723:
the translation of the genetic code. Subsequently he was one of the pioneering founders of protein engineering, developing it as an analytical procedure for understanding interactions in proteins and enzyme catalysis. This radical new approach unravelled the relationships between the structure, activity and function of proteins. The full power of his methods became apparent in his seminal and far reaching contributions to the field of protein folding and stability. These studies opened the way to development of novel therapies in cancer and other diseases. He currently works on mutations that affect the stability and activity of the tumour suppressor p53 and how mutants may be "rescued" by small molecule drugs. His contributions have been widely recognised nationally and internationally by prizes for both chemistry and molecular biology, and by memberships of foreign academies.
58:
1457:
488:
722:
Herchel Smith
Professor of Organic Chemistry at the MRC Centre for Protein Engineering, Cambridge, Sir Alan is one of the world's leading protein scientists. He was elected to the Royal Society in his late 30s in 1983 for his work illuminating enzymic catalysis and how enzymes attain high fidelity in
379:, where he obtained First Class in Pt I of the Natural Sciences Tripos in 1964, First Class in Pt II (Chemistry) in 1965 and was awarded his PhD degree in 1968. He was President of the University of Cambridge Chess Club in 1964–65 and awarded a half blue in 1965.
1250:
591:
of the transition. He elucidated the leaving-group specificity, leading to a detailed structural interpretation which showed the energetics of "strain" at the binding site. Another experiment dispelled final doubts about the role of a
2403:
2433:
2428:
2423:
1254:
359:, London. His father, Philip, was a ladies' tailor and his mother, Betty, a dressmaker. His grandparents were Jewish immigrants from Poland, Romania, Lithuania and Belarus. He was educated at
2448:
2398:
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1499:
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2082:
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600:. He demonstrated that their precise specificity depends on consecutive independent recognition steps, and under appropriate conditions he trapped a transiently discharged
324:
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of The Royal
Society, for his development and application of methods of protein engineering to provide descriptions of protein folding pathways at atomic resolution.
1233:
1142:
Fersht, A.; Matouschek, A.; Serrano, L. (1992). "The folding of an enzyme I. Theory of protein engineering analysis of stability and pathway of protein folding".
2408:
664:
660:
964:
878:(1993). "Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation".
450:, which he developed as a primary method for analysis of the structure, activity and folding of proteins. He has developed methods for the resolution of
259:
552:
307:
47:
1790:
1728:
692:
2473:
1177:
Fersht, A. R. (2024). "From covalent transition states in chemistry to noncovalent in biology: from β- to Φ-value analysis of protein folding".
604:. Fersht has shown how binding energy can be used to enhance either specificity or rate in an enzymatic reaction, leading to a demonstration of
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2001:
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for his pioneering work on protein science. His citation on election to the
Academy of Medical Sciences reads:
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404:
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871:
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1965:
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1935:
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372:
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371:, London. He was a keen chess player and was the Essex County Junior champion in 1961. He was awarded a
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2007:
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1989:
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from 1990 to 2010 when, on reaching the retirement age, he became an
Emeritus Group Leader at the
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1971:
1911:
1227:
1202:
Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding
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Fersht married
Marilyn Persell in 1966 and has one son and one daughter. His recreations include
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Scientists sharing L1 in Caius Court, Gonville and Caius
College, Cambridge, taken in 1994 (
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Structure and
Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding
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2019:
2013:
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1995:
1983:
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intermediate. More recently Fersht has studied a more complex group of enzymes, the
458:
for studying the folding transition states of proteins. His interests also include
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editor, ÖGV. (2015). Wilhelm Exner Medal. Austrian Trade
Association. ÖGV. Austria.
735:
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179:
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937:"Professor Sir Alan Fersht FRS, Department of Chemistry, University of Cambridge"
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1953:
1941:
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1073:
The selected papers of Sir Alan Fersht : development of protein engineering
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443:. He is a Fellow of both Gonville & Caius College and Imperial College.
