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Alkhurma virus

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496:, where any suspected case of ALKV must be reported immediately. Three forms must be filled out to properly ensure the virus is being sufficiently monitored: A suspect case form, an epidemiological investigation form, and a laboratory requisition form. The hospitals and health centers, either governmental or private, report the potential ALKV case to the desk officers in charge of viral hemorrhagic fevers at the Directorate of Health Affairs in their respective region. Afterward, the desk officer forwards the report to the Directorate of Infectious Diseases at the Preventive Medicine Department at the Ministry of Health. Before entering the case into the database system, the desk officer in charge of AHFV reviews the case reports for accuracy and completion. Subsequently, the desk officer at the Ministry of Health formulates daily reports for the higher directors at the Ministry of Health and forwards them as feedback to the regions and their respective health units. 441:, has been created or made readily available. The best measures for combating ALKV are basic tick bite prevention, such as using tick repellents and avoiding regions where ticks are found in abundance, and raising awareness. Limiting non-casual contact with livestock and domestic animals is also another way of prevention. Individuals should appropriately check for attached ticks and remove them as soon as possible if found. Tick collars for domestic animals and the use of 260: 242: 429:(ELISA) can be made afterward. Treatment consists of supportive therapy which balances the person's fluids and electrolytes, oxygen status and blood pressure monitored and maintained, and additional treatment for any further complications. The mortality rate of hospitalized patients ranges from 1 to 20%. 462:
and sheep have been linked to be the natural hosts of this virus. There appears to be more than one possible route of transmission seen in people who have become infected with this virus: one or more bites by an infected tick, crushing an infected tick with unprotected fingers, ingestion of
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Hoffman, Tove; Lindeborg, Mats; Barboutis, Christos; Erciyas-Yavuz, Kiraz; Evander, Magnus; Fransson, Thord; Figuerola, Jordi; Jaenson, Thomas G.T.; Kiat, Yosef; Lindgren, Per-Eric; Lundkvist, Åke; Mohamed, Nahla; Moutailler, Sara; Nyström, Fredrik; Olsen, Björn; Salaneck, Erik (2018).
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encoding over 3,000 amino acid polyproteins. The AnhC, PrM, M, NS2A, NS2B, NS3, NS4A, 2K, NS4B and NS5 proteins are all of the same length. ALKV owns the largest polyprotein of all TB-flaviviruses calculated as of yet. ALKV has been found to be closely related to the
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are efficient in killing ticks on livestock. People working with animals or animal products in farms or slaughterhouses should refrain from making unprotected contact with the blood, tissues, or fluids (such as consuming
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As a response to the troubling illness, the KSA (Kingdom of Saudi Arabia) is treating ALKV as one of the nationally notifiable diseases in the country. An effective surveillance system was established by the
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Charrel RN, Zaki AM, Attoui H, et al. (2001). "Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia".
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The geographic distribution of the virus has extended beyond Saudi Arabia; reports of ALKV have been documented in countries where there is no endemic vector of the disease, such as
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Charrel, Rémi; Zaki, Ali; Attoui, Houssam; Fakeeh, Mazen; Billoir, Frédérique; Yousef, Amany; Chesse, Reine; Micco, Philippe; Gould, Ernest; Lamballerie, Xavier (17 August 2001).
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Laboratory diagnosis of ALKV can be performed in the early stages of the illness by molecular detection of PCR or virus isolation from the blood. Serologic testing using
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Alzahrani, Abdullah; Al Shaiban, Hassan; Al Mazroa, Mohammed; Al-Hayani, Osama; MacNeil, Adam; Rollin, Pierre; Memish, Ziad (December 2010).
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After an incubation period lasting as short as 2–4 days or as long as 8 days, people with AHF develop symptoms including fever, headache,
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Memish, Ziad; Fagbo, Shamsudeen; Assiri, Abdullah; Rollin, Pierre; Zaki, Ali; Charrel, Remi; Mores, Chris; MacNeil, Adam (31 July 2012).
2967: 1941: 800:"Complete Coding Sequence of the Alkhurma Virus, a Tick-Borne Flavivirus Causing Severe Hemorrhagic Fever in Humans in Saudi Arabia" 493: 1563: 2453: 2293: 1826: 1821: 1619: 2963: 3102: 2971: 2228: 737:
Zaki AM (1997). "Isolation of a flavivirus related to the tick-borne encephalitis complex from human cases in Saudi Arabia".
