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Effects of high altitude on humans

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97:, increased capillary density in muscle and hypoxic pulmonary vasoconstriction–increased intracellular oxidative enzymes. There are a range of responses to hypoxia at the cellular level, shown by discovery of hypoxia-inducible factors (HIFs), which determine the general responses of the body to oxygen deprivation. Physiological functions at high altitude are not normal and evidence also shows impairment of neuropsychological function, which has been implicated in mountaineering and aviation accidents. Methods of mitigating the effects of the high altitude environment include oxygen enrichment of breathing air and/or an increase of pressure in an enclosed environment. Other effects of high altitude include 869: 291: 4655: 4703: 4691: 4679: 129: 4667: 31: 354: 636:
Room air at altitude can be enriched with oxygen without introducing an unacceptable fire hazard. At an altitude of 8000 m the equivalent altitude in terms of oxygen partial pressure can be reduced to below 4000 m without increasing the fire hazard beyond that of normal sea level atmospheric air. In
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Compared with acclimatized newcomers, native Andean and Himalayan populations have better oxygenation at birth, enlarged lung volumes throughout life, and a higher capacity for exercise. Tibetans demonstrate a sustained increase in cerebral blood flow, elevated resting ventilation, lower hemoglobin
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Full hematological adaptation to high altitude is achieved when the increase of red blood cells reaches a plateau and stops. The length of full hematological adaptation can be approximated by multiplying the altitude in kilometres by 11.4 days. For example, to adapt to 4,000 metres (13,000 ft)
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Dufour, SP; Ponsot, E.; Zoll, J.; Doutreleau, S.; Lonsdorfer-Wolf, E.; Geny, B.; Lampert, E.; Flück, M.; Hoppeler, H.; Billat, V.; Mettauer, B.; Richard, R.; Lonsdorfer, J. (April 2006). "Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity".
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This conundrum led to the development of the altitude training modality known as "Live-High, Train-Low", whereby the athlete spends many hours a day resting and sleeping at one (high) altitude, but performs a significant portion of their training, possibly all of it, at another (lower) altitude. A
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For athletes, high altitude produces two contradictory effects on performance. For explosive events (sprints up to 400 metres, long jump, triple jump) the reduction in atmospheric pressure means there is less resistance from the atmosphere and the athlete's performance will generally be better at
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Full acclimatization requires days or even weeks. Gradually, the body compensates for the respiratory alkalosis by renal excretion of bicarbonate, allowing adequate respiration to provide oxygen without risking alkalosis. It takes about four days at any given altitude and can be enhanced by drugs
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in the United States. The correlation between elevation and suicide risk was present even when the researchers control for known suicide risk factors, including age, gender, race, and income. Research has also indicated that oxygen levels are unlikely to be a factor, considering that there is no
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are mostly the consequences of reduced partial pressure of oxygen in the atmosphere. The medical problems that are direct consequence of high altitude are caused by the low inspired partial pressure of oxygen, which is caused by the reduced atmospheric pressure, and the constant gas fraction of
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The ambient air temperature is predictably affected by altitude, and this also has physiological effects on people exposed to high altitudes. The temperature effects and their mitigation are not inherently different from temperature effects from other causes, but the effects of temperature and
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Many deaths in high-altitude mountaineering have been caused by the effects of the death zone, either directly by loss of vital functions or indirectly through wrong decisions made under stress or physical weakening leading to accidents. In the death zone, the human body cannot acclimatize. An
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series of studies conducted in Utah in the late 1990s showed significant performance gains in athletes who followed such a protocol for several weeks. Another study from 2006 has shown performance gains from merely performing some exercising sessions at high altitude, yet living at sea level.
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People who develop acute mountain sickness can sometimes be identified before the onset of symptoms by changes in fluid balance hormones regulating salt and water metabolism. People who are predisposed to develop high-altitude pulmonary edema may present a reduction in urine production before
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Ponsot, E; Dufour, S.P.; Zoll, J.; Doutrelau, S.; N'Guessan, B.; Geny, B.; Hoppeler, H.; Lampert, E.; Mettauer, B.; Ventura-Clapier, R.; Richard, R. (April 2006). "Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle".
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Athletes can also take advantage of altitude acclimatization to increase their performance. The same changes that help the body cope with high altitude increase performance back at sea level. However, this may not always be the case. Any positive acclimatization effects may be negated by a
82:, the ambient pressure can drop below the vapor pressure of water at body temperature, but at such altitudes even pure oxygen at ambient pressure cannot support human life, and a pressure suit is necessary. A rapid depressurisation to the low pressures of high altitudes can trigger 659:, mostly caused by convection and the adiabatic expansion of air with decreasing pressure. At the peak of Mount Everest, the average summer temperature is −19 °C (−2 °F) and the average winter temperature is −36 °C (−33 °F). At such low temperatures, 3491: 3452: 765:
high altitude. For endurance events (races of 800 metres or more), the predominant effect is the reduction in oxygen, which generally reduces the athlete's performance at high altitude. One way to gauge this reduction is by monitoring VO
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qualifiers, including their capital cities. In their ruling, FIFA's executive committee specifically cited what they believed to be an unfair advantage possessed by home teams acclimated to the elevation. The ban was reversed in 2008.
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Mitigation may be by supplementary oxygen, pressurisation of the habitat or environmental protection suit, or a combination of both. In all cases the critical effect is the raising of oxygen partial pressure in the breathing gas.
580:(CMS). Andeans possess a similar suite of adaptations but exhibit elevated hemoglobin concentration and a normal resting ventilation. These adaptations may reflect the longer history of high altitude habitation in these regions. 564:. The indigenous inhabitants of these regions thrive well in the highest parts of the world. These humans have undergone extensive physiological and genetic changes, particularly in the regulatory systems of oxygen 267:
Humans have survived for two years at 5,950 m (19,520 ft, 475 millibars of atmospheric pressure), which is the highest recorded permanently tolerable altitude; the highest permanent settlement known,
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At altitudes above 7,500 m (24,600 ft, 383 millibars of atmospheric pressure), sleeping becomes very difficult, digesting food is near-impossible, and the risk of HAPE or HACE increases greatly.