320:
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He has written an account of the history of
Staunton and other chess sets.
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The
Selected Papers of Sir Alan Fersht: Development of Protein Engineering
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727:
487:
1376:"Royal Society announces 2020 winners of prestigious medals and awards"
312:
1300:"Alan R. Fersht receives Bader Award / Corey Award to David W. C. Mac
990:
715:
435:
at Cambridge from 1988 to 2010. He was the Director of the Cambridge
253:
683:, Stein and Moore Award of the Protein Society; Bader Award of the
647:
Anniversary Prize; Novo Biotechnology Award; Charmian Medal of the
823:
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726:
486:
454:
in the sub-millisecond time-scale and has pioneered the method of
961:"Professor Sir Alan Fersht FRS becomes the 42nd Master of Caius"
671:; Feldberg Foundation Prize, Distinguished Service Award, Miami
644:
2047:
1717:
2404:
Members of the University of Cambridge Department of Chemistry
446:
Alan Fersht is widely regarded as one of the main pioneers of
208:
395:. He returned to Cambridge in 1969 as a group leader at the
2434:
Fellows of the Academy of Medical Sciences (United Kingdom)
1269:"Alan Fersht, University of Cambridge, Election Year: 1993"
987:"Imperial College London: biographical summary Alan Fersht"
856:. University of Cambridge. 11 February 2014. Archived from
576:
643:
Fersht has received many prizes and medals including: the
1066:
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407:
until 1972. Fersht was Wolfson Research Professor of the
1108:
583:
between active and inactive forms, and investigated the
555:(FMedSci). His nomination for the Royal Society reads:
2429:
Members of the European Molecular Biology Organization
2424:
Foreign associates of the National Academy of Sciences
1004:
BBC: brief Fersht career summary at time of knighthood
679:
of the Protein Society; Natural Products Award of the
169:
Foreign Associate of the National Academy of Sciences
608:
limitations on mechanisms of the "induced fit" type.
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34:
1287:"Honorary doctorates – Uppsala University, Sweden"
1027:
531:. He is a Foreign Associate of the United States
519:(FRS) in 1983. The Royal Society awarded him the
415:from 1978 to 1988. He spent a sabbatical year at
387:Fersht spent a post-doctoral year (1968–1969) at
2449:Masters of Gonville and Caius College, Cambridge
2399:Fellows of Gonville and Caius College, Cambridge
1745:Masters of Gonville and Caius College, Cambridge
2394:Alumni of Gonville and Caius College, Cambridge
1500:Master of Gonville and Caius College, Cambridge
955:
953:
773:
771:
720:
557:
1271:. National Academy of Sciences. Archived from
667:; Jubilee Lecture and the Harden Medal of the
2059:
1729:
921:. Academy of Medical Sciences. Archived from
567:methods. He showed that a slow relaxation of
343:, and is sometimes described as a founder of
8:
2454:People educated at Sir George Monoux College
1110:Intramolecular Catalysis of Ester Hydrolysis
665:Federation of European Biochemical Societies
260:Intramolecular Catalysis of Ester Hydrolysis
1428:Jaques and British Chess Company Chess Sets
1339:"Alan Fersht. 2001 Stein and Moore Award".
1253:. London: The Royal Society. Archived from
523:in 1991 for molecular biology, in 1998 the
2066:
2052:
2044:
1736:
1722:
1714:
1481:
1232:: CS1 maint: location missing publisher (
1021:
1019:
1017:
1015:
1013:
1011:
419:on an Eleanor Roosevelt Fellowship of the
56:
31:
913:
911:
909:
553:Fellow of the Academy of Medical Sciences
411:and Professor of Biological Chemistry at
1245:
1243:
807:Studies of disulphide mutants of barnase
693:Bijvoet Center for Biomolecular Research
559:Distinguished for work on mechanisms of
1306:Angewandte Chemie International Edition
1042: ed.). A & C Black.
919:"Professor Sir Alan Fersht FRS FMedSci"
814:(PhD thesis). University of Cambridge.
