316:
UCST phase behavior. He postulated that the low sequence complexity, structural disorder, and phase separation behavior of these repetitive polypeptides make them an interesting class of minimal synthetic intrinsically disordered proteins IDPs (synIDPs), and suggested that these SynIDPs can provide insights into the behavior of other more complex, native IDPs. His group has started to exploit the phase transition behavior of two classes of SynIDPs—ELPs that exhibit LCST phase behavior and resilin-like polypeptides (RLPs) that exhibit UCST phase behavior—to create artificial condensates within cells whose material properties and function can be precisely programmed at the sequence level of the SynIDP to reprogram cellular function by spatio-temporally controlling the flow genetic information and biochemical signals within the cell. His later work on functional artificial condensates of SynIDPs in cells includes sequestration of mRNA in a condensate regulate protein translation, sequestration of an enzyme in an artificial condensate to amplify its activity, sequestration of a plasmid to control gene flow in bacteria and recruitment of the transcriptional machinery to amplify gene expression.
325:
their immunogenicity, but PEG has itself proven to be antigenic and can elicit a serious anaphylactic response. To overcome these limitations, he designed a new PEG-like stealth hyperbranched polymer that breaks up the long antigenic ethylene glycol sequence in PEG and presents them as much shorter side-chains along a polymer backbone. Peptides and proteins conjugated to this next-generation PEG-like polymer show even longer circulation than PEG conjugates, do not bind to pre-existing anti-PEG antibodies that most people have developed, and do not generate an immune response to this new polymer. He has demonstrated the utility of this technology with a peptide drug for type 2 diabetes, an enzyme drug used to treat gout and an aptamer drug.
307:
also pioneered the development of high-throughput and scalable methods for the recombinant synthesis of repetitive peptide polymers that are useful for the recombinant synthesis of ELPs and other repetitive polypeptides. He developed a new non-chromatographic method for the purification of proteins. He also pioneered the development of injectable depots of ELPs fused to peptide and protein drugs for sustained—week or longer—release, and ELP nanoparticles loaded with small molecule chemotherapeutics for cancer therapy. His research group also developed a new class of partially ordered polypeptides that undergo a phase transition from a liquid into a highly porous solid network at body temperature.
334:
then used these nonfouling polymer brushes to develop a protein microarray that enables multiplexed detection of protein analytes with a femtomolar limit-of-detection directly from whole blood. Building upon this work, his group then invented the D4 point-of-care testing (POCT) technology, which enables rapid and accurate disease diagnosis by the quantitative measurement of multiple analytes at sub-picomolar concentrations from a drop of blood without user intervention. This technology led to the formation of a startup company —Sentilus—‚ that was acquired by
Immucor in 2014. His group later used the D4 POCT for serology for COVID-19, COVID-19 variant detection, and detection of Ebolavirus.
343:
immobilized metal nanoparticle sensors. Moreover, he also conducted a study to discuss the applications of tunable absorption in designing controlled-emissivity surfaces for thermophotovoltaic devices, producing detector elements for imaging and tailoring an infrared spectrum for controlled thermal dissipation.
