410:
429:
274:
72:
40:
377:(PSRCCR) is rare, with a reported incidence of less than 1 percent. It has a poor prognosis because symptoms often develop late and it is usually diagnosed at an advanced stage. Five-year survival rates in previous studies ranged from nine to 30 percent. Average survival was between 20 and 45 months. It tends to affect younger adults with higher likelihood of
329:
Chemotherapy has relatively poor curative efficacy in SRCC patients and overall survival rates are lower compared to patients with more typical cancer pathology. SRCC cancers are usually diagnosed during the late stages of the disease, so the tumors generally spread more aggressively than non-signet
397:
When compared to adenocarcinoma stomach, SRCC in the stomach occurs more often in women and younger patients. Patients with SRCC of the stomach show similar clinicopathological features to patients with undifferentiated histology. A recent study found that patients with SRCC had a better prognosis
364:
Primary signet-ring cell carcinoma of the urinary bladder is extremely rare and patient survival is very poor and occurs mainly in men ages 38 to 83. However, one such patient treated with a radical cystectomy followed by combined S-1 and
Cisplatin adjuvant chemotherapy did demonstrate promising
355:
These aggressive tumors are generally diagnosed at advanced stages and survival is generally shorter. The prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more
259:. Cases of gastric carcinomas metastasizing to the breast and forming signet-ring cells have also been reported. One study suggests that when signet-ring cells are found in a breast tumor, the presence of gastric cancer should also be considered.
1140:
Hartman DJ, Nikiforova MN, Chang DT, Chu E, Bahary N, Brand RE, et al. (July 2013). "Signet ring cell colorectal carcinoma: a distinct subset of mucin-poor microsatellite-stable signet ring cell carcinoma associated with dismal prognosis".
827:
Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y, Horii A (November 1992). "Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma".
384:
In advanced gastric cancers, the prognosis for patients with the SRCCs was significantly worse than for the other histological types, which can be explained by the finding that advanced SRCC gastric cancers have a larger tumor size, more
316:
A study of SRCC colorectal cancers compared mucin-rich SRCC tumors and mucin-poor SRCC tumors. They concluded that the latter more frequently demonstrated adverse histologic features such as lymphatic invasion, venous invasion and
663:
Henson DE, Dittus C, Younes M, Nguyen H, Albores-Saavedra J (July 2004). "Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type".
224:. As a result, the ErbB2/ErbB3 signaling pathway becomes constitutively activated, cell–cell interactions are lost and signet carcinomas are formed. Constitutive action of the ErbB2/ErbB3 complex also enhances cell growth.
330:
cancers, making treatment challenging. In the future, case studies indicate that bone marrow metastases will likely play a larger role in the diagnosis and management of signet ring cell gastric cancer.
1097:
Huh CW, Jung DH, Kim JH, Lee YC, Kim H, Kim H, et al. (February 2013). "Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer".
398:
than patients with undifferentiated gastric carcinoma. However, when narrowed to patients with only advanced stage gastric cancer, those with SRCC had a worse prognosis than other cell types.
428:
409:
347:
There are reports of occasional pulmonary tumour thrombotic microangiopathy leading to pulmonary hypertension and coagulation problems that could be successfully treated with
Imatinib.
1720:
2406:
381:. It is worth noting that the overall survival rate of patients with SRCC was significantly poorer than that of patients with mucinous or poorly differentiated adenocarcinoma.
344:
In a single case study of a patient with SRCC of the bladder with recurrent metastases, the patient exhibited a treatment response to palliative FOLFOX-6 chemotherapy.
1555:
Lee WS, Chun HK, Lee WY, Yun SH, Cho YB, Yun HR, et al. (September 2007). "Treatment outcomes in patients with signet ring cell carcinoma of the colorectum".
1770:
337:
which is clearly superior to others, but most active regimens include 5-Fluorouracil (5-FU), Cisplatin, and/or
Etoposide. Some newer agents, including Taxol and
2637:
1457:"Long-term survival of a patient with invasive signet-ring cell carcinoma of the urinary bladder managed by combined s-1 and Cisplatin adjuvant chemotherapy"
356:
advanced stage. One study suggests that its dismal prognosis seems to be caused by its intrinsic tumor biology, suggesting an area for further research.
