231:
138:
374:
In April 2020, BioCryst began enrollment of a randomized, double-blind, placebo-controlled clinical trial to assess the safety, clinical impact and antiviral effects of galidesivir in patients with COVID-19. This clinical trial is (NCT03891420) is being funded by the
National Institute of Allergy and
370:
In March 2015, BioCryst announced that the
Biomedical Advanced Research and Development Authority (BARDA) within the U.S. Department of Health & Human Services’ Office of the Assistant Secretary for Preparedness and Response (ASPR) has awarded BioCryst a contract for the continued development of
758:
345:
Galidesivir was safe and generally well tolerated in Phase 1 clinical safety and pharmacokinetics trials conducted in 2019 by both intravenous and intramuscular routes of administration in healthy human
751:
1565:
1555:
767:
744:
1560:
1540:
1550:
1585:
1535:
1570:
349:
In animal studies, galidesivir has demonstrated survival benefits against a variety of serious pathogens, including Ebola, Marburg, Yellow Fever and Zika viruses.
445:
1249:
1239:
1229:
1219:
1209:
1199:
1189:
1179:
1169:
681:"A Study to Evaluate the Safety, Pharmacokinetics and Antiviral Effects of Galidesivir in Yellow Fever or COVID-19 - Full Text View - ClinicalTrials.gov"
1575:
217:, with plans for the combined company to change its name and move to Pennsylvania. However, BioCryst shareholders voted down the merger in July.
1590:
375:
Infectious
Diseases (NIAID), part of the National Institutes of Health. The company later made the decision to cease conducting further trials.
309:
1545:
628:
297:
478:
602:
706:
501:
174:. The company is a late stage biotech company that focuses on oral drugs for rare and serious diseases. BioCryst's antiviral drug
1514:
654:
526:
29:
1580:
1382:
921:
1140:
1497:
951:
213:, where the company has had an office since 2006. In January 2018, BioCryst signed a definitive merger agreement with
113:
946:
455:
395:
1120:
1090:
1075:
1003:
988:
926:
871:
1387:
1095:
430:
1452:
1302:
1023:
1013:
1008:
866:
806:
191:
186:
The company was founded in 1986 by
Charles E. Bugg and John A. Montgomery. In March 1994, BioCryst became a
117:
1407:
1377:
1327:
1282:
1130:
821:
210:
171:
99:
352:
BioCryst is developing galidesivir in collaboration with U.S. government agencies and other institutions.
1482:
1287:
1105:
1070:
916:
896:
356:
355:
In
September 2013, NIAID contracted with BioCryst for the development of galidesivir as a treatment for
331:
273:
318:(BCX4430) is a broad-spectrum antiviral in advanced development for the treatment of viruses including
285:
On
December 3, 2020, the FDA approved berotralstat as the first oral hereditary angioedema prophylaxis.
178:(Rapivab) was approved by FDA in December 2014. It has also been approved in Japan, Korea, and China.
1442:
1417:
1367:
1362:
1342:
1292:
1225:
1215:
1085:
1060:
968:
963:
931:
861:
831:
279:
FDA has approved
Expanded Access Program for berotralstat for eligible patients in the United States.
199:
1467:
1432:
1422:
1347:
1332:
1055:
1050:
791:
781:
1392:
1205:
1175:
1125:
891:
876:
371:
galidesivir as a potential treatment for diseases caused by RNA pathogens, including filoviruses.
61:
736:
450:
1372:
1337:
826:
305:
290:
1100:
1038:
1018:
973:
958:
901:
1447:
1357:
1352:
993:
941:
911:
244:
Please help update this article to reflect recent events or newly available information.
1277:
983:
198:
stock exchange. In 2008, the company was named one of the fastest growing companies by
187:
39:
1529:
1457:
1255:
1157:
1065:
577:
57:
47:
1235:
335:
265:
680:
1427:
1110:
978:
364:
315:
293:, an oral Factor D inhibitor for the treatment of complement-mediated diseases.
214:
1487:
1115:
846:
552:
339:
319:
269:
71:
409:
1437:
1307:
1080:
1045:
906:
881:
479:"BioCryst Pharmaceuticals to merge with Pennsylvania pharmaceutical company"
360:
175:
527:"FDA Approves Berotralstat as First Oral Hereditary Angioedema Prophylaxis"
28:
1317:
1312:
1195:
1185:
856:
323:
296:
FDA has granted Fast Track designation for BCX9930, for the treatment of
1472:
1322:
1245:
1165:
1135:
1033:
998:
936:
851:
811:
796:
629:"HHS Contracts with BioCryst Pharmaceuticals to Develop New Ebola Drug"
1477:
1412:
1402:
1297:
1028:
841:
786:
195:
53:
731:
282:
Berotralstat has a PDUFA date for FDA approval on
December 3, 2020.
