1399:, originated from two separate events. Following the divergence of New World monkeys from the human lineage, the apoC-I gene was duplicated. Old World monkeys and great apes other than humans have been shown to have two active genes. One of the duplicates encodes a basic protein designated apoC-IB that is orthologous to human apolipoprotein C-I. The other encodes an acidic protein, apoC-IA, that is orthologous to the virtual protein encoded by the pseudogene. The pseudogenization event occurred sometime between the divergence of bonobos and chimpanzees from the human lineage and the arrival of Denisovans and Neandertals. The pseudogene is due to a change in a single nucleotide in the codon for the penultimate amino acid, i.e. glutamine, in the signal sequence, resulting in a stop codon.
3041:
327:
304:
201:
226:
2907:
333:
232:
42:
2892:
1178:
3339:
68:
1350:
normally found in plasma and responsible for the activation of esterified lecithin cholesterol with an important role in the exchange of esterified cholesterol between lipoproteins and in removal of cholesterol from tissues. Its main function is inhibition of
1975:
Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC (January 1988). "Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia".
1374:, while after a meal it is found on the surface of other lipoproteins. When proteins rich in triglycerides like chylomicrons and VLDL are broken down, this apoprotein is transferred again to HDL. It is one of the most positively charged
1390:
of this gene is located 4 kb downstream from the apoC-I gene in the same orientation on chromosome 19, where both reside within an apolipoprotein gene cluster. This pseudogene, which was also reported to have been present in
2271:
Davison PJ, Norton P, Wallis SC, Gill L, Cook M, Williamson R, Humphries SE (May 1986). "There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E".
2480:
Rozek A, Buchko GW, Cushley RJ (June 1995). "Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy".
2241:
Smit M, van der Kooij-Meijs E, Woudt LP, Havekes LM, Frants RR (May 1988). "Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene".
1931:
Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, et al. (1985). "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19".
1736:
1424:
2572:
Kamino K, Yoshiiwa A, Nishiwaki Y, Nagano K, Yamamoto H, Kobayashi T, et al. (1996). "Genetic association study between senile dementia of
Alzheimer's type and APOE/C1/C2 gene cluster".
2673:
Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, et al. (July 1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis".
2644:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
3263:
3243:
340:
239:
2947:
1277:
2710:
Freitas EM, Zhang WJ, Lalonde JP, Tay GK, Gaudieri S, Ashworth LK, et al. (1999). "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1".
3291:
3040:
2906:
2301:
Myklebost O, Rogne S (August 1986). "The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19".
2416:
Servillo L, Brewer HB, Osborne JC (February 1981). "Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation".
162:
877:
858:
3153:
3186:
3413:
2741:"Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity"
2510:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1776:
1464:
1343:. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
1779:
1467:
3384:
1749:
1437:
3403:
2871:
1913:
1225:
3218:
2940:
2131:
Puppione DL (September 2014). "Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes".
1895:
1748:
1436:
1767:
1455:
2541:"Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers"
326:
2825:
1352:
1109:
2891:
1783:
1471:
3181:
1116:
303:
1769:
1457:
3301:
3004:
2019:
1780:
1468:
2933:
1882:
1861:
2603:"Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy"
225:
200:
1878:
1746:
1434:
1297:
2831:
1782:
1762:
1756:
1751:
1470:
1450:
1444:
1439:
65:
3191:
3173:
1774:
1754:
1462:
1442:
1857:
2990:
1806:
1747:
1435:
142:
1765:
1764:
1743:
1453:
1452:
1431:
1784:
1773:
1760:
1759:
1758:
1472:
1461:
1448:
1447:
1446:
339:
238:
1777:
1763:
1465:
1451:
3377:
1781:
1778:
1469:
1466:
332:
231:
2864:
2173:"Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins"
1761:
1449:
1787:
1786:
1744:
1740:
1475:
1474:
1432:
1428:
3408:
3025:
1785:
1775:
1772:
1771:
1770:
1755:
1753:
1752:
1750:
1742:
1741:
1739:
1473:
1463:
1460:
1459:
1458:
1443:
1441:
1440:
1438:
1430:
1429:
1427:
1371:
1360:
922:
150:
1768:
1757:
1745:
1456:
1445:
1433:
1285:
1766:
1454:
3009:
2447:"Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays"
903:
3370:
3201:
214:
2846:
provides an overview of all the structure information available in the PDB for Human
Apolipoprotein C-I
1281:
2857:
2539:
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, et al. (January 1993).
1238:
1182:
structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
3030:
2837:
1088:
1067:
1059:
1055:
1025:
1004:
1000:
996:
129:
3163:
2698:
2326:
2208:"Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene"
2001:
1957:
174:
1092:
1063:
1029:
992:
3105:
3100:
3095:
3090:
3060:
3000:
2805:
2762:
2739:
Gautier T, Masson D, de Barros JP, Athias A, Gambert P, Aunis D, et al. (December 2000).
