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316:"Scaffold Morphing and In Silico Design of Potential BACE-1 (β-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics"
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Although BACE cleaves the extracellular domains of several transmembrane proteins, its physiological function remains unknown.
163:
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268:
Besides their involvement in the pathogenesis of
Alzheimer's, these proteins also have other functional roles in the cell.
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601:
198:
closer to the cell surface than BACE. The non-pathogenic middle fragment formed by an α/γ cleavage sequence is called P3.
619:
93:
194:(α-secretase) acts on APP first instead of BACE, no amyloid beta is formed because α-secretase recognizes a target
255:. Presenilin is believed to harbor the protease domain and represents an important example of an uncommon type of
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166:(APP) to cleave the protein into three fragments. Sequential cleavage by
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has not been conclusively identified but is believed to be a
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BACE is a transmembrane protein with an extracellular
178:
peptide fragment that aggregates into clumps called
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60:. Unsourced material may be challenged and removed.
136:Processing of the amyloid-beta precursor protein
259:that cleaves targets within the cell membrane.
394:
8:
435:
401:
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379:
69:"Amyloid-beta precursor protein secretase"
371:at the U.S. National Library of Medicine
341:
331:
120:Learn how and when to remove this message
306:
210:of the three secretases varies widely.
271:γ-secretase plays a critical role in
7:
58:adding citations to reliable sources
771:Amyloid precursor protein secretase
18:Amyloid precursor protein secretase
25:
756:Proteasome endopeptidase complex
326:(16). Basel, Switzerland: 6032.
147:that "snip" pieces off a longer
34:
286:tail of Notch to travel to the
45:needs additional citations for
164:amyloid-beta precursor protein
1:
620:Serine type carboxypeptidases
602:Angiotensin-converting enzyme
314:Bhatia, S. (12 August 2023).
174:(γ-secretase) produces the
854:
838:Integral membrane proteins
235:γ-secretase is actually a
333:10.3390/molecules28166032
158:Among other roles in the
582:Tripeptidyl peptidase II
373:Medical Subject Headings
273:developmental signalling
162:, secretases act on the
151:that is embedded in the
751:Threonine endopeptidase
577:Tripeptidyl peptidase I
741:Aspartic acid protease
565:Dipeptidyl peptidase-4
277:transmembrane receptor
227:aspartic acid protease
137:
572:Tripeptidyl peptidase
135:
746:Metalloendopeptidase
651:Metalloexopeptidases
555:Dipeptidyl peptidase
292:transcription factor
54:improve this article
761:HslU—HslV peptidase
705:Metalloexopeptidase
188:Alzheimer's disease
138:
820:
819:
769:Other/ungrouped:
736:Cysteine protease
713:
712:
631:
220:metalloproteinase
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129:
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104:
16:(Redirected from
845:
786:Beta-secretase 2
781:Beta-secretase 1
657:Carboxypeptidase
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436:
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214:The α-secretase
196:protein sequence
168:beta-secretase 1
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791:Gamma secretase
776:Alpha secretase
731:Serine protease
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698:Other/ungrouped
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632:-Transpeptidase
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237:protein complex
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192:alpha-secretase
180:amyloid plaques
172:gamma-secretase
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812:Staphylokinase
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448:Aminopeptidase
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363:External links
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27:Type of enzyme
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723:Endopeptidase
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153:cell membrane
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71: –
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65:Find sources:
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43:This article
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32:
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19:
687:Glutamate II
482:
431:Exopeptidase
323:
319:
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290:to act as a
288:cell nucleus
270:
267:
205:
186:affected by
176:amyloid-beta
157:
140:
139:
116:
107:
97:
90:
83:
76:
64:
52:Please help
47:verification
44:
624:Cathepsin A
560:Cathepsin C
520:Dipeptidase
284:cytoplasmic
239:containing
170:(BACE) and
827:Categories
301:References
241:presenilin
141:Secretases
80:newspapers
805:: Unknown
483:Methionyl
414:proteases
410:Hydrolase
369:Secretase
320:Molecules
245:nicastrin
208:structure
202:Structure
110:June 2024
478:Glutamyl
468:Cystinyl
463:Aspartyl
352:37630283
343:10459662
264:Function
257:protease
833:Enzymes
458:Arginyl
453:Alanine
275:by the
182:in the
149:protein
145:enzymes
94:scholar
803:3.4.99
719:3.4.21
642:3.4.17
612:3.4.16
594:3.4.15
547:3.4.14
512:3.4.13
473:Leucyl
440:3.4.11
427:3.4.11
375:(MeSH)
350:
340:
251:, and
230:domain
184:brains
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89:
82:
75:
67:
721:-25:
429:-19:
280:Notch
253:PEN-2
249:APH-1
190:. If
101:JSTOR
87:books
420:3.4)
348:PMID
216:gene
206:The
160:cell
143:are
73:news
338:PMC
328:doi
56:by
829::
667:A2
630:DD
622::
418:EC
412::
346:.
336:.
324:28
322:.
318:.
294:.
247:,
243:,
155:.
682:E
677:C
672:B
662:A
535:3
530:2
525:1
500:O
493:2
488:1
416:(
402:e
395:t
388:v
354:.
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232:.
222:.
123:)
117:(
112:)
108:(
98:·
91:·
84:·
77:·
50:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
