31:
298:
and then
Professor, from 2001 to 2017. Between 2002 and 2006, she was vice-chair, then chair, of the Biomedical Sciences Graduate Program before becoming the Director of the Molecular Pharmacology Track in the Biomedical Sciences Graduate Program at the University of California San Diego. She was
1246:
350:
As of 2020, Newton has published over 190 peer-reviewed research articles that have been cited more than 25,000 times, been awarded 1 patent and co-edited two books on protein biochemistry and
304:
300:
386:
1191:
1201:
1206:
307:
Executive
Committee for Congresses and Conferences. Newton has supervised, and graduated, more 25 PhD postgraduate students and trained 23 Postdoctoral Fellows.
1118:
Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC (2015).
1251:
1037:
1012:
1196:
1120:"Protein kinase CΞ± gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation"
1055:"Protein kinase CΞ± gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation"
484:
Newton AC, Cook SL, Huestis WH (1983). "Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells".
1211:
291:
195:
130:
1241:
382:
271:
145:
377:
between 1995 and 2000, an associate editor of
Molecular Pharmacology (2000-2003) and since 1990, has been an expert reviewer for the
1216:
347:(PH domain and Leucine rich repeat Protein Phosphatases), which regulate intracellular signaling through dephosphorylation of AKT.
1221:
374:
1171:
1226:
1003:
Malacinski GM, Frielder D (1993). "Chapter 4: Essentials of
Molecular Biology: The physical structure of protein molecules".
219:
726:
Orr JW, Newton AC (1992). "Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding".
303:, having served, since 2016, as ASBMB representative to the IUBMB general assembly, and, since 2015, as a Member of the
299:
conferred with the title of
Distinguished Professor of Pharmacology in 2017. As of 2020, she is president-elect for the
378:
761:
Orr JW, Newton AC (1992). "Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation".
456:
1236:
215:
687:"Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol"
206:
biochemistry and cell biology research group in the School of
Medicine, investigating molecular mechanisms of
247:
150:
589:
442:
410:
1231:
838:"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth"
359:
320:
275:
975:
879:"Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer"
340:
287:
279:
259:
207:
140:
104:
63:
278:
between 1986 and 1988, and subsequently began her own independent research laboratory in 1988, as
336:
283:
135:
109:
560:
521:"Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells"
1149:
1086:
1033:
1008:
957:
908:
859:
818:
778:
743:
708:
667:
626:
542:
501:
255:
1139:
1131:
1076:
1066:
947:
939:
898:
890:
849:
808:
770:
735:
698:
657:
646:"High cooperativity, specificity, and multiplicity in the protein kinase C-lipd interaction"
616:
532:
493:
355:
351:
324:
316:
199:
89:
262:, working with Wray H. Huestis on a thesis examining band 3, a red cell membrane protein.
328:
243:
211:
1104:
1144:
1119:
1081:
1054:
1053:
Callender JA, Yang Y, LordΓ©n G, Stephenson NL, Jones AC, Brognard J, Newton AC (2018).
952:
927:
903:
878:
203:
94:
84:
30:
813:
797:
703:
686:
662:
645:
621:
604:
537:
520:
218:(PI3 kinase, or PI3-K) signaling pathways. She has been continuously funded by the US
1185:
470:
332:
62:
Julius
Axelrod Award in Pharmacology, ASPET (2019), Biophysics of Health and Disease
295:
251:
191:
1028:
Newton AC (2003). "Methods in
Molecular Biology 233: Protein Kinase C Protocols".
1167:
894:
854:
837:
1135:
270:
Following her PhD defense, Newton took up a postdoctoral research position at
1071:
235:
231:
42:
1247:
Presidents of the
International Union of Biochemistry and Molecular Biology
1153:
1090:
961:
912:
863:
798:"Requirement for negative charge on "activation loop" of protein kinase C."