767:
1225:
1113:(PhD thesis). University of Cambridge.
691:Prize and Medal; Bijvoet Medal of the
612:Fersht holds honorary doctorates from
1304:/ Breslow Award to Peter B. Dervan".
549:American Academy of Arts and Sciences
377:Gonville and Caius College, Cambridge
337:Gonville and Caius College, Cambridge
244:Gonville and Caius College, Cambridge
7:
2409:Academics of Imperial College London
1402:Jaques Staunton Chess Sets 1849–1939
1131:. London. 22 March 1965. p. 12.
1071:Fersht, Alan; Wang, Qinghua (2010).
632:(2008). He is an Honorary Fellow of
547:, an Honorary Foreign Member of the
355:Fersht was born on 21 April 1943 in
1048:10.1093/ww/9780199540884.013.U15668
317:MRC Laboratory of Molecular Biology
1075:. London: Imperial College Press.
967:from the original on 22 April 2015
734:In August 2020 he was awarded the
705:University of California, Berkeley
311:(born 21 April 1943) is a British
25:
854:"Women at Cambridge: Jane Clarke"
1455:
1127:"Sweeping Chess Win by Oxford".
675:Biotechnology Winter Symposium;
361:Sir George Monoux Grammar School
95:Sir George Monoux Grammar School
1179:Quarterly Reviews of Biophysics
661:The Datta Lectureship and Medal
571:was not a chemical step on the
441:Laboratory of Molecular Biology
397:Laboratory of Molecular Biology
339:from 2012 to 2018. He works on
228:Laboratory of Molecular Biology
133:
2474:Recipients of the Copley Medal
1251:"EC/1983/09: Fersht, Alan Roy"
626:Hebrew University of Jerusalem
537:American Philosophical Society
527:for chemistry and in 2008 the
437:Centre for Protein Engineering
1:
2112:Sivaramakrishna Chandrasekhar
622:Weizmann Institute of Science
2414:Fellows of the Royal Society
1156:10.1016/0022-2836(92)90561-W
1144:Journal of Molecular Biology
1055:UK public library membership
563:, especially by stopped and
533:National Academy of Sciences
375:to read Natural Sciences at
677:Christian B. Anfinsen Award
517:Fellow of the Royal Society
27:British chemist (born 1943)
2495:
2144:William Alexander Gambling
1856:Gonville and Caius College
689:Kaj Ulrik Linderstrøm-Lang
681:Royal Society of Chemistry
649:Royal Society of Chemistry
618:Vrije Universiteit Brussel
598:aminoacyl tRNA synthetases
539:, a Foreign Member of the
535:, a Foreign Member of the
2479:Jewish British scientists
1702:
1694:
1684:
1657:
1649:
1639:
1631:
1621:
1613:
1603:
1583:
1575:
1565:
1556:
1548:
1538:
1529:
1521:
1516:
1506:
1497:
1489:
1484:
685:American Chemical Society
634:Darwin College, Cambridge
293:
189:
55:
2469:Bijvoet Medal recipients
1599:Robert E. M. Hedges
1029:"Fersht, Sir Alan (Roy)"
780:publications indexed by
638:Jesus College, Cambridge
497:Samuel Frederick Edwards
405:Jesus College, Cambridge
399:until 1977 and a junior
351:Early life and education
2459:People from Walthamstow
1430:. Kaissa Publications.
1404:. Kaissa Publications.
1116:(subscription required)
1040:Oxford University Press
793:Alan Fersht LMB Profile
421:American Cancer Society
413:Imperial College London
329:University of Cambridge
325:Department of Chemistry
233:University of Cambridge
105:University of Cambridge
2134:Malcolm Ferguson-Smith
1966:Ernest Stewart Roberts
1960:Norman Macleod Ferrers
1936:Richard Fisher Belward
1643:C. N. R. Rao
1318:10.1002/anie.200462026
731:
725:
610:
512:
462:, disease and cancer.