247:
The pattern of metastasis is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. The SRCC tumor is often seen in the
313:
Stomach cancers with both adenocarcinoma and some SRC (known as mixed-SRCC) exhibit more aggressive behavior than purely SRCC or non-SRCC histologies.
2662:
2399:
2887:
114:
are most often found in the glandular cells of the stomach (SRCC originates in the stomach in 56 percent of patients), and less frequently in the
2747:
727:
1636:
1081:
737:
710:
189:
The role of other risk factors in gastric cancer such as salt-preserved food, smoking, auto-immune gastritis are not well studied in SRCC.
2957:
2936:
2892:
2392:
2245:
1814:
1763:
2499:
2795:
2295:
1508:"Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature"
559:"Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature"
2299:
2132:
145:
has declined in many countries over the past 50 years, there has been an increase in occurrences of gastric SRCC-type cancers.
2897:
2700:
2657:
2628:
1920:
2608:
2237:
1756:
2926:
2600:
2513:
2423:
2026:
290:. Signet ring cells are seen in the lower half of the image. Gastric epithelium is seen in the upper half of the image.
153:
1408:"Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis"
1186:"Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis"
984:
Duarte I, Llanos O (March 1981). "Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach".
2866:
2642:
2618:
2284:
2201:
1834:
2604:
2882:
2623:
2341:
2323:
2233:
183:
273:
198:
2790:
2719:
2415:
2318:
2241:
2078:
1904:
1867:
2742:
2596:
2346:
2279:
2214:
2088:
2068:
2035:
2013:
1975:
1731:
1590:
Kim JP, Kim SC, Yang HK (August 1994). "Prognostic significance of signet ring cell carcinoma of the stomach".
1021:"Breast metastases of gastric signet-ring cell carcinoma: a report of two cases and review of the literature"
333:
In SRCC of the stomach, removal of the stomach cancer is the treatment of choice. There is no combination of
2931:
2680:
2449:
1824:
1308:"Metastatic signet-ring cell carcinoma of the urinary bladder: A novel management approach to a rare tumour"
378:
2772:
2560:
2522:
2432:
2207:
2031:
1971:
753:
148:
SRCC tumors grow in characteristic sheets, which makes diagnosis using standard imaging techniques, like
2369:
2093:
338:
2632:
2777:
2197:
2056:
1993:
1829:
1809:
235:
causes an increase in differentiated tumor production. The reason for this increase is due to active
52:
2333:
1985:
1819:
1357:"Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge"
865:"Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge"
318:
71:
2837:
2819:
2759:
2588:
2584:
2166:
1998:
1961:
1839:
1683:
1235:"Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma"
1166:
1122:
1857:
1654:"Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach"
2904:
2856:
2847:
2570:
2472:
2441:
2310:
1675:
1632:
1607:
1572:
1537:
1488:
1437:
1388:
1337:
1264:
1215:
1158:
1114:
1077:
1052:
1001:
966:
931:
896:
845:
809:
733:
706:
681:
645:
627:
588:
539:
488:
256:
205:
138:
127:
60:
1406:
Nitsche U, Zimmermann A, Späth C, Müller T, Maak M, Schuster T, et al. (November 2013).
1184:
Nitsche U, Zimmermann A, Späth C, Müller T, Maak M, Schuster T, et al. (November 2013).
2705:
2579:
2494:
2482:
2271:
2189:
2003:
1915:
1665:
1599:
1564:
1527:
1519:
1478:
1468:
1427:
1419:
1378:
1368:
1327:
1319:
1254:
1246:
1205:
1197:
1150:
1106:
1042:
1032:
993:
958:
923:
886:
876:
837:
799:
791:
673:
635:
619:
578:
570:
529:
519:
478:
470:
279:
268:
104:
48:
607:
227:
The mechanism of this malignant cancer is still unclear; however, it has been found that a
17:
2547:
2530:
2289:
1952:
606:
Livieratos, Speros; Smith, James K.; Fatakhov, Eduard; Koch, Christopher F. (2013-09-20).