209:
In
October 2010, BioCryst announced its headquarters would move to
1492:
1462:
1397:
886:
816:
801:
502:"BioCryst stockholders call off merger with Idera Pharmaceuticals"
327:
1272:
740:
224:
655:"BioCryst starts COVID-19 trial of broad-spectrum antiviral"
603:"Broad-Spectrum Antiviral Effective Against Ebola, MERS-CoV"
159:
396:"BioCryst Pharmaceuticals Revenue 2006-2021 | BCRX"
170:
is an
American pharmaceutical company headquartered in
1265:
1156:
1149:
774:
155:
145:
132:
124:
106:
95:
77:
67:
45:
35:
578:"BioCryst | Oral Drugs for Viruses | Galidesivir"
433:. Birmingham Business Journal. November 26, 2008.
431:"BioCryst named 29th fastest growing tech firm"
707:"To conquer COVID-19, create the perfect pill"
553:"Orladeyo (berotralstat) FDA Approval History"
261:BioCryst’s core development programs include:
1566:Health care companies based in North Carolina
1556:Pharmaceutical companies of the United States
768:Pharmaceutical companies of the United States
752:
8:
1561:Pharmaceutical companies established in 1986
1541:Biotechnology companies of the United States
21:
1551:Biotechnology companies established in 1986
308:, an oral ALK-2 inhibitor for treatment of
1153:
759:
745:
737:
27:
20:
1586:Companies based in Durham, North Carolina
387:
268:(BCX7353), an oral inhibitor of plasma
1536:American companies established in 1986
1571:1986 establishments in North Carolina
310:fibrodysplasia ossificans progressiva
7:
477:Patchen, Tyler (January 23, 2018).
298:paroxysmal nocturnal hemoglobinuria
1046:Pharmaceutical Product Development
14:
709:. Chemical & Engineering News
705:Halford, Bethany (May 20, 2021).
444:Ranii, David (October 14, 2010).
1515:List of pharmaceutical companies
272:for prevention and treatment of
229:
137:
136:
16:American pharmaceutical company
1576:Companies listed on the Nasdaq
446:"BioCryst moving HQ to Durham"
168:BioCryst Pharmaceuticals, Inc.
22:BioCryst Pharmaceuticals, Inc.
1:
1591:1994 initial public offerings
922:Institute for OneWorld Health
500:Hale, Conor (July 11, 2018).
194:by listing its shares on the
1141:West Pharmaceutical Services
1546:Biopharmaceutical companies
83:; 38 years ago
1607:
947:McNeil Consumer Healthcare
359:and potentially for other
1510:
1453:Smith, Kline & French
1004:Northwest Biotherapeutics
989:Merrimack Pharmaceuticals
238:This section needs to be
26:
582:BioCryst Pharmaceuticals
633:Infection Control Today
481:. The Business Journals
192:initial public offering
1581:Life sciences industry
1378:Leiner Health Products
822:Amneal Pharmaceuticals
211:Durham, North Carolina
172:Durham, North Carolina
100:Durham, North Carolina
62:Russell 2000 Component
932:Johnson & Johnson
357:Marburg virus disease
274:hereditary angioedema
215:Idera Pharmaceuticals
200:Deloitte & Touche
190:when it completed an
1226:Jazz Pharmaceuticals
1216:Horizon Therapeutics
1086:Sarepta Therapeutics
1061:Proteon Therapeutics
1056:Procter & Gamble
969:Melinta Therapeutics
862:Bristol Myers Squibb
202:in its 2008 list of
1433:Repros Therapeutics
1348:Forest Laboratories
1333:Cutter Laboratories
1051:Prasco Laboratories
792:Acorda Therapeutics
782:Abbott Laboratories
458:on October 17, 2010
451:News & Observer
204:Technology Fast 500
147:Number of employees
141:$ 49 million (2019)
112:Jon P. Stonehouse (
23:
1393:Miles Laboratories
1383:Martek Biosciences
1206:Endo International
1126:Ventria Bioscience
892:Danco Laboratories
685:clinicaltrials.gov
533:. December 4, 2020
1523:
1522:
1506:
1505:
1338:DNAPrint Genomics
827:Avax Technologies
607:Global Biodefense
259:
258:
165:
164:
1598:
1154:
1101:Tec Laboratories
974:Melior Discovery
959:Kinetic Concepts
902:Galena Biopharma
761:
754:
747:
738:
719:
718:
716:
714:
702:
696:
695:
693:
691:
677:
671:
670:
668:
666:
661:. April 10, 2020
651:
645:
644:
642:
640:
635:. March 31, 2015
625:
619:
618:
616:
614:
599:
593:
592:
590:
588:
574:
568:
567:
565:
563:
549:
543:
542:
540:
538:
523:
517:
516:
514:
512:
497:
491:
490:
488:
486:
474:
468:
467:
465:
463:
454:. Archived from
441:
435:
434:
427:
421:
420:
418:
416:
406:
400:
399:
392:
254:
251:
245:
233:
232:
225:
160:www.biocryst.com
140:
139:
91:
89:
84:
31:
24:
1606:
1605:
1601:
1600:
1599:
1597:
1596:
1595:
1526:
1525:
1524:
1519:
1502:
1448:Schering-Plough
1358:ImClone Systems
1261:
1145:
994:Myriad Genetics
984:Merck & Co.