2727:
2690:
2661:
2632:
2589:
2560:
2527:
2498:
2468:
2433:
2404:
2361:
2318:
2289:
2259:
2229:
2194:
2148:
2113:
2064:
1993:
1949:
1272:
122:
58:
3354:
3132:
3122:
3117:
3112:
3082:
2795:
2787:
2752:
2719:
2682:
2653:
2622:
2614:
2581:
2552:
2519:
2490:
2458:
2425:
2394:
2386:
2351:
2310:
2281:
2251:
2219:
2184:
2140:
2103:
2095:
2054:
2046:
1985:
1941:
1332:
419:
350:
294:
249:
3278:
3253:
1264:
170:
3127:
2925:
2033:
Puppione DL, Ryan CM, Bassilian S, Souda P, Xiao X, Ryder OA, Whitelegge JP (March 2010).
1356:
394:
3158:
3049:
3020:
2627:
2602:
2108:
2083:
2059:
2034:
1367:
41:
2800:
2775:
2657:
2399:
2374:
2356:
2339:
2255:
2224:
2207:
2189:
2172:
1827:
1810:
1797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
656:
651:
646:
630:
625:
620:
615:
610:
3397:
3350:
2843:
2523:
2429:
2285:
2206:
Lauer SJ, Walker D, Elshourbagy NA, Reardon CA, Levy-Wilson B, Taylor JM (May 1988).
1230:
597:
2338:
Jackson RL, Sparrow JT, Baker HN, Morrisett JD, Taunton OD, Gotto AM (August 1974).
2330:
2005:
1961:
1735:
1423:
1206:
3286:
2981:
2702:
1260:
412:
191:
154:
1218:
178:
17:
2996:
2985:
2969:
2960:
2463:
2446:
1918:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1900:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1396:
1340:
1335:
family. This gene is expressed primarily in the liver, and it is activated when
1313:
495:
2723:
2375:"Characterisation of mRNAs encoding the precursor for human apolipoprotein CI"
2144:
2099:
2050:
1408:
Click on genes, proteins and metabolites below to link to respective articles.
1392:
1387:
1347:
311:
208:
158:
2373:
Knott TJ, Robertson ME, Priestley LM, Urdea M, Wallis S, Scott J (May 1984).
2390:
1336:
822:
555:
433:
378:
365:
277:
264:
166:
2809:
2766:
2757:
2740:
2731:
2694:
2618:
2556:
2152:
2117:
2068:
2665:
2636:
2593:
2564:
2531:
2502:
2472:
2437:
2408:
2365:
2322:
2293:
2263:
2233:
2133:
Comparative
Biochemistry and Physiology. Part D, Genomics & Proteomics
2039:
Comparative
Biochemistry and Physiology. Part D, Genomics & Proteomics
1997:
1953:
1234:
1177:
1156:
1151:
2198:
1213:
1140:
967:
948:
133:, Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1, Apolipoprotein C-I
2494:
2084:"Proteogenomic Review of the Changes in Primate apoC-I during Evolution"
2915:: PEPTIDE OF HUMAN APOLIPOPROTEIN C-I RESIDUES 1-38, NMR, 28 STRUCTURES
2314:
1989:
1945:
1375:
934:
889:
2791:
2585:
728:
negative regulation of very-low-density lipoprotein particle clearance
99:
95:
91:
87:
3210:
3145:
1292:
1124:
844:
3338:
2540:
3321:
3316:
3311:
3273:
3268:
3228:
3075:
3070:
3065:
2956:
2686:
2171:
Shulman RS, Herbert PN, Wehrly K, Fredrickson DS (January 1975).
807:
803:
3346:
3258:
3248:
3238:
3233:
3223:
1320:
1254:
1201:
146:
2929:
2853:
631:
phosphatidylcholine-sterol O-acyltransferase activator activity
2849:
2445:
Curry MD, McConathy WJ, Fesmire JD, Alaupovic P (April 1981).
1734:
1422:
718:
negative regulation of phosphatidylcholine catabolic process
1825:
The interactive pathway map can be edited at WikiPathways:
2601:
Rozek A, Buchko GW, Kanda P, Cushley RJ (September 1997).
2035:"Detection of two distinct forms of apoC-I in great apes"
2776:"DNA cloning using in vitro site-specific recombination"
402:
3358:
693:
negative regulation of fatty acid biosynthetic process
567:
1331:
The protein encoded by this gene is a member of the
738:
negative regulation of receptor-mediated endocytosis
3300:
3200:
3172:
3143:
3048:
2968:
2274:
2244:
1291:
1271:
1253:
1248:
1224:
1212:
1200:
1192:
1187:
1170:
1081:
1048:
1018:
985:
2774:Hartley JL, Temple GF, Brasch MA (November 2000).