228:
221:
2040:
2861:
2824:
2754:
2652:
2592:
2535:
2464:
2454:
1966:
1895:
1725:
1532:
1507:
1483:
1456:
1432:
1407:
1383:
1356:
1332:
1307:
1259:
1234:
1210:
1185:
1047:
1020:
891:
864:
804:
795:
779:
640:
583:
558:
534:
507:
459:"Early diagnosis of signet ring cell carcinoma of the stomach: role of the Genta stain"
389:
metastasis, a deeper invasive depth and more
Borrmann type 4 lesions than other types.
209:
142:
123:
85:
1455:
Hamakawa T, Kojima Y, Naiki T, Kubota Y, Yasui T, Tozawa K, et al. (April 2013).
1282:
1250:
997:
483:
458:
2951:
2805:
2487:
1603:
1126:
169:
141:, the prevalence of SRCC is less than one percent. Though incidence and mortality of
115:
1506:
Belli S, Aytac HO, Karagulle E, Yabanoglu H, Kayaselcuk F, Yildirim S (2014-01-01).
1170:
557:
Belli S, Aytac HO, Karagulle E, Yabanoglu H, Kayaselcuk F, Yildirim S (2014-01-01).
55:
with mucinous features, showing a tumor cell with a vacuole of mucin. H&E stain.
2767:
2224:
2176:
2120:
2021:
1687:
307:
172:
1748:
1568:
419:
291:
251:
and has also been known to spread to lymphatic permeation of the lungs and to the
1736:
1626:
1523:
1423:
1355:
Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J (October 2015).
1201:
1154:
1071:
1019:
Iesato A, Oba T, Ono M, Hanamura T, Watanabe T, Ito T, et al. (2014-12-29).
949:
Fukui Y (August 2014). "Mechanisms behind signet ring cell carcinoma formation".
914:
Fukui Y (August 2014). "Mechanisms behind signet ring cell carcinoma formation".
863:
Pernot S, Voron T, Perkins G, Lagorce-Pages C, Berger A, Taieb J (October 2015).
700:
574:
2832:
2785:
2728:
2672:
2162:
1937:
1849:
677:
299:
165:
119:
962:
927:
164:
Some cases are inherited, and these cases are often caused by mutations in the
39:
2918:
2073:
1942:
1932:
1788:
1670:
1653:
1373:
881:
386:
334:
248:
175:
96:
93:
2384:
1652:
Kwon KJ, Shim KN, Song EM, Choi JY, Kim SE, Jung HK, Jung SA (January 2014).
631:
2814:
2737:
2555:
2125:
2061:
1801:
1797:
1306:
Pugashetti N, Yap SA, Lara PN, Gandour-Edwards R, Dall'Era MA (2015-01-01).
623:
524:
282:
100:
1679:
1576:
1541:
1492:
1441:
1392:
1341:
1268:
1219:
1162:
1118:
1056:
970:
935:
900:
778:
Muta H, Noguchi M, Kanai Y, Ochiai A, Nawata H, Hirohashi S (August 1996).
685:
649:
592:
543:
1611:
1473:
1005:
849:
841:
813:
492:
474:
2877:
217:
179:
111:
65:
780:"E-cadherin gene mutations in signet ring cell carcinoma of the stomach"
197:
SRCCs are dedifferentiated adenocarcinomas that lose the capability for
2083:
1890:
1862:
1037:
415:
287:
232:
213:
149:
1712:
1323:
1110:
2360:
2153:
1947:
1780:
374:
220:
receptor. When MUC4 and ErbB2 are able to interact, they trigger an
1881:
435:
303:
272:
252:
89:
2874:
608:"Primary signet ring cell carcinoma of the lung: a rare subtype"
236:
131:
2388:
1752:
204:
Highly differentiated adenocarcinomas form SRCCs via a loss of
186:
have also been implicated in the development of gastric SRCCs.
302:, which result from the formation of large vacuoles full of
754:"Office of Rare Diseases Research: Diffuse Gastric Cancer"
1233:
Dittus C, Mathew H, Malek A, Negroiu A (December 2014).