273:(GRCs)—one on Biointerface Science in 2006 and a second on Bioinspired Materials in 2012. Furthermore, he is the founder of five start-ups. These companies include Sentilus, a clinical diagnostics company that was acquired by Immucor in 2014, Phase Bio Pharmaceuticals—a drug delivery company—that had an IPO on
324:
Chilkoti's research group has developed next-generation polyethylene glycol (PEG)-like conjugates that overcome the immunogenicity issues associated with traditional PEGylation. PEGylation—the attachment of polyethylene glycol (PEG) to biologics—is commonly used to increase their half-life or reduce
315:
Using a method for the rapid and multiplexed gene synthesis of repetitive polypeptides, Chilkoti created new variants of ELPs that show phase separation. He then built upon these findings to identify new sequence heuristics that enable the de novo design of repetitive polypeptides that show LCST and
306:
Chilkoti is most known for his work on genetically engineered elastin-like polypeptides (ELPs), which exhibit thermally responsive behavior and have been exploited by his group to develop new technologies and materials for protein purification, controlled drug release, and tissue engineering. He has
1497:
Heggestad, Jacob T.; Britton, Rhett J.; Kinnamon, David S.; Wall, Simone A.; Joh, Daniel Y.; Hucknall, Angus M.; Olson, Lyra B.; Anderson, Jack G.; Mazur, Anna; Wolfe, Cameron R.; Oguin, Thomas H.; Sullenger, Bruce A.; Burke, Thomas W.; Kraft, Bryan D.; Sempowski, Gregory D.; Woods, Christopher W.;
333:
Chilkoti has made contributions to biosensors and clinical diagnostics. His group was the first to demonstrate the use of surface-initiated polymerization to synthesize "nonfouling" polymer brushes from diverse surfaces that completely resist the adsorption of proteins and the adhesion of cells. He
342:
Chilkoti introduced an optical method to quantify biomolecular interactions in real time at the surface of an optically transparent substrate. He used this approach to design a label-free plasmonic biosensor in a chip format. Furthermore, he identified several factors to improve the performance of
261:
of the center from 2007 to 2011. In 2014, he became Chair of the
Department of Biomedical Engineering at Duke University and served as chair until 2022. As Chair of the Duke BME department, he launched an incubator—BRiDGE—for Biomedical Engineering faculty and student startups, and he created the
181:
science and he has pioneered the development of high-throughput and scalable methods for the recombinant synthesis of repetitive polypeptides, invented a method to purify protein drugs without chromatography, and developed a technology for point-of-care clinical diagnostics. He has founded five
1425:
Heggestad, J. T.; Kinnamon, D. S.; Olson, L. B.; Liu, J.; Kelly, G.; Wall, S. A.; Oshabaheebwa, S.; Quinn, Z.; Fontes, C. M.; Joh, D. Y.; Hucknall, A. M.; Pieper, C.; Anderson, J. G.; Naqvi, I. A.; Chen, L.; Que, L. G.; Oguin t, 3rd; Nair, S. K.; Sullenger, B. A.; Woods, C. W.; Burke, T. W.;
1375:
Fontes, C. M.; Lipes, B. D.; Liu, J.; Agans, K. N.; Yan, A.; Shi, P.; Cruz, D. F.; Kelly, G.; Luginbuhl, K. M.; Joh, D. Y.; Foster, S. L.; Heggestad, J.; Hucknall, A.; Mikkelsen, M. H.; Pieper, C. F.; Horstmeyer, R. W.; Geisbert, T. W.; Gunn, M. D.; Chilkoti, A. (2021).
277:
in 2018, Isolere Bio—that uses ELPs to purify complex biologics without chromatography—that was acquired by
Donaldson in 2023, and inSoma Bio, that has focused on commercializing injectable biomaterials developed in his laboratory for tissue reconstruction.
413:
Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006). Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the
National Cancer Institute, 98(5),
253:
in 2002 and
Professor in 2006. He was the Theo Pilkington Chair Professor of Biomedical Engineering from 2008 to 2013, and has been the Alan L. Kaganov Distinguished Professor of Biomedical Engineering at Duke University since 2013.
1153:
Dai, Yifan; Farag, Mina; Lee, Dongheon; Zeng, Xiangze; Kim, Kyeri; Son, Hye-in; Guo, Xiao; Su, Jonathan; Peterson, Nikhil; Mohammed, Javid; Ney, Max; Shapiro, Daniel Mark; Pappu, Rohit V.; Chilkoti, Ashutosh; You, Lingchong (2023).
417:
Ciracì, C., Hill, R. T., Mock, J. J., Urzhumov, Y., Fernández-DomĂnguez, A. I., Maier, S. A., ... & Smith, D. R. (2012). Probing the ultimate limits of plasmonic enhancement. Science, 337(6098), 1072–1074.