1874:
1872:
1870:
1853:
1851:
1849:
758:negative regulation of lipoprotein lipase activity
703:positive regulation of cholesterol esterification
349:
248:
2340:"The primary structure of apolopoprotein-serine"
1738:
1426:
788:very-low-density lipoprotein particle clearance
27:Protein-coding gene in the species Homo sapiens
2900:: HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES
1879:GRCm38: Ensembl release 89: ENSMUSG00000040564
778:negative regulation of lipid metabolic process
768:negative regulation of lipid catabolic process
763:very-low-density lipoprotein particle assembly
3378:
2941:
2865:
8:
753:negative regulation of cholesterol transport
743:high-density lipoprotein particle remodeling
1858:GRCh38: Ensembl release 89: ENSG00000130208
3385:
3371:
2948:
2934:
2926:
2872:
2858:
2850:
2082:Puppione D, Whitelegge JP (October 2013).
1245:
1176:
818:
593:
534:transitional epithelium of urinary bladder
390:
289:
186:
76:
2799:
2756:
2626:
2462:
2398:
2355:
2223:
2188:
2107:
2058:
783:positive regulation of catalytic activity
2887:
2020:"Entrez Gene: APOC1 apolipoprotein C-I"
1845:
1818:
1346:Apolipoprotein C-I has a length of 57
1167:
723:plasma lipoprotein particle remodeling
31:
652:very-low-density lipoprotein particle
354:
315:
310:
253:
212:
207:
7:
3335:
3333:
2745:The Journal of Biological Chemistry
2344:The Journal of Biological Chemistry
2212:The Journal of Biological Chemistry
2177:The Journal of Biological Chemistry
733:regulation of cholesterol transport
3357:. You can help Knowledge (XXG) by
1353:cholesteryl ester transfer protein
1078:
1045:
1015:
982:
958:
939:
913:
894:
868:
849:
572:
490:
428:
407:
25:
1370:C), it is found primarily within
1355:(CETP), probably by altering the
1316:that in humans is encoded by the
662:high-density lipoprotein particle
3337:
3039:
2905:
2890:
611:phospholipase inhibitor activity
338:
331:
325:
302:
237:
230:
224:
199:
40:
3414:Human chromosome 19 gene stubs
773:triglyceride metabolic process
556:More reference expression data
1:
2658:10.1016/S0378-1119(97)00411-3
2357:10.1016/S0021-9258(19)42365-X
2256:10.1016/S0006-291X(88)80424-8
2225:10.1016/S0021-9258(18)68638-7
2190:10.1016/S0021-9258(19)41998-4
1249:Available protein structures:
793:lipoprotein metabolic process
713:cholesterol metabolic process
688:chylomicron remnant clearance
323:
222:
3404:Genes on human chromosome 19
2524:10.1016/0378-1119(94)90802-8
2430:10.1016/0301-4622(81)80022-1
2286:10.1016/0006-291X(86)90414-6
1366:During fasting (like other
621:phosphatidylcholine binding
3430:
3332:
2836:gene details page in the
1312:is a protein component of
542:tunica adventitia of aorta
3037:
2885:
2724:10.3109/10425179809086433
2464:10.1093/clinchem/27.4.543
2145:10.1016/j.cbd.2014.08.001
2100:10.1007/s11515-013-1278-7
2051:10.1016/j.cbd.2009.12.003
1914:"Mouse PubMed Reference:"
1896:"Human PubMed Reference:"
1244:
1175:
1155:
1150:
1146:
1139:
1123:
1104:
1085:
1052:
1041:
1022:
989:
978:
965:
961:
946:
942:
933:
920:
916:
901:
897:
888:
875:
871:
856:
852:
843:
828:
821:
817:
801:
616:lipase inhibitor activity
596:
592:
580:
575:
566:
553:
502:
493:
440:
431:
401:
393:
389:
372:
359:
322:
301:
292:
288:
271:
258:
221:
198:
189:
185:
140:
137:
127:
120:
115:
84:
79:
62:
57:
52:
48:
39:
34:
1110:Chr 19: 44.91 – 44.92 Mb
3174:Lipid transfer proteins
1403:Interactive pathway map
1117:Chr 7: 19.42 – 19.43 Mb
3202:Cell surface receptors
2758:10.1074/jbc.M007210200
2619:10.1002/pro.5560060906
2557:10.1006/geno.1993.1021
2379:Nucleic Acids Research
1828:"Statin_Pathway_WP430"
1790:
1478:
2418:Biophysical Chemistry
2391:10.1093/nar/12.9.3909
1789:
1477:
657:endoplasmic reticulum
215:Chromosome 19 (human)
3304:cassette transporter
2830:genome location and
2088:Frontiers in Biology
1796:|alt=Statin pathway
667:extracellular region
526:skin of external ear
522:brown adipose tissue
452:right adrenal cortex
317:Chromosome 7 (mouse)
80:List of PDB id codes
53:Available structures
3031:Remnant cholesterol
2963:particle metabolism
2838:UCSC Genome Browser
2495:10.1021/bi00022a013
1378:in the human body.
