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182:. Individuals with two copies of the ApoE2 gene have substantially elevated risk of this condition. This defect prevents the normal metabolism of chylomicrons, IDL and VLDL, otherwise known as remnants, and therefore leads to accumulation of cholesterol within scavenger cells (macrophages) to enhance development and acceleration of atherosclerosis.
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Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart
Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, PA:Saunders Elsevier; 2011:chap
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346:"Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects"
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Familial dysbetalipoproteinemia is caused by this point mutation in ApoE
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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is a condition characterized by increased total cholesterol and
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James, William D.; Berger, Timothy G.; et al. (2006).
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over the elbows and knees. The disease leads to premature
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Skin conditions resulting from errors in metabolism
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146:or stroke in young adults or middle aged patients.
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122:(orange or yellow discoloration of the palms) and
154:This condition is more likely when a mutation in
554:Lecithin cholesterol acyltransferase deficiency
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118:Signs of familial dysbetaproteinemia include
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500:Familial apoprotein CII deficiency/Type Ib
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515:Familial dysbetalipoproteinemia/Type III
130:and therefore a possible early onset of
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505:Familial hypercholesterolemia/Type IIa
229:First line of management is fibrates.
520:Familial hypertriglyceridemia/Type IV
495:Lipoprotein lipase deficiency/Type Ia
180:very-low-density-lipoprotein receptor
7:
158:(ApoE) is present. ApoE serves as a
300:. Saunders Elsevier. p. 534.
110:levels, and decreased HDL levels.
25:
640:APOA1 familial renal amyloidosis
510:Combined hyperlipidemia/Type IIb
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138:leading to a heart attack, i.e.
142:, chest pain on exercise, i.e.
100:Familial dysbetalipoproteinemia
33:Familial dysbetalipoproteinemia
1:
587:Chylomicron retention disease
104:type III hyperlipoproteinemia
46:Remnant hyperlipoproteinaemia
546:Hypoalphalipoproteinemia/HDL
249:List of cutaneous conditions
239:Primary hyperlipoproteinemia
582:Apolipoprotein B deficiency
569:Hypobetalipoproteinemia/LDL
244:Apolipoprotein B deficiency
136:peripheral vascular disease
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666:Lipid metabolism disorders
609:Barraquer–Simons syndrome
273:Dermatology: 2-Volume Set
120:xanthoma striatum palmare
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59:
124:tuberoeruptive xanthomas
132:coronary artery disease
54:Remnant removal disease
527:Xanthoma/Xanthomatosis
202:This section is empty.
42:Remnant hyperlipidemia
140:myocardial infarction
577:Abetalipoproteinemia
490:Hypertriglyceridemia
486:Hypercholesterolemia
275:. St. Louis: Mosby.
537:Hypolipoproteinemia
635:Lipoid proteinosis
405:External resources
114:Signs and symptoms
50:Broad beta disease
18:Broad beta disease
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630:Adiposis dolorosa
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307:978-0-7216-2921-6
282:978-1-4160-2999-1
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16:(Redirected from
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625:Lipomatosis
414:MedlinePlus
332:"APOE gene"
38:Other names
655:Categories
255:References
225:Treatment
186:Diagnosis
75:Specialty
233:See also
162:for the
395:D006952
419:000402
384:107741
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160:ligand
150:Causes
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618:Other
164:liver
464:of
390:MeSH
379:OMIM
302:ISBN
277:ISBN
176:VLDL
174:and
134:and
52:and
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172:IDL
170:,
102:or
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