410:
Ma, H., Hyun, J. Chilkoti, A. (2004). “Nonfouling” oligoethylene glycol functionalized polymer brushes synthesized by surface-initiated atom transfer radical polymerization. Advanced
Materials, 16, 338–341.
1268:"Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart"
202:
456:
783:
Roberts, Stefan; Harmon, Tyler S.; Schaal, Jeffrey L.; Miao, Vincent; Li, Kan; Hunt, Andrew; Wen, Yi; Oas, Terrence G.; Collier, Joel H.; Pappu, Rohit V.; Chilkoti, Ashutosh (2018).
407:
Nath, N., & Chilkoti, A. (2002). A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface. Analytical chemistry, 74(3), 504–509.
190:
404:
Meyer, D. E., & Chilkoti, A. (1999). Purification of recombinant proteins by fusion with thermally-responsive polypeptides. Nature
Biotechnology, 17(11), 1112–1115.
1483:
257:
From 2002 till 2007, Chilkoti served as associate director of the Center for
Biologically Inspired Materials and Material Systems at Duke University and was the
1799:
1266:
Ozer, I.; Kelly, G.; Gu, R.; Li, X.; Zakharov, N.; Sirohi, P.; Nair, S. K.; Collier, J. H.; Hershfield, M. S.; Hucknall, A. M.; Chilkoti, A. (2022).
1814:
673:"One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer"
182:
start-up companies, including PhaseBio
Pharmaceuticals in 2002, Sentilus in 2011, Gateway Bio in 2017, Isolere Bio in 2018, and inSoma Bio in 2019.
671:
Luginbuhl, K. M.; Schaal, J. L.; Umstead, B.; Mastria, E. M.; Li, X.; Banskota, S.; Arnold, S.; Feinglos, M.; d'Alessio, D.; Chilkoti, A. (2017).
1824:
1317:"Simple fabrication of antibody microarrays on non-fouling polymer brushes with femtomolar sensitivity for protein analytes in serum and blood"
1633:
Moreau, Antoine; Ciracì, Cristian; Mock, Jack J.; Hill, Ryan T.; Wang, Qiang; Wiley, Benjamin J.; Chilkoti, Ashutosh; Smith, David R. (2012).
1203:
Qi, Y.; Simakova, A.; Ganson, N. J.; Li, X.; Luginbuhl, K. M.; Ă–zer, I.; Liu, W.; Hershfield, M. S.; Matyjaszewski, K.; Chilkoti, A. (2016).
262:
Duke
Engineering Entrepreneurship program (DEEP)—a post-doctoral fellowship program for recent PhD graduates of the department interested in
570:
233:
in Chemical Engineering in 1991, and carried out post-doctoral studies in the Center for Bioengineering from 1991 to 1995, also at the
1205:"A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity"
365:
470:
1819:
1253:"Injectable non-immunogenic PEG-like conjugate that forms a subcutaneous depot and enables sustained delivery of a peptide drug"
584:
391:
2020 - Fellow, Biomaterials Science and Engineering, International Union of Societies for Biomaterials Science and Engineering
1804:
198:
109:
68:
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194:
725:"Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection"
1315:
Hucknall, Angus; Kim, Dong-Hwan; Rangarajan, Srinath; Hill, Ryan T.; Reichert, William M.; Chilkoti, Ashutosh (2009).
270:
60:
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Andrew Mackay, J.; Chen, Mingnan; McDaniel, Jonathan R.; Liu, Wenge; Simnick, Andrew J.; Chilkoti, Ashutosh (2009).
1774:
266:. Since 2023, he has been serving as the Senior Associate Dean of Pratt School of Engineering at Duke University.