1283:"Signet Ring Cell Cancer | Oncolink - Cancer Resources"
1073:
Radiologic
Diagnosis of Gastric Cancer: A new Outlook
1702:
1628:
702:
373:
Primary signet ring cell carcinoma of the colon and
2917:
2846:
2804:
2727:
2718:
2693:
2671:
2569:
2546:
2521:
2512:
2463:
2440:
2431:
2422:
2359:
2332:
2309:
2270:
2259:
2223:
2175:
2152:
2141:
2106:
2049:
2012:
1984:
1903:
1889:
1880:
1848:
1796:
1787:
1706:
951:
916:
59:
32:
508:"Epidemiology of Signet Ring Cell Adenocarcinomas"
457:el-Zimaity HM, Itani K, Graham DY (October 1997).
729:Advances in Surgical Pathology: Prostate Cancer
666:Archives of Pathology & Laboratory Medicine
2400:
1764:
134:, though a few instances have been reported.
8:
298:SRCCs are named due to their resemblance to
2724:
2518:
2437:
2428:
2407:
2393:
2385:
2267:
2149:
1900:
1886:
1793:
1771:
1757:
1749:
1703:
1143:The American Journal of Surgical Pathology
84:(SRCC) is a rare form of highly malignant
70:
29:
2663:Hereditary nonpolyposis colorectal cancer
1669:
1631:. Springer Science & Business Media.
1531:
1482:
1472:
1431:
1382:
1372:
1331:
1258:
1209:
1076:. Springer Science & Business Media.
1046:
1036:
890:
880:
803:
705:. Springer Science & Business Media.
639:
582:
533:
523:
482:
239:that are converted to a SRCC-like cells.
2888:Intraductal papillary mucinous neoplasm
1312:Canadian Urological Association Journal
726:Ro JY, Ayala AG, Shen SS (2012-04-20).
449:
405:
732:. Lippincott Williams & Wilkins.
506:Benesch MG, Mathieson A (June 2020).
7:
1239:Journal of Gastrointestinal Oncology
130:. SRCCs do not normally form in the
2937:Desmoplastic small round cell tumor
2246:Papillary serous cystadenocarcinoma
784:Japanese Journal of Cancer Research
2638:Polymerase proofreading-associated
1815:Combined small-cell lung carcinoma
796:10.1111/j.1349-7006.1996.tb02109.x
434:Signet ring cell carcinoma of the
341:(Gemzar) are under investigation.
168:gene, which encodes the important
25:
2500:Hereditary diffuse gastric cancer
1361:World Journal of Gastroenterology
1251:10.3978/j.issn.2078-6891.2014.050
869:World Journal of Gastroenterology
365:long-term survival of 90 months.
216:, a mucin protein, and ErbB2, an
2796:Nodular regenerative hyperplasia
427:
408:
38:
2133:Syringocystadenoma papilliferum
2898:Solid pseudopapillary neoplasm
2701:Gastrointestinal stromal tumor
2658:Familial adenomatous polyposis
1921:Familial adenomatous polyposis
1625:Shah RB, Zhou M (2011-09-29).
699:Shah RB, Zhou M (2011-09-29).
1:
2706:Krukenberg tumor (metastatic)
2296:Paget's disease of the breast
2238:Pancreatic serous cystadenoma
1569:10.1016/j.amjsurg.2006.12.041
998:10.1016/S0046-8177(81)80124-4
463:Journal of Clinical Pathology
2927:Primary peritoneal carcinoma
2601:traditional serrated adenoma
2300:Extramammary Paget's disease
2027:Multiple endocrine neoplasia
1604:10.1016/0960-7404(94)90037-x
1524:10.9738/INTSURG-D-14-00067.1
1424:10.1097/SLA.0b013e3182a69f7e
1202:10.1097/SLA.0b013e3182a69f7e
1155:10.1097/PAS.0b013e3182851e2b
1099:Journal of Surgical Oncology
758:National Institute of Health
575:10.9738/INTSURG-D-14-00067.1
418:signet ring cell carcinoma.
