191:, as well as to high-mannose oligosaccharides found on the HIV envelope. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded
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that displays virucidal activity against several viruses, including human immunodeficiency virus (AIDS). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins
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Percudani R, Montanini B, Ottonello S (September 2005). "The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes".
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solution nmr structure of complex of 1:2 cyanovirin-n:man-alpha1,2-man-alpha restrained regularized mean coordinates
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Mori T, O'keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Blakeslee D, Buckheit R, Boyd MR (2003).
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359:"Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides"
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omology domain) is a conserved protein domain. It is found in the sugar-binding antiviral protein
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Wlodawer A, Botos I, Boyd MR, O Keefe BR, Cartner LK, Shenoy SR, Ratner DM, Seeberger PH (2002).
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310:"Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin"
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253:"Cyanovirin-N: a sugar-binding antiviral protein with a new twist"
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This article incorporates text from the public domain
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173:Cyanovirin-N (CV-N) is an 11-kDa protein from the
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160:(CVN) as well as proteins from filamentous
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326:10.1128/aac.47.8.2518-2525.2003
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77:Available protein structures:
314:Antimicrob. Agents Chemother
251:Wlodawer A, Botos I (2003).
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137:In molecular biology, the
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23:
376:10.1074/jbc.M205909200
167:Ceratopteris richardii
269:10.1007/s000180300023
179:Nostoc ellipsosporum
369:(37): 34336–34342.
257:Cell. Mol. Life Sci
230:10.1002/prot.20543
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126:structure summary
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320:(8): 2518–2525.
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164:and in the fern
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419:Protein domains
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263:(2): 277–287.
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175:cyanobacterium
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224:(4): 670–8.
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158:cyanovirin-N
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162:ascomycetes
139:CVNH domain
36:Identifiers
203:References
193:beta sheet
89:structures
405:IPR011058
67:IPR011058
413:Category
401:InterPro
385:12110688
344:12878514
295:10579615
287:12678493
278:11138712
238:16003744
218:Proteins
106:RCSB PDB
62:InterPro
55:PF08881
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335:166092
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121:PDBsum
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41:Symbol
291:S2CID
185:gp120
149:irin-
399:and
397:Pfam
381:PMID
340:PMID
283:PMID
234:PMID
195:and
189:gp41
187:and
145:yano
114:PDBj
110:PDBe
93:ECOD
83:Pfam
50:Pfam
44:CVNH
19:CVNH
371:doi
367:277
330:PMC
322:doi
273:PMC
265:doi
226:doi
101:PDB
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154:H
151:N
147:V
143:C
141:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