3027: 881:"Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts" 618: 2485: 2125: 1724: 1302: 370: 3468: 3006: 2776: 2771: 2379: 1163:
Memish, Ziad; Fagbo, Shamsudeen; Ali, Ahmed; AlHakeem, Rafat; Elnagi, Fatherlrhman; Bamgboye, Elijah (6 February 2014).
1115: 537:. Since then, over 40 cases of ALKV, with case fatality rates less than 1%, have been reported. ALKV is classified as a 711: 3037: 2986: 2406: 2401: 2389: 1931: 1814: 879:
Dodd, KA; Bird, BH; Khristova, ML; Albariño, CG; Carroll, SA; Comer, JA; Erickson, BR; Rollin, PE; Nichol, ST (2011).
799: 1350:"Alkhurma Viral Hemorrhagic Fever Virus: Proposed Guidelines for Detection, Prevention, and Control in Saudi Arabia" 259: 3445: 2495: 2413: 2394: 1760: 2618: 2081: 1225:"Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor" 518: 501: 1973: 3371: 2996: 2991: 2697: 2640: 2518: 2313: 1838: 3132: 3107: 2801: 2463: 2458: 2363: 2158: 2144: 2120: 2062: 1872: 1756: 406: 88: 3393: 3267: 3112: 2148: 2116: 2092: 1927: 1805: 1729: 1704: 1690: 1669: 1165:"Is the Epidemiology of Alkhurma Hemorrhagic Fever Changing? : A Three-Year Overview in Saudi Arabia" 458:
The route of transmission for ALKV is not fully understood and is filled with huge knowledge gaps, though
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Carletti, F; Castilletti, C; Di Caro, A; Capobianchi, MR; Nisii, C; Suter, F; et al. (2010).
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was retrieved from a person in Saudi Arabia during the 1990s. It was found to contain over 10,000
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Sometimes misidentified as "Al-Khumra" virus—"It's Al-Khurma, not Al-Khumra, says official",
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http://www.saudigazette.com.sa/index.cfm?method=home.regcon&contentID=2010011360023
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Charrel, RN; Fagbo, S; Moureau, G; Alqahtani, MH; Temmam, S; de Lamballerie, X (2007).
907: 880: 772: 595: 568: 534: 201: 197: 168:), or alternatively termed as Alkhurma hemorrhagic fever virus, and is mainly based in 750: 473:, as the vector. No cases of human-human transmission of AHF have ever been recorded. 3462: 3082: 3047: 2941: 2825: 2735: 2683: 2604: 2586: 2508: 2428: 2304: 2286: 2198: 1988: 1645: 1309: 654: 296: 3329: 3077: 3032: 2981: 2959: 2949: 2839: 2665: 2439: 2254: 2173: 2107: 2096: 2053: 1888: 1881: 1876: 1831: 1796: 1739: 1681: 344: 332: 320: 241: 221: 169: 156: 1649: 521:, Saudi Arabia during the 1990s, who became sick with an acute, fatal hemorrhagic 1366: 1189: 897: 629: 585: 3425: 3250: 3019: 2670: 2660: 2564: 2545: 2372: 2367: 2263: 2027: 1961: 1918: 1848: 1770: 1694: 1561:
Alkhurma haemorrhagic fever - European Centre for Disease Prevention and Control
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Due to limited information pertaining to ALKV, no specific treatment, such as a
397: 217: 205: 185: 3416: 3150: 2857: 2787: 2757: 2707: 2591: 2473: 2354: 2209: 2087: 2018: 1900: 1749: 1322: 442: 356: 181: 81: 3214: 3055: 2866: 1658: 1484:"Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999" 467:, or entry via a skin wound. There is evidence pointing to the sand tampan, 284: 209: 73: 1546: 1538: 1517: 1499: 1434: 1416: 1385: 1258: 1240: 1208: 1146: 1128: 1069: 1051: 916: 826: 818: 604: 758: 3410: 1642: 682: 481: 68: 64: 1582: 2796: 2745: 2723: 2242: 514: 438: 224:(which can result in death), have been found in hospitalized patients. 193: 77: 3279: 2834: 2613: 2342: 2331: 1594: 60: 3387: 1111:"Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010" 864: 847: 513:
This virus was first isolated from the blood of a 32-year-old male
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Supportive therapy, monitoring of blood pressure and oxygen status
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Molecular detection of PCR, virus isolation, serologic testing
1401:"Alkhurma Hemorrhagic Fever in Humans, Najran, Saudi Arabia" 1279:. Uppsala University. Uppsala University: News. 1 June 2018 220:
and thrombocytopenia, which leads to hemorrhagic fever and
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Tambo, Ernest; El-Dessouky, Ashraf (27 September 2018).
