295:"Allan Bradley has made important contributions to the technique of mutation of endogenous genes in mice, an approach that has opened up a new era of research in biology. It is impossible to open an issue of a major journal nowadays without coming across an article that describes the consequences of mutating an endogenous gene in mice. The generation of these mice is based on concepts and techniques that can be traced back to experiments performed and published by Bradley fifteen years ago. In the years since, he has not only used ES cell technology to provide key information on the functions of many genes including several important tumour suppressor genes, but has also continued to improve and develop the techniques, technology, and tools for genetic manipulation in the mouse. Today, mice can be generated with changes as subtle as an alteration in a single nucleotide or as extensive as the deletion of millions of base pairs. These alterations will gain increasing importance in genetic experiments aimed at understanding the function of genes in the mammalian genome in the post genome era."
40:
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Kile, B. T.; Hentges, K. E.; Clark, A. T.; Nakamura, H.; Salinger, A. P.; Liu, B.; Box, N.; Stockton, D. W.; Johnson, R. L.; Behringer, R. R.; Bradley, A.; Justice, M. J. (2003). "Functional genetic analysis of mouse chromosome 11".
39:
334:
Donehower, L. A.; Harvey, M.; Slagle, B. L.; McArthur, M. J.; Montgomery Jr, C. A.; Butel, J. S.; Bradley, A. (1992). "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours".
1807:
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949:
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Dalton, D.; Pitts-Meek, S.; Keshav, S.; Figari, I.; Bradley, A.; Stewart, T. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes".
991:
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96:
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Guo, G.; Wang, W.; Bradley, A. (2004). "Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells".
1476:
532:
553:
1309:
856:
714:"Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society – Wellcome Trust Sanger Institute"
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146:
141:
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20:
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102:
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136:
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1354:
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637:
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236:
90:
66:
1822:
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1031:
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1339:
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1025:
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1716:
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1413:
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852:
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1454:
1742:
1522:
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1165:
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626:
596:
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506:
454:
411:
360:
813:"Bradley – DeBakey Excellence in Research Awards- Baylor College of Medicine, Houston, Texas"
691:
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446:
403:
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Isolation characterization and developmental potential of murine embryo-derived stem cells
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163:
Isolation characterisation and developmental potential of murine embryo-derived stem cells
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1517:
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571:
Watts, Geoff (2007). "Martin Evans: joint winner of 2007 Nobel Prize in medicine".
518:
466:
372:
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244:
179:
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239:
where he earned
Bachelor of Arts, Master of Arts and PhD degrees in genetics from
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1314:
1119:
220:
592:
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1539:
407:
194:
790:
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510:
458:
1710:
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415:
364:
1139:
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123:
502:
450:
1079:
1703:
1401:
1104:
1047:
738:
356:
156:
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44:
Allan
Bradley at the launch of the Shakespeare review, organised by
688:"Professor Allan Bradley: a decade at Sanger | Wellcome Trust"
1073:
874:
1114:
1109:
255:
Following his PhD, Bradley was appointed assistant professor at
1458:
878:
936:
Sainsbury
Wellcome Centre for Neural Circuits and Behaviour
756:"New stem cell method could end need for liver transplants"
319:. European Molecular Biology Organization. Archived from
1808:
Members of the
European Molecular Biology Organization
1735:
1500:
1378:
1287:
1252:
1197:
1148:
1018:
984:
919:
912:
662:"Certificate of election EC/2002/01: Allan Bradley"
287:Bradley won a 1994 DeBakey Award and was elected a
189:
173:
155:
129:
119:
83:
73:
62:
52:
30:
625:
992:Wellcome Trust Centre for the History of Medicine
554:"Allan Bradley – Wellcome Trust Sanger Institute"
535:. Wellcome Trust Sanger Institute. Archived from
1053:Coalition for Epidemic Preparedness Innovations
791:"Searle Scholars Program: Allan Bradley (1988)"
293:
690:. Wellcome.ac.uk. 15 June 2010. Archived from
1470:
890:
8:
664:. London: The Royal Society. Archived from
533:"Mouse genomics – Allan Bradley laboratory"
1477:
1463:
1455:
916:
897:
883:
875:
834:
243:gained while working in the laboratory of
38:
27:
620:
618:
289:Fellow of the Royal Society (FRS) in 2002
267:Investigator in 1993 and director of the
19:For other people named Alan Bradley, see
1425:Wellcome Trust Principal Research Fellow
656:
654:
259:, beginning in 1987 where he was also a
305:
950:WTC for Gene Regulation and Expression
779:(PhD thesis). University of Cambridge.