1339:differentiate into
708:phospholipid efflux
448:left adrenal cortex
444:right lobe of liver
356:7 A3|7 9.94 cM
3345:This article on a
2451:Clinical Chemistry
2315:10.1007/BF00279087
1990:10.1007/BF00291243
1946:10.1007/BF00291654
1791:
1479:
1310:Apolipoprotein C-I
923:ENSMUSG00000040564
748:cholesterol efflux
676:Biological process
640:Cellular component
626:fatty acid binding
604:Molecular function
506:left lobe of liver
3366:
3365:
3330:
3329:
2923:
2922:
2792:10.1101/gr.143000
2586:10.1159/000213820
2580:(Suppl 1): 12–9.
1307:
1306:
1303:
1302:
1298:structure summary
1166:
1165:
1162:
1161:
1135:
1134:
1100:
1099:
1075:
1074:
1037:
1036:
1012:
1011:
974:
973:
955:
954:
929:
928:
910:
909:
884:
883:
865:
864:
813:
812:
588:
587:
584:
583:
562:
561:
549:
548:
487:
486:
456:nucleus accumbens
385:
384:
284:
283:
179:APOC1 - orthologs
111:
110:
107:
106:
63:Ortholog search:
18:Apolipoprotein C1
16:(Redirected from
3421:
3387:
3380:
3373:
3341:
3334:
3043:
2972:particle classes
2950:
2943:
2936:
2927:
2909:
2894:
2874:
2867:
2860:
2851:
2813:
2803:
2770:
2760:
2735:
2706:
2669:
2640:
2630:
2597:
2568:
2535:
2506:
2476:
2466:
2441:
2412:
2402:
2369:
2359:
2334:
2297:
2267:
2237:
2227:
2202:
2192:
2157:
2156:
2128:
2122:
2121:
2111:
2079:
2073:
2072:
2062:
2030:
2024:
2023:
2016:
2010:
2009:
1972:
1966:
1965:
1928:
1922:
1921:
1910:
1904:
1903:
1892:
1886:
1876:
1865:
1855:
1832:
1831:
1823:
1730:
1725:
1720:
1715:
1710:
1705:
1700:
1695:
1690:
1685:
1680:
1675:
1670:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1333:apolipoprotein C
1246:
1180:
1168:
1148:
1147:
1119:
1112:
1095:
1079:
1070:
1046:
1042:RefSeq (protein)
1032:
1016:
1007:
983:
959:
940:
914:
895:
869:
850:
819:
698:lipid metabolism
594:
573:
558:
498:
496:Top expressed in
491:
476:substantia nigra
436:
434:Top expressed in
429:
408:
391:
381:
368:
357:
342:
335:
329:
318:
306:
290:
280:
267:
256:
241:
234:
228:
217:
203:
187:
181:
132:
125:
102:
77:
71:
50:
49:
44:
32:
21:
3429:
3428:
3424:
3423:
3422:
3420:
3419:
3418:
3409:Apolipoproteins
3394:
3393:
3392:
3391:
3331:
3326:
3303:
3296:
3196:
3168:
3139:
3050:Apolipoproteins
3044:
3035:
2973:
2964:
2954:
2924:
2919:
2916:
2910:
2901:
2895:
2881:
2878:
2821:
2816:
2786:(11): 1788–95.
2780:Genome Research
2773:
2751:(48): 37504–9.
2738:
2709:
2675:Nature Genetics
2672:
2652:(1–2): 149–56.
2643:
2607:Protein Science
2600:
2571:
2538:
2509:
2479:
2444:
2415:
2372:
2350:(16): 5308–13.
2337:
2300:
2270:
2240:
2218:(15): 7277–86.