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Biochemical and Biophysical Research Communications
1482:Charrel RN, Zaki AM, Fakeeh M, et al. (2005). 1158: 1156: 807:
Biochemical and Biophysical Research Communications
129: 121: 111: 103: 87: 49: 37: 29: 24: 1453:European Centre for Disease Prevention and Control 619:"Tick-Borne Encephalitis Virus Complex Fact Sheet" 1084:"Alkhurma Hemorrhagic Fever (AHF) - Transmission" 779:. U.S. Department of Health & Human Services 983:"Alkhurma Hemorrhagic Fever (AHF) - Prevention" 545:agent, depending on the country's regulations. 1329:. U.S. Department of Health and Human Services 957:"Alkhurma Hemorrhagic Fever (AHF) - Treatment" 931:"Alkhurma Hemorrhagic Fever (AHF) - Diagnosis" 2901: 1627: 8: 3123:Severe fever with thrombocytopenia syndrome 2078:Severe fever with thrombocytopenia syndrome 427:enzyme-linked immunosorbent serologic assay 125:Tick repellents, limit contact with animals 3388: 3209: 2937: 2928: 2908: 2894: 2886: 2820: 2730: 2540: 2349: 2338: 2249: 2048: 1676: 1665: 1634: 1620: 1612: 1573: 1327:Centers for Disease Control and Prevention 1088:Centers for Disease Control and Prevention 987:Centers for Disease Control and Prevention 961:Centers for Disease Control and Prevention 935:Centers for Disease Control and Prevention 777:Centers for Disease Control and Prevention 718:. MD Medicus Reise- und Tropenmedizin GmbH 687:Centers for Disease Control and Prevention 240: 231: 21: 1507: 1449:"Facts about Alkhurma haemorrhagic fever" 1424: 1375: 1365: 1248: 1198: 1188: 1136: 1059: 906: 896: 863: 594: 584: 562: 560: 558: 554: 33:Alkhurma hemorrhagic fever virus (AHFV) 450:) of any potentially infected animal. 44:Infectious disease (medical specialty) 3177:Southern tick-associated rash illness 2449:Hemorrhagic fever with renal syndrome 160:virus family (class IV). ALKV causes 7: 706: 704: 1952:Venezuelan equine encephalomyelitis 151: 1323:"Alkhurma Hemorrhagic Fever (AHF)" 773:"Alkhurma Hemorrhagic Fever (AHF)" 655:"Alkhurma Hemorrhagic Fever (AHF)" 14: 3402:Alkhumra hemorrhagic fever virus 1942:Western equine encephalomyelitis 1932:Eastern equine encephalomyelitis 1455:. European Union. Archived from 529:imported from the small city of 258: 249:Flavivirus structure and genome 25:Alkhurma hemorrhagic fever (AHF) 3093:Crimean–Congo hemorrhagic fever 2067:Crimean–Congo hemorrhagic fever 1015:. Weizmann Institute of Science 683:"Tick-borne Encephalitis (TBE)" 3103:Kemerovo tickborne viral fever 2229:Kemerovo tickborne viral fever 1: 2486:Hantavirus pulmonary syndrome 1725:Jamestown Canyon encephalitis 751:10.1016/S0035-9203(97)90215-7 739:Trans. R. Soc. Trop. Med. Hyg 371:Kyasanur Forest disease virus 154:) is a zoonotic virus of the 3007:Rocky Mountain spotted fever 2380:Venezuelan hemorrhagic fever 1367:10.1371/journal.pntd.0001604 1229:Emerging Infectious Diseases 1190:10.1371/journal.pone.0085564 1116:Emerging Infectious Diseases 1009:"Alkhurma Hemorrhagic Fever" 898:10.1371/journal.pntd.0001352 852:Clinical Infectious Diseases 586:10.1371/journal.pntd.0006707 3038:Relapsing