1272:
1282:
88:); this leads to faster onset of anesthesia and faster emergence from anesthesia once application of the anesthetic is stopped, which may be preferable in certain clinical scenarios. If an anesthetic has a high coefficient, then a large amount of it will have to be taken up in the body's blood before being passed on to the fatty (lipid) tissues of the brain where it can exert its effect.
94:
Minimum alveolar concentration (MAC) is defined as the alveolar concentration of anesthetic gas that prevents a movement response in half of subjects undergoing a painful (surgical) stimulus; simplified, it is the exhaled gas concentration required to produce anaesthetic effects – an
53:
in both compartments is equal, is nearly constant at sufficiently low concentrations. The partition coefficient is defined as this ratio and, therefore, has no units. The concentration of the anesthetic in blood includes the portion that is undissolved in plasma and the portion that is dissolved
368:
Grossherr, M; Hengstenberg, A; Dibbelt, L; Igl, BW; Noel, R; Knesebeck, Av; Schmucker, P; Gehring, H (Oct 2009). "Blood gas partition coefficient and pulmonary extraction ratio for propofol in goats and pigs".
1212:
1023:
1227:
1257:
1242:
904:
1207:
1252:
859:
775:
604:
1237:
1176:
1155:
1217:
352:
531:
1247:
1058:
641:
1135:
934:
62:
the inhaled anesthetic is in blood compared to in air, the more it binds to plasma proteins in the blood and the higher the blood–gas
1311:
1145:
1053:
568:
1008:
686:
1186:
1140:
962:
656:
74:
91:
The potency of an anesthetic is associated with its lipid solubility, which is measured by its oil/gas partition coefficient.
1232:
1191:
838:
1222:
1181:
1074:
693:
587:
729:
1079:
744:
1125:
987:
899:
49:, the ratio of the concentration in blood to the concentration in gas that is in contact with that blood, when the
316:
1316:
1033:
739:
1094:
1048:
914:
805:
524:
785:
1275:
1099:
1089:
1043:
734:
724:
646:
609:
1150:
1038:
1285:
972:
661:
626:
63:
1084:
1018:
1013:
947:
924:
828:
70:
1306:
942:
800:
790:
681:
671:
636:
631:
575:
558:
517:
1028:
884:
754:
666:
651:
614:
599:
592:
394:
42:
73:. Induction rate is defined as the speed at which an agent produces anesthesia. The higher the
17:
1130:
957:
952:
843:
770:
676:
438:
386:
348:
342:
1120:
909:
869:
582:
465:
428:
378:
50:
874:
749:
709:
414:"Blood/gas partition coefficients of halothane, isoflurane and sevoflurane in horse blood"
982:
977:
889:
544:
259:
55:
46:
1300:
1104:
992:
894:
719:
469:
398:
134:
85:
344:
The
Physics, Clinical Measurement and Equipment of Anaesthetic Practice for the FRCA
967:
795:
780:
84:) typically have smaller blood–gas partition coefficients than older ones (such as
38:
1171:
879:
833:
621:
509:
209:
919:
714:
540:
382:
234:
184:
81:
413:
280:
159:
442:
390:
864:
563:
433:
412:
Bergadano, A; Lauber, R; Zbinden, A; Schatzmann, U; Moens, Y (Aug 2003).
59:
456:
Battino, Rubin (1984). "The
Ostwald coefficient of gas solubility".
513:
1213:
American
Society of Anesthesia Technologists & Technicians
485:
Pharmacokinetics of
Inhalation Anesthetics. Nurse anesthesia
1177:
Helsinki
Declaration for Patient Safety in Anaesthesiology
1024:
Effects of early-life exposures to anesthesia on the brain
1228:
1258:
European
Society of Anaesthesiology and Intensive Care
27:
Measure of solubility of general anaesthetics in blood
1243:
Australian and New
Zealand College of Anaesthetists
1200:
1164:
1113:
1067:
1001:
933:
852:
816:
763:
702:
551:
341:Magee, Patrick; Tooley, Mark (22 September 2011).
525:
95:inverse indicator of anesthetic gas potency.
8:
905:Intraoperative neurophysiological monitoring
1208:American Association of Nurse Anesthetists
532:
518:
510:
102:
1253:International Anesthesia Research Society
860:ASA physical status classification system
432:
605:Combined spinal and epidural anaesthesia
347:. Oxford University Press. p. 133.
1238:Association of Veterinary Anaesthetists
308:
41:to describe the solubility of inhaled
1218:American Society of Anesthesiologists
106:Partition coefficients at 37 °C
7:
1223:Anaesthesia Trauma and Critical Care
77:, the slower the rate of induction.