942:Janssen Biotech
912:Gilead Sciences
770:
765:
728:
723:
722:
712:
710:
704:
703:
699:
689:
687:
679:
678:
674:
664:
662:
653:
652:
648:
638:
636:
627:
626:
622:
612:
610:
609:. March 3, 2014
601:
600:
596:
586:
584:
576:
575:
571:
561:
559:
551:
550:
546:
536:
534:
525:
524:
520:
510:
508:
499:
498:
494:
484:
482:
476:
475:
471:
461:
459:
443:
442:
438:
429:
428:
424:
414:
412:
408:
407:
403:
394:
393:
389:
384:
255:
249:
246:
243:
234:
230:
223:
184:
148:
109:
87:
85:
82:
60:
50:
17:
12:
11:
5:
1604:
1602:
1594:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1528:
1527:
1521:
1520:
1518:
1517:
1511:
1508:
1507:
1504:
1503:
1501:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1278:Allergan, Inc.
1275:
1269:
1267:
1263:
1262:
1260:
1259:
1258:(Canada, 2010)
1253:
1243:
1233:
1223:
1213:
1203:
1193:
1183:
1173:
1162:
1160:
1151:
1147:
1146:
1144:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1042:
1041:
1036:
1026:
1021:
1016:
1011:
1009:Norwich Pharma
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
955:
954:
949:
944:
939:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
778:
776:
772:
771:
766:
764:
763:
756:
749:
741:
735:
734:
727:
726:External links
724:
721:
720:
697:
672:
646:
620:
594:
569:
544:
518:
506:Fierce Biotech
492:
469:
436:
422:
401:
386:
385:
383:
380:
379:
378:
377:
376:
372:
368:
353:
350:
347:
322:(the cause of
313:
303:
302:
301:
288:
287:
286:
283:
280:
257:
256:
237:
235:
228:
222:
219:
188:public company
183:
180:
163:
162:
157:
153:
152:
149:
146:
143:
142:
134:
130:
129:
126:
122:
121:
110:
107:
104:
103:
97:
93:
92:
79:
75:
74:
69:
65:
64:
51:
46:
43:
42:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1603:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1533:
1531:
1516:
1513:
1512:
1509:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1458:Sterling Drug
1456:
1454:
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1396:
1394:
1391:
1389:
1386:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1361:
1359:
1356:
1354:
1351:
1349:
1346:
1344:
1341:
1339:
1336:
1334:
1331:
1329:
1326:
1324:
1321:
1319:
1316:
1314:
1311:
1309:
1306:
1304:
1301:
1299:
1296:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1276:
1274:
1271:
1270:
1268:
1264:
1257:
1256:Bausch Health
1254:
1251:
1247:
1244:
1241:
1237:
1234:
1231:
1227:
1224:
1221:
1217:
1214:
1211:
1207:
1204:
1201:
1197:
1194:
1191:
1187:
1184:
1181:
1177:
1174:
1171:
1167:
1164:
1163:
1161:
1159:
1158:Tax inversion
1155:
1152:
1148:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1066:Purdue Pharma
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1040:
1037:
1035:
1032:
1031:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
953:
950:
948:
945:
943:
940:
938:
935:
934:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
779:
777:
773:
769:
762:
757:
755:
750:
748:
743:
742:
739:
733:
730:
729:
725:
708:
701:
698:
686:
682:
676:
673:
660:
659:FierceBiotech
656:
650:
647:
634:
630:
624:
621:
608:
604:
598:
595:
583:
579:
573:
570:
558:
554:
548:
545:
532:
528:
522:
519:
507:
503:
496:
493:
480:
473:
470:
457:
453:
452:
447:
440:
437:
432:
426:
423:
411:
405:
402:
397:
391:
388:
381:
373:
369:
366:
362:
358:
354:
351:
348:
344:
343:
341:
337:
333:
329:
325:
321:
317:
314:
311:
307:
304:
299:
295:
294:
292:
289:
284:
281:
278:
277:
275:
271:
267:
264:
263:
262:
253:
241:
236:
227:
226:
220:
218:
216:
212:
207:
205:
201:
197:
193:
189:
181:
179:
177:
173:
169:
161:
158:
154:
150:
144:
135:
131:
127:
123:
119:
115:
111:
105:
101:
98:
94:
80:
76:
73:
70:
66:
63:
59:
55:
52:
49:
44:
41:
38:
34:
30:
25:
19:
1236:Mallinckrodt
1121:Upsher-Smith
952:Ortho-McNeil
836:
711:. Retrieved
700:
688:. Retrieved
684:
675:
663:. Retrieved
658:
649:
637:. Retrieved
632:
623:
611:. Retrieved
606:
597:
585:. Retrieved
581:
572:
560:. Retrieved
556:
547:
535:. Retrieved
530:
521:
509:. Retrieved
505:
495:
483:. Retrieved
472:
460:. Retrieved
456:the original
449:
439:
425:
413:. Retrieved
404:
390:
363:, including
336:Yellow Fever
266:Berotralstat
260:
247:
239:
208:
203:
185:
167:
166:
96:Headquarters
36:Company type
18:
1428:Parke-Davis
1111:Trevena Inc
979:Mentholatum
787:AbbVie Inc.