2867:Pancreatic ductal carcinoma
2285:Pancreatic ductal carcinoma
2202:Mucinous cystadenocarcinoma
1835:Transitional cell carcinoma
1557:American Journal of Surgery
678:10.5858/2004-128-765-DTITIA
18:Carcinoma, signet ring cell
2974:
2958:Digestive system neoplasia
2883:Serous microcystic adenoma
2478:Signet ring cell carcinoma
2416:Digestive system neoplasia
2342:Medullary breast carcinoma
2324:Invasive lobular carcinoma
2234:Ovarian serous cystadenoma
2185:Signet ring cell carcinoma
963:10.1016/j.bbrc.2014.07.025
928:10.1016/j.bbrc.2014.07.025
266:
82:Signet ring cell carcinoma
33:Signet ring cell carcinoma
2791:Focal nodular hyperplasia
2319:Lobular carcinoma in situ
2242:Serous cystadenocarcinoma
2079:Clear-cell adenocarcinoma
1868:Bartholin gland carcinoma
1779:Glandular and epithelial
1671:10.1007/s10120-013-0234-1
1374:10.3748/wjg.v21.i40.11428
1070:Portnoy LM (2006-05-05).
882:10.3748/wjg.v21.i40.11428
310:to the cell's periphery.
46:
37:
2893:Mucinous cystic neoplasm
2743:Hepatocellular carcinoma
2597:sessile serrated adenoma
2347:Medullary thyroid cancer
2280:Mammary ductal carcinoma
2215:Mucoepidermoid carcinoma
2069:Adenoid cystic carcinoma
2036:Adrenocortical carcinoma
1976:Hepatocellular carcinoma
830:Human Molecular Genetics
212:that typically separate
2932:Peritoneal mesothelioma
2681:Squamous cell carcinoma
2450:Squamous cell carcinoma
1825:Squamous-cell carcinoma
1461:Case Reports in Urology
1025:OncoTargets and Therapy
624:10.1136/bcr-2013-200111
525:10.3390/cancers12061544
379:lymphovascular invasion
51:, as seen in a case of
2773:Hepatocellular adenoma
2561:Pseudomyxoma peritonei
2208:Pseudomyxoma peritonei
2032:Adrenocortical adenoma
1972:Hepatocellular adenoma
295:
193:Mechanism of formation
2370:Acinic cell carcinoma
2094:Papillary hidradenoma
1512:International Surgery
563:International Surgery
475:10.1136/jcp.50.10.867
276:
199:cell–cell interaction
99:characterized by the
2778:Cavernous hemangioma
2629:Familial adenomatous
2616:Polyposis syndromes:
2198:Mucinous cystadenoma
2057:Neuroendocrine tumor
1994:Renal cell carcinoma
1830:Basal-cell carcinoma
1810:Small-cell carcinoma
53:colon adenocarcinoma
2334:Medullary carcinoma
1820:Verrucous carcinoma
1474:10.1155/2013/915874
1367:(40): 11428–11438.
875:(40): 11428–11438.
842:10.1093/hmg/1.8.559
319:perineural invasion
306:that displaces the
2838:Gallbladder cancer
2820:Cholangiocarcinoma
2760:Liver angiosarcoma
2694:Upper and/or lower
2643:Serrated polyposis
2167:Cystadenocarcinoma
1999:Endometrioid tumor
1962:Cholangiocarcinoma
1850:Complex epithelial
1840:Inverted papilloma
1318:(3–4): E204–E207.
1038:10.2147/OTT.S67921
351:Prognosis by organ
296:
170:cell–cell adhesion
156:, less effective.
139:colorectal cancers
2945:
2944:
2913:
2912:
2905:Pancreatoblastoma
2857:exocrine pancreas
2714:
2713:
2689:
2688:
2508:
2507:
2473:Gastric carcinoma
2382:
2381:
2378:
2377:
2355:
2354:
2311:Lobular carcinoma
2255:
2254:
2102:
2101:
1876:
1875:
1746:
1745:
1638:978-3-642-21369-4
1592:Surgical Oncology
1412:Annals of Surgery
1324:10.5489/cuaj.2447
1190:Annals of Surgery
1111:10.1002/jso.23261
1083:978-3-540-29421-4
739:978-1-60831-434-8
712:978-3-642-21369-4
618:: bcr2013200111.