1809:
1596:"Label-Free Biosensing by Surface Plasmon Resonance of Nanoparticles on Glass: Optimization of Nanoparticle Size"
948:"Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes"
234:
226:
113:
1378:"Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR"
1557:"A Colorimetric Gold Nanoparticle Sensor To Interrogate Biomolecular Interactions in Real Time on a Surface"
201:, Controlled Release Society, International Union of Societies for Biomaterials Science and Engineering and
158:
and serial entrepreneur. He is the Alan L. Kaganov Professor of Biomedical Engineering and Senior Associate
1829:
214:
88:
842:"Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins"
512:
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93:
899:"Highly parallel method for synthesis of DNA repeats enables discovery of "smart" protein polymers"
598:
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1428:"Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test"
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997:"Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers"
967:
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McDaniel, Jonathan R.; MacKay, J. Andrew; Quiroz, Felipe GarcĂa; Chilkoti, Ashutosh (2010).
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785:"Injectable tissue integrating networks from recombinant polypeptides with tunable order"
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631:"Purification of recombinant proteins by fusion with thermally-responsive polypeptides"
170:
471:"SEVEN FROM DUKE NAMED FELLOWS OF AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE"
385:
2018 - Chandra P. Sharma award, Society for Biomaterials and Artificial Organs (India)
1788:
1252:
539:
370:
2011 - Clemson Award for “Contributions to the Literature”, Society for Biomaterials
178:
65:
Clemson Award for Contributions to the Literature, Society for Biomaterials (2011)
1732:
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2007 - Fellow, American Institute for Medical and Biological Engineering (AIMBE)
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104:
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1101:
Simon, J. R.; Eghtesadi, S. A.; Dzuricky, M.; You, L.; Chilkoti, A. (2019).
688:
630:
599:"Donaldson Acquires Isolere Bio, Continuing to Build Life Sciences Business"
222:
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585:"J&J, AstraZeneca-backed PhaseBio Pharmaceuticals closes downsized IPO"
373:
2013 - Pritzker Distinguished Lecture Award, Biomedical Engineering Society
169:
Chilkoti has published over 350 papers, has been cited 48,000 times, has a
1635:"Controlled-reflectance surfaces with film-coupled colloidal nanoantennas"
1103:"Engineered ribonucleoprotein granules inhibit translation in protocells"
151:
1658:
498:
1760:
1611:
1572:
1156:"Programmable synthetic biomolecular condensates for cellular control"
963:
177:
awarded. His research is focused on genetically encoded materials and
1705:"Awards and Recognition of Advancements in the Field of Biomaterials"
1020:
914:
865:
748:
274:
186:
174:
358:
2005 - Stansell Family Distinguished Research Award, Duke University
1500:"Rapid test to assess the escape of SARS-CoV-2 variants of concern"
646:
388:
2020 - Fellow, American Association for the Advancement of Science
51:
Biomedical engineer, academic, researcher, and serial entrepreneur
30:
897:
Amiram, M.; Quiroz, F. G.; Callahan, D. J.; Chilkoti, A. (2011).
540:"Encouraging Collaborations, Advancing Biomedical Research"
612:
203:
American Institute for Medical and Biological Engineering
394:
2022 – Outstanding Postdoc Mentor award, Duke university
1052:
Dai, Yifan; You, Lingchong; Chilkoti, Ashutosh (2023).
1426:
Sempowski, G. D.; Kraft, B. D.; Chilkoti, A. (2021).
352:
1998 - NSF CAREER Award, National Science Foundation
355:
2002 - 3M Nontenured Faculty Award, Duke University
191:
American Association for the Advancement of Science
124:
119:
103:
84:
79:
55:
47:
37:
25:
18:
995:Quiroz, Felipe GarcĂa; Chilkoti, Ashutosh (2015).
1775:"Chilkoti named 2022 Outstanding Postdoc Mentor"
1719:"Robert A. Pritzker Distinguished Lecture Award"
1054:"Engineering synthetic biomolecular condensates"
225:in 1985. He pursued his graduate studies at the
840:Tang, Nicholas C.; Chilkoti, Ashutosh (2016).
249:of Biomedical Engineering. He was promoted to
245:Chilkoti joined Duke University in 1996 as an
376:2013 - Fellow, Biomedical Engineering Society
8:
382:2014 - Fellow, National Academy of Inventors
1482:: CS1 maint: numeric names: authors list (
554:"Duke Engineering Entrepreneurship Program"
15:
1747:"2014 Archive – NAI Fellows in the Press"
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379:2013 - Fellow, Controlled Release Society
364:2010 - Humboldt Senior Researcher Award,
1594:Nath, Nidhi; Chilkoti, Ashutosh (2004).