fever borreliosis 2987:Spotted fever rickettsiosis 2402:Brazilian hemorrhagic fever 2390:Argentine hemorrhagic fever 519:Dr. Soliman Fakeeh Hospital 194:feeling of great discomfort 3490: 2414:Bolivian hemorrhagic fever 2294:Sandfly fever Naples virus 499:In 2018, the tick species 394:ALKV prototype strain 1776 162:Alkhurma hemorrhagic fever 3028:Baggio–Yoshinari syndrome 2082:Huaiyangshan banyangvirus 253: 248: 239: 234: 3372:Rhipicephalus sanguineus 2997:American tick bite fever 2992:Pacific Coast tick fever 2698:SARS-related coronavirus 2661:Henipavirus encephalitis 2519:Murid gammaherpesvirus 4 2364:Viral hemorrhagic fevers 2145:Viral hemorrhagic fevers 2117:Arbovirus encephalitides 2093:Arbovirus encephalitides 2063:Viral hemorrhagic fevers 2028:Banna virus encephalitis 1928:Arbovirus encephalitides 1873:Viral hemorrhagic fevers 1839:Saint Louis encephalitis 1806:Arbovirus encephalitides 1757:Viral hemorrhagic fevers 1691:Arbovirus encephalitides 716:Gesundes Reisen (German) 3133:Tick-borne encephalitis 3108:Kyasanur Forest disease 2802:Yaba monkey tumor virus 2159:Kyasanur Forest disease 2121:Tick-borne encephalitis 1822:Australian encephalitis 1715:California encephalitis 712:"Alkhurma Virus (AHFV)" 407:Kyasanur Forest disease 208:, and life-threatening 3268:Dermacentor variabilis 3113:Omsk hemorrhagic fever 2149:Omsk hemorrhagic fever 1730:La Crosse encephalitis 1539:10.1006/bbrc.2001.5610 1500:10.3201/eid1105.041298 1417:10.3201/eid1612.100417 1241:10.3201/eid2405.171369 1129:10.3201/eid1612.101092 1052:10.3201/eid1301.061094 819:10.1006/bbrc.2001.5610 411:Omsk hemorrhagic fever 214:Elevated liver enzymes 3261:Dermacentor andersoni 3239:Amblyomma triguttatum 3118:Powassan encephalitis 2582:Marburg virus disease 2133:Powassan encephalitis 1810:Japanese encephalitis 525:after slaughtering a 470:Ornithodoros savignyi 3354:Ornithodoros moubata 3340:Ornithodoros gurneyi 3232:Amblyomma cajennense 3225:Amblyomma americanum 3143:Protozoan infections 3128:Tete orthobunyavirus 3098:Heartland bandavirus 2968:Human monocytotropic 2933:Bacterial infections 2008:Semliki Forest virus 1488:Emerging Infect. Dis 1040:Emerging Infect. Dis 463:unpasteurised camel 255:Virus classification 3469:Tick-borne diseases 3347:Ornithodoros hermsi 3088:Colorado tick fever 2917:Tick-borne diseases 2555:Ebola virus disease 2219:Colorado tick fever 1974:O'nyong'nyong fever 1181:2014PLoSO...985564M 858:(4): iii–iv. 2010. 848:"In the Literature" 635:on 6 September 2017 98:meningoencephalitis 2964:Human granulocytic 2767:Simian foamy virus 1566:2019-09-25 at the 1459:on 16 January 2019 1354:PLOS Negl Trop Dis 1277:Uppsala University 885:PLOS Negl Trop Dis 573:PLOS Negl Trop Dis 494:Ministry of Health 448:unpasteurized milk 190:a loss of appetite 176:Signs and symptoms 3456: 3455: 3394:Taxon identifiers 3385: 3384: 3381: 3380: 3318:Ixodes scapularis 3297:Ixodes holocyclus 3206:Species and bites 3185: 3184: 3172:Alpha-gal allergy 3064: 3063: 2955:Boutonneuse fever 2883: 2882: 2879: 2878: 2875: 2874: 2810: 2809: 2718: 2717: 2528: 2527: 2326: 2325: 2322: 2321: 2237: 2236: 2036: 2035: 1781:Rift Valley fever 1609: 1608: 1411:(12): 1882–1888. 