640: ed.). A & C Black.
548:
546:
1429:Wellcome Trust Senior Research Fellow
291:. His certificate of election reads:
7:
1803:Alumni of Trinity College, Cambridge
1779:List of fellows of the Royal Society
1394:Institutional Strategic Support Fund
1833:Howard Hughes Medical Investigators
1813:Baylor College of Medicine faculty
838:Non-profit organization positions
14:
271:, from October 2000 (preceded by
263:in 1988. Bradley was appointed a
1439:
1438:
1009:
754:Kate Kelland (12 October 2011).
1388:Collaborative Awards in Science
1100:Malawi Liverpool Wellcome Trust
857:Wellcome Trust Sanger Institute
269:Wellcome Trust Sanger Institute
265:Howard Hughes Medical Institute
225:Wellcome Trust Sanger Institute
147:Howard Hughes Medical Institute
142:Wellcome Trust Sanger Institute
1391:Investigator Awards in Science
997:Wellcome Research Laboratories
962:WTC for Molecular Parasitology
959:WTC for Mitochondrial Research
556:. Sanger.ac.uk. Archived from
275:) to April 2010, succeeded by
1:
585:10.1016/S0140-6736(07)61889-3
21:Alan Bradley (disambiguation)
1818:Fellows of the Royal Society
945:WTC for Cell-Matrix Research
735:Allan Bradley's publications
645:UK public library membership
235:Bradley was educated at the
1090:Genome Reference Consortium
1038:Cambridge Biomedical Campus
314:"The EMBO Pocket Directory"
1849:
1615:David Malcolm James Lilley
971:WTC for Stem Cell Research
257:Baylor College of Medicine
241:Trinity College, Cambridge
137:Baylor College of Medicine
18:
1776:
1436:
1198:Executive leadership team
1007:
976:Wellcome Sanger Institute
863:
850:
842:
837:
815:. Bcm.edu. Archived from
636:. Vol. 2014 (online
185:
112:
37:
1637:Brian Cecil Joseph Moore
940:Science Learning Centres
741:bibliographic database.
1575:Christopher Hawkesworth
1397:Science Strategic Award
1156:Eliza Manningham-Buller
1019:Projects and facilities
927:Francis Crick Institute
743:(subscription required)
638:Oxford University Press
408:10.1126/science.8456300
237:University of Cambridge
67:University of Cambridge
1608:John Vincent Kilmartin
1379:Awards and fellowships
1130:Wellcome Genome Campus
1058:COSMIC cancer database
955:WTC for Human Genetics
913:Centres and institutes
627:"BRADLEY, Prof. Allan"
297:
1704:Andrew Benjamin Smith
1421:Wellcome Trust Centre
1418:Wellcome Image Awards
1043:Cancer Genome Project
1518:Michael John Crawley
1095:Human Genome Project
1068:Diamond Light Source
1026:1000 Genomes Project
966:WTC for Neuroimaging
793:. Searlescholars.net
773:Bradley, A. (1985).
560:on 13 November 2013.
78:Embryonic stem cells
1798:British geneticists
1717:Nicholas Strausfeld
1683:Thomas Maurice Rice
1678:David William Rhind
1545:David Henry Dolphin
1414:Wellcome Book Prize
1406:Sir Henry Wellcome
1125:Wellcome Collection
668:on 3 September 2015
503:10.1038/nature01865
495:2003Natur.425...81K
451:10.1038/nature02653
443:2004Natur.429..891G
400:1993Sci...259.1739D
394:(5102): 1739–1742.
