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is a skin condition characterized by small, tender, reddened nodules on the legs, mostly on the calves and shins. Microscopically there are epithelioid granulomas and vasculitis in the subcutaneous tissue, making it a form of panniculitis. Most of these cases are now thought to be manifestation of
625:
Erythema nodosum is a form of panniculitis characterised by tender red nodules, 1–10 cm, associated with systemic symptoms including fever, malaise, and joint pain. Nodules may become bluish-purple, yellowing, and green, and subside over a period of 2–6 weeks without ulcerating or scarring.
945:
Smith K J, Skeleton H J, Yeagre J, Angritt P, Wagner K, James W. D., Giblin W. J., Lupton G. P. Cutaneous histopathological, immunohistochemical, and clinical manifestations inpatients with hemophagocytic syndrome. Military
Medical old Consortium for Applied Retroviral Research (MMCARR).
216:
Restated, an inflammatory disorder primarily localized in the subcutaneous fat is termed a "panniculitis", a group of disorders that may be challenging both for the clinician and the dermatopathologist. The general term for inflammation of any adipose tissue is
1180:
1165:
456:(HPS). CHP is a rare and often fatal form of panniculitis with multisystem involvement. But it can also present in a benign form involving only the subcutaneous tissue, thus having a broad clinical spectrum.
890:
763:
1245:
46:
1507:
472:, and therefore is sometimes referred to as "popsicle panniculitis." The term was coined when a patient with a rash of unknown origin on her cheek was taken to a
468:
is a panniculitis occurring after exposure to cold, most often seen in infants and young children. This condition has been described in children who suck ice or
335:
characteristics based on the location of the inflammatory cells (within fatty lobules or in the septa which separate them) and on the presence or absence of
1537:
1387:
1238:
1320:
553:
1231:
496:(also known as enzymatic panniculitis, Pancreatic fat necrosis, and subcutaneous fat necrosis) is a panniculitis most commonly associated with
1024:
974:
917:
815:
1497:
895:
768:
1286:
149:
1446:
1125:
932:
Winkelmann RK, Bowie EJ. Hemorrhagic diathesis associated with benign histiocytic cytophagic panniculitis and systemic histiocytosis.
597:
Forms associated with use of high doses of systemic corticosteroids during rapid corticosteroid withdrawal, and from the injection of
1347:
587:
1542:
1502:
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107:
79:
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1414:
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543:
539:
1342:
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54:
86:
376:, or "Bazin disease", is a panniculitis on the back of the calves. It was formerly thought to be a reaction to the
542:
that presents with brown indurations on the front of the shins. It may be associated with pain and other signs of
65:
50:
1461:
1330:
1402:
1352:
1195:
635:
93:
1481:
1301:
453:
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Bruce AJ. et al., Lipodermatosclerosis: Review of cases evaluated at Mayo Clinic. J Am Acad
Dermatol. 2002.
17:
1471:
1397:
1306:
1291:
908:
Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).
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75:
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380:. It is now considered a panniculitis that is not associated with a single defined pathogen.
1392:
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1086:
1053:
620:
990:
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236:
100:
1075:"Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management"
452:
abnormalities. CHP may occur either isolated or as part of cutaneous manifestations of
410:
1189:
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584:, a symmetrical form of the disease of unknown origin occurring in middle-aged women.
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Panniculitis can also be classified based on the presence or absence of systemic
1223:
647:
631:
602:
449:
403:
310:(the loss of subcutaneous adipose tissue) can occur in any of these conditions.
303:
251:
206:
1211:
1040:
Garg, Taru; Ahmed, Riaz; Bharadwaj, Apoorva V.; Shukla, Shailaja (April 2022).
346:
lobular panniculitis without vasculitis (acute panniculitis, previously termed
1174:
501:
336:
1058:
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is a panniculitis that may be induced by the injection of organic materials,
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tuberculosis and indeed they respond well to anti-tuberculous treatment.
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if you can. Unsourced or poorly sourced material may be challenged and
1157:
1169:
659:
519:
328:
687:
panniculitis is a panniculitis associated with a deficiency of the α
27:
Inflammation of the fatty layer under the skin (panniculus adiposus)
993:"The New England Journal of Medicine", 282 (17) : 966-67, 1970
515:
421:
281:
sarcoidosis with cutaneous involvement (seen in up to 20 percent);
1015:
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
965:
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
832:"eMedicine - Cold Panniculitis: Article by Geromanta Baleviciene"
912:(7th ed.). St. Louis, Mo: Elsevier Saunders. p. 1265.
487:
327:
or visceral) and is often diagnosed on the basis of a deep skin
1227:
872:"eMedicine - Weber-Christian Disease: Article by Moise L Levy"
698:
239:
or cold. Panniculitis with systemic disease can be caused by:
29:
395:
Non-vasculitis forms of panniculitis that may occur include:
806:
James, William D.; Berger, Timothy G.; et al. (2006).
