351:
328:
225:
250:
602:
609:
4466:
4451:
4436:
357:
256:
42:
4481:
68:
1856:
variants are likely not disease-causing as single entities, they may confer risk when examined as part of a panel of related cellβcell adhesion genes. Further studies in larger cohorts will be required to unequivocally determine this.
2888:
Hertig CM, Eppenberger-Eberhardt M, Koch S, Eppenberger HM (January 1996). "N-cadherin in adult rat cardiomyocytes in culture. I. Functional role of N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant".
2466:
Angst BD, Khan LU, Severs NJ, Whitely K, Rothery S, Thompson RP, et al. (January 1997). "Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium".
3218:
Tsipis A, Athanassiadou AM, Athanassiadou P, Kavantzas N, Agrogiannis G, Patsouris E (September 2010). "Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy".
4144:
Gaidar YA, Lepekhin EA, Sheichetova GA, Witt M (February 1998). "Distribution of N-cadherin and NCAM in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system".
1809:
Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the
2920:
Ferreira-Cornwell MC, Luo Y, Narula N, Lenox JM, Lieberman M, Radice GL (April 2002). "Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart".
4173:
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity".
5382:
2791:
Zuppinger C, Schaub MC, Eppenberger HM (April 2000). "Dynamics of early contact formation in cultured adult rat cardiomyocytes studied by N-cadherin fused to green fluorescent protein".
3918:
Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N, Goodfellow PN (September 1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene".
2075:
Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N, Goodfellow PN (September 1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene".
4521:
3489:
Besco JA, Hooft van
Huijsduijnen R, Frostholm A, Rotter A (October 2006). "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)".
1715:. In agreement with this, mice with ablation of N-cadherin in adult hearts via a cardiac-specific tamoxifen-inducible Cre N-cadherin transgene showed disrupted assembly of
6558:
1593:
with sustained expression through adulthood. Cadherin-2 mutation during development has the most significant effect on cell adhesion in the primitive heart; dissociated
364:
263:
2219:
2250:
1797:
5372:
1904:
2423:
GarcΓa-Castro MI, Vielmetter E, Bronner-Fraser M (May 2000). "N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry".
3118:
Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D (March 2009). "Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis".
2172:"De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects"
5352:
4383:
1127:
186:
1108:
6214:
4538:
4514:
2376:"The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species"
1864:, it was shown that Cadherin-2 expression was enhanced and arranged in a disarrayed fashion, suggesting that disorganization of Cadherin-2 protein in
2853:
Goncharova EJ, Kam Z, Geiger B (January 1992). "The involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes".
6707:
3807:
Salomon D, Ayalon O, Patel-King R, Hynes RO, Geiger B (May 1992). "Extrajunctional distribution of N-cadherin in cultured human endothelial cells".
3624:"Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy"
5945:
4292:
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (July 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes".
5933:
5711:
4103:"Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization"
1752:
7097:
6551:
5997:
5992:
5938:
5718:
4499:
4415:
2032:
65:
4465:
4450:
4435:
2014:
7102:
5451:
5377:
4507:
2668:"Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium"
350:
6480:
6475:
6470:
6465:
5392:
4008:
Wallis J, Fox MF, Walsh FS (July 1994). "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2".
3675:
Doherty P, Smith P, Walsh FS (1997). "Shared cell adhesion molecule (CAM) homology domains point to CAMs signalling via FGF receptors".
1821:. This causes the intercellular connection between two adjacent endothelial cells to fail and allows the cancer cell to slip through.
1801:). Loss of N-cadherin is also associated with attention-deficit hyperactivity disorder in humans, and impaired synaptic functioning.
1339:
4356:
3696:
Makrigiannakis A, Coukos G, Blaschuk O, Coutifaris C (2000). "Follicular atresia and luteolysis. Evidence of a role for N-cadherin".
1346:
327:
7076:
6445:
2586:"N-cadherin-catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart development"
1597:
and abnormal heart tube development occur. Cadherin-2 plays a role in the development of the vertebrate heart at the transition of
6544:
5681:
3171:"Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes"
3047:
1794:
is mediated at least in part by
Cadherin-2. N-cadherins interact with catenins to play an important role in learning and memory (
1877:
6606:
6249:
5743:
5429:
2001:
1980:
5888:
5424:
249:
224:
1997:
6596:
6385:
5857:
5852:
5797:
5531:
4980:
4368:
3575:"Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development"
2227:
1845:
1641:
structures which provide end-on cellβcell connections that facilitate mechanical and electrical coupling between adjacent
1976:
6079:
5802:
4480:
1447:. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human
166:
5397:
1834:
1496:
1492:
1456:
363:
262:
7024:
6109:
4534:
1421:
4975:
4408:
1735:, and a loss in muscular tension. Mice died within two months of transgene expression, mainly due to spontaneous
1586:
356:
255:
3063:"CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice"
7056:
6159:
5054:
4350:
2170:
Accogli A, Calabretta S, St-Onge J, Boudrahem-Addour N, Dionne-Laporte A, Joset P, et al. (October 2019).
1172:
174:
2957:"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure"
2707:
Forbes MS, Sperelakis N (1985). "Intercalated discs of mammalian heart: a review of structure and function".
6123:
2545:"Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos"
1736:
1153:
3311:"N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane"
6786:
6579:
6571:
5466:
5461:
5456:
5446:
4753:
4681:
3786:
Cavallaro U (December 2004). "N-cadherin as an invasion promoter: a novel target for antitumor therapy?".
1861:
1720:
1708:
1532:
1448:
3957:"Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene"
3834:"Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin"
3352:"Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses"
6763:
4810:
4728:
1524:
238:
6735:
6721:
6047:
5760:
4401:
3968:
3750:
3705:
3127:
3074:
2432:
2262:
1484:
1425:
3741:
Hazan RB, Qiao R, Keren R, Badano I, Suyama K (April 2004). "Cadherin switch in tumor progression".
3622:
Schroen B, Leenders JJ, van Erk A, Bertrand AT, van Loon M, van
Leeuwen RE, et al. (May 2007).
153:
6600:
6074:
5893:
4374:
4362:
1293:
1242:
3534:"Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin"
1301:
5481:
5215:
4346:
4327:
3943:
3774:
3729:
3604:
3514:
3151:
2304:
Buxton RS, Magee AI (June 1992). "Structure and interactions of desmosomal and other cadherins".
2286:
2100:
1575:
198:
1322:
1297:
1267:
1246:
4319:
4280:
4237:
4190:
4161:
4132:
4089:
4072:
Matsuyoshi N, Imamura S (June 1997). "Multiple cadherins are expressed in human fibroblasts".
4060:
4025:
3996:
3935:
3906:
3863:
3820:
3795:
3766:
3721:
3684:
3653:
3596:
3555:
3506:
3471:
3422:
3373:
3332:
3286:
3236:
3200:
3143:
3100:
3029:
2978:
2937:
2902:
2870:
2835:
2808:
2773:
2724:
2689:
2648:
2607:
2566:
2525:
2484:
2448:
2405:
2356:
2339:
Takeichi M (1990). "Cadherins: a molecular family important in selective cell-cell adhesion".
2321:
2278:
2201:
2149:
2092:
1849:
1716:
1712:
1690:
1674:
1662:
1650:
1646:
1638:
1440:
1436:
146:
58:
6536:
6901:
6567:
6254:
5987:
5908:
5471:
4664:
4590:
4309:
4301:
4270:
4262:
4227:
4219:
4182:
4153:
4122:
4114:
4081:
4050:
4017:
3986:
3976:
3927:
3896:
3888:
3853:
3845:
3812:
3758:
3713:
3643:
3635:
3586:
3545:
3498:
3461:
3453:
3412:
3404:
3393:"Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo"
3363:
3322:
3276:
3228:
3190:
3182:
3169:
Moya PR, Dodman NH, Timpano KR, Rubenstein LM, Rana Z, Fried RL, et al. (August 2013).
3135:
3090:
3082:
3019:
3009:
2968:
2929:
2894:
2862:
2800:
2763:
2755:
2716:
2679:
2638:
2597:
2556:
2515:
2476:
2440:
2395:
2387:
2348:
2313:
2270:
2249:
Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, GrΓΌbel G, et al. (March 1995).
2191:
2183:
2139:
2131:
2084:
1787:
1748:
1740:
601:
443:
374:
318:
273:
3440:
Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (April 1998).
2627:"Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity"
1935:
6314:
4850:
4845:
4768:
4249:
Shan WS, Tanaka H, Phillips GR, Arndt K, Yoshida M, Colman DR, Shapiro L (February 2000).
1838:
1598:
608:
418:
194:
3972:
3754:
3709:
3131:
3078:
2955:
Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, et al. (February 2005).
2436:
2352:
2266:
6099:
5521:
5032:
4835:
4275:
4250:
4232:
4208:"delta-catenin, an adhesive junction-associated protein which promotes cell scattering"
4207:
4127:
4102:
4055:
4038:
3931:
3858:
3833:
3717:
3648:
3623:
3466:
3441:
3417:
3392:
3263:
Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, et al. (December 2003).
3195:
3170:
3139:
3095:
3062:
3024:
2997:
2973:
2956:
2768:
2743:
2391:
2196:
2171:
2088:
1704:
1634:
1516:
1432:
4157:
3901:
3876:
2400:
2375:
2317:
2144:
2119:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
41:
7091:
6883:
6069:
5526:
4617:
4387:
4039:"Expression and localization of N- and E-cadherin in the human testis and epididymis"
3991:
3956:
3155:
2720:
1865:
1791:
1693:
1642:
1613:
expressing a dominant negative
Cadherin-2 mutant showed significant abnormalities in
1508:
1444:
637:
4331:
3955:
Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (April 1995).
3947:
3778:
3733:
3608:
3518:
3265:"A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells"
2502:
Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO (January 1997).