462:October 14,
365:Ebola virus
361:filoviruses
316:Galidesivir
1530:Categories
1488:ViroPharma
1388:Massengill
1116:Ultragenyx
847:Bioverativ
690:January 9,
665:January 9,
639:January 9,
613:January 9,
587:January 9,
562:January 9,
537:January 9,
410:"About us"
382:References
320:SARS-CoV-2
270:kallikrein
108:Key people
72:Healthcare
1438:Qualitest
1308:CancerVax
1091:Sheffield
1081:RespireRx
1076:Regeneron
927:Intercept
907:Genentech
897:Eli Lilly
882:CytoSport
872:Ceragenix
557:Drugs.com
346:subjects.
176:peramivir
114:president
48:Traded as
1318:CoTherix
1313:Cephalon
1196:Covidien
1186:Allergan
1176:Alkermes
1096:Spectrum
964:McKesson
857:Biovista
837:BioCryst
732:BioCryst
713:June 22,
511:April 9,
485:April 7,
415:July 17,
324:COVID-19
250:May 2021
221:Pipeline
125:Products
68:Industry
1473:Trubion
1323:Covance
1303:Bradley
1252:, 2013)
1250:Ireland
1246:Perrigo
1242:, 2013)
1240:Ireland
1232:, 2012)
1230:Ireland
1222:, 2014)
1220:Ireland
1212:, 2014)
1210:Ireland
1202:, 2007)
1200:Ireland
1192:, 2015)
1190:Ireland
1182:, 2011)
1180:Ireland
1172:, 2013)
1170:Ireland
1166:Actavis
1136:Viatris
1034:Hospira
1024:Ovation
1019:Organon
1014:NovaBay
999:Moderna
937:Ethicon
867:Century
852:Biovest
812:Alnylam
807:Alexion
797:Advaxis
775:Current
531:HCPLive
332:Marburg
306:BCX9250
291:BCX9930
276:(HAE).
240:updated
182:History
156:Website
133:Revenue
128:RABIVAP
86: (
78:Founded
56::
1498:Zonite
1478:Upjohn
1413:Nuvelo
1408:Nereus
1403:Naurex
1328:Cubist
1298:Biolex
1283:Amylin
1150:Former
1131:Vertex
1039:Searle
1029:Pfizer
842:Biogen
832:Baxter
312:(FOP).
300:(PNH).
196:NASDAQ
54:Nasdaq
40:Public
1493:Wyeth
1483:Verus
1463:Tanox
1443:Rib-X
1418:Ortho
1398:Mylan
1353:Genta
1288:ARIAD
1266:Other
1106:Titan
1071:Quark
917:Ionis
887:CytRx
877:Combe
817:Amgen
802:Alcon
328:Ebola
1368:King
1363:ISTA
1343:Epix
1293:Barr
1273:Alza
715:2021
692:2021
667:2021
641:2021
615:2021
589:2021
564:2021
539:2021
513:2021
487:2021
464:2010
417:2023
340:Zika
338:and
116:and
102:, US
88:1986
81:1986
58:BCRX
1468:TAP
1423:OSI
326:),
151:110
118:CEO
1532::
1373:KV
683:.
657:.
631:.
605:.
580:.
555:.
529:.
504:.
448:.
342:.
334:,
330:,
206:.
1248:(
1238:(
1228:(
1218:(
1208:(
1198:(
1188:(
1178:(
1168:(
760:e
753:t
746:v
717:.
694:.
669:.
643:.
617:.
591:.
566:.
541:.
515:.
489:.
466:.
419:.
398:.
367:.
252:)
248:(
242:.
120:)
90:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