402:Additional images
257:Krukenberg tumors
180:Somatic mutations
105:signet ring cells
79:
78:
27:Medical condition
16:(Redirected from
2965:
2725:
2624:MUTYH-associated
2609:Cronkhite–Canada
2580:Colorectal polyp
2519:
2495:Linitis plastica
2483:Gastric lymphoma
2438:
2429:
2409:
2402:
2395:
2386:
2302:
2272:Ductal carcinoma
2268:
2248:
2204:
2190:Krukenberg tumor
2150:
2004:Renal oncocytoma
1916:Linitis plastica
1905:Gastrointestinal
1901:
1887:
1794:
1773:
1766:
1759:
1750:
1704:
1692:
1691:
1673:
1649:
1643:
1642:
1622:
1616:
1615:
1587:
1581:
1580:
1552:
1546:
1545:
1535:
1503:
1497:
1496:
1486:
1476:
1452:
1446:
1445:
1435:
1403:
1397:
1396:
1386:
1376:
1352:
1346:
1345:
1335:
1303:
1297:
1296:
1294:
1293:
1287:www.oncolink.org
1279:
1273:
1272:
1262:
1245:(6): E113–E116.
1230:
1224:
1223:
1213:
1181:
1175:
1174:
1137:
1131:
1130:
1094:
1088:
1087:
1067:
1061:
1060:
1050:
1040:
1016:
1010:
1009:
981:
975:
974:
957:(4): 1231–1233.
946:
940:
939:
922:(4): 1231–1233.
911:
905:
904:
894:
884:
860:
854:
853:
824:
818:
817:
807:
775:
769:
768:
766:
765:
760:. pp. 84–85
750:
744:
743:
723:
717:
716:
696:
690:
689:
660:
654:
653:
643:
603:
597:
596:
586:
554:
548:
547:
537:
527:
503:
497:
496:
486:
454:
431:
412:
280:signet ring cell
269:signet ring cell
75:
74:
49:signet ring cell
42:
30:
21:
2973:
2972:
2968:
2967:
2966:
2964:
2963:
2962:
2948:
2947:
2946:
2941:
2909:
2842:
2800:
2710:
2685:
2667:
2565:
2542:
2531:Duodenal cancer
2523:Small intestine
2504:
2459:
2418:
2413:
2383:
2374:
2351:
2328:
2305:
2294:
2290:Comedocarcinoma
2263:
2261:
2251:
2232:
2219:
2196:
2171:
2145:
2143:
2137:
2108:
2098:
2045:
2008:
1980:
1953:Somatostatinoma
1896:adenocarcinomas
1894:
1872:
1858:Warthin's tumor
1844:
1783:
1777:
1747:
1742:
1741:
1715:
1701:
1696:
1695:
1651:
1650:
1646:
1639:
1624:
1623:
1619:
1589:
1588:
1584:
1554:
1553:
1549:
1505:
1504:
1500:
1454:
1453:
1449:
1405:
1404:
1400:
1354:
1353:
1349:
1305:
1304:
1300:
1291:
1289:
1281:
1280:
1276:
1232:
1231:
1227:
1183:
1182:
1178:
1139:
1138:
1134:
1096:
1095:
1091:
1084:
1069:
1068:
1064:
1018:
1017:
1013:
986:Human Pathology
983:
982:
978:
948:
947:
943:
913:
912:
908:
862:
861:
857:
826:
825:
821:
777:
776:
772:
763:
761:
752:
751:
747:
740:
725:
724:
720:
713:
698:
697:
693:
662:
661:
657:
605:
604:
600:
556:
555:
551:
505:
504:
500:
469:(10): 867–868.
