186:
acknowledged that the whole is greater than the sum of its parts, with the various active ingredients all potentiating the morphine or other opioid in their own ways. The synergy between opioid analgesics and centrally-acting stimulants is widely reported and commonly used: for example, the caffeine content of many codeine-based pain relievers, and prescription of dextroamphetamine or methylphenidate to patients on high doses of opioids both to combat somnolence from the painkillers and to boost their pain-killing ability.
109:. It was in common use in the late 19th and early 20th centuries. However, a series of trials in 1977-79 found that the diacetylmorphine was no more effective than an equivalent amount of morphine, while tolerance caused the cocaine to become ineffective within a few days. As a result, pain management shifted to using morphine alone, which is more convenient to prepare, easier to
185:
While each of the ingredients combats pain or other problems that occur with it in those who may be nauseated from effects of chemotherapy, radiation or high and escalating doses of morphine (which can also cause somnolence or sleepiness, necessitating the stimulant), it is also anecdotally
173:, cherry syrup to help mask the bitter taste of some of the components, and distilled water in some quantity to dilute the chloroform (hence, chloroform water) or to add volume to allow for more precise
78:
of 98% ethyl alcohol, 5 mL of syrup BP and a variable amount of chloroform water." Brompton's cocktail was given most in the mid twentieth century. It is now considered obsolete.
305:""Innovation in Pain Management: The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 12 December 2002"
325:
Glover, D. D.; Lowry, T. F.; Jacknowitz, A. I. (1980). "Brompton's mixture in alleviating pain of terminal neoplastic disease: Preliminary results".
450:
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113:, and avoids side effects. While use of the Brompton cocktail has been rare in the 21st century, it is not entirely unheard of today.
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The original idea for an oral mixture of morphine and cocaine helping patients in agony with advanced disease is credited to surgeon
85:. According to legend (and perhaps in fact) doctors would provide a large dose to terminally ill patients who wished to die.
281:
228:
ed. Ajemian, Ina & Balfour M. Mount. Palliative Care
Service: Royal Victoria Hospital, Montreal, Quebec. 1980. p. 172.
224:
Melzak, R., B.M. Mount, and J.M. Gordon. "The
Brompton mixture versus morphine solution given orally: effects on pain."
356:"Changes in prescribing for terminal care patients in general practice, hospital and hospice over a five-year period"
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169:, or other stimulants in the place of cocaine. The original recipe for Brompton cocktail also calls for
105:, England, where the formulation of this mixture was standardized in the late 1920s for patients with
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and promote sociability near death. A common formulation included "a variable amount of morphine, 10
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245:"The Brompton Cocktail: 19th century origins to 20th century demise"
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Some specifications for variants of
Brompton cocktail call for
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In popular culture it also came to be associated with medical
226:
The RVH Manual on
Palliative/Hospice Care: A Resource Book.
360:
The
Journal of the Royal College of General Practitioners
97:in 1896. The Brompton cocktail is named after the
58:(Thorazine) to counteract nausea, it was given to
54:(some recipes specify gin), and sometimes with
34:meant for use as a pain suppressant dosed for
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280:"Terry Pratchett" (1 February 2010).
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145:in place of the chlorpromazine; and
282:"My case for a euthanasia tribunal"
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303:L A Reynolds; E M Tansey (eds.).
391:"A personal therapeutic journey"
339:10.1097/00007611-198003000-00004
16:Obsolete pain suppressant elixir
451:Historical polysubstance drinks
1:
270:, Hospice Education Institute
395:BMJ (Clinical Research Ed.)
467:
243:David Clark (2014-08-01).
181:Synergy among constituents
137:in the place of morphine;
133:(heroin), or other strong
407:10.1136/bmj.313.7072.1599
327:Southern Medical Journal
62:individuals (especially
99:Royal Brompton Hospital
389:Saunders, C. (1996).
66:patients) to relieve
354:Rees, W. D. (1987).
143:tincture of cannabis
268:Brompton's Cocktail
249:End of life studies
28:Brompton's cocktail
22:, sometimes called
401:(7072): 1599–601.
157:, co-phenylcaine (
155:dextroamphetamine
20:Brompton cocktail
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366:(304): 504–506.
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44:diacetylmorphine
24:Brompton mixture
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139:diphenhydramine
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52:ethyl alcohol
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429:the original
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286:. Retrieved
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252:. Retrieved
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95:Herbert Snow
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38:. Made from
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19:
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151:amphetamine
131:diamorphine
36:prophylaxis
440:Categories
254:2017-01-02
212:References
177:of doses.
171:chloroform
83:euthanasia
46:(heroin),
288:29 August
175:titration
159:lidocaine
123:methadone
30:, was an
190:See also
117:Variants
40:morphine
425:8991003
416:2359110
382:3505644
373:1711087
347:7361128
135:opioids
111:titrate
89:History
48:cocaine
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107:cancer
103:London
64:cancer
32:elixir
308:(PDF)
421:PMID
378:PMID
343:PMID
290:2023
161:and
68:pain
411:PMC
403:doi
399:313
368:PMC
335:doi
141:or
101:in
42:or
26:or
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233:^
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76:mL
72:mg
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