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life for an extended time span. This point is generally tagged as 8,000 m (26,000 ft, less than 356 millibars of atmospheric pressure). All 14 summits in the death zone above 8000 m, called
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Gore, CJ; Hopkins, WG (November 2005). "Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume".
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to altitude that allow it to partially compensate for the lack of oxygen. There is a limit to the level of adaptation; mountaineers refer to the altitudes above 8,000 metres (26,000 ft) as the
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Levine, BD; Stray-Gundersen, J (November 2005). "Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume".
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from enhancing the respiratory rate as much as would be required. Inability to increase the breathing rate can be caused by inadequate carotid body response or pulmonary or renal disease.
526:, even in acclimatized women, which interferes with fetal growth. Consequently, children born at high-altitudes are found to be born shorter on average than children born at sea level. 1436:(Report). Vol. USARIEM-TN94-2. US Army Research Inst. of Environmental Medicine Thermal and Mountain Medicine Division Technical Report. Archived from the original on 23 April 2009 540:
It is estimated that 81.6 million people live at elevations above 2,500 metres (8,200 ft). Genetic changes have been detected in high-altitude population groups in
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Stray-Gundersen, J; Chapman, RF; Levine, BD (September 2001). ""Living high-training low" altitude training improves sea level performance in male and female elite runners".
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The human body can adapt to high altitude through both immediate and long-term acclimatization. At high altitude, in the short term, the lack of oxygen is sensed by the
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reaches around 2,100 metres (6,900 ft) above sea level, the saturation of oxyhemoglobin begins to decrease rapidly. However, the human body has both short-term and
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Levine, BD; Stray-Gundersen, J (July 1997). ""Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance".
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The performance-enhancing effect of altitude training could be due to increased red blood cell count, more efficient training, or changes in muscle physiology.
260:, to treat these conditions on site. Research also indicates elevated risk of permanent brain damage in people climbing to above 5,500 m (18,045 ft). 843: 826:, Italy, from 1988 to 1996, and again in 2004. The advantage of its high altitude in sprinting and jumping events held out hope of world records, with sponsor 831: 599:
prevalence in the United States. This is not explained by migration alone. On the other hand, people living at higher elevations also have a higher rate of
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Moore, LG; Shriver, M; Bemis, L; Hickler, B; et al. (April 2004). "Maternal Adaptation to High-altitude Pregnancy: An Experiment of Nature—A Review".
839: 404:. A sudden change from sea-level pressure to pressures as low as those at 5,500 m (18,000 ft) can cause altitude-induced decompression sickness. 439:
is slightly decreased; and non-essential bodily functions are suppressed, resulting in a decline in food digestion efficiency (as the body suppresses the
807:. The world records in most short sprint and jump records were broken there. Other records were also set at altitude in anticipation of those Olympics. 2865: 3912: 993: 4019: 777:
max begins to decrease significantly at moderate elevation, starting at 1,500 metres and dropping 8 to 11 percent for every additional 1000 metres.
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Beall, C. M.; Goldstein, M. C. (August 1987). "Hemoglobin concentration of pastoral nomads permanently resident at 4,850-5,450 meters in Tibet".
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The International Society for Mountain Medicine recognizes three altitude regions which reflect the lowered amount of oxygen in the atmosphere:
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Rose, MS; Houston, CS; Fulco, CS; Coates, G; Sutton, JR; Cymerman, A (December 1988). "Operation Everest. II: Nutrition and body composition".
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oxygen in atmospheric air over the range in which humans can survive. The other major effect of altitude is due to lower ambient temperature.
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Hamlin, Michael J; Hopkins, Will G; Hollings, Stephen C (Oct 2015). "Effects of altitude on performance of elite track-and-field athletes".
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matches held at more than 2,500 metres above sea level, effectively barring select stadiums in Bolivia, Colombia, and Ecuador from hosting
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Zubieta-Calleja, G. R.; Paulev, P-E.; Zubieta-Calleja, L.; Zubieta-Castillo, G. (2007). "Altitude adaptation through hematocrit change".
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de-training effect as the athletes are usually not able to exercise with as much intensity at high altitudes compared to sea level.
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Anand, Inder S.; Chandrashekhar, Y. (1996). "18, Fluid Metabolism at High Altitudes.". In Marriott, B.M.; Carlson, S.J. (eds.).
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decreases with altitude as well. It is about half of its sea-level value at 5,000 m (16,000 ft), the altitude of the
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Bigard, AX; Brunet, A; Guezennec, CY; Monod, H (1991). "Skeletal muscle changes after endurance training at high altitude".
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Grocott, Michael P.W.; Martin, Daniel S.; Levett, Denny Z.H.; McMorrow, Roger; Windsor, Jeremy; Montgomery, Hugh E. (2009).
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of altitude would require 45.6 days. The upper altitude limit of this linear relationship has not been fully established.
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Tibetans and Andeans are two groups which are relatively well adapted to high altitude, but display noticeably different
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increases approximately 9% with every increase of altitude by 1,000 metres (3,300 ft). Symptoms of sunburn include
249: 51: 1728: 4167: 3921: 3870: 3721: 1552:. Washington (DC): National Academies Press (US): Institute of Medicine (US) Committee on Military Nutrition Research. 937: 922: 389:. Exposure to pressure below this limit results in a rapid loss of consciousness, followed by a series of changes to 1549:
Nutritional Needs In Cold And In High-Altitude Environments: Applications for Military Personnel in Field Operations
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Sports organizations acknowledge the effects of altitude on performance: for example, the governing body for the
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Even below the Armstrong limit, an abrupt decrease in atmospheric pressure can cause venous gas bubbles and
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Ward-Smith, AJ (1983). "The influence of aerodynamic and biomechanical factors on long jump performance".