2205:
2170:
2166:
2164:Further reading
2161:
2160:
2130:
2129:
2125:
2081:
2080:
2076:
2032:
2031:
2027:
2018:
2017:
2013:
1974:
1973:
1969:
1930:
1929:
1925:
1912:
1911:
1907:
1894:
1893:
1889:
1877:
1868:
1856:
1847:
1842:
1837:
1836:
1835:
1826:
1824:
1820:
1815:
1814:
1813:
1809:Statin pathway
1808:
1803:
1802:
1801:
1795:
1794:
1793:
1792:
1788:
1732:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1616:
1613:
1611:
1608:
1606:
1603:
1601:
1598:
1596:
1593:
1591:
1588:
1586:
1583:
1581:
1578:
1576:
1573:
1571:
1568:
1566:
1563:
1561:
1558:
1556:
1553:
1551:
1548:
1546:
1543:
1541:
1538:
1536:
1533:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1480:
1476:
1405:
1384:
1357:electric charge
1329:
1183:
1157:View/Edit Mouse
1152:View/Edit Human
1115:
1108:
1105:Location (UCSC)
1091:
1087:
1066:
1062:
1058:
1054:
1028:
1024:
1003:
999:
995:
991:
904:ENSG00000130208
797:
683:lipid transport
671:
635:
554:
545:
540:
536:
532:
528:
524:
520:
516:
512:
508:
494:
483:
478:
474:
470:
466:
464:caudate nucleus
462:
458:
454:
450:
446:
432:
376:
363:
355:
345:
344:
343:
336:
316:
293:Gene location (
275:
262:
254:
244:
243:
242:
235:
213:
190:Gene location (
141:
128:
121:
86:
64:
28:
23:
22:
15:
12:
11:
5:
3427:
3425:
3417:
3416:
3411:
3406:
3396:
3395:
3390:
3389:
3382:
3375:
3367:
3364:
3363:
3342:
3328:
3327:
3325:
3324:
3319:
3314:
3308:
3306:
3298:
3297:
3295:
3294:
3289:
3283:
3282:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:
3214:
3213:
3206:
3204:
3198:
3197:
3195:
3194:
3189:
3184:
3178:
3176:
3170:
3169:
3167:
3166:
3161:
3156:
3150:
3148:
3144:Extracellular
3141:
3140:
3138:
3137:
3136:
3135:
3125:
3120:
3115:
3110:
3109:
3108:
3103:
3098:
3093:
3085:
3080:
3079:
3078:
3073:
3068:
3063:
3054:
3052:
3046:
3045:
3038:
3036:
3034:
3033:
3028:
3023:
3018:
3015:
3012:
3007:
2993:
2988:
2977:
2975:
2974:and subclasses
2966:
2965:
2955:
2953:
2952:
2945:
2938:
2930:
2921:
2920:
2918:
2917:
2911:
2904:
2902:
2896:
2889:
2886:
2883:
2882:
2879:
2877:
2876:
2869:
2862:
2854:
2848:
2847:
2841:
2820:
2819:External links
2817:
2815:
2814:
2771:
2736:
2707:
2670:
2641:
2613:(9): 1858–68.
2598:
2569:
2536:
2518:(1–2): 171–4.
2507:
2489:(22): 7401–8.
2477:
2442:
2413:
2385:(9): 3909–15.
2370:
2335:
2303:Human Genetics
2298:
2268:
2238:
2203:
2167:
2165:
2162:
2159:
2158:
2123:
2094:(5): 533–548.
2074:
2025:
2011:
1978:Human Genetics
1967:
1934:Human Genetics
1923:
1905:
1887:
1866:
1844:
1843:
1841:
1838:
1834:
1833:
1817:
1816:
1805:
1804:
1733:
1727:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1597:
1592:
1587:
1582:
1577:
1572:
1567:
1562:
1557:
1552:
1547:
1542:
1537:
1532:
1527:
1522:
1517:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1481:
1421:
1420:
1419:
1418:
1416:
1415:
1414:
1413:
1412:
1411:
1404:
1401:
1383:
1380:
1368:apolipoprotein
1328:
1325:
1305:
1304:
1301:
1300:
1295:
1289:
1288:
1275:
1269:
1268:
1258:
1251:
1250:
1242:
1241:
1228:
1222:
1221:
1216:
1210:
1209:
1204:
1198:
1197:
1194:
1190:
1189:
1185:
1184:
1181:
1173:
1172:
1164:
1163:
1160:
1159:
1154:
1144:
1143:
1137:
1136:
1133:
1132:
1130:
1128:
1121:
1120:
1113:
1106:
1102:
1101:
1098:
1097:
1083:
1082:
1076:
1073:
1072:
1050:
1049:
1043:
1039:
1038:
1035:
1034:
1020:
1019:
1013:
1010:
1009:
987:
986:
980:
976:
975:
972:
971:
963:
962:
956:
953:
952:
944:
943:
937:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
882:
881:
873:
872:
866:
863:
862:
854:
853:
847:
841:
840:
835:
830:
826:
825:
815:
814:
811:
810:
799:
798:
796:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
654:
649:
643:
641:
637:
636:
634:
633:
628:
623:
618:
613:
607:
605:
601:
600:
590:
589:
586:
585:
582:
581:
578:
577:
570:
564:
563:
560:
559:
551:
550:
547:
546:
544:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
500:
499:
488:
485:
484:
482:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
438:
437:
425:
424:
416:
405:
399:
398:
395:RNA expression
387:
386:
383:
382:
374:
370:
369:
361:
358:
353:
347:
346:
337:
330:
324:
320:
319:
314:
308:
307:
299:
298:
286:
285:
282:
281:
273:
269:
268:
260:
257:
252:
246:
245:
236:
229:
223:
219:
218:
211:
205:
204:
196:
195:
183:
182:
139:
135:
134:
126:
118:
117:
113:
112:
109:
108:
105:
104:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3426:
3415:
3412:
3410:
3407:
3405:
3402:
3401:
3399:
3388:
3383:
3381:
3376:
3374:
3369:
3368:
3362:
3360:
3356:
3352:
3351:chromosome 19
3348:
3343:
3340:
3336:
3323:
3320:
3318:
3315:
3313:
3310:
3309:
3307:
3305:
3299:
3293:
3290:
3288:
3284:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3221:
3220:
3216:
3215:
3212:
3208:
3207:
3205:
3203:
3199:
3193:
3190:
3188:
3185:
3183:
3180:
3179:
3177:
3175:
3171:
3165:
3162:
3160:
3157:
3155:
3152:
3151:
3149:
3147:
3142:
3134:
3131:
3130:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3088:
3086:
3084:
3081:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3058:
3056:
3055:
3053:
3051:
3047:
3042:
3032:
3029:
3027:
3024:
3022:
3019:
3016:
3013:
3011:
3008:
3006:
3002:
2998:
2994:
2992:
2989:
2987:
2983:
2979:
2978:
2976:
2971:
2967:
2962:
2958:
2951:
2946:
2944:
2939:
2937:
2932:
2931:
2928:
2914:
2908:
2903:
2899:
2893:
2888:
2884:
2875:
2870:
2868:
2863:
2861:
2856:
2855:
2852:
2845:
2842:
2839:
2835:
2834:
2829:
2828:
2823:
2822:
2818:
2811:
2807:
2802:
2797:
2793:
2789:
2785:
2781:
2777:
2772:
2768:
2764:
2759:
2754:
2750:
2746:
2742:
2737:
2733:
2729:
2725:
2721:
2718:(2): 89–100.