349:1992Natur.356..215D
1711:Anthony John Stace
1663:Peter J. Ratcliffe
1590:David Ish-Horowicz
1565:Jean-Pierre Hansen
1221:Peter Pereira Gray
1149:Board of governors
694:on 3 December 2010
283:Awards and honours
16:British geneticist
1785:
1784:
1601:Bruce Ernest Kemp
1523:Stuart Cull-Candy
1452:
1451:
1166:Tobias Bonhoeffer
1005:
1004:
873:
872:
864:Succeeded by
643:(Subscription or
437:(6994): 891–895.
343:(6366): 215–221.
323:on 16 March 2015.
211:
210:
114:Scientific career
1840:
1648:Martyn Poliakoff
1595:James A. Jackson
1534:Roger John Davis
1479:
1472:
1465:
1456:
1442:
1441:
1288:Other key people
1253:Former directors
1227:Chonnettia Jones
1161:Michael Ferguson
1135:Wellcome Library
1013:
932:Gurdon Institute
917:
899:
892:
885:
876:
867:Michael Stratton
843:Preceded by
835:
829:
828:
826:
824:
809:
803:
802:
800:
798:
787:
781:
780:
770:
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704:
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649:
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629:
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568:
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550:
541:
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539:on 1 April 2010.
529:
523:
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477:
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426:
420:
419:
383:
377:
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357:10.1038/356215a0
331:
325:
324:
318:
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277:Michael Stratton
207:
204:
202:
200:
198:
196:
175:Doctoral advisor
169:
42:
28:
1848:
1847:
1843:
1842:
1841:
1839:
1838:
1837:
1788:
1787:
1786:
1781:
1772:
1758:Alexander Pines
1731:
1570:Nicholas Hastie
1496:
1483:
1453:
1448:
1432:
1400:Sir Henry Dale
1374:
1305:Dominic Cadbury
1300:William Castell
1283:
1266:Bridget Ogilvie
1248:
1212:Stephen Caddick
1193:
1144:
1014:
1001:
980:
908:
903:
869:
860:
848:
833:
832:
822:
820:
819:on 19 July 2012
811:
810:
806:
796:
794:
789:
788:
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772:
771:
767:
753:
752:
748:
742:
737:indexed by the
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729:
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712:
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489:(6953): 81–86.
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428:
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385:
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63:Alma mater
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48:
46:Policy Exchange
33:
24:
17:
12:
11:
5:
1846:
1844:
1836:
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1830:
1828:Wellcome Trust
1825:
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1810:
1805:
1800:
1790:
1789:
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1773:
1771:
1770:
1765:
1763:Peter H. Raven
1760:
1755:
1750:
1745:
1743:Claude Allègre
1739:
1737:
1733:
1732:
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1729:
1724:
1719:
1714:
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1618:
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1560:Graham Goodwin
1557:
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1385:Capital Awards
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1380:
1376:
1375:
1373:
1372:
1370:Henry Wellcome
1367:
1362:
1357:
1352:
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1307:
1302:
1297:
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1272:Michael Dexter
1269:
1263:
1260:Peter Williams
1256:
1254:
1250:
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1234:
1231:
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1224:Mark Henderson
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1213:
1210:
1207:
1201:
1199:
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1186:
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1179:Bryan Grenfell
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906:Wellcome Trust
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716:. Sanger.ac.uk
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679:
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614:
579:(9605): 2095.
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261:Searle Scholar
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203:/bradley-allan
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1823:Living people
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1626:Georgina Mace
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1516:
1514:
1513:Robin Carrell
1511:
1509:
1508:Allan Bradley
1506:
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1490:Royal Society
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1335:Richard Hynes
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1320:Oliver Franks
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1217:
1215:Simon Chaplin
1214:
1211:
1208:
1206:
1205:Jeremy Farrar
1203:
1202:
1200:
1196:
1190:
1187:
1185:
1184:Naguib Kheraj
1182:
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1175:
1174:William Burns
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760:National Post
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1280:(2003–2013)
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1268:(1991–1998)
1262:(1965–1991)
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1233:Nick Moakes
1032:Big Picture
672:14 November
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1792:Categories
1727:Ian Wilmut
1673:Miles Reid
1410:Fellowship
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1330:Henry Dale
1315:Kay Davies
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647:required.)
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