2104:
6854:
6850:
6846:
6842:
6635:
6425:
5733:
5723:
5254:
5220:
3502:
2290:
1885:
1814:
1771:
1703:
Mouse models employing transgenesis have highlighted the function of N-cadherin in
1697:
1678:
1658:
1571:
1567:
1555:
1528:
436:
215:
2444:
178:
2759:
2050:
1747:
remodeling and aberrant Kv1.5 channel function. These animals showed a prolonged
1566:
Cadherin-2 plays a role in development as a calcium dependent cellβcell adhesion
202:
6927:
6860:
6820:
6810:
6435:
6084:
5862:
5837:
5536:
5158:
5084:
4558:
4203:
2744:"N-cadherin/catenin complex as a master regulator of intercalated disc function"
2666:
Peters NS, Severs NJ, Rothery SM, Lincoln C, Yacoub MH, Green CR (August 1994).
2037:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2019:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1929:
1818:
1744:
1618:
883:
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
3961:
Proceedings of the
National Academy of Sciences of the United States of America
3086:
2187:
519:
7033:
7004:
6999:
6994:
6917:
6838:
6365:
6089:
5770:
5511:
5387:
5020:
5015:
5010:
4865:
4649:
3232:
3061:
Halperin D, Stavsky A, Kadir R, Drabkin M, Wormser O, Yogev Y (October 2021).
1810:
1775:
1686:
1685:. Expression of a mutant form of Cadherin-2 harboring a large deletion in the
1666:
1622:
1606:
1602:
1540:
1536:
1520:
1472:
1431:
expressed in multiple tissues and functions to mediate cellβcell adhesion. In
335:
232:
182:
3892:
3550:
3533:
2135:
6830:
6630:
6204:
6199:
6194:
6184:
6179:
6174:
6169:
3762:
3014:
2684:
2667:
1728:
1724:
1654:
1544:
1488:
1072:
579:
457:
402:
389:
301:
288:
190:
4323:
4284:
4186:
4118:
4085:
4021:
3981:
3799:
3770:
3725:
3657:
3600:
3510:
3377:
3368:
3351:
3336:
3327:
3310:
3290:
3240:
3204:
3147:
3104:
3033:
2998:"Cortactin is required for N-cadherin regulation of Kv1.5 channel function"
2982:
2941:
2933:
2839:
2812:
2804:
2777:
2643:
2626:
2602:
2585:
2570:
2561:
2544:
2520:
2503:
2480:
2452:
2205:
888:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
4266:
4241:
4223:
4194:
4165:
4136:
4093:
4064:
4029:
4000:
3939:
3910:
3867:
3849:
3824:
3688:
3559:
3475:
3457:
3426:
3408:
3186:
2906:
2874:
2866:
2728:
2693:
2652:
2611:
2529:
2488:
2409:
2360:
2325:
2282:
2153:
2096:
1386:
1381:
7039:
6986:
6795:
6699:
6588:
6510:
6410:
6224:
6209:
5412:
5407:
5315:
5005:
3639:
1590:
1480:
1476:
1370:
1217:
1198:
3816:
2898:
1707:. Mice with altered expression of N-cadherin and/or E-cadherin showed a
6460:
6455:
6450:
6350:
6164:
6154:
5981:
5960:
5955:
5923:
5728:
5648:
5643:
5638:
5633:
5628:
5546:
5239:
5079:
5074:
5069:
5064:
5059:
4530:
3591:
3574:
1682:
1670:
1614:
1610:
1594:
1548:
1468:
1428:
1184:
1139:
3281:
3264:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
6896:
6767:
6657:
6620:
6610:
6400:
6360:
6345:
6329:
6324:
6304:
6299:
6234:
6042:
6012:
5976:
5967:
5780:
5748:
5612:
5607:
5577:
5556:
5516:
5476:
5342:
5320:
5279:
5203:
5198:
5193:
5188:
5183:
5178:
5047:
5042:
5037:
4985:
4970:
4840:
4830:
4793:
4788:
4706:
4701:
2274:
1940:
1898:
1665:, which enables cellβcell adhesion and force transmission across the
1582:
1512:
1354:
1094:
4314:
17:
7071:
7048:
7044:
6972:
6962:
6957:
6952:
6947:
6942:
6891:
6771:
6753:
6749:
6739:
6725:
6711:
6687:
6682:
6677:
6672:
6667:
6662:
6645:
6640:
6614:
6525:
6500:
6420:
6415:
6405:
6395:
6380:
6375:
6370:
6355:
6309:
6294:
6259:
6244:
6239:
6229:
6149:
6144:
6139:
6118:
6114:
6104:
6017:
5918:
5913:
5872:
5822:
5817:
5812:
5807:
5792:
5785:
5765:
5753:
5696:
5691:
5686:
5676:
5671:
5664:
5602:
5592:
5587:
5582:
5572:
5551:
5541:
5506:
5501:
5496:
5491:
5486:
5441:
5436:
5402:
5367:
5362:
5357:
5347:
5335:
5330:
5310:
5305:
5300:
5295:
5249:
5141:
5136:
4955:
4939:
4932:
4927:
4922:
4917:
4912:
4907:
4882:
4860:
4855:
4748:
4674:
4669:
4659:
4305:
1953:
1923:
1916:
1910:
1891:
1768:
1760:
1756:
1552:
1443:, which function to mechanically and electrically couple adjacent
1739:. Further analysis of N-cadherin knockout mice revealed that the
1539:
that mediate homophilic interactions between adjacent cells, and
1479:
from the cadherin superfamily, is composed of five extracellular
1057:
1053:
7066:
7061:
7028:
6967:
6937:
6932:
6922:
6872:
6868:
6864:
6815:
6757:
6743:
6729:
6715:
6650:
6625:
6520:
6515:
6505:
6495:
6490:
6485:
6440:
6430:
6390:
6319:
6289:
6284:
6279:
6274:
6269:
6264:
6219:
6189:
6094:
6062:
6057:
6037:
6027:
6022:
6007:
6002:
5903:
5898:
5867:
5847:
5842:
5832:
5827:
5706:
5659:
5619:
5274:
5269:
5264:
5259:
5244:
5235:
5230:
5225:
5210:
5168:
5163:
5153:
5148:
5131:
5126:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5027:
5000:
4995:
4990:
4965:
4960:
4897:
4892:
4887:
4877:
4872:
4825:
4820:
4815:
4805:
4800:
4783:
4778:
4773:
4763:
4758:
4743:
4738:
4733:
4723:
4718:
4713:
4696:
4691:
4686:
4637:
4605:
4600:
4595:
4578:
4573:
4568:
4563:
3532:
Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (August 1995).
3309:
Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003).
1764:
1732:
1413:
948:
neuroligin clustering involved in postsynaptic membrane assembly
170:
6540:
4503:
4397:
2625:
Ong LL, Kim N, Mima T, Cohen-Gould L, Mikawa T (January 1998).
998:
homophilic cell adhesion via plasma membrane adhesion molecules
617:
6032:
4644:
4632:
4627:
4622:
4612:
4585:
4553:
4393:
3877:"Human N-cadherin: nucleotide and deduced amino acid sequence"
3442:"Dynamic interaction of PTPmu with multiple cadherins in vivo"
2120:"Human N-cadherin: nucleotide and deduced amino acid sequence"
3350:
Izawa I, Nishizawa M, Ohtakara K, Inagaki M (February 2002).
3048:"Entrez Gene: CDH2 cadherin 2, type 1, N-cadherin (neuronal)"
1677:
function. Cadherin-2 appears at cellβcell junctions prior to
1507:
Cadherin-2, originally named Neural cadherin for its role in
1696:, and neighboring cardiomyocytes lost cellβcell contact and
2504:"Developmental defects in mouse embryos lacking N-cadherin"
1499:, thus creating a linear, adhesive "zipper" between cells.
1621:, resulting in defects in trabecular formation within the
867:
integral component of postsynaptic specialization membrane
1689:
inhibited the function of endogenous
Cadherin-2 in adult
4037:
Andersson AM, Edvardsen K, Skakkebaek NE (August 1994).
2543:
Kostetskii I, Moore R, Kemler R, Radice GL (June 2001).
908:
regulation of postsynaptic density protein 95 clustering
426:
3573:
Sinn HW, Balsamo J, Lilien J, Lin JJ (September 2002).
2996:
Cheng L, Yung A, Covarrubias M, Radice GL (June 2011).
2224:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
1609:
cell layer formation. An additional study showed that
988:
negative regulation of canonical Wnt signaling pathway
938:
regulation of oligodendrocyte progenitor proliferation
862:
integral component of presynaptic active zone membrane
157:, CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
4474:: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
4459:: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
4444:: STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
2251:"Structural basis of cell-cell adhesion by cadherins"
2220:"Protein sequence of human CDH2 (Uniprot ID: P19022)"
591:
2826:
Dou JP, Jiao B, Sheng JJ, Yu ZB (October 2014). "".
7017:
6985:
6910:
6882:
6829:
6803:
6794:
6785:
6698:
6587:
6578:
6338:
6132:
5881:
5565:
5288:
4948:
4546:
4251:"Functional cis-heterodimers of N- and R-cadherins"
4074:
1786:In neural cells, at certain central nervous system
1315:
1286:
1260:
1235:
3391:Brady-Kalnay SM, Rimm DL, Tonks NK (August 1995).
1993:
1991:
1989:
1972:
1970:
1968:
1841:, axon, cardiac, ocular, and genital differences.
1038:regulation of synaptic transmission, glutamatergic
953:positive regulation of synaptic vesicle clustering
903:positive regulation of muscle cell differentiation
1844:One study investigating genetic underpinnings of
1409:), is a protein that in humans is encoded by the
373:
272:
3304:
3302:
3300:
3258:
3256:
3254:
3252:
3250:
1817:attached to both Cadherin-2 (this protein) and
1798:Cadherin-catenin complex in learning and memory
1533:calcium-dependent cell adhesion molecule family
1455:have also been identified to cause a syndromic
4202:Lu Q, Paredes M, Medina M, Zhou J, Cavallo R,
1998:GRCm38: Ensembl release 89: ENSMUSG00000024304
1491:tail. Cadherin-2, as well as other cadherins,
6552:
4515:
4409:
8:
2793:Journal of Molecular and Cellular Cardiology
2374:Ozawa M, Baribault H, Kemler R (June 1989).