462:
is a panniculitis that occurs following trauma to the skin.
235:. Panniculitis without systemic disease can be a result of
500:, and more rarely with anatomic pancreatic abnormalities,
560:
that is usually self-resolving, that may be a result of
714:
402:
was first described in 1980 by
Winkelmann as a chronic
61:
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1436:
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1151:
808:
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157:Erythema induratum, a form of lobular panniculitis
342:There are thus four main histological subtypes:
295:This is not a complete list of possible causes.
1042:"Poststeroid panniculitis – A rare case report"
1010:
1008:
960:
958:
956:
910:Robbins and Cotran pathologic basis of disease
801:
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413:, which is characterized clinically by tender
60:Please review the contents of the article and
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779:
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8:
1073:Gilchrist, H; Patterson, JW (Jul–Aug 2010).
1388:Alpha-1 antitrypsin deficiency panniculitis
18:Alpha-1 antitrypsin deficiency panniculitis
1508:Marfanoid–progeroid–lipodystrophy syndrome
1433:
1268:
1246:
1232:
1224:
1148:
538:is a form of panniculitis associated with
482:is a panniculitis caused by deposition of
172:
148:
139:
1090:
1057:
197:tissue (the fatty layer under the skin –
186:is a group of diseases whose hallmark is
1321:Subcutaneous fat necrosis of the newborn
1046:Indian Journal of Paediatric Dermatology
554:Subcutaneous fat necrosis of the newborn
756:
556:, a form of panniculitis occurring in
356:septal panniculitis without vasculitis
7:
1498:Congenital generalized lipodystrophy
626:Erythema nodosum is associated with
353:lobular panniculitis with vasculitis
400:Cytophagic histiocytic panniculitis
359:septal panniculitis with vasculitis
331:, and can be further classified by
1538:Conditions of the subcutaneous fat
1447:Acquired generalized lipodystrophy
969:. St. Louis: Mosby. p. 1515.
323:It can occur in any fatty tissue (
25:
1348:Lupus erythematosus panniculitis
1130:dermal-infiltrative/panniculitis
1092:10.1111/j.1529-8019.2010.01332.x
989:Epstein, Ervin and Oren, Mark,
702:
588:Lupus erythematosus panniculitis
350:, systemic nodular panniculitis)
201:). Symptoms include tender skin
126:
34:
691:-antitrypsin enzyme inhibitor.
590:, panniculitis associated with
504:, or drug-induced pancreatitis.
1503:Familial partial lipodystrophy
1457:Acquired partial lipodystrophy
685:Alpha-1 antitrypsin deficiency
680:Alpha-1 antitrypsin deficiency
546:. The exact cause is unknown.
285:Alpha 1-antitrypsin deficiency
62:add the appropriate references
1:
564:to relatively high levels of
205:, and systemic signs such as
1467:HIV-associated lipodystrophy
1415:Superficial thrombophlebitis
896:Dorland's Medical Dictionary
769:Dorland's Medical Dictionary
745:List of cutaneous conditions
544:chronic venous insufficiency
540:chronic venous insufficiency
47:reliable medical references
1559:
852:"Panniculitis. DermNet NZ"
677:
674:A1AT-deficiency-associated
618:
1462:Centrifugal lipodystrophy
1331:Post-steroid panniculitis
1017:Dermatology: 2-Volume Set
967:Dermatology: 2-Volume Set
531:With needle-shaped clefts
156:
147:
53:or relies too heavily on
1353:Sclerosing lipogranuloma
1059:10.4103/ijpd.ijpd_116_21
654:, medications including
1482:Localized lipodystrophy
1343:Weber–Christian disease
991:"Popsicle Panniculitis"
582:Weber–Christian disease
494:Pancreatic panniculitis
454:hemophagocytic syndrome
348:Weber–Christian disease
1472:Lipoatrophia annularis
1287:Cytophagic histiocytic
711:This section is empty.
508:Factitial panniculitis
460:Traumatic panniculitis
1543:Soft tissue disorders
810:. Saunders Elsevier.
549:Other forms include:
299:Associated conditions
1338:Lipodermatosclerosis
1316:needle-shaped clefts
1079:Dermatologic Therapy
1019:. St. Louis: Mosby.