1299:The Saudi Gazette 1123:(12): 1979–1982. 1090:. U.S. Government 989:. U.S. Government 963:. U.S. Government 937:. U.S. Government 390: 389: 137: 136: 113:Diagnostic method 72:Severe symptoms: 19:Medical condition 3481: 3449: 3448: 3436: 3435: 3434: 3421: 3420: 3419: 3389: 3304:Ixodes pacificus 3290:Ixodes cornuatus 3210: 3197:Tick infestation 3070:Viral infections 2938: 2929: 2919:and infestations 2910: 2903: 2896: 2887: 2821: 2731: 2541: 2350: 2339: 2314:Chandipura virus 2250: 2190:Orthomyxoviridae 2049: 1996:Ross River fever 1761:Bunyamwera fever 1677: 1666: 1636: 1629: 1622: 1613: 1574: 1550: 1521: 1511: 1469: 1468: 1466: 1464: 1445: 1439: 1438: 1428: 1405:Emerg Infect Dis 1396: 1390: 1389: 1379: 1369: 1345: 1339: 1338: 1336: 1334: 1319: 1313: 1301:, 13 Jan 2010, 1295: 1289: 1288: 1286: 1284: 1269: 1263: 1262: 1252: 1219: 1213: 1212: 1202: 1192: 1160: 1151: 1150: 1140: 1106: 1100: 1099: 1097: 1095: 1080: 1074: 1073: 1063: 1031: 1025: 1024: 1022: 1020: 1005: 999: 998: 996: 994: 979: 973: 972: 970: 968: 953: 947: 946: 944: 942: 927: 921: 920: 910: 900: 876: 870: 869: 867: 844: 838: 837: 835: 833: 804: 795: 789: 788: 786: 784: 769: 763: 762: 734: 728: 727: 725: 723: 708: 699: 698: 696: 694: 679: 673: 672: 670: 668: 659: 651: 645: 644: 642: 640: 634: 628:. Archived from 623: 615: 609: 608: 598: 588: 564: 415:Royal Farm virus 400:, with a single 263: 262: 244: 232: 153: 94:Thrombocytopenia 22: 16:Species of virus 3489: 3488: 3484: 3483: 3482: 3480: 3479: 3478: 3459: 3458: 3457: 3452: 3444: 3439: 3430: 3429: 3424: 3415: 3414: 3409: 3396: 3386: 3377: 3359: 3323: 3273: 3244: 3201: 3181: 3155: 3137: 3060: 3042: 3014: 2920: 2914: 2884: 2871: 2851: 2816: 2806: 2781: 2751: 2725: 2714: 2677: 2652:Paramyxoviridae 2645: 2598: 2535: 2524: 2502: 2433: 2344: 2333: 2318: 2298: 2282:Pappataci fever 2275:Oropouche virus 2270:Oropouche fever 2244: 2233: 2203: 2183: 2101: 2073:Heartland virus 2043: 2032: 2012: 1984:Pogosta disease 1912: 1859:West Nile fever 1790: 1671: 1660: 1653: 1640: 1610: 1605: 1604: 1585: 1568:Wayback Machine 1557: 1524: 1481: 1478: 1476:Further reading 1473: 1472: 1462: 1460: 1447: 1446: 1442: 1398: 1397: 1393: 1347: 1346: 1342: 1332: 1330: 1321: 1320: 1316: 1296: 1292: 1282: 1280: 1271: 1270: 1266: 1221: 1220: 1216: 1162: 1161: 1154: 1108: 1107: 1103: 1093: 1091: 1082: 1081: 1077: 1033: 1032: 1028: 1018: 1016: 1007: 1006: 1002: 992: 990: 981: 980: 976: 966: 964: 955: 954: 950: 940: 938: 929: 928: 924: 878: 877: 873: 846: 845: 841: 831: 829: 802: 797: 796: 792: 782: 780: 771: 770: 766: 736: 735: 731: 721: 719: 710: 709: 702: 692: 690: 689:. US Government 681: 680: 676: 666: 664: 657: 653: 652: 648: 638: 636: 632: 621: 617: 616: 612: 579:(9): e0006707. 