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US Army Research Inst. Of Environmental Medicine Thermal and Mountain Medicine Division Technical Report
421: 157: 1753: 1092: 3485: 3421: 4683: 4671: 4551: 3952: 3807: 3771: 3606: 3601: 3469: 2526: 2053: 1526: 1449: 904: 793:, has ruled that performances achieved at an altitude greater than 1,000 metres will be approved for 627: 370: 141: 2671: 1207: 1087: 4695: 4638: 4546: 4499: 4373: 4212: 3634: 3383: 3046: 488: 322:, a Swiss physician and alpinist. It refers to altitudes above a certain point where the amount of 319: 4702: 2624:
West, J.B. (Spring 2001). "Safe upper limits for oxygen enrichment of room air at high altitude".
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Zubieta-Castillo, G.; Zubieta-Calleja, G.R.; Zubieta-Calleja, L.; Zubieta-Castillo, Nancy (2008).
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or in heavy smokers at high altitude. The cause for the increased suicide risk is as yet unknown.
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production (because reduced glucose breakdown decreases the amount of lactate formed), decreased
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will result in deterioration of bodily functions, loss of consciousness, and, ultimately, death.
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Travel to each of these altitude regions can lead to medical problems, from the mild symptoms of
188: 256:). The higher the altitude, the greater the risk. Expedition doctors commonly stock a supply of 4659: 4591: 4571: 4465: 4307: 4238: 4000: 3916: 3882: 3684: 3639: 3621: 3481: 3473: 3461: 3354: 3318: 3283: 3240: 3205: 3169: 3126: 3011: 2990: 2984: 2965: 2930: 2886:
Blumthaler, M; Ambach, W; Ellinger, R (1997). "Increase in solar UV radiation with altitude".
2819: 2786: 2723: 2641: 2606: 2554: 2495: 2454: 2413: 2378: 2337: 2329: 2288: 2239: 2231: 2163: 2130: 2081: 2022: 1971: 1933: 1906: 1857: 1822: 1653: 1618: 1583: 1518: 1496:"Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging" 1474: 1286: 1230: 1185: 1141: 1047: 978: 953: 943: 868: 863: 819:. Many of the other records set at Mexico City were later surpassed by marks set at altitude. 800: 299: 204: 153: 3477: 3465: 1709: 1027: 4566: 4420: 4137: 3817: 3766: 3676: 3591: 3346: 3310: 3275: 3232: 3197: 3161: 3118: 2957: 2922: 2895: 2778: 2715: 2633: 2596: 2588: 2544: 2534: 2485: 2444: 2405: 2368: 2319: 2278: 2270: 2223: 2120: 2112: 2071: 2061: 2012: 2002: 1963: 1896: 1849: 1812: 1645: 1610: 1575: 1510: 1222: 1177: 1039: 932: 703: 605: 440: 331: 165: 90: 2433:"Lower Mortality From Coronary Heart Disease and Stroke at Higher Altitudes in Switzerland" 1853: 4707: 4534: 4440: 4389: 4247: 3995: 3843: 3812: 1277:
Fulco, CS; Cymerman, A (1998). "Maximal and submaximal exercise performance at altitude".
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Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG (December 2017).
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due to the reduced blocking of ultraviolet by the thinner atmosphere. The amount of
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functions, and eventually death, unless pressure is restored within 60–90 seconds.
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Brenner, Barry; Cheng, David; Clark, Sunday; Camargo, Carlos A. Jr (Spring 2011).
1253:"Facts that Prove that Adaptation to life at Extreme Altitude (8842m) is possible" 3314: 3165: 2813: 2539: 2157: 1614: 1514: 1407: 4425: 4399: 4394: 4100: 4090: 3926: 3122: 2308:"Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia" 1547: 877: 804: 718: 664: 609: 472: 452: 432: 110: 102: 3081: 3062: 2769:
Brown DJ, Brugger H, Boyd J, Paal P (November 2012). "Accidental hypothermia".
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Proceedings of the National Academy of Sciences of the United States of America
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Medical Problems in High Mountain Environments. A Handbook for Medical Officers
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Even when acclimatized, prolonged exposure to high altitude can interfere with
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Westerterp, Klaas (1 June 2001). "Energy and Water Balance at High Altitude".
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purposes, but carry the notation of "A" to denote they were set at altitude.
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Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
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The Pocket Outdoor Survival Guide: The Ultimate Guide for Short-Term Survival
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concentration (at elevations below 4000 metres), and less susceptibility to
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held for almost 23 years and has only been beaten once without altitude or
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Moore, Lorna G (June 2001). "Human Genetic Adaptation to High Altitude".
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10.1002/(SICI)1096-8644(1998)107:27+<25::AID-AJPA3>3.0.CO;2-L
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max, a measurement of the maximum capacity of an individual to utilize O
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Philosophical Transactions of the Royal Society B: Biological Sciences
1208:"Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest" 30: 3569: 3495: 3456: 679: 671: 451:. Eventually, the body undergoes physiological changes such as lower 323: 59: 1252: 353: 2866:"High Elevation Travel & Altitude Illness CDC Yellow Book 2024" 1636:
Kayser, B. (October 1992). "Nutrition and high altitude exposure".
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Voss, JD; Masuoka, P; Webber, BJ; Scher, AI; Atkinson, RL (2013).
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that occurs when exposed to extreme low temperatures, causing the
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fraction remains constant to about 100 km (62 mi), so pO
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below 35.0 °C (95.0 °F) in humans. Symptoms range from
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EMedicine Specialties > Emergency Medicine > Environmental
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Voss, JD; Allison, DB; Webber, BJ; Otto, JL; Clark, LL (2014).
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Very high altitude = 3,500–5,500 metres (11,500–18,000 ft)
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Into Thin Air: A Personal Account of the Mt. Everest Disaster
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during strenuous exercise. For an unacclimated individual, VO
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Handford, C; Thomas, O; Imray, CHE (May 2017). "Frostbite".