456:
455:
451:
446:
439:
438:. H&E stain
432:
423:
413:
404:
395:
371:
362:
353:
327:
271:
265:
245:
229:colon carcinoma
222:activation loop
210:tight junctions
195:
162:
124:urinary bladder
69:
28:
23:
22:
15:
12:
11:
5:
2971:
2969:
2961:
2960:
2950:
2949:
2943:
2942:
2940:
2939:
2934:
2929:
2923:
2921:
2915:
2914:
2911:
2910:
2908:
2907:
2901:
2900:
2895:
2890:
2885:
2870:
2869:
2864:
2862:Adenocarcinoma
2852:
2850:
2844:
2843:
2841:
2840:
2828:
2827:
2825:Klatskin tumor
2822:
2810:
2808:
2802:
2801:
2799:
2798:
2793:
2781:
2780:
2775:
2763:
2762:
2757:
2755:Hepatoblastoma
2752:
2751:
2750:
2733:
2731:
2722:
2716:
2715:
2712:
2711:
2709:
2708:
2703:
2697:
2695:
2691:
2690:
2687:
2686:
2684:
2683:
2677:
2675:
2669:
2668:
2666:
2665:
2660:
2655:
2653:Adenocarcinoma
2646:
2645:
2640:
2635:
2626:
2621:
2612:
2611:
2575:
2573:
2567:
2566:
2564:
2563:
2558:
2552:
2550:
2544:
2543:
2541:
2540:
2539:
2538:
2536:Adenocarcinoma
2527:
2525:
2516:
2510:
2509:
2506:
2505:
2503:
2502:
2497:
2492:
2491:
2490:
2480:
2475:
2469:
2467:
2461:
2460:
2458:
2457:
2455:Adenocarcinoma
2452:
2446:
2444:
2435:
2426:
2420:
2419:
2414:
2412:
2411:
2404:
2397:
2389:
2380:
2379:
2376:
2375:
2373:
2372:
2366:
2364:
2357:
2356:
2353:
2352:
2350:
2349:
2344:
2338:
2336:
2330:
2329:
2327:
2326:
2321:
2315:
2313:
2307:
2306:
2304:
2303:
2292:
2287:
2282:
2276:
2274:
2265:
2257:
2256:
2253:
2252:
2250:
2249:
2229:
2227:
2221:
2220:
2218:
2217:
2212:
2211:
2210:
2194:
2193:
2192:
2181:
2179:
2173:
2172:
2170:
2169:
2159:
2157:
2147:
2139:
2138:
2136:
2135:
2130:
2129:
2128:
2123:
2112:
2110:
2109:skin appendage
2104:
2103:
2100:
2099:
2097:
2096:
2091:
2086:
2081:
2076:
2071:
2066:
2065:
2064:
2053:
2051:
2050:Other/multiple
2047:
2046:
2044:
2043:
2038:
2029:
2024:
2018:
2016:
2010:
2009:
2007:
2006:
2001:
1996:
1990:
1988:
1982:
1981:
1979:
1978:
1969:
1967:Klatskin tumor
1964:
1958:
1957:
1956:
1955:
1950:
1945:
1940:
1935:
1924:
1923:
1918:
1909:
1907:
1898:
1884:
1878:
1877:
1874:
1873:
1871:
1870:
1865:
1860:
1854:
1852:
1846:
1845:
1843:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1806:
1804:
1791:
1785:
1784:
1778:
1776:
1775:
1768:
1761:
1753:
1744:
1743:
1740:
1739:
1728:
1716:
1711:
1710:
1708:
1707:Classification
1700:
1699:External links
1697:
1694:
1693:
1658:Gastric Cancer
1644:
1637:
1617:
1598:(4): 221–227.
1582:
1563:(3): 294–298.
1547:
1518:(6): 691–698.
1498:
1447:
1418:(5): 775–783.
1398:
1347:
1298:
1274:
1225:
1196:(5): 775–783.
1176:
1149:(7): 969–977.
1132:
1105:(2): 124–129.
1089:
1082:
1062:
1011:
992:(3): 237–242.
976:
941:
906:
855:
836:(8): 559–563.
819:
790:(8): 843–848.
770:
745:
738:
718:
711:
691:
672:(7): 765–770.