2717:
2713:
2708:
2704:
2700:
2696:
2692:
2688:
2687:10.1038/10297
2684:
2681:(3): 239–47.
2680:
2676:
2671:
2667:
2663:
2659:
2655:
2651:
2647:
2642:
2638:
2634:
2629:
2624:
2620:
2616:
2612:
2608:
2604:
2599:
2595:
2591:
2587:
2583:
2579:
2575:
2570:
2566:
2562:
2558:
2554:
2551:(1): 133–45.
2550:
2546:
2542:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2508:
2504:
2500:
2496:
2492:
2488:
2484:
2478:
2474:
2470:
2465:
2460:
2456:
2452:
2448:
2443:
2439:
2435:
2431:
2427:
2423:
2419:
2414:
2410:
2406:
2401:
2396:
2392:
2388:
2384:
2380:
2376:
2371:
2367:
2363:
2358:
2353:
2349:
2345:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2304:
2299:
2295:
2291:
2287:
2283:
2280:(3): 876–84.
2279:
2275:
2269:
2265:
2261:
2257:
2253:
2250:(3): 1282–8.
2249:
2245:
2239:
2235:
2231:
2226:
2221:
2217:
2213:
2209:
2204:
2200:
2196:
2191:
2186:
2183:(1): 182–90.
2182:
2178:
2174:
2169:
2168:
2163:
2154:
2150:
2146:
2142:
2138:
2134:
2127:
2124:
2119:
2115:
2110:
2105:
2101:
2097:
2093:
2089:
2085:
2078:
2075:
2070:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2029:
2026:
2021:
2015:
2012:
2007:
2003:
1999:
1995:
1991:
1987:
1983:
1979:
1971:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1927:
1924:
1919:
1915:
1909:
1906:
1901:
1897:
1891:
1888:
1884:
1880:
1875:
1873:
1871:
1867:
1863:
1859:
1854:
1852:
1850:
1846:
1839:
1829:
1822:
1819:
1812:
1807:
1799:
1737:
1425:
1410:
1409:
1402:
1400:
1398:
1394:
1389:
1381:
1379:
1377:
1373:
1369:
1364:
1362:
1358:
1354:
1349:
1344:
1342:
1338:
1334:
1326:
1324:
1322:
1319:
1315:
1311:
1299:
1296:
1294:
1290:
1287:
1283:
1279:
1276:
1274:
1270:
1266:
1262:
1259:
1256:
1252:
1247:
1243:
1240:
1236:
1232:
1229:
1227:
1223:
1220:
1217:
1215:
1211:
1208:
1205:
1203:
1199:
1195:
1191:
1186:
1179:
1174:
1169:
1158:
1153:
1149:
1145:
1142:
1138:
1131:
1129:
1126:
1122:
1118:
1114:
1111:
1107:
1103:
1096:
1094:
1090:
1084:
1080:
1077:
1071:
1069:
1065:
1061:
1057:
1051:
1047:
1044:
1040:
1033:
1031:
1027:
1021:
1017:
1014:
1008:
1006:
1002:
998:
994:
988:
984:
981:
979:RefSeq (mRNA)
977:
970:
969:
964:
960:
957:
951:
950:
945:
941:
938:
936:
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
839:
836:
834:
831:
827:
824:
820:
816:
809:
805:
800:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
644:
642:
639:
638:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
608:
606:
603:
602:
599:
598:Gene ontology
595:
591:
579:
574:
571:
569:
565:
557:
552:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
504:
501:
497:
492:
489:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
442:
439:
435:
430:
427:
426:
423:
421:
417:
415:
414:
410:
409:
406:
404:
400:
396:
392:
388:
380:
375:
371:
367:
362:
352:
348:
341:
334:
328:
321:
313:
309:
305:
300:
296:
291:
287:
279:
274:
270:
266:
261:
251:
247:
240:
233:
227:
220:
216:
210:
206:
202:
197:
193:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
136:
131:
124:
119:
114:
103:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
3359:expanding it
3344:
3302:ATP-binding
2995:delivery of
2980:delivery of
2912:
2897:
2832:
2826:
2783:
2779:
2748:
2744:
2715:
2712:DNA Sequence
2711:
2678:
2674:
2649:
2645:
2610:
2606:
2577:
2573:
2548:
2544:
2515:
2511:
2486:
2483:Biochemistry
2482:
2457:(4): 543–8.