190:
is a
Canadian and American biochemist. She is a Distinguished Professor of
822:
782:
747:
712:
671:
630:
546:
505:
354:. Her work straddles basic research and has illuminated understanding of
943:
774:
739:
497:
471:"Professor Wray Huestis Laboratory - University of California, Stanford"
976:"Alexandra Newton Google Scholar β University of California, San Diego"
363:
928:"PHLPPing through history: a decade in the life of PHLPP phosphatases"
425:"Health Sciences International β University of California, San Diego"
239:
160:
385:. She has been chair, or co-chair, for multiple committees of the
344:
114:
605:"Protein Kinase C Autophosphorylates by an Intrapeptide Reaction"
439:"PKC Signaling Laboratory - University of California, San Diego"
407:"PKC Signaling Laboratory - University of California, San Diego"
99:
250:
in Canada, where she was awarded a 1st-class honours degree in
1105:"Podcast: PKCalpha in Alzheimer's disease - Science Signaling"
585:
438:
406:
369:
Editorials, research honours, scientific service and outreach
323: She helped define the multiple different mechanisms of
179:
991:
Chimeric phosphorylation indicator: US Patent No. 8,669,074
561:"International Union of Biochemistry and Molecular Biology"
305:
International Union of Biochemistry and Molecular Biology
301:
International Union of Biochemistry and Molecular Biology
424:
319:
research field since the 1980s, working originally with
387:
American Society for Biochemistry and Molecular Biology
877:
Baffi TR, Van AN, Zhao W, Mills GB, Newton AC (2019).
564:
175:
159:
123:
77:
58:
50:
37:
21:
373:Newton was a member of the editorial board of the
54:Simon Fraser University, Stanford University (PhD)
258:. She received her PhD in chemistry in 1986 from
989:Violin JD, Newton AC, Tsien RJ, Zhang J (2004),
339:She has also made important discoveries in the
8:
1192:University of California, San Diego faculty
457:"Inspiring Alumna, Simon Fraser University"
331:and its interaction with specific membrane
1202:University of California, Berkeley faculty
29:
18:
1207:Academic staff of Simon Fraser University
1143:
1080:
1070:
951:
902:
853:
812:
702:
661:
620:
536:
294:in 1995, first as associate professor in
398:
1005:Jones & Bartlett Publishers,Boston
685:Orr JW, Keranen LM, Newton AC (1992).
315:Newton has been a major driver in the
7:
836:Gao T, Furnari F, Newton AC (2005).
234:, South Africa, and was schooled in
362:and as a tumor suppressor in human
292:University of California, San Diego
286:, subsequently receiving tenure as
196:University of California, San Diego
131:University of California, San Diego
1168:"Lipid Division Spotlight - ASBMB"
383:Medical Research Council of Canada
272:University of California, Berkeley
246:. She graduated in 1980 from the
198:. Newton runs a multidisciplinary
146:University of California, Berkeley
14:
166:'Intermembrane Protein Transfer'
1174:from the original on 2018-08-27.
932:Biochemical Society Transactions
926:Grzechnik AT, Newton AC (2019).
592:from the original on 2006-08-29.
445:from the original on 2006-08-29.
413:from the original on 2006-08-29.
16:US-based Protein Kinase C expert
801:Journal of Biological Chemistry
691:Journal of Biological Chemistry
650:Journal of Biological Chemistry
609:Journal of Biological Chemistry
525:Journal of Biological Chemistry
375:Journal of Biological Chemistry
1252:Simon Fraser University alumni
644:Newton A, Koshland DE (1989).
603:Newton A, Koshland DE (1987).
519:Huestis WH, Newton AC (1986).
343:field, discovering and naming
1:
814:10.1016/S0021-9258(18)47044-5
704:10.1016/S0021-9258(19)49525-2
663:10.1016/S0021-9258(18)63788-3
622:10.1016/S0021-9258(18)61095-6
538:10.1016/S0021-9258(18)66712-2
220:National Institutes of Health
895:10.1016/j.molcel.2019.02.018
855:10.1016/j.molcel.2005.03.008
1197:Stanford University faculty
379:National Science Foundation
1268:
1212:Stanford University alumni
1136:10.1016/j.cell.2015.01.001
1242:Scientists from Cape Town
796:Orr JW, Newton A (1994).
216:Phosphoinositide 3-kinase
180:http://newtonlab.ucsd.edu
171:
70:
28:
1217:American pharmacologists
226:Early life and education
1222:British pharmacologists
1072:10.1073/pnas.1805046115
248:Simon Fraser University
151:Simon Fraser University
321:Daniel E. Koshland Jr.
290:in 1994. She moved to
276:Daniel E. Koshland Jr.
1227:Women pharmacologists
274:in the laboratory of
944:10.1042/BST20160170
807:(44): 27715β27718.
775:10.1021/bi00134a019
740:10.1021/bi00134a018
697:(22): 15263β15266.
656:(25): 14909β14915.
615:(21): 10185β10188.
531:(34): 16274β16278.