427:(1978–79). Fersht was
2444:English biophysicists
2358:Frank Westheimer
1400:Fersht, Alan (2007).
1200:Fersht, Alan (2017).
804:Clarke, Jane (1993).
730:
515:Fersht was elected a
490:
466:Selected publications
2340:G. Evelyn Hutchinson
2334:Anatole Abragam
2231:Michael J. D. Powell
2117:Pierre Deslongchamps
1426:Alan Fersht (2010).
756:wildlife photography
541:Accademia dei Lincei
319:, Cambridge, and an
2439:Royal Medal winners
1990:Nevill Francis Mott
1978:John Forbes Cameron
1876:William Branthwaite
1660:Wilhelm Exner Medal
1569:Malcolm H. Chisholm
1493:Sir Christopher Hum
892:10.1021/bi00067a022
834:on 22 December 2018
709:Wilhelm Exner Medal
669:Biochemical Society
448:protein engineering
417:Stanford University
389:Brandeis University
383:Career and research
345:protein engineering
300:Sir Alan Roy Fersht
2352:Henry Stommel
2312:David Attenborough
2179:Christopher Hooley
1972:Hugh Kerr Anderson
1312:(41): 5430. 2004.
1257:on 9 January 2016.
828:uk.bl.ethos.318014
732:
697:Utrecht University
657:Harvard University
655:Lecture and Prize
614:Uppsala University
513:
511:, and Alan Fersht)
483:Awards and honours
460:protein misfolding
456:phi value analysis
367:grammar school in
288:Andreas Matouschek
2366:
2365:
2317:Margaret Thatcher
2286:Charles Weissmann
2169:Richard Henderson
2041:
2040:
1888:Thomas Batchcroft
1827:William Buckenham
1779:William Somersham
1712:
1711:
1703:Succeeded by
1685:Succeeded by
1669:Christian Wandrey
1640:Succeeded by
1622:Succeeded by
1604:Succeeded by
1566:Succeeded by
1542:Charles Weissmann
1539:Succeeded by
1507:Succeeded by
1485:Academic offices
1411:978-0-9557325-0-8
1380:The Royal Society
1275:on 17 April 2015.
1211:978-981-322-519-0
1082:978-1-84816-554-0
1053:(Subscription or
925:on 17 April 2015.
860:on 24 March 2015.
630:Aarhus University
545:Academia Europaea
433:Organic Chemistry
373:State Scholarship
323:Professor in the
297:
296:
284:Sophie E. Jackson
271:Doctoral students
191:Scientific career
16:(Redirected from
2486:
2419:Knights Bachelor
2389:British chemists
2068:
2061:
2054:
2045:
1948:Benedict Chapman
1738:
1731:
1724:
1715:
1695:Preceded by
1688:Bertil Andersson
1681:
1653:Zdeněk P. Bažant
1650:Preceded by
1632:Preceded by
1614:Preceded by
1595:Sir Philip Cohen
1576:Preceded by
1549:Preceded by
1522:Preceded by
1490:Preceded by
1482:
1459:
1458:
1442:
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1422:
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1397:
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1390:
1388:
1386:
1372:
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1347:(4): 905. 2001.
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1297:
1291:
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1247:
1238:
1237:
1231:
1223:
1197:
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1190:
1174:
1168:
1167:
1139:
1133:
1132:
1124:
1118:
1117:
1114:
1105:Fersht, Alan Roy
1101:
1095:
1094:
1068:
1059:
1058:
1051:
1031:
1023:
1006:
1001:
995:
994:
993:on 27 June 2009.
