63:
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The spin probe molecules bound on albumin have restricted mobility that changes the EPR spectrum, which reflects characteristics of the protein site where the spin probe is located and allows estimating the conformation of the albumin globule. Some part of the spin probe remains in the serum in the
884:
Gelos, Marcos; Hinderberger, Dariush; Welsing, Ellen; Belting, Julia; Schnurr, Kerstin; Mann, Benno (2010). "Analysis of albumin fatty acid binding capacity in patients with benign and malignant colorectal diseases using electron spin resonance (ESR) spectroscopy".
330:
unbound state. The ratio of the fractions of bound and unbound spin probes allows estimating the functional activity of albumin molecules. Analysis of the EPR spectrum allows assessment of the conformation and functional activity of albumin molecules.
35:
832:
Gurachevsky, Andrey; Muravskaya, Ekaterina; Gurachevskaya, Tatjana; Smirnova, Lena; Muravsky, Vladimir (2007). "Cancer-Associated
Alteration in Fatty Acid Binding to Albumin Studied by Spin-Label Electron Spin Resonance".
589:
Kalachyk, A.; Ugolev, I.; Zabello, T.; Voitovich, V. (2014). "Electron Spin
Resonance Spectroscopy of Albumin Transport Quality Is a New Test for Diagnosis of Kidney Transplant Acute Rejection.: Abstract# A232".
936:
Gurachevsky, Andrey; Kazmierczak, Steven C.; Jörres, Achim; Muravsky, Vladimir (2008-01-01). "Application of spin label electron paramagnetic resonance in the diagnosis and prognosis of cancer and sepsis".
41:
348:, incubating the mixture, measuring the EPR spectrum of a serum with a spin probe, and analyzing the EPR spectrum by calculating the conformation and functional indicators of albumin molecules.
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183:
1037:"Economical Justification of the Innovation Method of Laboratory Diagnostic of the Structural and Functional Changes of Serum Albumin in Septic Complications (Ata-Test)"
521:
127:
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Seidel P, Gurachevsky A, Muravsky V, Schnurr K, Seibt G, Matthes G (2005). "Recognition of malignant processes with neural nets from ESR spectra of serum albumin".
99:
106:
1073:"Detoxifying activity of serum albumin demonstrated diagnostic utility in patients with kidney transplant dysfunction and pregnant women with preeclampcia"
113:
95:
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Klinkmann, Gerd; Waterstradt, Katja; Klammt, Sebastian; Schnurr, Kerstin; Schewe, Jens-Christian; Wasserkort, Reinhold; Mitzner, Steffen (2023).
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1091:"Electron spin resonance spectroscopy of serum albumin is a novel test for diagnosis of the kidney transplant acute rejection"
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Reduced functional activity of serum albumin (reduced binding efficacy) is associated with toxemia (an increase in the
377:
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V.Muravsky; A.Gurachevsky; G.Matthes (2007). "Disease-specific albumin patterns defined by electron spin resonance".
1136:
73:
1141:
697:
Lance A. Liotta; Emanuel F. Petricoin; David A. Fishman; Vincent Fusaro; Mark S. Lowenthal; Sally Ross (2003).
650:"Electron Spin Resonance Spectroscopy of Serum Albumin: A Novel New Test for Cancer Diagnosis and Monitoring"
440:
433:
245:
515:
537:"Exploring Albumin Functionality Assays: A Pilot Study on Sepsis Evaluation in Intensive Care Medicine"
990:"Spin electron paramagnetic resonance of albumin for diagnosis of oral squamous cell carcinoma (OSCC)"
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A specific change to the conformation of albumin molecules that is associated with the growth of a
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750:"Analysis of Albumin-Associated Peptides and Proteins from Ovarian Cancer Patients"
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Vorobiev P, Bezmelnitsyna L, Krasnova L, Muravsky V, Davidova T, Sytov A (2013).
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to determine whether the cancer growth has stopped or the disease is progressing;
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476:"Binding and detoxification efficiency of albumin decline after haemodialysis"
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Kazmierczak, S. C.; Gurachevsky, A.; Matthes, G.; Muravsky, V. (2006-09-21).
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Maximilian
Moergel; Peer W. Kämmerer; Kerstin Schnurr; et al. (2012).
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A. Kalachyk; I. Ugolev; T. Zabello; E. Oganova; V. Muravsky (2014-01-01).
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to determine when cancer treatment is effective or needs to be changed.
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cancer cells uptake and release metabolites in abnormal quantities).
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16-doxyl stearate. Spin probe molecules bind specifically to albumin
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Clinical studies of the EPR test of serum albumin showed diagnostic
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Kristina Boss, Katja
Waterstradt, Kerstin Schnurr (2023-10-29).
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of toxic molecules in the blood) and is manifested before other
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carried by serum albumin during the growth of a malignant tumor
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is caused by (or associated with) changes in the composition of
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The procedure includes mixing a serum sample with a spin probe
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prognosis and early diagnosis of sepsis (1 to 2 hours after
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to detect cancer-specific metabolic alterations in patients;
699:"Biomarker Amplification by Serum Carrier Protein Binding"
96:"Albumin transport function analysis by EPR spectroscopy"
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area between the protein domains in the interior of the
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Albumin transport function analysis by EPR spectroscopy
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may be too technical for most readers to understand
287:with serum albumin by means of EPR spectroscopy.
1071:U. Muravski; A. Kalachyk; T. Ivanets (2015).
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520:: CS1 maint: multiple names: authors list (
887:International Journal of Colorectal Disease
541:International Journal of Molecular Sciences
50:Learn how and when to remove these messages
1095:Clinical Chemistry and Laboratory Medicine
939:Clinical Chemistry and Laboratory Medicine
439:diagnostics of the functional status of a
244:that detects changes to the transport and
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280:The test is based on the interaction of
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432:(gestosis) in women in the 2nd and 3rd
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302:where they occupy two main positions:
83:Please improve this article by adding
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480:Nephrology, Dialysis, Transplantation
184:make it understandable to non-experts
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604:10.1097/00007890-201407151-01549
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748:Lowenthal, M. S. (2005-10-01).
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85:secondary or tertiary sources
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667:10.1373/clinchem.2006.073148
378:sensitivity and specificity
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1006:10.1007/s00784-011-0655-3
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847:10.1080/07357900701407947
333:The test material is 100
317:the relatively spacious
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434:trimesters of pregnancy
417:Clinical applications:
383:Clinical applications:
256:. The test is used for
1108:10.1515/cclm-2014-4035
246:molecular conformation
72:relies excessively on
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554:10.3390/ijms241612551
835:Cancer Investigation
428:diagnosis of severe
252:using the method of
716:10.1155/2003/104879
489:10.1093/ndt/gfad133
445:early diagnosis of
754:Clinical Chemistry
654:Clinical Chemistry
402:Sepsis and toxemia
294:is subjected to a
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482:: gfad133.
367:metabolites
319:hydrophobic
310:located in
292:blood serum
285:fatty acids
1131:Categories
627:Tumor Biol
461:References
447:congenital
296:spin probe
276:Principles
242:blood test
107:newspapers
74:references
36:improve it
1117:1437-4331
959:1437-4331
907:0179-1958
855:0735-7907
776:0009-9147
676:0009-9147
635:1423-0380
612:0041-1337
450:pneumonia
337:serum or
300:molecules
258:diagnosis
42:talk page
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454:newborns
380:of 90%.
306:primary
238:in vitro
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423:surgery
346:reagent
270:toxemia
178:Please
121:scholar
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266:sepsis
262:cancer
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387:as a
128:JSTOR
114:books
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1010:PMID
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268:and
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1103:doi
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