1248:Australian Society of Anaesthetists
1156:Physicians' assistant (anaesthesia)
1059:Postoperative residual curarization
1136:Operating department practitioners
25:
1146:Certified anesthesia technologist
1054:Postoperative nausea and vomiting
569:Procedural sedation and analgesia
35:Ostwald coefficient for blood–gas
1280:
1271:
1270:
687:Transverse abdominis plane block
317:"Ostwald solubility coefficient"
1281:
1187:History of neuraxial anesthesia
1141:Certified anesthesia technician
963:Double-lumen endobronchial tube
824:Blood–gas partition coefficient
657:Intravenous regional anesthesia
75:blood:gas partition coefficient
31:Blood–gas partition coefficient
18:Blood/gas partition coefficient
1233:Royal College of Anaesthetists
1192:History of tracheal intubation
839:Minimum alveolar concentration
776:Anesthesia provision in the US
421:British Journal of Anaesthesia
1:
1182:History of general anesthesia
694:Total intravenous anaesthesia
642:Inferior alveolar nerve block
588:Continuous wound infiltration
745:Neuromuscular-blocking drugs
502:(5th ed.). p. 156.
470:10.1016/0378-3812(84)87009-0
1080:Critical emergency medicine
487:(5th ed.). p. 79.
80:Newer anesthetics (such as
69:It is inversely related to
1333:
1126:Anesthesiologist assistant
988:Relative analgesia machine
1266:
1034:Local anesthetic toxicity
483:Nagelhout, J. J. (2014).
383:10.1080/00498250903056109
105:
99:Inhalational anaesthetics
1312:Concentration indicators
1049:Postanesthetic shivering
915:Neuromuscular monitoring
806:Rapid sequence induction
735:Inhalational anesthetics
1100:Oral sedation dentistry
1090:Intensive care medicine
1044:Perioperative mortality
900:Guedel's classification
647:Intercostal nerve block
500:Clinical Anesthesiology
45:in blood. According to
1151:Anaesthetic technician
1039:Malignant hyperthermia
498:Morgan, G. E. (2013).
458:Fluid Phase Equilibria
321:Medical Dictionary.com
973:Laryngeal mask airway
817:Scientific principles
786:Dogliotti's principle
662:Occipital nerve block
627:Brachial plexus block
64:partition coefficient
1019:Drug-induced amnesia
1014:Anesthesia awareness
948:Anesthetic vaporizer
925:Thyromental distance
829:Concentration effect
703:Pharmacologic agents
672:Pudendal nerve block
37:, is a term used in
943:Anaesthetic machine
801:Tracheal intubation
791:Intravenous therapy
730:General anesthetics
682:Sciatic nerve block
637:Femoral nerve block
632:Fascia iliaca block
610:Epidural anesthesia
576:Twilight anesthesia
43:general anesthetics
1029:Emergence delirium
1009:Allergic reactions
885:Entropy monitoring
667:Paracervical block
652:Interpleural block
615:Spinal anaesthesia
600:Neuraxial blockade
434:10.1093/bja/aeg151
1294:
1293:
1131:Nurse anesthetist
958:Bronchial blocker
953:Arterial catheter
844:Second gas effect
771:Airway management
740:Local anesthetics
677:Retrobulbar block
354:978-0-19-959515-0
300:
299:
16:(Redirected from
1324:
1317:Pharmacokinetics
1284:
1283:
1274:
1273:
1121:Anesthesiologist
910:Mallampati score
870:Bispectral index
710:Anticholinergics
534:
527:
520:
511:
504:
503:
495:
489:
488:
480:
474:
473:
453:
447:
446:
436:
418:
409:
403:
402:
365:
359:
358:
338:
332:
331:
329:
327:
313:
103:
51:partial pressure
33:, also known as
21:
1332:
1331:
1327:
1326:
1325:
1323:
1322:
1321:
1297:
1296:
1295:
1290:
1262:
1196:
1160:
1109:
1063:
997:
929:
875:Body mass index
848:
812:
759:
725:Benzodiazepines
698:
547:
538:
508:
507:
497:
496:
492:
482:
481:
477:
455:
454:
450:
416:
411:
410:
406:
377:(10): 782–787.
367:
366:
362:
355:
340:
339:
335:
325:
323:
315:
314:
310:
305:
101:
56:plasma proteins
28:
23:
22:
15:
12:
11:
5:
1330:
1328:
1320:
1319:
1314:
1309:
1299:
1298:
1292:
1291:
1289:
1288:
1278:
1267:
1264:
1263:
1261:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1204:
1202:
1198:
1197:
1195:
1194:
1189:
1184:
1179:
1174:
1168:
1166:
1162:
1161:
1159:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1117:
1115:
1111:
1110:
1108:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1075:Cardiothoracic
1071:
1069:
1068:Subspecialties
1065:
1064:
1062:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1005:
1003:
999:
998:
996:
995:
990:
985:
983:Magill forceps
980:
978:Laryngeal tube
975:
970:
965:
960:
955:
950:
945:
939:
937:
931:
930:
928:
927:
922:
917:
912:
907:
902:
897:
892:
890:Fick principle
887:
882:
877:
872:
867:
862:
856:
854:
850:
849:
847:
846:
841:
836:
831:
826:
820:
818:
814:
813:
811:
810:
809:
808:
798:
793:
788:
783:
778:
773:
767:
765:
761:
760:
758:
757:
752:
747:
742:
737:
732:
727:
722:
720:Butyrophenones
717:
712:
706:
704:
700:
699:
697:
696:
691:
690:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
619:
618:
617:
612:
607:
597:
596:
595:
590:
580:
579:
578:
573:
572:
571:
555:
553:
549:
548:
545:anesthesiology
539:
537:
536:
529:
522:
514:
506:
505:
490:
475:
464:(3): 231–240.