1555:Nath, Nidhi; Chilkoti, Ashutosh (2002).
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162:in the Pratt School of Engineering at
67:Pritzker Distinguished Lecture Award,
7:
1800:American academics of Indian descent
1691:"Pratt School of Engineering Awards"
629:Meyer, D. E.; Chilkoti, A. (1999).
286:Chilkoti's research has focused on
14:
366:Alexander von Humboldt Foundation
311:Intrinsically disordered proteins
1815:University of Washington alumni
1382:Science Translational Medicine
573:(Press release). October 2014.
199:Biomedical Engineering Society
110:Indian Institute of Technology
69:Biomedical Engineering Society
1:
1825:21st-century Indian engineers
1209:Nature Biomedical Engineering
1058:Nature Reviews Bioengineering
677:Nature Biomedical Engineering
195:National Academy of Inventors
173:H-index of 116 and has 62 US
1394:10.1126/scitranslmed.abd9696
1119:10.1016/j.molcel.2019.05.010
302:Genetically encoded polymers
294:, biointerface science, and
1498:Chilkoti, Ashutosh (2021).
571:"Immucor Acquires Sentilus"
271:Gordon Research Conferences
61:National Science Foundation
1846:
1172:10.1038/s41589-022-01252-8
1070:10.1038/s44222-023-00052-6
527:"ASHUTOSH CHILKOTI, PH.D."
443:"Ashutosh Chilkoti - Duke"
320:Next generation PEGylation
1761:"Chandra P. Sharma Award"
809:10.1038/s41563-018-0182-6
134:
75:
513:"Ashutosh Chilkoti, PhD"
235:University of Washington
227:University of Washington
114:University of Washington
1820:Duke University faculty
1221:10.1038/s41551-016-0002
1160:Nature Chemical Biology
689:10.1038/s41551-017-0078
1733:"BMES List of Fellows"
1524:10.1126/sciadv.abl7682
1452:10.1126/sciadv.abg4901
1341:10.1002/adma.200803125
1284:10.1002/advs.202103672
499:"BMES List of Fellows"
229:, where he earned his
215:Bachelor of Technology
213:Chilkoti obtained his
91:, Chemical Engineering
1805:Indian businesspeople
269:Chilkoti founded two
1795:Biomedical engineers
1600:Analytical Chemistry
1561:Analytical Chemistry
635:Nature Biotechnology
485:"Fellows List - NAI"
338:Plasmonic biosensors
329:Clinical diagnostics
219:Chemical Engineering
98:Chemical Engineering
1659:10.1038/nature11615
1651:2012Natur.492...86M
1516:2021SciA....7.7682H
1444:2021SciA....7.4901H
1333:2009AdM....21.1968H
1013:2015NatMa..14.1164Q
858:2016NatMa..15..419T
801:2018NatMa..17.1154R
741:2009NatMa...8..993A
473:. 26 November 2019.
288:protein engineering
251:Associate Professor
247:Assistant Professor
148:biomedical engineer
80:Academic background
1321:Advanced Materials
59:NSF CAREER Award,
1612:10.1021/ac049741z
1606:(18): 5370–5378.
1573:10.1021/ac015657x
1327:(19): 1968–1971.
1007:(11): 1164–1171.
964:10.1021/bm901387t
952:Biomacromolecules
795:(12): 1154–1163.
641:(11): 1112–1115.
399:Selected articles
347:Awards and honors
296:nanobiotechnology
292:polymer chemistry
141:Ashutosh Chilkoti
138:
137:
20:Ashutosh Chilkoti
1837:
1810:IIT Delhi alumni
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1749:. 22 April 2024.
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1272:Advanced Science
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1113:(1): 66–75.e5.
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164:Duke University
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