2454:
2450:
2424:(1): 29–38.
2421:
2417:
2382:
2378:
2347:
2343:
2309:(4): 286–9.
2306:
2302:
2277:
2273:
2247:
2243:
2215:
2211:
2180:
2176:
2136:
2132:
2126:
2091:
2087:
2077:
2042:
2038:
2028:
2014:
1981:
1977:
1970:
1940:(4): 345–9.
1937:
1933:
1926:
1917:
1908:
1899:
1890:
1821:
1407:
1406:
1385:
1365:
1345:
1330:
1317:
1314:lipoproteins
1309:
1308:
1089:NP_001103479
1086:
1068:NP_001366616
1060:NP_001307995
1056:NP_001307994
1053:
1026:NM_001110009
1023:
1005:NM_001379687
1001:NM_001321066
997:NM_001321065
990:
966:
947:
921:
902:
876:
857:
837:
832:
480:hypothalamus
418:
411:
138:External IDs
85:
29:
2986:Chylomicron
2970:Lipoprotein
2961:lipoprotein
2880:PDB gallery
2574:Gerontology
2045:(1): 73–9.
1984:(1): 90–3.
1397:Neandertals
1363:molecules.
1348:amino acids
1341:macrophages
1188:Identifiers
647:chylomicron
510:gallbladder
377:19,426,585
364:19,423,406
276:44,919,349
263:44,914,247
116:Identifiers
3398:Categories
1885:, May 2017
1864:, May 2017
1840:References
1393:Denisovans
1388:pseudogene
1382:Pseudogene
1261:structures
518:blastocyst
468:right lung
422:(ortholog)
159:HomoloGene
3349:on human
1337:monocytes
1219:IPR006781
1093:NP_031495
1064:NP_001636
1030:NM_007469
993:NM_001645
823:Orthologs
538:esophagus
167:GeneCards
2810:11076863
2767:10978346
2732:10520737
2695:10391210
2545:Genomics
2331:11662593
2153:25160599
2139:: 45–8.
2118:28757862
2069:20209111
2006:22711986
1962:32767041
1881:–
1860:–
1376:proteins
1327:Function
1278:RCSB PDB
1214:InterPro
1141:Wikidata
802:Sources:
530:yolk sac
255:19q13.32
3146:enzymes
2844:PDBe-KB
2703:4636523
2666:9373149
2637:9300485
2628:2143781
2594:8804993
2565:8432525
2532:8125298
2503:7779782
2473:7471419
2438:6789904
2409:6328444
2366:4369340
2323:3017837
2294:3013172
2264:2897845
2234:2835369
2109:5528196
2060:2830554
1998:2892779
1954:2985493
1883:Ensembl
1862:Ensembl
1417:[[File:
1207:PF04691
935:UniProt
890:Ensembl
829:Species
808:QuickGO
460:putamen
397:pattern
123:Aliases
3292:LRPAP1
3211:SCARB1
3017:sd LDL
3014:lb LDL
2957:Lipids
2824:Human
2808:
2801:310948
2798:
2765:
2730:
2701:
2693:
2664:
2635:
2625:
2592:
2563:
2530:
2501:
2471:
2436:
2407:
2400:318798
2397:
2364:
2329:
2321:
2292:
2262:
2232:
2199:166984
2197:
2151:
2116:
2106:
2067:
2057:
2004:
1996:
1960:
1952:
1293:PDBsum
1267:
1257:
1239:SUPFAM
1196:ApoC-I
1193:Symbol
1171:ApoC-I
1127:search
1125:PubMed
968:P34928
949:P02654
845:Entrez
568:BioGPS
472:spleen
163:136749
147:107710
3353:is a
3322:ABCG8
3317:ABCG5
3312:ABCA1
3285:LDL:
3279:LRP12
3274:LRP11
3269:LRP10
3254:LRP5L
3229:LRP1B
3217:IDL:
3209:HDL:
3087:APOC
3057:APOA
3021:Lp(a)
2833:APOC1
2827:APOC1
2699:S2CID
2327:S2CID
2002:S2CID
1958:S2CID
1729:]
1318:APOC1
1235:SCOPe
1226:SCOP2
878:11812
838:Mouse
833:Human
804:Amigo
420:Mouse
413:Human
360:Start
295:Mouse
259:Start
192:Human
171:APOC1
155:88053
130:APOC1
35:APOC1
3355:stub
3347:gene
3287:LDLR
3264:LRP8
3259:LRP6
3249:LRP5
3244:LRP4
3239:LRP3
3234:LRP2
3224:LRP1
3192:PLTP
3187:MTTP
3182:CETP
3159:LIPC
3154:LCAT
3133:SAA1
3123:APOH
3118:APOE
3113:APOD
3083:APOB
2999:and
2991:VLDL
2913:1opp
2898:1ioj
2806:PMID
2763:PMID
2728:PMID
2691:PMID
2662:PMID
2646:Gene
2633:PMID
2590:PMID
2561:PMID
2528:PMID
2512:Gene
2499:PMID
2469:PMID
2434:PMID
2405:PMID
2362:PMID
2319:PMID
2290:PMID
2260:PMID
2230:PMID
2195:PMID
2149:PMID
2114:PMID
2065:PMID
1994:PMID
1950:PMID
1811:edit
1798:edit
1395:and
1321:gene
1286:PDBj
1282:PDBe
1265:ECOD
1255:Pfam
1231:1ale
1202:Pfam
403:Bgee
351:Band
312:Chr.