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is observed for residents at higher altitudes. Similarly, a
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In addition to cold injuries, breathing cold air can cause
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International Journal of Sports Physiology and Performance
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to high-altitude environments, associated with heritable
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High altitude = 1,500–3,500 metres (4,900–11,500 ft)
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Witt, Kelsey E.; Huerta-Sánchez, Emilia (22 July 2019).
420:). However, hyperpnea also causes the adverse effect of 132:
Pressure as a function of the height above the sea level
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Faeh, David; Gutzwiller, Felix; Bopp, Matthias (2009).
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West, JB (2002). "Highest permanent human habitation".
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offering a car as a bonus. One record was set, in the
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practice this can be done using oxygen concentrators.
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in favor of increasing its cardiopulmonary reserves).
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At an altitude of 19,000 m (63,000 ft), the
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Extreme altitude = above 5,500 metres (18,000 ft)
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Journal of Photochemistry and Photobiology B: Biology
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of the skin or other tissues, commonly affecting the
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The physiological responses to high altitude include
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Environmental effects on physiology and mental health
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Borden Institute, Washington, DC. 1032:Journal of Respiratory and Critical Care Medicine 655:The temperature of the atmosphere decreases by a 3063:"All-time men's best long jump: Non-legal marks" 822:An elite athletics meeting was held annually in 298:is in the death zone, as are the summits of all 1801:"Effect of Altitude on the Heart and the Lungs" 1072:"Human Adaptation to High Terrestrial Altitude" 552:in Africa. This adaptation means irreversible, 3104: 3102: 1370:). Archived from the original on 23 April 2009 4027: 3540: 3384:"Fifa suspends ban on high-altitude football" 2983:Kenney, WL; Wilmore, JH; Costill, DL (2019). 2191:. National Geographic Society. Archived from 1065: 1063: 1061: 710:and mental confusion, to hallucinations and 187:Atmospheric pressure decreases following the 8: 2764: 2762: 2659:Richard M. Goody; James C.G. Walker (1972). 2355:Moore, LG; Niermeyer, S; Zamudio, S (1998). 1494:Fayed, N; Modrego, P.J.; Morales, H (2006). 3378: 3376: 3041:"Anche il volo di Bubka finisce in Ferrari" 2708:Emergency Medicine Clinics of North America 1279:Aviation, Space, and Environmental Medicine 1137:Wild winds: adventures in the highest Andes 1021: 1019: 1017: 1015: 1013: 1011: 1009: 4678: 4054: 4034: 4020: 4012: 3547: 3533: 3525: 3435: 2570: 2568: 1116:: CS1 maint: location missing publisher ( 124:Pressure effects as a function of altitude 2600: 2548: 2538: 2489: 2448: 2372: 2323: 2282: 2216:American Journal of Physical Anthropology 2124: 2075: 2065: 2016: 2006: 1900: 1883:Martin, D; Windsor, J (1 December 2008). 1816: 1775: 1773: 1754:"Altitude-induced Decompression Sickness" 1358:Muza, SR; Fulco, CS; Cymerman, A (2004). 1246: 1244: 1201: 1199: 1086: 1070:Young, Andrew J; Reeves, John T. (2002). 1949: 1947: 1129: 1127: 702:areas. Hypothermia is defined as a body 346:extended stay in the death zone without 127: 1782:"Altitude Illness – Cerebral Syndromes" 1005: 667:become risks to humans. Frostbite is a 272:, is at 5,100 m (16,700 ft). 2689:"12 Extreme Facts about Mount Everest" 1989:Baye, Kaleab; Hirvonen, Kalle (2020). 1926:Journal of Physiology and Pharmacology 1854:10.1152/physiologyonline.2001.16.3.134 1759:. U.S. Federal Aviation Administration 1447: 1381: 1159: 1157: 1109: 872:Athletes training at high altitude in 264:respiratory symptoms become apparent. 4193:Radiation-induced erythema multiforme 3086:Track and Field all-time performances 3067:Track and Field all-time performances 2306:Beall, Cynthia M. (1 February 2006). 1079:Medical Aspects of Harsh Environments 7: 4666: 3913:oxygen–hemoglobin dissociation curve 3431:, High Altitude Pathology Institute. 