566: 565: 556: 551: 511: 456: 435: 423: 386: 374: 334:Amarillovirales 310:Kitrinoviricota 257: 235:Alkhurma virus 230: 178: 71: 55:Mild symptoms: 20: 17: 12: 11: 5: 3487: 3485: 3477: 3476: 3471: 3461: 3460: 3454: 3453: 3451: 3450: 3437: 3432:Alkhurma virus 3422: 3406: 3404: 3398: 3397: 3392: 3383: 3382: 3379: 3378: 3376: 3375: 3367: 3365: 3361: 3360: 3358: 3357: 3350: 3343: 3335: 3333: 3325: 3324: 3322: 3321: 3314: 3311:Ixodes ricinus 3307: 3300: 3293: 3285: 3283: 3275: 3274: 3272: 3271: 3264: 3256: 3254: 3246: 3245: 3243: 3242: 3235: 3228: 3220: 3218: 3207: 3203: 3202: 3200: 3199: 3193: 3191: 3187: 3186: 3183: 3182: 3180: 3179: 3174: 3169: 3167:Tick paralysis 3163: 3161: 3160:Other diseases 3157: 3156: 3154: 3153: 3147: 3145: 3139: 3138: 3136: 3135: 3130: 3125: 3120: 3115: 3110: 3105: 3100: 3095: 3090: 3085: 3080: 3074: 3072: 3066: 3065: 3062: 3061: 3059: 3058: 3052: 3050: 3044: 3043: 3041: 3040: 3035: 3030: 3024: 3022: 3016: 3015: 3013: 3012: 3011: 3010: 3004: 3002:rickettsialpox 2999: 2994: 2984: 2979: 2957: 2952: 2946: 2944: 2935: 2926: 2922: 2921: 2915: 2913: 2912: 2905: 2898: 2890: 2881: 2880: 2877: 2876: 2873: 2872: 2870: 2869: 2863: 2861: 2853: 2852: 2850: 2849: 2844: 2843: 2842: 2831: 2829: 2818: 2812: 2811: 2808: 2807: 2805: 2804: 2799: 2793: 2791: 2783: 2782: 2780: 2779: 2774: 2769: 2763: 2761: 2753: 2752: 2750: 2749: 2741: 2739: 2728: 2720: 2719: 2716: 2715: 2713: 2712: 2711: 2710: 2705: 2695: 2689: 2687: 2679: 2678: 2676: 2675: 2674: 2673: 2668: 2657: 2655: 2647: 2646: 2644: 2643: 2638: 2637: 2636: 2631: 2626: 2621: 2610: 2608: 2600: 2599: 2597: 2596: 2595: 2594: 2589: 2579: 2578: 2577: 2572: 2567: 2562: 2551: 2549: 2538: 2530: 2529: 2526: 2525: 2523: 2522: 2514: 2512: 2504: 2503: 2501: 2500: 2499: 2498: 2493: 2483: 2482: 2481: 2476: 2471: 2466: 2461: 2456: 2445: 2443: 2435: 2434: 2432: 2431: 2426: 2421: 2420: 2419: 2411: 2410: 2409: 2399: 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1746: 1745: 1737: 1736: 1735: 1727: 1722: 1721: 1720: 1712: 1711: 1710: 1702: 1701: 1700: 1687: 1685: 1674: 1663: 1655: 1654: 1646:viral diseases 1641: 1639: 1638: 1631: 1624: 1616: 1607: 1606: 1603: 1602: 1586: 1581: 1580: 1578: 1577:Classification 1571: 1570: 1556: 1555:External links 1553: 1552: 1551: 1522: 1477: 1474: 1471: 1470: 1440: 1391: 1340: 1314: 1308:2014-01-19 at 1290: 1264: 1235:(5): 879–882. 1214: 1152: 1101: 1075: 1026: 1000: 974: 948: 922: 871: 865:10.1086/656326 839: 813:(2): 455–461. 790: 764: 729: 700: 674: 646: 610: 553: 552: 550: 547: 535:Mecca province 510: 507: 455: 452: 434: 431: 422: 419: 388: 387: 384:Alkhurma virus 382: 380: 376: 375: 368: 366: 362: 361: 354: 350: 349: 342: 338: 337: 330: 326: 325: 322:Flasuviricetes 318: 314: 313: 306: 302: 301: 294: 290: 289: 282: 275: 274: 269: 265: 264: 251: 250: 246: 245: 237: 236: 229: 226: 216:, leukopenia, 202:disorientation 198:hallucinations 177: 174: 140:Alkhurma virus 135: 134: 131: 127: 126: 123: 119: 118: 115: 109: 108: 107:Alkhurma virus 105: 101: 100: 91: 85: 84: 53: 47: 46: 41: 35: 34: 31: 27: 26: 18: 15: 13: 10: 9: 6: 4: 3: 2: 3486: 3475: 3472: 3470: 3467: 3466: 3464: 3447: 3442: 3438: 3433: 3427: 3423: 3418: 3412: 3408: 3407: 3405: 3403: 3399: 3395: 3390: 3374: 3373: 3369: 3368: 3366: 3362: 3356: 3355: 3351: 3349: 3348: 3344: 3342: 3341: 3337: 3336: 3334: 3332: 3331: 3326: 3320: 3319: 3315: 3313: 3312: 3308: 3306: 3305: 3301: 3299: 