989:. Archived from
983:
977:
976:
974:
972:
957:
948:
947:
945:
943:
933:
927:
926:
915:
904:
903:
868:
862:
861:
850:
844:
843:
841:
839:
830:. Archived from
801:
795:
790:
784:
775:
701:Gilbert N. Lewis
699:in 2008 and the
573:reaction pathway
561:enzyme catalysis
310:
266:
238:Imperial College
137:
135:
82:
78:
76:
60:
50:
32:
21:
2494:
2493:
2489:
2488:
2487:
2485:
2484:
2483:
2464:Jewish chemists
2369:
2368:
2367:
2362:
2346:Jean Leray
2321:
2300:
2296:Dudley Williams
2206:C David Marsden
2149:Ian Graham Gass
2123:William Douglas
2102:Patrick Bateson
2085:
2072:
2042:
2037:
2020:Christopher Hum
2014:Neil McKendrick
1850:
1809:Henry Costessey
1803:Edmund Sheriffe
1785:John Rickingale
1767:William Rougham
1747:
1742:
1708:
1700:
1690:
1671:
1665:
1663:
1655:
1645:
1637:
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1619:
1609:
1591:
1589:
1581:
1571:
1562:
1554:
1552:Jean-Marie Lehn
1544:
1535:
1527:
1512:
1503:
1495:
1480:
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1478:
1460:
1456:
1451:
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1445:
1438:
1425:
1423:
1419:
1412:
1399:
1398:
1394:
1384:
1382:
1374:
1373:
1369:
1364:
1360:
1341:Protein Science
1338:
1337:
1333:
1299:
1298:
1294:
1285:
1284:
1280:
1267:
1266:
1262:
1249:
1248:
1241:
1224:
1212:
1199:
1198:
1194:
1176:
1175:
1171:
1141:
1140:
1136:
1126:
1125:
1121:
1115:
1103:
1102:
1098:
1083:
1070:
1069:
1062:
1052:
1025:
1024:
1009:
1002:
998:
985:
984:
980:
970:
968:
959:
958:
951:
941:
939:
935:
934:
930:
917:
916:
907:
870:
869:
865:
852:
851:
847:
837:
835:
803:
802:
798:
791:
787:
776:
769:
764:
744:
714:In 2003 he was
505:David Shoenberg
485:
468:
452:protein folding
425:Arthur Kornberg
401:research fellow
385:
353:
341:protein folding
302:
282:
264:
248:
216:
204:Protein folding
185:
151:Knight Bachelor
139:
136: 1966)
131:
127:
126:Marilyn Persell
115:Protein folding
101:Alma mater
86:
85:London, England
83:
80:
74:
72:
71:
70:
69:Alan Roy Fersht
51:
42:
40:
37:
28:
23:
22:
18:Sir Alan Fersht
15:
12:
11:
5:
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2471:
2466:
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2456:
2451:
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2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2371:
2370:
2364:
2363:
2361:
2360:
2354:
2348:
2342:
2336:
2329:
2327:
2323:
2322:
2320:
2319:
2314:
2308:
2306:
2302:
2301:
2299:
2298:
2293:
2288:
2283:
2281:Felix Weinberg
2278:
2273:
2268:
2266:Brian Spalding
2263:
2261:Edwin Southern
2258:
2253:
2248:
2243:
2238:
2233:
2228:
2226:Michael Pepper
2223:
2218:
2213:
2211:Donald Metcalf
2208:
2203:
2201:George Lusztig
2198:
2193:
2191:Peter Lawrence
2188:
2181:
2176:
2171:
2166:
2161:
2156:
2151:
2146:
2141:
2136:
2131:
2126:
2119:
2114:
2109:
2107:Edward Cocking
2104:
2099:
2093:
2091:
2087:
2086:
2073:
2071:
2070:
2063:
2056:
2048:
2039:
2038:
2036:
2035:
2032:Pippa Rogerson
2029:
2023:
2017:
2011:
2005:
1999:
1996:Joseph Needham
1993:
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602:aminoacyl tRNA
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81:(age 81)
79:21 April 1943
67:
63:
59:
54:
49:
45:
33:
30:
19:
2183:
2164:Ray Guillery
2138:
2121:
2025:
2002:William Wade
1918:Thomas Gooch
1906:James Halman
1900:Robert Brady
1894:William Dell
1890:(1626, 1660)
1882:John Gostlin
1870:Thomas Legge
1845:Thomas Bacon
1839:John Styrmin
1821:Edmund Stubb
1667:
1664:2009
1658:
1617:Cyril Hilsum
1607:Chris Dobson
1593:
1590:2008
1584:
1557:
1530:
1498:
1471:
1470:
1469:profile for
1466:
1427:
