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40:
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InChI=1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1
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intellectual property licensed from several universities including elamipretide; it subsequently changed its name to
Stealth BioTherapeutics.
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and had started a Phase III trial in that indication. As of
January 2020, trial expectations were not met.
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334:) that appears to reduce the production of toxic reactive oxygen species and stabilize
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As of
November 2017 Stealth had obtained an orphan designation in the US for use in
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421:"New therapies for reducing post-myocardial left ventricular remodeling"
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508:"Elamipretide Failed to Meet Promise of Earlier Trial Results for..."
96:)-6-Amino-2-amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-
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Stealth
Peptides, a privately held company, was founded in 2006 to
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470:"Stealth Peptides sees positive results from Bendavia"
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489:"New drugs offer hope for mitochondrial disease"
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419:Kloner RA, Shi J, Dai W (February 2015).
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437:10.3978/j.issn.2305-5839.2015.01.13
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55:H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2;
506:PhD, Alberto Molano (2020-01-10).
25:
425:Annals of Translational Medicine
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293:Key:SFVLTCAESLKEHH-WKAQUBQDSA-N
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1:
487:Dolgin E (11 February 2016).
468:Valigra L (April 9, 2012).
330:-Arg-dimethylTyr-Lys-Phe-NH
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511:Mitochondrial Disease News
226:Chemical and physical data
370:"Recommended INN List 75"
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37:
474:Boston Business Journal
350:mitochondrial myopathy
59:-Arginyl-2,6-dimethyl-
377:WHO Drug Information
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542:Experimental drugs
71:-phenylalaninamide
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195:CompTox Dashboard
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27:Chemical compound
16:(Redirected from
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383:(1): 111. 2016.
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320:mitochondrially
306:(also known as
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398:"Elamipretide"
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514:. Retrieved
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402:. Retrieved
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324:tetrapeptide
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304:Elamipretide
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32:Elamipretide
404:29 November
336:cardiolipin
272: g·mol
119:736992-21-5
100:-hexanamide
76:Identifiers
52:Other names
531:Categories
516:2020-02-24
356:References
322:-targeted
265:Molar mass
164:87GWG91S09
110:CAS Number
85:IUPAC name
431:(2): 20.
63:-tyrosyl-
455:25738140
316:Bendavia
144:11764719
18:Bendavia
446:4322169
343:develop
312:MTP-131
270:639.802
232:Formula
130:PubChem
67:-lysyl-
453:
443:
184:D10925
373:(PDF)
308:SS-31
281:InChI
493:STAT
451:PMID
406:2017
314:and
310:, ,
175:KEGG
155:UNII
441:PMC
433:doi
200:EPA
134:CID
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389:^
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20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