2581:High Altitude Medicine & Biology 2398:High Altitude Medicine & Biology 1473:. New York: Anchor Books/Doubleday. 1311:from the original on 18 October 2012 994:Oxygen–hemoglobin dissociation curve 216: 180:, the oxygen-binding red pigment in 164:) in sea-level air is 20.9%, so the 4510:Pseudoverrucous papules and nodules 4198:Radiation-induced hypertrophic scar 2771:The New England Journal of Medicine 2312:Integrative and Comparative Biology 2183:Hillary Mayell (24 February 2004). 431:In addition, at high altitude, the 136:The human body can perform best at 3839:hypoxic pulmonary vasoconstriction 3010:Valsecchi, Piero (6 August 1996). 2159:Human Adaptation and Accommodation 2040:Tremblay, JC; Ainslie, PN (2021). 536:High-altitude adaptation in humans 497:hypoxic pulmonary vasoconstriction 491:enzyme concentration, increase in 44:effects of high altitude on humans 25: 2989:. United States: Human Kinetics. 2742:"Frostbite - Symptoms and causes" 2450:10.1161/CIRCULATIONAHA.108.819250 1818:10.1161/CIRCULATIONAHA.106.650796 1404:"Non-Physician Altitude Tutorial" 756:, swelling, itching, and nausea. 622:High altitude breathing apparatus 554:long-term physiological responses 318:) was first conceived in 1953 by 4701: 4689: 4677: 4665: 4654: 4653: 4296:Inner ear decompression sickness 3274:(5): 2055–7, discussion 2057–8. 2986:Physiology of Sport and Exercise 2478:International Journal of Obesity 2008:10.1001/jamapediatrics.2020.2386 1503:The American Journal of Medicine 1360:"Altitude Acclimatization Guide" 1331:"Introduction to the Atmosphere" 880:(elevation 1,856 m or 6,089 ft). 471:mass, a higher concentration of 385:. This altitude is known as the 363:second highest mountain on Earth 4690: 3351:10.1152/japplphysiol.00361.2005 3280:10.1152/japplphysiol.00820.2005 3237:10.1152/japplphysiol.00877.2005 3202:10.1152/japplphysiol.00742.2005 3080:Larsson, Peter (10 June 2020). 2670:. Prentice-Hall. Archived from 1799:Bärtsch, P; Gibbs, JSR (2007). 1260:Adaptation Biology and Medicine 1170:Journal of Experimental Biology 940:, adaptation to chronic hypoxia 928:1999 South Dakota Learjet crash 724:There is also a higher risk of 608:at high altitude in those with 516:intrauterine growth restriction 373:is sufficiently low that water 84:altitude decompression sickness 3418:Essentials of Human Physiology 3061:Larsson, Peter (10 May 2020). 2864:Hackett, Peter; Shlim, David. 2812:Fears, J. Wayne (2011-02-14). 1968:10.1016/j.placenta.2004.01.008 1842:News in Physiological Sciences 1305:"Hypoxemia (low blood oxygen)" 215:drops, the body responds with 1: 4530:environmental skin conditions 4323:High-altitude pulmonary edema 3303:Journal of Applied Physiology 3268:Journal of Applied Physiology 3225:Journal of Applied Physiology 3190:Journal of Applied Physiology 3154:Journal of Applied Physiology 3111:Journal of Applied Physiology 2900:10.1016/S1011-1344(96)00018-8 2105:Journal of Molecular Medicine 1679:Wyss-Dunant, Edouard (1953). 1568:High Altitude Medical Biology 501:right ventricular hypertrophy 242:high-altitude pulmonary edema 4520:Tropical anhidrotic asthenia 4329:High-altitude cerebral edema 3315:10.1152/jappl.1991.71.6.2114 3166:10.1152/jappl.2001.91.3.1113 3050:. 1 August 1994. p. 23. 2927:10.1016/0021-9290(83)90116-1 2540:10.1371/journal.pone.0093493 1889:Postgraduate Medical Journal 1615:10.1152/jappl.1988.65.6.2545 1515:10.1016/j.amjmed.2005.07.062 736:that is hot to the touch or 250:high-altitude cerebral edema 4542:frictional/traumatic/sports 4168:Chronic radiation keratosis 3871:Ventilation/perfusion ratio 3722:pulmonary stretch receptors 3123:10.1152/jappl.1997.83.1.102 2840:"Adapting to High Altitude" 938:2,3-bisphosphoglyceric acid 923:1996 Mount Everest disaster 326:is insufficient to sustain 4751: 4634:Pseudoacanthosis nigricans 3903:alveolar–arterial gradient 2661:"Atmospheric Temperatures" 2638:10.1089/152702901750067918 2410:10.1089/152702901750265341 1729:"Human Exposure to Vacuum" 1140:. Ed Darack. p. 153. 1044:10.1164/rccm.201207-1323CI 989:Organisms at high altitude 861: 644: 625: 619: 593:dose–response relationship 533: 283: 58:determines the content of 4730:Mountaineering and health 4649: 4405:Space adaptation syndrome 4313:Chronic mountain sickness 4218:Radiation recall reaction 4208:Radiation-induced morphea 4111:Warm water immersion foot 3784:respiratory minute volume 3696:ventral respiratory group 3414:"Section 4/4ch7/s4ch7_32" 2720:10.1016/j.emc.2016.12.006 2117:10.1007/s00109-017-1584-7 1932:(Suppl 5(Pt 2)): 811–18. 