1673:has been described as a master regulator of
1977:GRCh38: Ensembl release 89: ENSG00000170558
1515:and later was found to also play a role in
1471:with molecular weight of 99.7 kDa, and 906
6800:
6791:
6584:
6559:
6545:
6537:
4522:
4508:
4500:
4416:
4402:
4394:
4384:United States National Library of Medicine
4101:Navarro P, Ruco L, Dejana E (March 1998).
3743:Annals of the New York Academy of Sciences
3698:Annals of the New York Academy of Sciences
3677:Perspectives on Developmental Neurobiology
2584:Linask KK, Knudsen KA, Gui YH (May 1997).
1833:have been identified to cause a syndromic
1661:; Cadherin-2 is an essential component in
1495:with Cadherin-2 on an adjacent cell in an
1068:
633:
414:
313:
210:
76:
4539:list of human clusters of differentiation
4349:at the U.S. National Library of Medicine
4313:
4274:
4231:
4126:
4054:
3990:
3980:
3900:
3857:
3647:
3590:
3549:
3465:
3416:
3367:
3326:
3280:
3194:
3094:
3023:
3013:
2972:
2767:
2683:
2642:
2601:
2560:
2519:
2399:
2195:
2143:
1435:, Cadherin-2 is an integral component in
933:neuronal stem cell population maintenance
4382:This article incorporates text from the
3788:Current Opinion in Investigational Drugs
1711:phenotype, likely due to malfunction of
857:collagen-containing extracellular matrix
4431:
3832:Knudsen KA, Wheelock MJ (August 1992).
1964:
1723:, impaired cardiac function, decreased
1617:distribution and migration towards the
1013:protein localization to plasma membrane
1008:post-translational protein modification
923:cell-cell adhesion mediated by cadherin
554:cardiac muscle tissue of left ventricle
1681:formation, and is critical for normal
1581:Cadherin-2 is widely expressed in the
31:
3875:Reid RA, Hemperly JJ (October 1990).
2118:Reid RA, Hemperly JJ (October 1990).
1574:and is required for establishment of
842:integral component of plasma membrane
496:cardiac muscle tissue of right atrium
378:
339:
334:
277:
236:
231:
7:
3628:The Journal of Experimental Medicine
2165:
2163:
973:striated muscle cell differentiation
918:neuroepithelial cell differentiation
3538:The Journal of Biological Chemistry
3356:The Journal of Biological Chemistry
3315:The Journal of Biological Chemistry
3002:The Journal of Biological Chemistry
2353:10.1146/annurev.bi.59.070190.001321
1551:, which in turn interact with the
1475:in length. Cadherin-2, a classical
1416:. CDH2 has also been designated as
993:positive regulation of MAPK cascade
4056:10.1111/j.1365-2605.1994.tb01239.x
4043:International Journal of Andrology
3932:10.1111/j.1471-4159.1990.tb04563.x
3718:10.1111/j.1749-6632.2000.tb06215.x
3175:European Journal of Human Genetics
2974:10.1161/01.RES.0000156274.72390.2c
2392:10.1002/j.1460-2075.1989.tb03563.x
2176:American Journal of Human Genetics
2089:10.1111/j.1471-4159.1990.tb04563.x
1868:may be a component of remodeling.
1753:inward rectifier potassium channel
1312:
1283:
1257:
1232:
1208:
1189:
1163:
1144:
1118:
1099:
596:
514:
452:
431:
25:
4489:: N-CADHERIN, TWO-DOMAIN FRAGMENT
2748:Cell Communication & Adhesion
963:regulation of signal transduction
928:radial glial cell differentiation
706:protein homodimerization activity
4479:
4464:
4449:
4434:
3221:Pathology, Research and Practice
1897:type IIb RPTPs including PTPmu (
607:
600:
558:dorsomedial hypothalamic nucleus
362:
355:
349:
326:
261:
254:
248:
223:
40:
4206:, et al. (February 1999).
2742:Vite A, Radice GL (June 2014).
3503:10.1016/j.brainres.2006.07.122
1813:pathway, which phosphorylates
1790:, presynaptic to postsynaptic
1649:are three types of junctions:
1547:tails that mediate binding to
978:adherens junction organization
898:homeostasis of number of cells
732:integral component of membrane
618:More reference expression data
580:More reference expression data
1:
4158:10.1016/s0065-1281(98)80008-1
2445:10.1126/science.288.5468.1047
2341:Annual Review of Biochemistry
2318:10.1016/s1043-4682(10)80012-1
1876:Cadherin-2 has been shown to
1846:obsessive-compulsive disorder
1751:duration, reduced density of
1589:, showing high levels in the
347:
246:
7098:Genes on human chromosome 18
3140:10.1088/1478-3975/6/1/016008
2760:10.3109/15419061.2014.908853
2721:10.1016/0040-8166(85)90001-1
1755:and decreased expression of
701:cytoskeletal protein binding
484:myocardium of left ventricle
7103:Clusters of differentiation
4535:clusters of differentiation
4361:human gene location in the
4255:The Journal of Cell Biology
4212:The Journal of Cell Biology
4107:The Journal of Cell Biology
3838:The Journal of Cell Biology
3446:The Journal of Cell Biology
3397:The Journal of Cell Biology
1835:neurodevelopmental disorder
1457:neurodevelopmental disorder
1023:cell-cell junction assembly
968:cerebral cortex development
822:endoplasmic reticulum lumen
787:cortical actin cytoskeleton
777:basolateral plasma membrane
676:protein phosphatase binding
476:stromal cell of endometrium
7119:
7025:Lymphocyte homing receptor
4373:human gene details in the
3087:10.1038/s41467-021-26426-1
2188:10.1016/j.ajhg.2019.09.005
1669:. Cadherin-2 complexed to
1497:anti-parallel conformation
1422:cluster of differentiation
1033:regulation of axonogenesis
913:glial cell differentiation
893:blood vessel morphogenesis
550:lateral geniculate nucleus
4429:
3920:Journal of Neurochemistry
3811:. 102 ( Pt 1) (1): 7β17.
3233:10.1016/j.prp.2010.05.007
2893:. 109 ( Pt 1) (1): 1β10.
2077:Journal of Neurochemistry
2033:"Mouse PubMed Reference:"
2015:"Human PubMed Reference:"
1805:Role in cancer metastasis
1637:, Cadherin-2 is found at
1385:
1380:
1376:
1369:
1353:
1334:
1319:
1290:
1279:
1264:
1239:
1228:
1215:
1211:
1196:
1192:
1183:
1170:
1166:
1151:
1147:
1138:
1125:
1121:
1106:
1102:
1093:
1078:
1071:
1067:
1051:
943:telencephalon development
696:identical protein binding
636:
632:
615:
599:
590:
577:
526:
517:
464:
455:
425:
417:
413:
396:
383:
346:
325:
316:
312:
295:
282:
245:
222:
213:
209:
164:
161:
151:
144:
139:
84:
79:
62:
57:
52:
48:
39:
34:
7057:Carcinoembryonic antigen
6911:Unconventional/ungrouped
4351:Medical Subject Headings
3551:10.1074/jbc.270.34.20201
2306:Seminars in Cell Biology
1767:combined with disrupted
1731:thickness, decreases in
1347:Chr 18: 16.72 β 16.94 Mb
1340:Chr 18: 27.93 β 28.18 Mb
6572:cell adhesion molecules
3809:Journal of Cell Science
3763:10.1196/annals.1294.016
3269:Journal of Cell Science
3015:10.1074/jbc.m111.218560
2922:Journal of Cell Science
2891:Journal of Cell Science
2685:10.1161/01.cir.90.2.713
1737:Ventricular tachycardia
1487:and a highly conserved
542:myocardium of ventricle
27:Protein found in humans
4187:10.1006/geno.1998.5281
4119:10.1083/jcb.140.6.1475
4086:10.1006/bbrc.1997.6707
4022:10.1006/geno.1994.1358
3982:10.1073/pnas.92.9.3702
3893:10.1093/nar/18.19.5896
3881:Nucleic Acids Research
3579:Developmental Dynamics
3369:10.1074/jbc.M110052200
3328:10.1074/jbc.M211452200
2934:10.1242/jcs.115.8.1623
2805:10.1006/jmcc.1999.1086
2644:10.1006/dbio.1997.8775
2603:10.1006/dbio.1997.8570
2562:10.1006/dbio.2001.0250
2521:10.1006/dbio.1996.8443
2481:10.1161/01.res.80.1.88
2136:10.1093/nar/18.19.5896
2124:Nucleic Acids Research
1862:dilated cardiomyopathy
1721:dilated cardiomyopathy
1709:dilated cardiomyopathy
1629:Role in cardiac muscle
1570:that functions during
1535:. These proteins have
1449:dilated cardiomyopathy
1424:325). Cadherin-2 is a
782:apical plasma membrane
686:protein kinase binding
538:lateral septal nucleus
6764:Glycoprotein IIb/IIIa
4267:10.1083/jcb.148.3.579
4224:10.1083/jcb.144.3.519
3850:10.1083/jcb.118.3.671
3458:10.1083/jcb.141.1.287
3409:10.1083/jcb.130.4.977
3187:10.1038/ejhg.2012.245
3067:Nature Communications
2867:10.1242/dev.114.1.173
2631:Developmental Biology
2590:Developmental Biology
2549:Developmental Biology
2508:Developmental Biology
1825:Clinical significance
1796:For full article see
1537:extracellular domains
802:extracellular exosome
681:alpha-catenin binding
656:gamma-catenin binding
504:middle temporal gyrus
380:18 A1|18 10.1 cM
341:Chromosome 18 (mouse)
239:Chromosome 18 (human)
6736:Macrophage-1 antigen
6722:Integrin alphaXbeta2
3640:10.1084/jem.20070145
2961:Circulation Research
2469:Circulation Research
2230:on 24 September 2015
1687:extracellular domain
1576:left-right asymmetry
1485:transmembrane region
837:extracellular matrix
812:postsynaptic density
757:plasma membrane raft
691:beta-catenin binding
546:ventromedial nucleus
80:List of PDB id codes
53:Available structures
6601:Myelin protein zero
6580:Calcium-independent
4375:UCSC Genome Browser
4363:UCSC Genome Browser
4347:CDH2+protein,+human
4294:Nature Neuroscience
3973:1995PNAS...92.3702S
3817:10.1242/jcs.102.1.7
3755:2004NYASA1014..155H
3710:2000NYASA.900...46M
3132:2009PhBio...6a6008R
3079:2021NatCo..12.6187H
2899:10.1242/jcs.109.1.1
2437:2000Sci...288.1047G
2267:1995Natur.374..327S
1743:were likely due to
1562:Role in development
1003:brain morphogenesis
852:apical part of cell
651:calcium ion binding
492:ganglionic eminence
4386:, which is in the
3592:10.1002/dvdy.10131
3275:(Pt 24): 4985β95.