250:Band
209:Chr.
143:OMIM
100:1OPP
96:1IOJ
92:1ALF
88:1ALE
69:RCSB
66:PDBe
3219:LRP
3164:LPL
3128:SAA
3026:HDL
3010:LDL
3005:IDL
2982:TGs
2796:PMC
2788:doi
2753:doi
2749:275
2720:doi
2683:doi
2654:doi
2650:200
2623:PMC
2615:doi
2582:doi
2553:doi
2520:doi
2516:138
2491:doi
2459:doi
2426:doi
2395:PMC
2387:doi
2352:doi
2348:249
2311:doi
2282:doi
2278:136
2252:doi
2248:152
2220:doi
2216:263
2185:doi
2181:250
2141:doi
2104:PMC
2096:doi
2055:PMC
2047:doi
1986:doi
1942:doi
1372:HDL
1361:HDL
1359:of
1273:PDB
859:341
576:n/a
514:lip
373:End
272:End
175:OMA
151:MGI
59:PDB
3400::
3003::
3001:CE
2984::
2959::
2804:.
2794:.
2784:10
2782:.
2778:.
2761:.
2747:.
2743:.
2726:.
2714:.
2697:.
2689:.
2679:22
2677:.
2660:.
2648:.
2631:.
2621:.
2609:.
2605:.
2588:.
2578:42
2576:.
2559:.
2549:15
2547:.
2543:.
2526:.
2514:.
2497:.
2487:34
2485:.
2467:.
2455:27
2453:.
2449:.
2432:.
2422:13
2420:.
2403:.
2393:.
2383:12
2381:.
2377:.
2360:.
2346:.
2342:.
2325:.
2317:.
2307:73
2305:.
2288:.
2276:.
2258:.
2246:.
2228:.
2214:.
2210:.
2193:.
2179:.
2175:.
2147:.
2137:11
2135:.
2112:.
2102:.
2090:.
2086:.
2063:.
2053:.
2041:.
2037:.
2000:.
1992:.
1982:78
1980:.
1956:.
1948:.
1938:69
1936:.
1916:.
1898:.
1869:^
1848:^
1800:]]
1386:A
1323:.
1284:;
1280:;
1263:/
1237:/
1233:/
806:/
379:bp
366:bp
278:bp
265:bp
173:;
169::
165:;
161::
157:;
153::
149:;
145::
98:,
94:,
90:,
3386:e
3379:t
3372:v
3361:.
3106:4
3101:3
3096:2
3091:1
3076:5
3071:4
3066:2
3061:1
2997:C
2949:e
2942:t
2935:v
2873:e
2866:t
2859:v
2840:.
2812:.
2790::
2769:.
2755::
2734:.
2722::
2716:9
2705:.
2685::
2668:.
2656::
2639:.
2617::
2611:6
2596:.
2584::
2567:.
2555::
2534:.
2522::
2505:.
2493::
2475:.
2461::
2440:.
2428::
2411:.
2389::
2368:.
2354::
2333:.
2313::
2296:.
2284::
2266:.
2254::
2236:.
2222::
2201:.
2187::
2155:.
2143::
2120:.
2098::
2092:8
2071:.
2049::
2043:5
2022:.
2008:.
1988::
1964:.
1944::
1920:.
1902:.
1830:.
1724:]
1719:]
1714:]
1709:]
1704:]
1699:]
1694:]
1689:]
1684:]
1679:]
1674:]
1669:]
1664:]
1659:]
1654:]
1649:]
1644:]
1639:]
1634:]
1629:]
1624:]
1619:]
1614:]
1609:]
1604:]
1599:]
1594:]
1589:]
1584:]
1579:]
1574:]
1569:]
1564:]
1559:]
1554:]
1549:]
1544:]
1539:]
1534:]
1529:]
1524:]
1519:]
1514:]
1509:]
1504:]
1499:]
1494:]
1489:]
1484:]
297:)
194:)
177::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