1580:10.1089/15270290260512882 1454:: CS1 maint: unfit URL ( 1388:: CS1 maint: unfit URL ( 964:Helios Airways Flight 522 803:were held at altitude in 748:. Other symptoms include 652:pressure are cumulative. 578:chronic mountain sickness 240:to the potentially fatal 4587:Weathering nodule of ear 4203:Radiation-induced keloid 4188:Radiation-induced cancer 4118:Non-freezing cold injury 4096:Immersion foot syndromes 3691:dorsal respiratory group 3585:obligate nasal breathing 2189:National Geographic News 1902:10.1136/pgmj.2008.068296 1716:. PBS. 24 February 1998. 1710:"Everest:The Death Zone" 1028:"High-Altitude Medicine" 969:High-altitude adaptation 901:a short-lived moratorium 801:The 1968 Summer Olympics 604:indication of increased 217:altitude acclimatization 18:Altitude acclimatization 4515:Sclerosing lymphangitis 4106:Tropical immersion foot 3893:pulmonary gas pressures 2962:10.1123/ijspp.2014-0261 2915:Journal of Biomechanics 2228:10.1002/ajpa.1330730404 2067:10.1073/pnas.2102463118 1432:Cymerman, A; Rock, PB. 1182:10.1242/jeb.204.18.3115 647:Atmospheric temperature 365:, is in the death zone. 238:acute mountain sickness 158:concentration of oxygen 4735:Respiratory physiology 4602:Painful fat herniation 4582:Vibration white finger 4291:Decompression sickness 4148:Erythrocyanosis crurum 3647:mechanical ventilation 3556:Respiratory physiology 2818:. Simon and Schuster. 2361:Am. J. Phys. Anthropol 2275:10.1098/rstb.2018.0235 1650:10.1055/s-2007-1024616 1469:Krakauer, Jon (1999). 1026:West, John B. (2012). 881: 850:were also beaten, but 589:cardiovascular disease 402:decompression sickness 366: 303: 156:, by definition). The 133: 39: 4557:Fissure of the nipple 4525:UV-sensitive syndrome 4450:Adverse drug reaction 4279:Middle ear barotrauma 4269:Arterial gas embolism 3898:alveolar gas equation 3834:pulmonary circulation 2783:10.1056/NEJMra1114208 2593:10.1089/ham.2010.1058 2156:Frisancho AR (1993). 1335:PhysicalGeography.net 1227:10.1056/NEJMoa0801581 871: 548:of the Americas, and 422:respiratory alkalosis 356: 334:, are located in the 293: 131: 68:long-term adaptations 33: 4552:Equestrian perniosis 3953:respiratory quotient 3808:body plethysmography 3727:Hering–Breuer reflex 3602:pulmonary surfactant 1727:Geoffrey A. Landis. 1644:(Suppl 1): S129–32. 1532:on 22 November 2010. 1098:on 16 September 2012 760:Athletic performance 628:Supplementary oxygen 371:atmospheric pressure 348:supplementary oxygen 142:atmospheric pressure 62:in blood. After the 4639:Narcotic dermopathy 4547:Black heel and palm 4500:Dermatosis neglecta 4374:Psychological abuse 4213:Radiation poisoning 3796:Lung function tests 3630:hyperresponsiveness 3047:Corriere della Sera 2531:2014PLoSO...993493V 2058:2021PNAS..11802463T 2052:(18): e2102463118. 1266:(Suppl 5): 348–355. 1134:Darack, Ed (2002). 734:red or reddish skin 320:Edouard Wyss-Dunant 4609:Uranium dermatosis 4562:Pulling boat hands 4471:Lightning injuries 3963:diffusion capacity 3958:arterial blood gas 3938:carbonic anhydrase 3672:pneumotaxic center 2693:New Zealand Herald 2491:10.1038/ijo.2013.5 2325:10.1093/icb/icj004 2269:(1777): 20180235. 1688:The Mountain World 882: 787:sport of athletics 479:tissue, increased 459:volume, increased 433:heart beats faster 426:respiratory center 379:normal temperature 367: 304: 189:Barometric formula 134: 40: 4717: 4716: 4466:Electrical injury 4308:Altitude sickness 4156: 4155: 4009: 4008: 3917:Oxygen saturation 3883:zones of the lung 3622:airway resistance 3522: 3521: 3424:on 24 March 2016. 3412:Nosek, Thomas M. 2996:978-1-4925-7485-9 2825:978-1-62636-680-0 2626:High Alt Med Biol 2195:on March 30, 2021 2169:978-0-472-09511-7 2111:(12): 1269–1282. 1811:(19): 2191–2202. 1681:"Acclimatisation" 1480:978-0-385-49478-6 1147:978-1-884980-81-7 1038:(12): 1229–1237. 979:Hypoxia (medical) 954:Aviation medicine 944:Altitude sickness 903:on international 864:Altitude training 811:'s record in the 606:mood disturbances 424:, inhibiting the 342:mountain ranges. 