3298: 3294: 3292: 3291: 3287: 3286: 3284: 3282: 3281: 3276: 3270: 3269: 3265: 3263: 3262: 3258: 3257: 3255: 3253: 3252: 3247: 3241: 3240: 3236: 3234: 3233: 3229: 3227: 3226: 3222: 3221: 3219: 3217: 3216: 3211: 3208: 3204: 3198: 3195: 3194: 3192: 3188: 3178: 3175: 3173: 3170: 3168: 3165: 3164: 3162: 3158: 3152: 3149: 3148: 3146: 3144: 3140: 3134: 3131: 3129: 3126: 3124: 3121: 3119: 3116: 3114: 3111: 3109: 3106: 3104: 3101: 3099: 3096: 3094: 3091: 3089: 3086: 3084: 3083:Bourbon virus 3081: 3079: 3076: 3075: 3073: 3071: 3067: 3057: 3054: 3053: 3051: 3049: 3048:Thiotrichales 3045: 3039: 3036: 3034: 3031: 3029: 3026: 3025: 3023: 3021: 3017: 3008: 3005: 3003: 3000: 2998: 2995: 2993: 2990: 2989: 2988: 2985: 2983: 2980: 2977: 2975: 2969: 2965: 2961: 2958: 2956: 2953: 2951: 2948: 2947: 2945: 2943: 2942:Rickettsiales 2939: 2936: 2934: 2930: 2927: 2923: 2918: 2911: 2906: 2904: 2899: 2897: 2892: 2891: 2888: 2868: 2865: 2864: 2862: 2860: 2859: 2854: 2848: 2845: 2841: 2838: 2837: 2836: 2833: 2832: 2830: 2828: 2827: 2826:Rhabdoviridae 2822: 2819: 2813: 2803: 2800: 2798: 2795: 2794: 2792: 2790: 2789: 2784: 2778: 2775: 2773: 2770: 2768: 2765: 2764: 2762: 2760: 2759: 2754: 2748: 2747: 2743: 2742: 2740: 2738: 2737: 2736:Herpesviridae 2732: 2729: 2727: 2721: 2709: 2706: 2704: 2701: 2700: 2699: 2696: 2694: 2691: 2690: 2688: 2686: 2685: 2684:Coronaviridae 2680: 2672: 2669: 2667: 2664: 2663: 2662: 2659: 2658: 2656: 2654: 2653: 2648: 2642: 2639: 2635: 2632: 2630: 2627: 2625: 2622: 2620: 2617: 2616: 2615: 2612: 2611: 2609: 2607: 2606: 2605:Rhabdoviridae 2601: 2593: 2590: 2588: 2585: 2584: 2583: 2580: 2576: 2573: 2571: 2568: 2566: 2563: 2561: 2558: 2557: 2556: 2553: 2552: 2550: 2548: 2547: 2542: 2539: 2537: 2531: 2521: 2520: 2516: 2515: 2513: 2511: 2510: 2509:Herpesviridae 2505: 2497: 2494: 2492: 2489: 2488: 2487: 2484: 2480: 2477: 2475: 2472: 2470: 2467: 2465: 2462: 2460: 2457: 2455: 2452: 2451: 2450: 2447: 2446: 2444: 2442: 2441: 2436: 2430: 2427: 2425: 2422: 2417: 2416: 2415: 2412: 2408: 2405: 2404: 2403: 2400: 2396: 2393: 2392: 2391: 2388: 2383: 2382: 2381: 2378: 2374: 2371: 2370: 2369: 2365: 2362: 2361: 2359: 2357: 2356: 2351: 2348: 2346: 2340: 2337: 2335: 2329: 2315: 2312: 2311: 2309: 2307: 2306: 2305:Rhabdoviridae 2301: 2295: 2292: 2288: 2287:Toscana virus 2285: 2284: 2283: 2280: 2276: 2273: 2272: 2271: 2268: 2265: 2262: 2261: 2259: 2257: 2256: 2251: 2248: 2246: 2240: 2230: 2227: 2222: 2221: 2220: 2217: 2216: 2214: 2212: 2211: 2206: 2200: 2199:Bourbon virus 2197: 2196: 2194: 2192: 2191: 2186: 2177: 2176: 2175: 2172: 2168: 2165: 2162: 2161: 2160: 2157: 2152: 2151: 2150: 2146: 2143: 2139: 2136: 2135: 2134: 2131: 2127: 2124: 2123: 2122: 2118: 2115: 2114: 2112: 2110: 2109: 2104: 2098: 2094: 2091: 2089: 2086: 2083: 2079: 2076: 2074: 2071: 2068: 2064: 2061: 2060: 2058: 2056: 2055: 2050: 2047: 2045: 2039: 2029: 2026: 2025: 2023: 2021: 2020: 2015: 2009: 2006: 2002: 1999: 1998: 1997: 1994: 1990: 1989:Sindbis virus 1987: 1986: 1985: 1982: 1977: 1976: 1975: 1972: 1968: 1965: 1964: 1963: 1960: 1955: 1954: 1953: 1950: 1945: 1944: 1943: 1940: 1935: 1934: 