1420:
1401:
1395:
1383:. Retrieved
1379:
1370:
1361:
1344:
1340:
1334:
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1301:
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1281:
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1263:
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1172:
1147:
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1137:
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999:
991:the original
981:
969:. Retrieved
940:. Retrieved
931:
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883:
880:Biochemistry
879:
875:
866:
858:the original
848:
836:. Retrieved
832:the original
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806:
799:
788:
745:
736:Copley Medal
733:
721:
713:
642:
628:(2006), and
611:
569:chymotrypsin
558:
543:, Member of
514:
476:
471:
445:
386:
354:
299:
298:
258:
221:Institutions
190:
180:Copley Medal
29:
2379:1943 births
2271:Nigel Unwin
2256:Ian Sneddon
2196:John Lawson
2174:Peter Higgs
2159:George Gray
2154:Ian Gibbons
2139:Alan Fersht
2026:Alan Fersht
1954:Edwin Guest
1942:Martin Davy
1761:John Colton
1672: [
1586:Royal Medal
1532:Gabor Medal
1473:Alan Fersht
971:21 November
778:Alan Fersht
653:Max Tishler
636:(2014) and
594:tetrahedral
579:-dependent
529:Royal Medal
521:Gabor Medal
509:Rodney Hill
501:David Tabor
493:Nevill Mott
369:Walthamstow
278:Jane Clarke
174:Royal Medal
157:Gabor Medal
39:Alan Fersht
2373:Categories
2305:Statute 12
2241:Ivan Roitt
2008:Peter Gray
1930:John Smith
1912:John Ellys
1864:John Caius
1833:John Skypp
1815:John Barly
1706:Ada Yonath
1625:Ron Laskey
1559:Davy Medal
1504:2012–2018
1181:. 57 e4.
1057:required.)
812:jisc.ac.uk
762:References
707:, and the
589:equilibria
585:energetics
525:Davy Medal
163:Davy Medal
75:1943-04-21
2221:Ted Paige
1579:Jim Feast
1228:cite book
1220:986523773
1129:The Times
1091:646400491
1035:Who's Who
872:Clarke, J
711:in 2009.
331:. He was
91:Education
2276:Ian Ward
2081:elected
1385:9 August
1353:11345067
1326:15484254
1187:38597675
1107:(1968).
1038:(online
965:Archived
820:53666398
752:horology
716:knighted
640:(2017).
624:(2004),
620:(1999),
616:(1999),
575:, but a
365:all-boys
321:Emeritus
240:, London
2326:Foreign
2090:Fellows
2083:in 1983
2077:of the
2075:Fellows
1517:Awards
1465:has an
1463:Scholia
1164:1569556
942:26 July
900:8476861
838:17 June
663:of the
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327:at the
315:at the
313:chemist
308:FMedSci
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2028:(2012)
2022:(2006)
2016:(1996)
2010:(1988)
2004:(1976)
1998:(1966)
1992:(1959)
1986:(1948)
1980:(1928)
1974:(1912)
1968:(1903)
1962:(1880)
1956:(1852)
1950:(1839)
1944:(1803)
1938:(1795)
1932:(1764)
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1914:(1703)
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673:Nature
551:and a
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263:
254:Thesis
213:Cancer
197:Fields
182:(2020)
176:(2008)
165:(1998)
159:(1991)
153:(2003)
144:Awards
121:Spouse
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1563:1998
1536:1991
824:EThOS
748:chess
423:with
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1234:link
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1206:ISBN
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1160:PMID
1087:OCLC
1077:ISBN
973:2012
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896:PMID
840:2019
816:OCLC
754:and
645:FEBS
587:and
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1314:doi
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