:HIV Haemophilia Litigation
446:HIV Haemophilia Litigation
247:human coagulation proteins
1737:History of blood donation
1581:www.penroseinquiry.org.uk
832:Health Committee (2001).
174:Creutzfeldt–Jakob disease
164:, Non A Non B Hepatitis,
326:chronic fatigue syndrome
1698:"Blood: Contamination"
423:Hepatitis C Litigation
189:Meetings of the ACVSB
172:and the prion disease
107:Dr E L Harris (chair);
1363:penroseinquiry.org.uk
1302:penroseinquiry.org.uk
1270:penroseinquiry.org.uk
1212:penroseinquiry.org.uk
1180:penroseinquiry.org.uk
1148:penroseinquiry.org.uk
1116:penroseinquiry.org.uk
1084:penroseinquiry.org.uk
1049:penroseinquiry.org.uk
1017:penroseinquiry.org.uk
959:penroseinquiry.org.uk
927:penroseinquiry.org.uk
898:penroseinquiry.org.uk
748:penroseinquiry.org.uk
695:. BSE Inquiry. No 116
660:penroseinquiry.org.uk
628:penroseinquiry.org.uk
54:Dr H. H. Gunson, and
1643:. London. p. 28
1391:. TaintedBlood. 2006
621:"Terms of Reference"
407:Destruction of files
224:Human Growth Hormone
133:Department of Health
400:in blood products.
190:
23:
1681:– via Gale.
1494:on 29 January 2022
555:Preliminary Report
390:Fourteenth meeting
379:Thirteenth meeting
188:
1389:taintedblood.info
693:bseinquiry.gov.uk
404:
403:
393:29 September 1992
332:in blood donors.
239:gamma irradiation
200:Topics discussed
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363:21 February 1992
348:Eleventh meeting
316:25 February 1991
305:21 November 1990
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987:. 26 March 2001
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542: QB 446
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477:Penrose Inquiry
458:
431:
409:
360:Twelfth meeting
351:29 October 1991
287:Seventh meeting
268:17 January 1990
257:6 November 1989
182:
108:
104:
97:
92:
17:
12:
11:
5:
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1610:www.bailii.org
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911:
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764:
750:. 4 April 1989
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421:list from the
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398:parvovirus B19
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302:Eighth meeting
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150:donor organs
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46:8 March 1989
27:Abbreviation
18:
1727:Hepatitis C
444:During the
382:2 July 1992
340:21 May 1991
290:2 July 1990
234:3 July 1989
219:22 May 1989
1721:Categories
1677:31 January
1647:31 January
1641:The People
1616:31 January
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1424:28 January
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514:23 January
483:References
170:parvovirus
103:Key people
591:The Times
418:The Times
129:ministers
121:committee
43:Formation
35:Successor
1684:viruses.
1564:start...
594:. London
456:See also
372:Yersinia
180:Meetings
131:and the
86:Location
73:Advisory
1593:1991...
1531:29 June
414:Hansard
241:on the
194:Meeting
176:(CJD).
62:Defunct
51:Founder
1612:. 2001
723:,
540:,
450:waiver
330:prions
295:plasma
162:HTLV-I
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321:NIBSC
78:Focus
30:ACVSB
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368:PHLS
245:and
197:Date
158:HIV2
156:and
154:HIV1
148:and
115:The
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725:446
166:CMV
138:HCV
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