1933: 1929: 1926: 1925: 1923: 1921: 1920: 1915: 1907: 1904: 1903: 1902: 1899: 1895: 1892: 1891: 1890: 1887: 1883: 1880: 1879: 1878: 1874: 1871: 1870: 1865: 1862: 1861: 1860: 1857: 1852: 1851: 1850: 1847: 1842: 1841: 1840: 1837: 1833: 1830: 1828: 1825: 1824: 1823: 1820: 1816: 1813: 1812: 1811: 1807: 1804: 1803: 1801: 1799: 1798: 1793: 1784: 1783: 1782: 1779: 1774: 1773: 1772: 1769: 1764: 1763: 1762: 1758: 1755: 1754: 1751: 1748: 1743: 1742: 1741: 1738: 1733: 1732: 1731: 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1057: 1053: 1049: 1045: 1041: 1037: 1030: 1027: 1014: 1010: 1004: 1001: 988: 984: 978: 975: 962: 958: 952: 949: 936: 932: 926: 923: 918: 914: 909: 904: 899: 894: 891:(10): e1352. 890: 886: 882: 875: 872: 866: 861: 857: 853: 849: 843: 840: 828: 824: 820: 816: 812: 808: 801: 794: 791: 778: 774: 768: 765: 760: 756: 752: 748: 745:(2): 179–81. 744: 740: 733: 730: 717: 713: 707: 705: 701: 688: 684: 678: 675: 663: 656: 650: 647: 631: 627: 620: 614: 611: 606: 602: 597: 592: 587: 582: 578: 574: 570: 563: 561: 559: 555: 548: 546: 544: 540: 536: 532: 528: 524: 520: 516: 508: 506: 504: 503: 497: 495: 489: 487: 483: 479: 474: 472: 471: 466: 461: 453: 451: 449: 444: 440: 432: 430: 428: 420: 418: 416: 412: 408: 403: 399: 395: 385: 381: 378: 377: 373: 372: 367: 364: 363: 360: 359: 355: 352: 351: 348: 347: 343: 340: 339: 336: 335: 331: 328: 327: 324: 323: 319: 316: 315: 312: 311: 307: 304: 303: 300: 299: 298:Orthornavirae 295: 292: 291: 288: 287: 283: 280: 277: 276: 273: 270: 267: 266: 261: 256: 252: 247: 243: 238: 233: 227: 225: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 183: 175: 173: 171: 167: 163: 159: 158: 149: 145: 141: 132: 128: 124: 120: 116: 114: 110: 106: 102: 99: 95: 92: 90: 89:Complications 86: 83: 79: 75: 70: 66: 62: 58: 54: 52: 48: 45: 42: 40: 36: 32: 28: 23: 3474:Flaviviruses 3401: 3370: 3352: 3345: 3338: 3330:Ornithodoros 3328: 3316: 3309: 3302: 3295: 3288: 3278: 3266: 3259: 3249: 3237: 3230: 3223: 3213: 3190:Infestations 3078:Bhanja virus 3033:Lyme disease 2982:Scrub typhus 2973: 2960:Ehrlichiosis 2950:Anaplasmosis 2856: 2847:Mokola virus 2824: 2786: 2758:Retroviridae 2756: 2744: 2734: 2682: 2650: 2603: 2544: 2517: 2507: 2440:Bunyavirales 2438: 2355:Arenaviridae 2353: 2303: 2255:Bunyavirales 2253: 2208: 2188: 2174:Langat virus 2166: 2108:Flaviviridae 2106: 2097:Bhanja virus 2054:Bunyavirales 2052: 2017: 1917: 1889:Yellow fever 1877:Dengue fever 1797:Flaviviridae 1795: 1740:Tahyna virus 1705:Bwamba Fever 1682:Bunyavirales 1680: 1589: 1530: 1526: 1494:(5): 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Index

Specialty
Infectious disease (medical specialty)
Symptoms
Fever
chills
headache
vomiting
Epistaxis
purpura
leukopenia
Complications
Thrombocytopenia
meningoencephalitis
Diagnostic method
Arabic
Flaviviridae
Saudi Arabia
joint pain
muscle pain
a loss of appetite
feeling of great discomfort
hallucinations
disorientation
convulsions
epistaxis
Elevated liver enzymes
proteinuria
encephalitis
Flavivirus structure and genome
Virus classification

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