332:eight-thousanders 300:eight-thousanders 205:Everest Base Camp 80:extreme altitudes 52:oxygen saturation 16:(Redirected from 4742: 4705: 4693: 4692: 4681: 4680: 4669: 4668: 4657: 4656: 4493:physical factors 4489:skin conditions 4421:Hypersensitivity 4138:Cold intolerance 4055: 4042:Consequences of 4036: 4029: 4022: 4013: 3818:nitrogen washout 3677:apneustic center 3592:respiratory rate 3549: 3542: 3535: 3526: 3436: 3425: 3420:. Archived from 3400: 3399: 3397: 3395: 3380: 3371: 3370: 3339:J. Appl. Physiol 3333: 3327: 3326: 3298: 3292: 3291: 3263: 3257: 3256: 3220: 3214: 3213: 3184: 3178: 3177: 3149: 3143: 3142: 3106: 3097: 3096: 3094: 3092: 3077: 3075: 3073: 3058: 3052: 3051: 3043: 3036: 3027: 3026: 3024: 3022: 3007: 3001: 3000: 2980: 2974: 2973: 2945: 2939: 2938: 2910: 2904: 2903: 2883: 2877: 2876: 2874: 2872: 2861: 2855: 2854: 2852: 2850: 2836: 2830: 2829: 2809: 2803: 2802: 2766: 2757: 2756: 2754: 2752: 2738: 2732: 2731: 2703: 2697: 2696: 2685: 2679: 2678: 2676: 2665: 2656: 2650: 2649: 2621: 2615: 2614: 2604: 2572: 2563: 2562: 2552: 2542: 2510: 2504: 2503: 2493: 2469: 2463: 2462: 2452: 2428: 2422: 2421: 2393: 2387: 2386: 2376: 2352: 2346: 2345: 2327: 2303: 2297: 2296: 2286: 2254: 2248: 2247: 2211: 2205: 2204: 2202: 2200: 2180: 2174: 2173: 2153: 2147: 2146: 2128: 2096: 2090: 2089: 2079: 2069: 2037: 2031: 2030: 2020: 2010: 1986: 1980: 1979: 1951: 1942: 1941: 1921: 1915: 1914: 1904: 1895:(998): 622–627. 1880: 1874: 1873: 1837: 1831: 1830: 1820: 1796: 1790: 1789: 1777: 1768: 1767: 1765: 1764: 1758: 1750: 1744: 1743: 1741: 1740: 1731:. Archived from 1724: 1718: 1717: 1706: 1700: 1699: 1697: 1695: 1685: 1676: 1670: 1669: 1638:Int J Sports Med 1633: 1627: 1626: 1603:J. Appl. Physiol 1598: 1592: 1591: 1563: 1554: 1553: 1543: 1534: 1533: 1531: 1525:. Archived from 1500: 1491: 1485: 1484: 1466: 1460: 1459: 1453: 1445: 1443: 1441: 1429: 1420: 1419: 1417: 1415: 1400: 1394: 1393: 1387: 1379: 1377: 1375: 1368:USARIEM–TN–04–05 1355: 1346: 1345: 1343: 1341: 1327: 1321: 1320: 1318: 1316: 1301: 1295: 1294: 1274: 1268: 1267: 1257: 1248: 1239: 1238: 1212: 1203: 1194: 1193: 1161: 1152: 1151: 1131: 1122: 1121: 1115: 1107: 1105: 1103: 1097: 1091:. Archived from 1090: 1076: 1067: 1056: 1055: 1023: 933:2008 K2 disaster 858:Endurance events 832:men's pole vault 781:Explosive events 704:core temperature 441:digestive system 314:(originally the 166:partial pressure 91:hyperventilation 21: 4750: 4749: 4745: 4744: 4743: 4741: 4740: 4739: 4720: 4719: 4718: 4713: 4645: 4535:Electrical burn 4492: 4491:resulting from 4490: 4488: 4482: 4454: 4441:Arthus reaction 4409: 4390:Motion sickness 4378: 4352: 4336: 4252: 4248:Oxygen toxicity 4227: 4152: 4079: 4046: 4044:external causes 4040: 4010: 4005: 3996:oxygen toxicity 3972: 3860:ventilation (V) 3848: 3844:pulmonary shunt 3822: 3813:peak flow meter 3733: 3651: 3558: 3553: 3523: 3518: 3517: 3447: 3411: 3408: 3403: 3393: 3391: 3382: 3381: 3374: 3335: 3334: 3330: 3300: 3299: 3295: 3265: 3264: 3260: 3222: 3221: 3217: 3186: 3185: 3181: 3151: 3150: 3146: 3108: 3107: 3100: 3090: 3088: 3079: 3071: 3069: 3060: 3059: 3055: 3038: 3037: 3030: 3020: 3018: 3009: 3008: 3004: 2997: 2982: 2981: 2977: 2947: 2946: 2942: 2912: 2911: 2907: 2885: 2884: 2880: 2870: 2868: 2863: 2862: 2858: 2848: 2846: 2844:www.palomar.edu 2838: 2837: 2833: 2826: 2811: 2810: 2806: 2768: 2767: 2760: 2750: 2748: 2740: 2739: 2735: 2705: 2704: 2700: 2687: 2686: 2682: 2674: 2663: 2658: 2657: 2653: 2623: 2622: 2618: 2574: 2573: 2566: 2512: 2511: 2507: 2484:(10): 1407–12. 2471: 2470: 2466: 2430: 2429: 2425: 2395: 2394: 2390: 2354: 2353: 2349: 2305: 2304: 2300: 2256: 2255: 2251: 2213: 2212: 2208: 2198: 2196: 2182: 2181: 2177: 2170: 2155: 2154: 2150: 2098: 2097: 2093: 2039: 2038: 2034: 2001:(10): 977–984. 1995:JAMA Pediatrics 1988: 1987: 1983: 1953: 1952: 1945: 1923: 1922: 1918: 1882: 1881: 1877: 1839: 1838: 1834: 1798: 1797: 1793: 1779: 1778: 1771: 1762: 1760: 1756: 1752: 1751: 1747: 1738: 1736: 1726: 1725: 1721: 1708: 1707: 1703: 1693: 1691: 1683: 1678: 1677: 1673: 1635: 1634: 1630: 1600: 1599: 1595: 1565: 1564: 1557: 1545: 1544: 1537: 1529: 1509:(2): 168.e1–6. 1498: 1493: 1492: 1488: 1481: 1468: 1467: 1463: 1446: 1439: 1437: 1431: 1430: 1423: 1413: 1411: 1410:on 24 June 2011 1402: 1401: 1397: 1380: 1373: 1371: 1357: 1356: 1349: 1339: 1337: 1329: 1328: 1324: 1314: 1312: 1307:. Mayo Clinic. 1303: 1302: 1298: 1276: 1275: 1271: 1255: 1250: 1249: 1242: 1210: 1205: 1204: 1197: 1163: 1162: 1155: 1148: 1133: 1132: 1125: 1108: 1101: 1099: 1095: 1088:10.1.1.175.3270 1074: 1069: 1068: 1059: 1025: 1024: 1007: 1003: 998: 918: 866: 860: 817:wind assistance 791:World Athletics 783: 776: 772: 768: 762: 649: 643: 630: 624: 618: 562:genetic changes 538: 532: 477:skeletal muscle 410: 408:Acclimatization 387:Armstrong limit 288: 282: 214: 202: 198: 182:red blood cells 175: 171: 163: 126: 28: 23: 22: 15: 12: 11: 5: 4748: 4746: 4738: 4737: 4732: 4722: 4721: 4715: 4714: 4712: 4711: 4699: 4687: 4675: 4663: 4650: 4647: 4646: 4644: 4643: 4642: 4641: 4636: 4631: 4626: 4621: 4611: 4606: 4605: 4604: 4599: 4594: 4592:Wrestler's ear 4589: 4584: 4579: 4574: 4572:Surfer's knots 4569: 4564: 4559: 4554: 4549: 4539: 4538: 4537: 4527: 4522: 4517: 4512: 4507: 4502: 4496: 4494: 4484: 4483: 4481: 4480: 4475: 4474: 4473: 4462: 4460: 