1727:length, increased
1717:intercalated discs
1713:intercalated discs
1683:myofibrillogenesis
1663:adherens junctions
1651:adherens junctions
1647:intercalated discs
1523:. Cadherin-2 is a
1511:, plays a role in
1441:intercalated discs
1437:adherens junctions
1173:ENSMUSG00000024304
1043:cell-cell adhesion
1018:cell morphogenesis
876:Biological process
747:cell-cell junction
720:Cellular component
644:Molecular function
7085:
7084:
7013:
7012:
6981:
6980:
6787:Calcium-dependent
6781:
6780:
6568:Membrane proteins
6534:
6533:
4497:
4496:
4146:Acta Histochemica
3282:10.1242/jcs.00815
2928:(Pt 8): 1623β34.
2709:Tissue & Cell
2431:(5468): 1047β51.
1852:found that while
1850:Tourette disorder
1837:characterized by
1700:plaques as well.
1675:intercalated disc
1639:intercalated disc
1531:belonging to the
1396:
1395:
1392:
1391:
1365:
1364:
1330:
1329:
1309:
1308:
1275:
1274:
1254:
1253:
1224:
1223:
1205:
1204:
1179:
1178:
1160:
1159:
1134:
1133:
1115:
1114:
1063:
1062:
847:neuron projection
762:adherens junction
742:intercalated disc
661:metal ion binding
628:
627:
624:
623:
586:
585:
573:
572:
511:
510:
409:
408:
308:
307:
135:
134:
131:
130:
63:Ortholog search:
16:(Redirected from
7110:
6801:
6792:
6585:
6561:
6554:
6547:
6538:
4524:
4517:
4510:
4501:
4483:
4468:
4453:
4438:
4418:
4411:
4404:
4395:
4335:
4317:
4288:
4278:
4245:
4235:
4198:
4169:
4140:
4130:
4097:
4068:
4058:
4033:
4004:
3994:
3984:
3951:
3914:
3904:
3871:
3861:
3828:
3803:
3782:
3737:
3692:
3662:
3661:
3651:
3619:
3613:
3612:
3594:
3570:
3564:
3563:
3553:
3529:
3523:
3522:
3486:
3480:
3479:
3469:
3437:
3431:
3430:
3420:
3388:
3382:
3381:
3371:
3347:
3341:
3340:
3330:
3321:(19): 17269β76.
3306:
3295:
3294:
3284:
3260:
3245:
3244:
3215:
3209:
3208:
3198:
3166:
3160:
3159:
3120:Physical Biology
3115:
3109:
3108:
3098:
3058:
3052:
3051:
3044:
3038:
3037:
3027:
3017:
3008:(23): 20478β89.
2993:
2987:
2986:
2976:
2952:
2946:
2945:
2917:
2911:
2910:
2885:
2879:
2878:
2850:
2844:
2843:
2828:Sheng Li Xue Bao
2823:
2817:
2816:
2788:
2782:
2781:
2771:
2739:
2733:
2732:
2704:
2698:
2697:
2687:
2663:
2657:
2656:
2646:
2622:
2616:
2615:
2605:
2581:
2575:
2574:
2564:
2540:
2534:
2533:
2523:
2499:
2493:
2492:
2463:
2457:
2456:
2420:
2414:
2413:
2403:
2380:The EMBO Journal
2371:
2365:
2364:
2336:
2330:
2329:
2301:
2295:
2294:
2275:10.1038/374327a0
2261:(6520): 327β37.
2246:
2240:
2239:
2237:
2235:
2226:. Archived from
2216:
2210:
2209:
2199:
2167:
2158:
2157:
2147:
2115:
2109:
2108:
2072:
2066:
2065:
2063:
2061:
2047:
2041:
2040:
2029:
2023:
2022:
2011:
2005:
1995:
1984:
1974:
1749:action potential
1599:epithelial cells
1481:cadherin repeats
1467:Cadherin-2 is a
1378:
1377:
1349:
1342:
1325:
1313:
1304:
1284:
1280:RefSeq (protein)
1270:
1258:
1249:
1233:
1209:
1190:
1164:
1145:
1119:
1100:
1069:
1028:synapse assembly
711:cadherin binding
634:
620:
611:
604:
597:
582:
522:
520:Top expressed in
515:
500:Brodmann area 23
488:endothelial cell
472:ventricular zone
460:
458:Top expressed in
453:
432:
415:
405:
392:
381:
366:
359:
353:
342:
330:
314:
304:
291:
280:
265:
258:
252:
241:
227:
211:
205:
203:CDH2 - orthologs
156:
149:
126:
77:
71:
50:
49:
44:
32:
21:
7118:
7117:
7113:
7112:
7111:
7109:
7108:
7107:
7088:
7087:
7086:
7081:
7009:
6977:
6906:
6878:
6825:
6777:
6694:
6574:
6565:
6535:
6530:
6334:
6128:
5877:
5561:
5284:
4944:
4542:
4528:
4498:
4493:
4490:
4484:
4475:
4469:
4460:
4454:
4445:
4439:
4425:
4422:
4343:
4338:
4291:
4248:
4201:
4172:
4143:
4100:
4071:
4036:
4007:
3954:
3917:
3874:
3831:
3806:
3785:
3740:
3695:
3683:(2β3): 157β68.
3674:
3670:
3668:Further reading
3665:
3621:
3620:
3616:
3572:
3571:
3567:
3544:(34): 20201β6.
3531:
3530:
3526:
3488:
3487:
3483:
3439:
3438:
3434:
3390:
3389:
3385:
3349:
3348:
3344:
3308:
3307:
3298:
3262:
3261:
3248:
3217:
3216:
3212:
3168:
3167:
3163:
3117:
3116:
3112:
3060:
3059:
3055:
3046:
3045:
3041:
2995:
2994:
2990:
2954:
2953:
2949:
2919:
2918:
2914:
2887:
2886:
2882:
2852:
2851:
2847:
2825:
2824:
2820:
2790:
2789:
2785:
2741:
2740:
2736:
2706:
2705:
2701:
2665:
2664:
2660:
2624:
2623:
2619:
2583:
2582:
2578:
2542:
2541:
2537:
2501:
2500:
2496:
2465:
2464:
2460:
2422:
2421:
2417:
2373:
2372:
2368:
2338:
2337:
2333:
2303:
2302:
2298:
2248:
2247:
2243:
2233:
2231:
2218:
2217:
2213:
2169:
2168:
2161:
2117:
2116:
2112:
2074:
2073:
2069:
2059:
2057:
2055:www.uniprot.org
2049:
2048:
2044:
2031:
2030:
2026:
2013:
2012:
2008:
1996:
1987:
1975:
1966:
1962:
1950:
1945:
1874:
1839:Corpus callosum
1827:
1807:
1784:
1782:Role in neurons
1631:
1564:
1505:
1465:
1403:Neural cadherin
1387:View/Edit Mouse
1382:View/Edit Human
1345:
1338:
1335:Location (UCSC)
1321:
1300:
1296:
1292:
1266:
1245:
1241:
1154:ENSG00000170558
1047:
871:
797:fascia adherens
792:catenin complex
767:plasma membrane
715:
666:protein binding
616:
606:
605:
578:
569:
566:arcuate nucleus
564:
562:mammillary body
560:
556:
552:
548:
544:
540:
536:
532:
530:median eminence
518:
507:
502:
498:
494:
490:
486:
482:
478:
474:
470:
468:right ventricle
456:
400:
387:
379:
369:
368:
367:
360:
340:
317:Gene location (
299:
286:
278:
268:
267:
266:
259:
237:
214:Gene location (
165:
152:
145:
86:
64:
28:
23:
22:
15:
12:
11:
5:
7116:
7114:
7106:
7105:
7100:
7090:
7089:
7083:
7082:
7080:
7079:
7074:
7069:
7064:
7059:
7053:
7052:
7036:
7031:
7021:
7019:
7015:
7014:
7011:
7010:
7008:
7007:
7002:
6997:
6991:
6989:
6983:
6982:
6979:
6978:
6976:
6975:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6914:
6912:
6908:
6907:
6905:
6904:
6899:
6894:
6888:
6886:
6880:
6879:
6877:
6876:
6858:
6835:
6833:
6827:
6826:
6824:
6823:
6818:
6813:
6807:
6805:
6798:
6789:
6783:
6782:
6779:
6778:
6776:
6775:
6761:
6747:
6733:
6719:
6704:
6702:
6696:
6695:
6693:
6692:
6691:
6690:
6685:
6680:
6675:
6670:
6665:
6655:
6654:
6653:
6648:
6643:
6638:
6628:
6623:
6618:
6604:
6593:
6591:
6582:
6576:
6575:
6566:
6564:
6563:
6556:
6549:
6541:
6532:
6531:
6529:
6528:
6523:
6518:
6513:
6508:
6503:
6498:
6493:
6488:
6483:
6478:
6473:
6468:
6463:
6458:
6453:
6448:
6443:
6438:
6433:
6428:
6423:
6418:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6368:
6363:
6358:
6353:
6348:
6342:
6340:
6336:
6335:
6333:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6157:
6152:
6147:
6142:
6136:
6134:
6130:
6129:
6127:
6126:
6121:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6066:
6065:
6060:
6050:
6045:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5995:
5990:
5985:
5979:
5970:
5965:
5964:
5963:
5958:
5948:
5943:
5942:
5941:
5936:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5891:
5885:
5883:
5879:
5878:
5876:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5800:
5795:
5790:
5789:
5788:
5783:
5773:
5768:
5763:
5758:
5757:
5756:
5751:
5746:
5736:
5731:
5726:
5721:
5716:
5715:
5714:
5709:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5668:
5667:
5662:
5652:
5646:
5641:
5636:
5631:
5622:
5617:
5616:
5615:
5610:
5605:
5595:
5590:
5585:
5580:
5575:
5569:
5567:
5563:
5562:
5560:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5439:
5434:
5433:
5432:
5427:
5417:
5416:
5415:
5410:
5400:
5395:
5390:
5385:
5380:
5375:
5370:
5365:
5360:
5355:
5350:
5345:
5340:
5339:
5338:
5333:
5323:
5318:
5313:
5308:
5303:
5298:
5292:
5290:
5286:
5285:
5283:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5233:
5228:
5223:
5218:
5213:
5208:
5207:
5206:
5201:
5196:
5191:
5186:
5181:
5171:
5166:
5161:
5156:
5151:
5146:
5145:
5144:
5139:
5129:
5124:
5119:
5114:
5109:
5104:
5099:
5094:
5089:
5088:
5087:
5082:
5077:
5072:
5067:
5062:
5052:
5051:
5050:
5045:
5040:
5030:
5025:
5024:
5023:
5018:
5013:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4952:
4950:
4946:
4945:
4943:
4942:
4937:
4936:
4935:
4930:
4925:
4920:
4915:
4910:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4869:
4868:
4863:
4858:
4853:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4797:
4796:
4791:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4716:
4711:
4710:
4709:
4704:
4694:
4689:
4684:
4679:
4678:
4677:
4672:
4667:
4662:
4652:
4647:
4642:
4641:
4640:
4630:
4625:
4620:
4615:
4610:
4609:
4608:
4603:
4598:
4588:
4583:
4582:
4581:
4576:
4571:
4566:
4561:
4550:
4548:
4544:
4543:
4529:
4527:
4526:
4519:
4512:
4504:
4495:
4494:
4492:
4491:
4485:
4478:
4476:
4470:
4463:
4461:
4455:
4448:
4446:
4440:
4433:
4430:
4427:
4426:
4423:
4421:
4420:
4413:
4406:
4398:
4379:
4378:
4366:
4354:
4342:
4341:External links
4339:
4337:
4336:
4289:
4246:
4199:
4170:
4141:
4113:(6): 1475β84.
4098:
4069:
4034:
4005:
3952:
3915:
3872:
3829:
3804:
3794:(12): 1274β8.
3783:
3738:
3693:
3671:
3669:
3666:
3664:
3663:
3634:(5): 1227β35.
3614:
3565:
3524:
3491:Brain Research
3481:
3432:
3383:
3362:(7): 5345β50.
3342:
3296:
3246:
3210:
3161:
3110:
3073:(12): 625β30.
3053:
3039:
2988:
2947:
2912:
2880:
2845:
2818:
2783:
2734:
2699:
2658:
2617:
2576:
2535:
2494:
2458:
2415:
2366:
2331:
2296:
2241:
2211:
2182:(4): 854β868.
2159:
2110:
2067:
2042:
2024:
2006:
1985:
1963:
1961:
1958:
1957:
1956:
1949:
1946:
1944:
1943:
1938:
1933:
1927:
1920:
1914:
1908:
1902:
1895:
1889:
1882:
1873:
1870:
1826:
1823:
1806:
1803:
1783:
1780:
1705:cardiac muscle
1694:cardiomyocytes
1643:cardiomyocytes
1635:cardiac muscle
1630:
1627:
1563:
1560:
1519:and in cancer
1517:cardiac muscle
1504:
1501:
1464:
1461:
1451:. Variants in
1445:cardiomyocytes
1433:cardiac muscle
1401:also known as
1394:
1393:
1390:
1389:
1384:
1374:
1373:
1367:
1366:
1363:
1362:
1360:
1358:
1351:
1350:
1343:
1336:
1332:
1331:
1328:
1327:
1317:
1316:
1310:
1307:
1306:
1288:
1287:
1281:
1277:
1276:
1273:
1272:
1262:
1261:
1255:
1252:
1251:
1237:
1236:
1230:
1226:
1225:
1222:
1221:
1213:
1212:
1206:
1203:
1202:
1194:
1193:
1187:
1181:
1180:
1177:
1176:
1168:
1167:
1161:
1158:
1157:
1149:
1148:
1142:
1136:
1135:
1132:
1131:
1123:
1122:
1116:
1113:
1112:
1104:
1103:
1097:
1091:
1090:
1085:
1080:
1076:
1075:
1065:
1064:
1061:
1060:
1049:
1048:
1046:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
983:cell migration
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
879:
877:
873:
872:
870:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
752:focal adhesion
749:
744:
739:
734:
729:
723:
721:
717:
716:
714:
713:
708:
703:
698:
693:
688:
683:
678:
673:
671:enzyme binding
668:
663:
658:
653:
647:
645:
641:
640:
630:
629:
626:
625:
622:
621:
613:
612:
594:
588:
587:
584:
583:
575:
574:
571:
570:
568:
567:
563:
559:
555:
551:
547:
543:
539:
535:
531:
527:
524:
523:
512:
509:
508:
506:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
462:
461:
449:
448:
440:
429:
423:
422:
419:RNA expression
411:
410:
407:
406:
398:
394:
393:
385:
382:
377:
371:
370:
361:
354:
348:
344:
343:
338:
332:
331:
323:
322:
310:
309:
306:
305:
297:
293:
292:
284:
281:
276:
270:
269:
260:
253:
247:
243:
242:
235:
229:
228:
220:
219:
207:
206:
163:
159:
158:
150:
142:
141:
137:
136:
133:
132:
129:
128:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7115:
7104:
7101:
7099:
7096:
7095:
7093:
7078:
7075:
7073:
7070:
7068:
7065:
7063:
7060:
7058:
7055:
7054:
7050:
7046:
7042:
7041:
7037:
7035:
7032:
7030:
7026:
7023:
7022:
7020:
7016:
7006:
7003:
7001:
6998:
6996:
6993:
6992:
6990:
6988:
6984:
6974:
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6915:
6913:
6909:
6903:
6900:
6898:
6895:
6893:
6890:
6889:
6887:
6885:
6884:Protocadherin
6881:
6874:
6870:
6866:
6862:
6859:
6856:
6852:
6848:
6844:
6840:
6837:
6836:
6834:
6832:
6828:
6822:
6819:
6817:
6814:
6812:
6809:
6808:
6806:
6802:
6799:
6797:
6793:
6790:
6788:
6784:
6773:
6769:
6765:
6762:
6759:
6755:
6751:
6748:
6745:
6741:
6737:
6734:
6731:
6727:
6723:
6720:
6717:
6713:
6709:
6706:
6705:
6703:
6701:
6697:
6689:
6686:
6684:
6681:
6679:
6676:
6674:
6671:
6669:
6666:
6664:
6661:
6660:
6659:
6656:
6652:
6649:
6647:
6644:
6642:
6639:
6637:
6634:
6633:
6632:
6629:
6627:
6624:
6622:
6619:
6616:
6612:
6608:
6605:
6602:
6598:
6595:
6594:
6592:
6590:
6586:
6583:
6581:
6577:
6573:
6569:
6562:
6557:
6555:
6550:
6548:
6543:
6542:
6539:
6527:
6524:
6522:
6519:
6517:
6514:
6512:
6509:
6507:
6504:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6472:
6469:
6467:
6464:
6462:
6459:
6457:
6454:
6452:
6449:
6447:
6444:
6442:
6439:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6372:
6369:
6367:
6364:
6362:
6359:
6357:
6354:
6352:
6349:
6347:
6344:
6343:
6341:
6337:
6331:
6328:
6326:
6323:
6321:
6318:
6316:
6313:
6311:
6308:
6306:
6303:
6301:
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6241:
6238:
6236:
6233:
6231:
6228:
6226:
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6156:
6153:
6151:
6148:
6146:
6143:
6141:
6138:
6137:
6135:
6131:
6125:
6122:
6120:
6116:
6113:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6064:
6061:
6059:
6056:
6055:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5983:
5980:
5978:
5974:
5971:
5969:
5966:
5962:
5959:
5957:
5954:
5953:
5952:
5949:
5947:
5944:
5940:
5937:
5935:
5932:
5931:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5890:
5887:
5886:
5884:
5880:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5794:
5791:
5787:
5784:
5782:
5779:
5778:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5755:
5752:
5750:
5747:
5745:
5742:
5741:
5740:
5737:
5735:
5732:
5730:
5727:
5725:
5722:
5720:
5717:
5713:
5710:
5708:
5705:
5704:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5666:
5663:
5661:
5658:
5657:
5656:
5653:
5650:
5647:
5645:
5642:
5640:
5637:
5635:
5632:
5630:
5626:
5623:
5621:
5618:
5614:
5611:
5609:
5606:
5604:
5601:
5600:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5570:
5568:
5564:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5431:
5428:
5426:
5423:
5422:
5421:
5418:
5414:
5411:
5409:
5406:
5405:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5354:
5351:
5349:
5346:
5344:
5341:
5337:
5334:
5332:
5329:
5328:
5327:
5324:
5322:
5319:
5317:
5314:
5312:
5309:
5307:
5304:
5302:
5299:
5297:
5294:
5293:
5291:
5287:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5176:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5143:
5140:
5138:
5135:
5134:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5098:
5095:
5093:
5090:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5057:
5056:
5053:
5049:
5046:
5044:
5041:
5039:
5036:
5035:
5034:
5031:
5029:
5026:
5022:
5019:
5017:
5014:
5012:
5009:
5008:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4953:
4951:
4947:
4941:
4938:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4905:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4848:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4795:
4792:
4790:
4787:
4786:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4708:
4705:
4703:
4700:
4699:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4657:
4656:
4653:
4651:
4648:
4646:
4643:
4639:
4636:
4635:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4607:
4604:
4602:
4599:
4597:
4594:
4593:
4592:
4589:
4587:
4584:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4556:
4555:
4552:
4551:
4549:
4545:
4540:
4536:
4532:
4525:
4520:
4518:
4513:
4511:
4506:
4505:
4502:
4488:
4482:
4477:
4473:
4467:
4462:
4458:
4452:
4447:
4443:
4437:
4432:
4428:
4419:
4414:
4412:
4407:
4405:
4400:
4399:
4396:
4392:
4391:
4389:
4388:public domain
4385:
4376:
4372:
4371:
4367:
4364:
4360:
4359:
4355:
4352:
4348:
4345:
4344:
4340:
4333:
4329:
4325:
4321:
4316:
4311:
4307:
4306:10.1038/76615
4303:
4299:
4295:
4290:
4286:
4282:
4277:
4272:
4268:
4264:
4261:(3): 579β90.