891:"erythema induratum"
664:Non-Hodgkin lymphoma
536:Lipodermatosclerosis
498:pancreatic carcinoma
1385:without vasculitis:
1326:Sclerema neonatorum
1278:without vasculitis
740:Panniculus carnosus
592:lupus erythematosus
572:Sclerema neonatorum
378:tuberculum bacillus
258:lymphoproliferative
248:lupus erythematosus
199:panniculus adiposus
1367:Erythema induratum
1363:Nodular vasculitis
950:1992; 128: 193-200
936:.1980; 140: 1460-3
480:Gouty panniculitis
391:Without vasculitis
384:Nodular vasculitis
374:Erythema induratum
246:disorders such as
227:Signs and symptoms
1525:
1524:
1521:
1520:
1423:
1422:
1221:
1220:
1026:978-1-4160-2999-1
976:978-1-4160-2999-1
919:978-0-7216-0187-8
817:978-0-7216-2921-6
731:
730:
668:pancreatic cancer
466:Cold panniculitis
420:, recurrent high
276:pancreatic cancer
244:connective tissue
181:
180:
137:Medical condition
135:
134:
111:
16:(Redirected from
1550:
1434:
1412:with vasculitis:
1393:Erythema nodosum
1360:with vasculitis:
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713:You can help by
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621:Erythema nodosum
615:Erythema nodosum
576:premature births
448:dysfunction and
260:disease such as
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406:disease of the
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369:With vasculitis
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290:Crohn's disease
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43:This article
41:
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19:
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1444:generalized:
1443:
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1264:Panniculitis
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1085:(4): 320–7.
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875:. Retrieved
866:
855:. Retrieved
846:
835:. Retrieved
826:
807:
767:
759:
719:
715:adding to it
710:
683:
662:, including
656:sulfonamides
640:tuberculosis
630:, including
624:
603:mineral oils
574:, affecting
548:
534:
507:
493:
486:crystals in
479:
465:
459:
442:pancytopenia
434:organomegaly
415:erythematous
408:subcutaneous
399:
394:
382:
372:
341:
333:histological
322:
302:
294:
272:pancreatitis
230:
218:
215:
192:subcutaneous
188:inflammation
184:Panniculitis
183:
182:
168:Rheumatology
143:Panniculitis
114:
104:
97:
90:
83:
71:
51:verification
44:
658:, and some
648:sarcoidosis
632:Hepatitis C
526:, and oils.
502:pseudocysts
450:coagulation
440:effusions,
404:histiocytic
304:Lipoatrophy
252:scleroderma
207:weight loss
45:needs more
1532:Categories
1491:Congenital
1479:localized:
1302:Pancreatic
1207:DiseasesDB
1142:-639418194
1052:(2): 165.
877:2008-03-25
857:2010-05-17
837:2008-03-25
751:References
678:See also:
628:infections
337:vasculitis
87:newspapers
1307:Traumatic
1292:Factitial
1138:DermAtlas
695:Treatment
652:pregnancy
566:brown fat
484:uric acid
470:popsicles
325:cutaneous
314:Diagnosis
220:steatitis
163:Specialty
1454:partial:
1437:Acquired
1109:39695627
1101:20666819
734:See also
599:silicone
558:newborns
512:povidone
430:jaundice
262:lymphoma
233:symptoms
1403:Chronic
1272:Lobular
1201:D015434
1126:DermNet
660:cancers
446:hepatic
438:serosal
426:malaise
418:nodules
364:Lobular
211:fatigue
203:nodules
195:adipose
101:scholar
66:removed
1377:Septal
1107:
1099:
1023:
973:
916:
814:
610:Septal
520:saliva
329:biopsy
237:trauma
170:
103:
96:
89:
82:
74:
1398:Acute
1297:Gouty
1212:29081
1190:729.3
1175:M79.3
1105:S2CID
516:feces
422:fever
108:JSTOR
94:books
1282:Cold
1196:MeSH
1185:9-CM
1097:PMID
1021:ISBN
971:ISBN
914:ISBN
812:ISBN
666:and
646:and
638:and
488:gout
209:and
80:news
49:for
1181:ICD
1166:ICD
1087:doi
1054:doi
893:at
766:at
717:.
636:EBV
601:or
306:or
274:or
264:or
250:or
190:of
1534::
1210::
1199::
1188::
1173::
1170:10
1103:.
1095:.
1083:23
1081:.
1077:.
1050:23
1048:.
1044:.
1007:^
955:^
776:^
670:.
650:,
642:,
634:,
522:,
518:,
514:,
444:,
436:,
432:,
428:,
424:,
339:.
223:.
213:.
68:.
1365:/
1247:e
1240:t
1233:v
1183:-
1168:-
1158:D
1111:.
1089::
1062:.
1056::
1029:.
979:.
922:.
880:.
860:.
840:.
820:.
724:)
720:(
689:1
605:.
594:.
578:.
568:.
490:.
476:.
278:;
268:;
254:;
119:)
115:(
105:·
98:·
91:·
84:·
58:.
20:)
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