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of barnase versus that of the same mutation to barnase's native state, he was able to gain insight about the transition state of barnase and its folding pathway. After receiving his PhD in 1992, Matouschek continued his work with Fersht, serving as a research fellow at the
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Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate proteins.
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in combination with extensive protein engineering enabled an understanding of the kinetic intermediates during protein folding of barnase. In subsequent postdoctoral work at the
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Matouschek, Andreas; Kellis, James T.; Serrano, Luis; Bycroft, Mark; Fersht, Alan R. (1990). "Transient folding intermediates characterized by protein engineering".
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Matouschek, A; Kellis, JT; Serrano, L; Fersht, AR (1989). "Mapping the transition state and pathway of protein folding by protein engineering".
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in combination with protein engineering in order to study the transition state of the bacterial protein
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At the
University of Basel, Matoschek was a postdoctorate fellow under Gottfried (Jeff) Schatz.
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resulted in the seminal application of phi-value analysis to the study of
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Schrader, Erin K; Harstad, Kristine G; Matouschek, Andreas (2009).
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refold proteins after importing them. In 1996, he moved to
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This article about a biologist from the United States is a
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At
Cambridge, Matouschek was a graduate student under
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from 1988 to 1992. In 1989, he pioneered the use of
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345:"Targeting proteins for degradation"
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195:. In 2012, he moved to
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16:American biologist
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265:References
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95:Biophysics
66:Proteasome
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629:Paul Berg
261:in 2012.
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