4260:
4256:
4252:
4247:
4243:
4239:
4234:
4229:
4225:
4221:
4218:(3): 519β32.
4217:
4213:
4209:
4205:
4200:
4196:
4192:
4188:
4184:
4181:(3): 467β71.
4180:
4176:
4171:
4167:
4163:
4159:
4155:
4151:
4147:
4142:
4138:
4134:
4129:
4124:
4120:
4116:
4112:
4108:
4104:
4099:
4095:
4091:
4087:
4083:
4079:
4075:
4070:
4066:
4062:
4057:
4052:
4049:(4): 174β80.
4048:
4044:
4040:
4035:
4031:
4027:
4023:
4019:
4015:
4011:
4006:
4002:
3998:
3993:
3988:
3983:
3978:
3974:
3970:
3967:(9): 3702β6.
3966:
3962:
3958:
3953:
3949:
3945:
3941:
3937:
3933:
3929:
3926:(3): 805β12.
3925:
3921:
3916:
3912:
3908:
3903:
3898:
3894:
3890:
3886:
3882:
3878:
3873:
3869:
3865:
3860:
3855:
3851:
3847:
3843:
3839:
3835:
3830:
3826:
3822:
3818:
3814:
3810:
3805:
3801:
3797:
3793:
3789:
3784:
3780:
3776:
3772:
3768:
3764:
3760:
3756:
3752:
3749:(1): 155β63.
3748:
3744:
3739:
3735:
3731:
3727:
3723:
3719:
3715:
3711:
3707:
3703:
3699:
3694:
3690:
3686:
3682:
3678:
3673:
3672:
3667:
3659:
3655:
3650:
3645:
3641:
3637:
3633:
3629:
3625:
3618:
3615:
3610:
3606:
3602:
3598:
3593:
3588:
3584:
3580:
3576:
3569:
3566:
3561:
3557:
3552:
3547:
3543:
3539:
3535:
3528:
3525:
3520:
3516:
3512:
3508:
3504:
3500:
3496:
3492:
3485:
3482:
3477:
3473:
3468:
3463:
3459:
3455:
3452:(1): 287β96.
3451:
3447:
3443:
3436:
3433:
3428:
3424:
3419:
3414:
3410:
3406:
3403:(4): 977β86.
3402:
3398:
3394:
3387:
3384:
3379:
3375:
3370:
3365:
3361:
3357:
3353:
3346:
3343:
3338:
3334:
3329:
3324:
3320:
3316:
3312:
3305:
3303:
3301:
3297:
3292:
3288:
3283:
3278:
3274:
3270:
3266:
3259:
3257:
3255:
3253:
3251:
3247:
3242:
3238:
3234:
3230:
3227:(9): 625β30.
3226:
3222:
3214:
3211:
3206:
3202:
3197:
3192:
3188:
3184:
3180:
3176:
3172:
3165:
3162:
3157:
3153:
3149:
3145:
3141:
3137:
3133:
3129:
3126:(1): 016008.
3125:
3121:
3114:
3111:
3106:
3102:
3097:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3057:
3054:
3049:
3043:
3040:
3035:
3031:
3026:
3021:
3016:
3011:
3007:
3003:
2999:
2992:
2989:
2984:
2980:
2975:
2970:
2967:(3): 346β54.
2966:
2962:
2958:
2951:
2948:
2943:
2939:
2935:
2931:
2927:
2923:
2916:
2913:
2908:
2904:
2900:
2896:
2892:
2884:
2881:
2876:
2872:
2868:
2864:
2861:(1): 173β83.
2860:
2856:
2849:
2846:
2841:
2837:
2834:(5): 569β74.
2833:
2829:
2822:
2819:
2814:
2810:
2806:
2802:
2799:(4): 539β55.
2798:
2794:
2787:
2784:
2779:
2775:
2770:
2765:
2761:
2757:
2754:(3): 169β79.
2753:
2749:
2745:
2738:
2735:
2730:
2726:
2722:
2718:
2715:(5): 605β48.
2714:
2710:
2703:
2700:
2695:
2691:
2686:
2681:
2678:(2): 713β25.
2677:
2673:
2669:
2662:
2659:
2654:
2650:
2645:
2640:
2636:
2632:
2628:
2621:
2618:
2613:
2609:
2604:
2599:
2596:(2): 148β64.
2595:
2591:
2587:
2580:
2577:
2572:
2568:
2563:
2558:
2554:
2550:
2546:
2539:
2536:
2531:
2527:
2522:
2517:
2513:
2509:
2505:
2498:
2495:
2490:
2486:
2482:
2478:
2474:
2470:
2462:
2459:
2454:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2419:
2416:
2411:
2407:
2402:
2397:
2393:
2389:
2386:(6): 1711β7.
2385:
2381:
2377:
2370:
2367:
2362:
2358:
2354:
2350:
2346:
2342:
2335:
2332:
2327:
2323:
2319:
2315:
2312:(3): 157β67.
2311:
2307:
2300:
2297:
2292:
2288:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2245:
2242:
2229:
2225:
2221:
2215:
2212:
2207:
2203:
2198:
2193:
2189:
2185:
2181:
2177:
2173:
2166:
2164:
2160:
2155:
2151:
2146:
2141:
2137:
2133:
2129:
2125:
2121:
2114:
2111:
2106:
2102:
2098:
2094:
2090:
2086:
2083:(3): 805β12.
2082:
2078:
2071:
2068:
2056:
2052:
2046:
2043:
2038:
2034:
2028:
2025:
2020:
2016:
2010:
2007:
2003:
1999:
1994:
1992:
1990:
1986:
1982:
1978:
1973:
1971:
1969:
1965:
1959:
1955:
1952:
1951:
1947:
1942:
1939:
1937:
1934:
1931:
1928:
1925:
1921:
1918:
1915:
1912:
1909:
1906:
1903:
1900:
1896:
1893:
1890:
1887:
1884:
1883:
1881:
1879:
1871:
1869:
1867:
1866:heart disease
1863:
1858:
1855:
1851:
1847:
1842:
1840:
1836:
1832:
1824:
1822:
1820:
1816:
1815:beta-catenins
1812:
1804:
1802:
1800:
1799:
1793:
1789:
1781:
1779:
1777:
1773:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1710:
1706:
1701:
1699:
1695:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1659:gap junctions
1656:
1652:
1648:
1644:
1640:
1636:
1628:
1626:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1579:
1577:
1573:
1569:
1561:
1559:
1557:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1527:, homophilic
1526:
1525:transmembrane
1522:
1518:
1514:
1510:
1509:neural tissue
1502:
1500:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1462:
1460:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1427:
1426:transmembrane
1423:
1419:
1415:
1412:
1408:
1404:
1400:
1388:
1383:
1379:
1375:
1372:
1368:
1361:
1359:
1356:
1352:
1348:
1344:
1341:
1337:
1333:
1326:
1324:
1318:
1314:
1311:
1305:
1303:
1299:
1295:
1289:
1285:
1282:
1278:
1271:
1269:
1263:
1259:
1256:
1250:
1248:
1244:
1238:
1234:
1231:
1229:RefSeq (mRNA)
1227:
1220:
1219:
1214:
1210:
1207:
1201:
1200:
1195:
1191:
1188:
1186:
1182:
1175:
1174:
1169:
1165:
1162:
1156:
1155:
1150:
1146:
1143:
1141:
1137:
1130:
1129:
1124:
1120:
1117:
1111:
1110:
1105:
1101:
1098:
1096:
1092:
1089:
1086:
1084:
1081:
1077:
1074:
1070:
1066:
1059:
1055:
1050:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
958:cell adhesion
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
880:
878:
875:
874:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
832:cell junction
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
807:lamellipodium
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
724:
722:
719:
718:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
639:
638:Gene ontology
635:
631:
619:
614:
610:
603:
598:
595:
593:
589:
581:
576:
565:
561:
557:
553:
549:
545:
541:
537:
533:
529:
528:
525:
521:
516:
513:
503:
499:
495:
491:
487:
483:
479:
475:
471:
467:
466:
463:
459:
454:
451:
450:
447:
445:
441:
439:
438:
434:
433:
430:
428:
424:
420:
416:
412:
404:
399:
395:
391:
386:
376:
372:
365:
358:
352:
345:
337:
333:
329:
324:
320:
315:
311:
303:
298:
294:
290:
285:
275:
271:
264:
257:
251:
244:
240:
234:
230:
226:
221:
217:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
160:
155:
148:
143:
138:
127:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
7038:
6052:
5972:
5950:
5928:
5775:
5738:
5701:
5654:
5624:
5597:
5419:
5325:
5173:
4902:
4654:
4486:
4471:
4456:
4441:
4381:
4380:
4369:
4357:
4300:(7): 661β9.