498:10.1021/bi00295a011
360:Alzheimer's disease
341:protein phosphatase
288:associate professor
280:assistant professor
260:Stanford University
230:Newton was born in
208:signal transduction
188:Alexandra C. Newton
141:Stanford University
105:Protein phosphatase
64:Biophysical Society
23:Alexandra C. Newton
337:phosphatidylserine
284:Indiana University
136:Indiana University
1237:People from Wigan
1065:(24): 5497β5505.
1039:978-1-59259-397-2
1014:978-0-8672-0137-6
769:(19): 4667β4673.
734:(19): 4661β4667.
492:(26): 6110β6117.
256:French literature
185:
184:
72:Scientific career
1259:
1176:
1175:
1164:
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1115:
1109:
1108:
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1095:
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1025:
1019:
1018:
1000:
994:
993:
986:
980:
979:
972:
966:
965:
955:
938:(6): 1675β1682.
923:
917:
916:
906:
874:
868:
867:
857:
833:
827:
826:
816:
793:
787:
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594:
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563:. Archived from
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481:
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467:
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282:in Chemistry at
200:Protein kinase C
90:Protein kinase C
33:
19:
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405:
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400:
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371:
329:phosphorylation
313:
268:
244:Aix-en-Provence
228:
212:Phospholipase C
155:
119:
51:Alma mater
46:
24:
17:
12:
11:
5:
1265:
1263:
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1234:
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1224:
1219:
1214:
1209:
1204:
1199:
1194:
1184:
1183:
1178:
1177:
1159:
1130:(3): 489β502.
1110:
1096:
1045:
1038:
1020:
1013:
995:
981:
967:
918:
889:(2): 378β392.
883:Molecular Cell
869:
842:Molecular Cell
828:
788:
753:
718:
677:
636:
595:
577:
552:
511:
476:
462:
448:
430:
416:
397:
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370:
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327:regulation by
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227:
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204:Cell signaling
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95:Protein Kinase
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85:Cell Signaling
81:
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60:
56:
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52:
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45:, South Africa
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3:
2:
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1232:Living people
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581:
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567:on 2019-03-24
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333:phospholipids
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27:
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1030:Humana Press
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1023:
1004:
998:
990:
984:
970:
935:
931:
921:
886:
882:
872:
848:(1): 13β24.
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841:
831:
804:
800:
791:
766:
763:Biochemistry
762:
756:
731:
728:Biochemistry
727:
721:
694:
690:
680:
653:
649:
639:
612:
608:
598:
586:"PhD awards"
580:
569:. Retrieved
565:the original
555:
528:
524:
514:
489:
486:Biochemistry
485:
479:
465:
451:
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419:
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372:
349:
314:
296:pharmacology
269:
252:biochemistry
229:
222:since 1988.
192:pharmacology
187:
186:
165:
124:Institutions
71:
110:Diglcyeride
1186:Categories
571:2020-04-01
393:References
335:, such as
214:(PLC) and
236:Vancouver
232:Cape Town
43:Cape Town
1172:Archived
1154:25619690
1091:29844158
962:27913677
913:30904392
864:15808505
590:Archived
443:Archived
411:Archived
311:Research
1145:4313737
1082:6004447
1032:: 584.
1007:: 335.
953:5783572
904:6504549
823:7961692
783:1581317
748:1581316
713:1639770
672:2768246
631:3611058
547:3782118
506:6661430
364:cancers
210:in the
194:at the
176:Website
1152:
1142:
1089:
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1036:
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960:
950:
911:
901:
862:
821:
781:
746:
711:
670:
629:
545:
504:
266:Career
242:, and
240:Athens
161:Thesis
78:Fields
66:(2020)
59:Awards
345:PHLPP
115:PHLPP
1150:PMID
1124:Cell
1087:PMID
1059:PNAS
1034:ISBN
1009:ISBN
958:PMID
909:PMID
860:PMID
819:PMID
779:PMID
744:PMID
709:PMID
668:PMID
627:PMID
543:PMID
502:PMID
381:and
254:and
202:and
100:AKT1
38:Born
1140:PMC
1132:doi
1128:160
1077:PMC
1067:doi
1063:115
948:PMC
940:doi
899:PMC
891:doi
850:doi
809:doi
805:269
771:doi
736:doi
699:doi
695:267
658:doi
654:264
617:doi
613:262
533:doi
529:261
494:doi
358:in
356:PKC
352:PKC
325:PKC
317:PKC
1188::
1170:.
1148:.
1138:.
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1122:.
1085:.
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956:.
946:.
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978:.
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773::
750:.
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715:.
701::
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633:.
619::
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549:.
535::
508:.
496::
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459:.
427:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
