46:. Therefore, it can provide a direct assessment of regional bone metabolism. Hence, the reason why this method is considered the gold-standard technique for measuring bone remodelling. Patients undergo double tetracycline labelling, and then samples of bone are collected using trephine under local anesthetic from the iliac crest as it is the only readily accessible site for bone biopsy. This technique is subject to large measurement errors; it is complex and costly to perform and is invasive, meaning that it is painful to the patients. For these reasons, a bone biopsy is not readily acceptable to patients. Moreover, multiple biopsies using double tetracycline labelling are necessary for the same patient to assess treatment response or disease progression. Another drawback is that the iliac crest may not provide a true measurement of changes in bone metabolism at the lumbar spine or hip as considerable differences in regional bone metabolism estimates are observed at different skeletal sites. Revell et al. describes the measurement of various parameters such as trabecular bone volume, osteoid volume, osteoid surface, active osteoblastic surface, resorption surface, osteoclastic resorption surface, mineralization front, osteoid index, appositional rate, and osteoclastic index via histomorphometric analysis of bone samples.
537:
Serrano, S.; Mariñoso, M.L.; Soriano, J.C.; Rubiés-Prat, J.; Aubia, J.; Coll, J.; Bosch, J.; Del Rio, L.; Vila, J.; Goday, A.; Nacher, M. (1995). "Bone remodelling in human immunodeficiency virus-1-infected patients. A histomorphometric study".
273:
Flygare, Lennart; Hosoki, Hidehiko; Rohlin, Madeleine; Petersson, Arne (1997). "Bone
Histomorphometry using interactive image analysis. A methodological study with application on the human temporomandibular joint".
168:
Arlot, Monique; Meunier, Pierre J; Boivin, Georges; Haddock, Lillian; Tamayo, Juan; Correa-Rotter, Ricardo; Jasqui, Salomón; Donley, David W; Dalsky, Gail P; Martin, Javier San; Eriksen, Erik Fink (2005).
49:
If a biopsy is to be obtained along with medical imaging examinations, as a rule, biopsy should be done after all necessary imaging has been performed. A bone biopsy can also be used to find out if
380:
Dempster, David W.; Cosman, Felicia; Kurland, Etah S.; Zhou, Hua; Nieves, Jeri; Woelfert, Lillian; Shane, Elizabeth; Plavetić, Katarina; Müller, Ralph; Bilezikian, John; Lindsay, Robert (2001).
74:
Steiniche, Torben (1995). "Bone histomorphometry in the pathophysiological evaluation of primary and secondary osteoporosis and various treatment modalities".
34:, which involves the innermost part of the bone. The bone biopsy sample retains the architecture of bone when seen using histopathological examination slide.
382:"Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study*"
322:"Effects Of a One-Month Treatment With PTH(1-34) on Bone Formation on Cancellous, Endocortical, and Periosteal Surfaces of the Human Ilium"
171:"Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric Parameters"
223:"Recombinant Human Parathyroid Hormone (1-34) [Teriparatide] Improves Both Cortical and Cancellous Bone Structure"
122:
Compston, J.E.; Croucher, P.I. (1991). "Histomorphometric assessment of trabecular bone remodelling in osteoporosis".
320:
Lindsay, Robert; Zhou, Hua; Cosman, Felicia; Nieves, Jeri; Dempster, David W; Hodsman, Anthony B (2007).
42:
The technique of bone biopsy allows the histomorphometric analysis of the bone samples obtained from the
221:
Jiang, Yebin; Zhao, Jenny J; Mitlak, Bruce H; Wang, Ouhong; Genant, Harry K; Eriksen, Erik F (2003).
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Leeuw, Jan A; Koudstaal, Jan; Wiersema-Buist, Janneke; Kamps, Willem A; Timens, Wim (2003).
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490:"Bone Histomorphometry in Children with Newly Diagnosed Acute Lymphoblastic Leukemia"
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sample is removed from the outer layers of bone for examination, unlike a
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57:, or other abnormal cells are present in the bone tissue.
16:Medical test involving removal of sample from bone
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386:Journal of Bone and Mineral Research
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326:Journal of Bone and Mineral Research
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507:10.1203/01.pdr.0000090929.16450.de
288:10.1111/j.1600-0722.1997.tb00182.x
88:10.1111/j.1600-0463.1995.tb05544.x
14:
276:European Journal of Oral Sciences
26:is a procedure in which a small
1:
435:Journal of Clinical Pathology
552:10.1016/8756-3282(94)00028-x
399:10.1359/jbmr.2001.16.10.1846
240:10.1359/jbmr.2003.18.11.1932
136:10.1016/0169-6009(91)90086-f
609:
431:"Histomorphometry of bone"
448:10.1136/jcp.36.12.1323
429:Revell, P A (1983).
339:10.1359/jbmr.070104
188:10.1359/jbmr.050309
494:Pediatric Research
32:bone marrow biopsy
441:(12): 1323–1331.
392:(10): 1846–1853.
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181:(7): 1244–1253.
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82:(S51): 5–44.
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44:iliac crest
582:Categories
61:References
560:8756-3282
516:0031-3998
457:0021-9746
408:0884-0431
348:0884-0431
296:0909-8836
249:0884-0431
197:0884-0431
144:0169-6009
96:0903-4641
55:infection
38:Technique
524:12930910
416:11585349
356:17227219
257:14606504
205:15940379
104:24954648
568:7756046
475:6361070
304:9085031
152:1912765
588:Biopsy
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51:cancer
23:biopsy
593:Bones
360:S2CID
100:S2CID
76:APMIS
53:, or
21:bone
564:PMID
556:ISSN
540:Bone
520:PMID
512:ISSN
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300:PMID
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193:ISSN
148:PMID
140:ISSN
92:ISSN
28:bone
548:doi
502:doi
461:PMC
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