4297:
4293:
4258:
4254:
4215:
4211:
4178:
4174:
4152:(1): 83β97.
4149:
4145:
4110:
4106:
4080:(2): 355β8.
4077:
4073:
4046:
4042:
4016:(1): 172β9.
4013:
4009:
3964:
3960:
3923:
3919:
3887:(19): 5896.
3884:
3880:
3844:(3): 671β9.
3841:
3837:
3808:
3791:
3787:
3746:
3742:
3704:(1): 46β55.
3701:
3697:
3680:
3676:
3631:
3627:
3617:
3582:
3578:
3568:
3541:
3537:
3527:
3494:
3490:
3484:
3449:
3445:
3435:
3400:
3396:
3386:
3359:
3355:
3345:
3318:
3314:
3272:
3268:
3224:
3220:
3213:
3181:(8): 850β4.
3178:
3174:
3164:
3123:
3119:
3113:
3070:
3066:
3056:
3042:
3005:
3001:
2991:
2964:
2960:
2950:
2925:
2921:
2915:
2890:
2883:
2858:
2854:
2848:
2831:
2827:
2821:
2796:
2792:
2786:
2751:
2747:
2737:
2712:
2708:
2702:
2675:
2671:
2661:
2634:
2630:
2620:
2593:
2589:
2579:
2552:
2548:
2538:
2514:(1): 64β78.
2511:
2507:
2497:
2475:(1): 88β94.
2472:
2468:
2461:
2428:
2424:
2418:
2383:
2379:
2369:
2344:
2340:
2334:
2309:
2305:
2299:
2258:
2254:
2244:
2232:. Retrieved
2228:the original
2223:
2214:
2179:
2175:
2130:(19): 5896.
2127:
2123:
2113:
2080:
2076:
2070:
2058:. Retrieved
2054:
2045:
2036:
2027:
2018:
2009:
1886:Beta-catenin
1875:
1872:Interactions
1859:
1853:
1843:
1830:
1829:Variants in
1828:
1808:
1795:
1785:
1772:cytoskeleton
1702:
1698:gap junction
1679:gap junction
1632:
1605:and compact
1587:implantation
1580:
1572:gastrulation
1568:glycoprotein
1565:
1556:cytoskeleton
1529:glycoprotein
1506:
1466:
1452:
1439:residing at
1417:
1410:
1406:
1402:
1398:
1397:
1320:
1294:NP_001295105
1291:
1265:
1243:NM_001308176
1240:
1216:
1197:
1171:
1152:
1126:
1107:
1087:
1082:
827:cell surface
442:
435:
162:External IDs
85:
29:
6861:Desmocollin
4424:PDB gallery
3585:(1): 1β13.
3497:(1): 50β7.
2855:Development
2672:Circulation
2555:(1): 72β9.
1930:Plakoglobin
1819:E-cadherins
1745:ion channel
1741:arrhythmias
1733:connexin 43
1691:ventricular
1619:endocardium
1545:cytoplasmic
1489:cytoplasmic
1473:amino acids
1302:NP_001783.2
401:16,942,303
388:16,721,934
300:28,177,946
287:27,932,879
140:Identifiers
7092:Categories
7034:L-selectin
7005:P-selectin
7000:L-selectin
6995:E-selectin
6918:T-cadherin
6839:Desmoglein
6831:Desmosomal
4537:(see also
2637:(1): 1β9.
2347:: 237β52.
2004:, May 2017
1983:, May 2017
1960:References
1811:src kinase
1776:sarcolemma
1667:sarcolemma
1655:desmosomes
1623:myocardium
1607:myocardial
1603:trabecular
1541:C-terminal
1521:metastasis
1407:N-cadherin
1399:Cadherin-2
817:sarcolemma
480:myocardium
446:(ortholog)
183:HomoloGene
6987:Selectins
6804:Classical
6796:Cadherins
6700:Integrins
6631:L1 family
3156:206096620
2060:26 August
2051:"UniProt"
1860:In human
1765:cortactin
1725:sarcomere
1645:. Within
1463:Structure
1323:NP_031690
1298:NP_001783
1268:NM_007664
1247:NM_001792
1073:Orthologs
727:cytoplasm
191:GeneCards
7040:integrin
6589:IgSF CAM
4531:Proteins
4332:14392630
4324:10862698
4315:1842/742
4285:10662782
4204:Peifer M
4175:Genomics
4010:Genomics
3948:29840435
3800:15648948
3779:37486403
3771:15153430
3734:30583247
3726:10818391
3658:17485520
3609:23393425
3601:12203715
3519:23343123
3511:16973135
3378:11729199
3337:12604612
3291:14625392
3241:20591580
3205:23321619
3148:19321920
3105:34702855
3034:21507952
2983:15662031
2942:11950881
2840:25332002
2813:10756112
2778:24766605
2571:11356020
2453:10807574
2206:31585109
2105:29840435
2000:–
1979:–
1948:See also
1922:PTPrho (
1878:interact
1792:adhesion
1788:synapses
1671:catenins
1611:myocytes
1595:myocytes
1591:mesoderm
1549:catenins
1503:Function
1493:interact
1477:cadherin
1371:Wikidata
1052:Sources:
737:membrane
6339:301β350
6133:251β300
6085:CD240CE
5882:201β250
5566:151β200
5289:101β150
4276:2174798
4242:9971746
4233:2132907
4195:9615235
4166:9542583
4137:9508779
4128:2132661
4094:9199196
4065:7995652
4030:7959764
4001:7731968
3969:Bibcode
3940:2384753
3911:2216790
3868:1639850
3859:2289540
3825:1500442
3751:Bibcode
3706:Bibcode
3689:9168198
3649:2118572
3560:7650039
3476:9531566
3467:2132733
3427:7642713
3418:2199947
3196:3722668
3128:Bibcode
3096:8548587
3075:Bibcode
3025:3121477
2907:8834785
2875:1576958
2769:6054126
2729:3904080
2694:8044940
2653:9466883
2612:9187080
2530:9015265
2489:8978327
2433:Bibcode
2425:Science
2410:2788574
2361:2197976
2326:1623205
2291:4314442
2283:7885471
2263:Bibcode
2234:20 July
2197:6817525
2154:2216790
2097:2384753
2002:Ensembl
1981:Ensembl
1774:at the
1615:myocyte
1513:neurons
1469:protein
1429:protein
1185:UniProt
1140:Ensembl
1079:Species
1058:QuickGO
772:synapse
421:pattern
279:18q12.1
147:Aliases
6902:PCDH19
6897:PCDH15
6768:ITGA2B
6658:Nectin
6636:L1-CAM
6626:PE-CAM
6621:VCAM-1
6346:CD300A
6305:CDw293
6090:CD240D
5951:CD213a
5929:CDw210
5894:CD202b
5868:CDw199
5863:CDw198
5517:CD140b
4949:51β100
4353:(MeSH)
4330:
4322:
4283:
4273:
4240:
4230:
4193:
4164:
4135:
4125:
4092:
4063:
4028:
3999:
3989:
3946:
3938:
3909:
3902:332345
3899:
3866:
3856:
3823:
3798:
3777:
3769:
3732:
3724:
3687:
3656:
3646:
3607:
3599:
3558:
3517:
3509:
3474:
3464:
3425:
3415:
3376:
3335:
3289:
3239:
3203:
3193:
3154:
3146:
3103:
3093:
3032:
3022:
2981:
2940:
2905:
2873:
2838:
2811:
2776:
2766:
2727:
2692:
2651:
2610:
2569:
2528:
2487:
2451:
2408:
2401:401013
2398:
2359:
2324:
2289:
2281:
2255:Nature
2204:
2194:
2152:
2145:332345
2142:
2103:
2095:
1941:SCARB2
1926:), and
1905:CTNNA1
1899:CTNND1
1880:with:
1729:Z-line
1583:embryo
1357:search
1355:PubMed
1218:P15116
1199:P19022
1095:Entrez
592:BioGPS
534:atrium
171:114020
7077:EpCAM
7072:CD146
7049:LFA-1
7045:VLA-4
7018:Other
6973:CDH10
6963:CDH17
6958:CDH16
6953:CDH15
6948:CDH12
6943:CDH11
6892:PCDH1
6772:ITGB3
6754:CD49d
6750:VLA-4
6740:CD11b
6726:CD11c
6712:CD11a
6708:LFA-1
6688:CD155
6683:CADM3
6678:CADM1
6673:PVRL3
6668:PVRL2
6663:PVRL1
6646:NFASC
6641:NRCAM
6597:N-CAM
6526:CD350
6521:CD349
6516:CD344
6511:CD340
6506:CD339
6501:CD338
6496:CD337
6491:CD336
6486:CD335
6481:CD334
6476:CD333
6471:CD332
6466:CD331
6461:CD329
6456:CD328
6451:CD327
6446:CD326
6441:CD325
6436:CD324
6431:CD322
6426:CD321
6421:CD320
6416:CD318
6411:CD317
6406:CD316
6401:CD315
6396:CD314
6391:CD312
6386:CD309
6381:CD307
6376:CD306
6371:CD305
6366:CD304
6361:CD303
6356:CD302
6351:CD301
6330:CD299
6325:CD298
6320:CD297
6315:CD295
6310:CD294
6300:CD292
6295:CD290
6290:CD289
6285:CD288
6280:CD286
6275:CD284