4456: 4455: 4453: 4452: 4446: 4445: 4444: 4443: 4438: 4433: 4428: 4417: 4415: 4414:Adverse effect 4411: 4410: 4408: 4407: 4402: 4397: 4392: 4386: 4384: 4380: 4379: 4377: 4376: 4371: 4366: 4364:Physical abuse 4360: 4358: 4354: 4353: 4351: 4350: 4344: 4342: 4338: 4337: 4335: 4334: 4333: 4332: 4326: 4320: 4315: 4310: 4300: 4299: 4298: 4288: 4287: 4286: 4281: 4276: 4271: 4260: 4258: 4254: 4253: 4251: 4250: 4245: 4235: 4233: 4229: 4228: 4226: 4225: 4220: 4215: 4210: 4205: 4200: 4195: 4190: 4185: 4183:Radiation burn 4180: 4178:Radiation acne 4175: 4170: 4164: 4162: 4158: 4157: 4154: 4153: 4151: 4150: 4145: 4140: 4135: 4130: 4125: 4120: 4115: 4114: 4113: 4108: 4103: 4093: 4087: 4085: 4081: 4080: 4078: 4077: 4072: 4067: 4061: 4059: 4052: 4048: 4047: 4041: 4039: 4038: 4031: 4024: 4016: 4007: 4006: 4004: 4003: 3998: 3993: 3992: 3991: 3980: 3978: 3974: 3973: 3971: 3970: 3960: 3955: 3950: 3945: 3942:chloride shift 3935: 3932:Haldane effect 3929: 3924: 3919: 3910: 3905: 3900: 3895: 3890: 3885: 3880: 3879: 3878: 3873: 3862: 3856: 3854: 3850: 3849: 3847: 3846: 3841: 3836: 3830: 3828: 3824: 3823: 3821: 3820: 3815: 3810: 3805: 3800: 3798: 3792: 3791: 3789:FEV1/FVC ratio 3786: 3781: 3779: 3775: 3774: 3769: 3764: 3759: 3754: 3749: 3743: 3741: 3735: 3734: 3732: 3731: 3730: 3729: 3719: 3718: 3717: 3712: 3704:chemoreceptors 3700: 3699: 3698: 3693: 3681: 3680: 3679: 3674: 3661: 3659: 3653: 3652: 3650: 3649: 3644: 3643: 3642: 3637: 3632: 3624: 3619: 3614: 3612:elastic recoil 3609: 3604: 3599: 3594: 3589: 3588: 3587: 3582: 3577: 3566: 3564: 3560: 3559: 3554: 3552: 3551: 3544: 3537: 3529: 3520: 3519: 3516: 3515: 3488: 3448: 3443: 3442: 3440: 3439:Classification 3433: 3432: 3426: 3407: 3406:External links 3404: 3402: 3401: 3372: 3345:(4): 1249–57. 3328: 3309:(6): 2114–21. 3293: 3258: 3215: 3196:(4): 1238–48. 3179: 3160:(3): 1113–20. 3144: 3098: 3053: 3028: 3002: 2995: 2975: 2940: 2905: 2894:(2): 130–134. 2878: 2856: 2831: 2824: 2804: 2777:(20): 1930–8. 2758: 2733: 2714:(2): 281–299. 2698: 2680: 2677:on 2016-06-03. 2651: 2616: 2564: 2505: 2464: 2443:(6): 495–501. 2423: 2404:(2): 257–279. 2388: 2367:(S27): 25–64. 2347: 2298: 2249: 2222:(4): 433–438. 2206: 2175: 2168: 2148: 2091: 2032: 1981: 1943: 1916: 1875: 1832: 1791: 1769: 1745: 1719: 1701: 1671: 1628: 1609:(6): 2545–51. 1593: 1555: 1535: 1486: 1479: 1461: 1421: 1395: 1347: 1322: 1296: 1285:(8): 793–801. 1269: 1240: 1195: 1176:(18): 3115–9. 1153: 1146: 1123: 1057: 1004: 1002: 999: 997: 996: 991: 986: 981: 976: 971: 966: 961: 956: 951: 946: 941: 935: 930: 925: 919: 917: 914: 862:Main article: 859: 856: 782: 779: 774: 770: 766: 761: 758: 712:cardiac arrest 642: 639: 620:Main article: 617: 614: 585:mortality rate 534:Main article: 531: 528: 414:carotid bodies 409: 406: 391:cardiovascular 357:The summit of 312:mountaineering 294:The summit of 284:Main article: 281: 278: 234: 233: 230: 227: 212: 200: 196: 173: 169: 161: 125: 122: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4747: 4736: 4733: 4731: 4728: 4727: 4725: 4710: 4709: 4704: 4700: 4698: 4697: 4688: 4686: 4685: 4676: 4674: 4673: 4664: 4662: 4661: 4652: 4651: 4648: 4640: 4637: 4635: 4632: 4630: 4627: 4625: 4622: 4620: 4619:Skin pop scar 4617: 4616: 4615: 4612: 4610: 4607: 4603: 4600: 4598: 4595: 4593: 4590: 4588: 4585: 4583: 4580: 4578: 4575: 4573: 4570: 4568: 4567:Runner's rump 4565: 4563: 4560: 4558: 4555: 4553: 4550: 4548: 4545: 4544: 4543: 4540: 4536: 4533: 4532: 4531: 4528: 4526: 4523: 4521: 4518: 4516: 4513: 4511: 4508: 4506: 4503: 4501: 4498: 4497: 4495: 4485: 4479: 4476: 4472: 4469: 4468: 4467: 4464: 4463: 4461: 4457: 4451: 4448: 4447: 4442: 4439: 4437: 4434: 4432: 4429: 4427: 4424: 4423: 4422: 4419: 4418: 4416: 4412: 4406: 4403: 4401: 4398: 4396: 4393: 4391: 4388: 4387: 4385: 4381: 4375: 4372: 4370: 4367: 4365: 4362: 4361: 4359: 4355: 4349: 4346: 4345: 4343: 4339: 4330: 4327: 4324: 4321: 4319: 4316: 4314: 4311: 4309: 4306: 4305: 4304: 4303:High altitude 4301: 4297: 4294: 4293: 4292: 4289: 4285: 4282: 4280: 4277: 4275: 4274:Aerosinusitis 4272: 4270: 4267: 4266: 4265: 4262: 4261: 4259: 4255: 4249: 4246: 4244: 4240: 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Index

Altitude acclimatization

Mount Rainier
oxygen saturation
hemoglobin
oxygen
human body
long-term adaptations
death zone
acclimatize
extreme altitudes
altitude decompression sickness
hyperventilation
polycythemia
frostbite
hypothermia
sunburn
dehydration
phenotypes

sea level
atmospheric pressure
Pa
millibars
atm
concentration of oxygen
partial pressure
hemoglobin
red blood cells
Barometric formula

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