448:
427:(2): 276–278.
404:
360:
353:
333:
307:
306:
304:
301:
298:
297:
295:
293:
291:
289:
286:
283:
277:
276:
274:
272:
270:
268:
265:
262:
260:Methoxyflurane
256:
255:
252:
249:
246:
243:
240:
237:
231:
230:
227:
224:
221:
218:
215:
212:
206:
205:
202:
199:
196:
193:
190:
187:
181:
180:
177:
174:
171:
168:
165:
162:
156:
155:
152:
149:
146:
143:
140:
137:
131:
130:
127:
124:
121:
118:
115:
112:
108:
107:
100:
97:
71:induction rate
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1329:
1318:
1315:
1313:
1310:
1308:
1305:
1304:
1302:
1287:
1279:
1277:
1269:
1268:
1265:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1214:
1211:
1209:
1206:
1205:
1203:
1201:Organizations
1199:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1169:
1167:
1163:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1118:
1116:
1112:
1106:
1105:Pain medicine
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1072:
1070:
1066:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1006:
1004:
1002:Complications
1000:
994:
993:Tracheal tube
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
940:
938:
936:
932:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
895:Goldman index
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
857:
855:
851:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
821:
819:
815:
807:
804:
803:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
768:
766:
762:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
701:
695:
692:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
623:
620:
616:
613:
611:
608:
606:
603:
602:
601:
598:
594:
591:
589:
586:
585:
584:
581:
577:
574:
570:
567:
566:
565:
562:
561:
560:
557:
556:
554:
550:
546:
542:
535:
530:
528:
523:
521:
516:
515:
512:
501:
494:
491:
486:
479:
476:
471:
467:
463:
459:
452:
449:
444:
440:
435:
430:
426:
422:
415:
408:
405:
400:
396:
392:
388:
384:
380:
376:
372:
364:
361:
356:
350:
346:
345:
337:
334:
322:
318:
312:
309:
302:
296:
294:
292:
290:
287:
284:
282:
279:
278:
275:
273:
271:
269:
266:
263:
261:
258:
257:
253:
250:
247:
244:
241:
238:
236:
233:
232:
228:
225:
222:
219:
216:
213:
211:
208:
207:
203:
200:
197:
194:
191:
188:
186:
183:
182:
178:
175:
172:
169:
166:
163:
161:
158:
157:
153:
150:
147:
144:
141:
138:
136:
135:Nitrous oxide
133:
132:
128:
125:
122:
119:
116:
113:
110:
109:
104:
98:
96:
92:
89:
87:
83:
78:
76:
72:
67:
65:
61:
57:
52:
48:
44:
40:
36:
32:
19:
968:Gas cylinder
853:Measurements
823:
796:Laryngoscopy
781:Bronchoscopy
499:
493:
484:
478:
461:
457:
451:
424:
420:
407:
374:
370:
363:
343:
336:
324:. Retrieved
320:
311:
126:Muscle/blood
93:
90:
79:
68:
58:). The more
39:pharmacology
34:
30:
29:
1172:ACE mixture
1114:Professions
935:Instruments
880:Capnography
834:Fink effect
715:Antiemetics
622:Nerve block
371:Xenobiotica
326:14 February
210:Sevoflurane
123:Brain/blood
47:Henry's law
1307:Anesthesia
1301:Categories
920:Pain scale
764:Techniques
541:Anesthesia
303:References
235:Desflurane
185:Isoflurane
129:Fat/blood
111:Anesthetic
82:desflurane
54:(bound to
1095:Obstetric
1085:Geriatric
755:Sedatives
399:205462293
281:Enflurane
160:Halothane
117:Blood/gas
1276:Category
865:Baricity
564:Sedation
443:12878628
391:19548775
1286:Outline
1165:History
750:Opioids
593:Topical
559:General
120:Oil/gas
114:MAC (%)
60:soluble
441:
397:
389:
351:
583:Local
552:Types
417:(PDF)
395:S2CID
86:ether
543:and
439:PMID
387:PMID
349:ISBN
328:2020
285:1.58
245:18.7
242:0.45
217:0.65
189:1.15
164:0.74
154:2.3
142:0.47
466:doi
429:doi
379:doi
288:1.9
264:0.2
254:27
251:2.0
248:1.3
239:5.8
229:48
226:3.1
223:1.7
204:45
201:4.0
198:2.6
192:1.4
179:60
176:3.5
173:2.9
170:224
167:2.4
151:1.2
148:1.1
145:1.4
139:105
1303::
462:15
460:.
437:.
425:91
423:.
419:.
393:.
385:.
375:39
373:.
319:.
267:12
220:42
195:97
66:.
533:e
526:t
519:v
472:.
468::
445:.
431::
401:.
381::
357:.
330:.
214:2
20:)
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