6270:CD283
6265:CD282
6260:CD281
6255:CD280
6250:CD279
6245:CD278
6240:CD276
6235:CD275
6230:CD274
6225:CD273
6220:CD272
6215:CD271
6210:CD269
6205:CD268
6200:CD267
6195:CD266
6190:CD265
6185:CD264
6180:CD263
6175:CD262
6170:CD261
6165:CD258
6160:CD257
6155:CD256
6150:CD254
6145:CD253
6140:CD252
6124:CD249
6119:CD248
6115:CD247
6110:CD246
6105:CD244
6100:CD243
6095:CD241
6080:CD239
6075:CD238
6070:CD236
6053:CD235
6048:CD234
6043:CD233
6038:CD230
6033:CD229
6028:CD228
6023:CD227
6018:CD226
6013:CD225
6008:CD224
6003:CD223
5998:CD222
5993:CD221
5988:CD220
5973:CD218
5968:CD217
5946:CD212
5924:CD209
5919:CD208
5914:CD207
5909:CD206
5904:CD205
5899:CD204
5889:CD201
5873:CD200
5858:CD197
5853:CD196
5848:CD195
5843:CD194
5838:CD193
5833:CD192
5828:CD191
5823:CD186
5818:CD185
5813:CD184
5808:CD183
5803:CD182
5798:CD181
5793:CD180
5776:CD179
5771:CD178
5766:CD177
5761:CD174
5739:CD172
5734:CD171
5729:CD170
5724:CD169
5719:CD168
5702:CD167
5697:CD166
5692:CD164
5687:CD163
5682:CD162
5677:CD161
5672:CD160
5655:CD159
5625:CD158
5620:CD157
5598:CD156
5593:CD155
5588:CD154
5583:CD153
5578:CD152
5573:CD151
5557:CD150
5552:CD148
5547:CD147
5542:CD146
5537:CD144
5532:CD143
5527:CD142
5522:CD141
5512:CD138
5507:CD137
5502:CD136
5497:CD135
5492:CD134
5487:CD133
5482:CD132
5477:CD131
5472:CD130
5467:CD129
5462:CD127
5457:CD126
5452:CD125
5447:CD124
5442:CD123
5437:CD122
5420:CD121
5403:CD120
5398:CD119
5393:CD118
5388:CD117
5383:CD116
5378:CD115
5373:CD114
5368:CD113
5363:CD112
5358:CD111
5353:CD110
5348:CD109
5343:CD108
5326:CD107
5321:CD106
5316:CD105
5311:CD104
5306:CD103
5301:CD102
5296:CD101
5280:CD100
4328:S2CID
3992:42029
3944:S2CID
3775:S2CID
3730:S2CID
3605:S2CID
3515:S2CID
3152:S2CID
2287:S2CID
2101:S2CID
1954:ADH-1
1936:XIRP1
1924:PTPRT
1917:PTPRM
1911:LRRC7
1892:CDH11
1769:actin
1761:KCNE2
1757:Kv1.5
1585:post-
1553:actin
1418:CD325
1128:12558
1088:Mouse
1083:Human
1054:Amigo
444:Mouse
437:Human
384:Start
319:Mouse
283:Start
216:Human
187:20424
179:88355
7067:CD44
7062:CD24
7029:CD44
6968:CDH9
6938:CDH8
6933:CDH6
6928:CDH5
6923:CDH4
6873:DSC3
6869:DSC2
6865:DSC1
6855:DSG4
6851:DSG3
6847:DSG2
6843:DSG1
6821:CDH3
6816:CDH2
6811:CDH1
6758:CD29
6744:CD18
6730:CD18
6716:CD18
6651:CHL1
6607:ICAM
5275:CD99
5270:CD98
5265:CD97
5260:CD96
5255:CD95
5250:CD94
5245:CD93
5240:CD92
5236:CD91
5231:CD90
5226:CD89
5221:CD88
5216:CD87
5211:CD86
5174:CD85
5169:CD84
5164:CD83
5159:CD82
5154:CD81
5149:CD80
5132:CD79
5127:CD78
5122:CD74
5117:CD73
5112:CD72
5107:CD71
5102:CD70
5097:CD69
5092:CD68
5055:CD66
5033:CD64
5028:CD63
5006:CD62
5001:CD61
4996:CD59
4991:CD58
4986:CD57
4981:CD56
4976:CD55
4971:CD54
4966:CD53
4961:CD52
4956:CD51
4940:CD50
4903:CD49
4898:CD48
4893:CD47
4888:CD46
4883:CD45
4878:CD44
4873:CD43
4846:CD42
4841:CD41
4836:CD40
4831:CD39
4826:CD38
4821:CD37
4816:CD36
4811:CD35
4806:CD34
4801:CD33
4784:CD32
4779:CD31
4774:CD30
4769:CD29
4764:CD28
4759:CD27
4754:CD26
4749:CD25
4744:CD24
4739:CD23
4734:CD22
4729:CD21
4724:CD20
4719:CD19
4714:CD18
4697:CD16
4692:CD15
4687:CD14
4682:CD13
4655:CD11
4650:CD10
4547:1β50
4487:1ncj
4472:1nci
4457:1nch
4442:1ncg
4370:CDH2
4358:CDH2
4320:PMID
4281:PMID
4238:PMID
4191:PMID
4162:PMID
4133:PMID
4090:PMID
4061:PMID
4026:PMID
3997:PMID
3936:PMID
3907:PMID
3864:PMID
3821:PMID
3796:PMID
3767:PMID
3747:1014
3722:PMID
3685:PMID
3654:PMID
3597:PMID
3556:PMID
3507:PMID
3495:1116
3472:PMID
3423:PMID
3374:PMID
3333:PMID
3287:PMID
3237:PMID
3201:PMID
3144:PMID
3101:PMID
3071:6187
3030:PMID
2979:PMID
2938:PMID
2903:PMID
2871:PMID
2836:PMID
2809:PMID
2774:PMID
2725:PMID
2690:PMID
2649:PMID
2608:PMID
2567:PMID
2526:PMID
2485:PMID
2449:PMID
2406:PMID
2357:PMID
2322:PMID
2279:PMID
2236:2015
2202:PMID
2150:PMID
2093:PMID
2062:2022
1854:CDH2
1848:and
1831:CDH2
1763:and
1657:and
1483:, a
1453:CDH2
1414:gene
1411:CDH2
1109:1000
427:Bgee
375:Band
336:Chr.
274:Band
233:Chr.
195:CDH2
167:OMIM
154:CDH2
124:4NUQ
120:4NUP
116:4NUM
112:3Q2W
108:2QVI
104:1OP4
100:1NCJ
96:1NCI
92:1NCH
88:1NCG
69:RCSB
66:PDBe
35:CDH2
18:CDH2
4645:CD9
4633:CD8
4628:CD7
4623:CD6
4618:CD5
4613:CD4
4591:CD3
4586:CD2
4559:a-c
4554:CD1
4310:hdl
4302:doi
4271:PMC
4263:doi
4259:148
4228:PMC
4220:doi
4216:144
4183:doi
4154:doi
4150:100
4123:PMC
4115:doi
4111:140
4082:doi
4078:235
4051:doi
4018:doi
3987:PMC
3977:doi
3928:doi
3897:PMC
3889:doi
3854:PMC
3846:doi
3842:118
3813:doi
3759:doi
3714:doi
3702:900
3644:PMC
3636:doi
3632:204
3587:doi
3583:225
3546:doi
3542:270
3499:doi
3462:PMC
3454:doi
3450:141
3413:PMC
3405:doi
3401:130
3364:doi
3360:277
3323:doi
3319:278
3277:doi
3273:116
3229:doi
3225:206
3191:PMC
3183:doi
3136:doi
3091:PMC
3083:doi
3020:PMC
3010:doi
3006:286
2969:doi
2930:doi
2926:115
2895:doi
2863:doi
2859:114
2801:doi
2764:PMC
2756:doi
2717:doi
2680:doi
2639:doi
2635:193
2598:doi
2594:185
2557:doi
2553:234
2516:doi
2512:181
2477:doi
2441:doi
2429:288
2396:PMC
2388:doi
2349:doi
2314:doi
2271:doi
2259:374
2192:PMC
2184:doi
2180:105
2140:PMC
2132:doi
2085:doi
1633:In
1601:to
397:End
296:End
199:OMA
175:MGI
59:PDB
7094::
7047:,
7027::
6871:,
6867:,
6853:,
6849:,
6845:,
6613:,
6570::
6117:-
5238:-
4579:1E
4574:1D
4569:1B
4564:1A
4533::
4326:.
4318:.
4308:.
4296:.
4279:.
4269:.
4257:.
4253:.
4236:.
4226:.
4214:.
4210:.
4189:.
4179:49
4177:.
4160:.
4148:.
4131:.
4121:.
4109:.
4105:.
4088:.
4076:.
4059:.
4047:17
4045:.
4041:.
4024:.
4014:22
4012:.
3995:.
3985:.
3975:.
3965:92
3963:.
3959:.
3942:.
3934:.
3924:55
3922:.
3905:.
3895:.
3885:18
3883:.
3879:.
3862:.
3852:.
3840:.
3836:.
3819:.
3790:.
3773:.
3765:.
3757:.
3745:.
3728:.
3720:.
3712:.
3700:.
3679:.
3652:.
3642:.
3630:.
3626:.
3603:.
3595:.
3581:.
3577:.
3554:.
3540:.
3536:.
3513:.
3505:.
3493:.
3470:.
3460:.
3448:.
3444:.
3421:.
3411:.
3399:.
3395:.
3372:.
3358:.
3354:.
3331:.
3317:.
3313:.
3299:^
3285:.
3271:.
3267:.
3249:^
3235:.
3223:.
3199:.
3189:.
3179:21
3177:.
3173:.
3150:.
3142:.
3134:.
3122:.
3099:.
3089:.
3081:.
3069:.
3065:.
3028:.
3018:.
3004:.
3000:.
2977:.
2965:96
2963:.
2959:.
2936:.
2924:.
2901:.
2869:.
2857:.
2832:66
2830:.
2807:.
2797:32
2795:.
2772:.
2762:.
2752:21
2750:.
2746:.
2723:.
2713:17
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2676:90
2674:.
2670:.
2647:.
2633:.
2629:.
2606:.
2592:.
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