655:
598:
569:(6): 691–698.
549:
498:
448:
447:
445:
442:
441:
440:
433:
426:
424:
414:
407:
403:
400:
394:
391:
370:
367:
361:
358:
352:
349:
326:
323:
267:Main article:
264:
261:
244:
241:
231:cell known as
194:
191:
161:
158:
143:gastric cancer
103:appearance of
88:that produces
86:adenocarcinoma
77:
76:
63:
57:
56:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2970:
2959:
2956:
2955:
2953:
2938:
2935:
2933:
2930:
2928:
2925:
2924:
2922:
2920:
2916:
2906:
2903:
2902:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2880:
2879:
2876:
2872:
2871:
2868:
2865:
2863:
2860:
2858:
2854:
2853:
2851:
2849:
2845:
2839:
2836:
2834:
2830:
2829:
2826:
2823:
2821:
2818:
2816:
2812:
2811:
2809:
2807:
2806:Biliary tract
2803:
2797:
2794:
2792:
2789:
2787:
2783:
2782:
2779:
2776:
2774:
2771:
2769:
2765:
2764:
2761:
2758:
2756:
2753:
2749:
2748:Fibrolamellar
2746:
2745:
2744:
2741:
2739:
2735:
2734:
2732:
2730:
2726:
2723:
2721:
2717:
2707:
2704:
2702:
2699:
2698:
2696:
2692:
2682:
2679:
2678:
2676:
2674:
2670:
2664:
2661:
2659:
2656:
2654:
2651:
2648:
2647:
2644:
2641:
2639:
2636:
2634:
2630:
2627:
2625:
2622:
2620:
2617:
2614:
2613:
2610:
2606:
2605:Peutz–Jeghers
2602:
2598:
2594:
2590:
2586:
2583:
2581:
2577:
2576:
2574:
2572:
2568:
2562:
2559:
2557:
2554:
2553:
2551:
2549:
2545:
2537:
2534:
2533:
2532:
2529:
2528:
2526:
2524:
2520:
2517:
2515:
2511:
2501:
2498:
2496:
2493:
2489:
2488:MALT lymphoma
2486:
2485:
2484:
2481:
2479:
2476:
2474:
2471:
2470:
2468:
2466:
2462:
2456:
2453:
2451:
2448:
2447:
2445:
2443:
2439:
2436:
2434:
2430:
2427:
2425:
2421:
2417:
2410:
2405:
2403:
2398:
2396:
2391:
2390:
2387:
2371:
2368:
2367:
2365:
2362:
2358:
2348:
2345:
2343:
2340:
2339:
2337:
2335:
2331:
2325:
2322:
2320:
2317:
2316:
2314:
2312:
2308:
2301:
2297:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2277:
2275:
2273:
2269:
2266:
2264:and medullary
2258:
2247:
2243:
2239:
2235:
2231:
2230:
2228:
2226:
2222:
2216:
2213:
2209:
2206:
2205:
2203:
2199:
2195:
2191:
2188:
2187:
2186:
2183:
2182:
2180:
2178:
2174:
2168:
2164:
2161:
2160:
2158:
2155:
2151:
2148:
2140:
2134:
2131:
2127:
2124:
2122:
2119:
2118:
2117:
2114:
2113:
2111:
2105:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2075:
2072:
2070:
2067:
2063:
2060:
2059:
2058:
2055:
2054:
2052:
2048:
2042:
2039:
2037:
2033:
2030:
2028:
2025:
2023:
2020:
2019:
2017:
2015:
2011:
2005:
2002:
2000:
1997:
1995:
1992:
1991:
1989:
1987:
1983:
1977:
1973:
1970:
1968:
1965:
1963:
1960:
1959:
1954:
1951:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1930:
1929:
1926:
1925:
1922:
1919:
1917:
1914:
1911:
1910:
1908:
1906:
1902:
1899:
1897:
1892:
1888:
1885:
1883:
1879:
1869:
1866:
1864:
1861:
1859:
1856:
1855:
1853:
1851:
1847:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1807:
1805:
1803:
1799:
1795:
1792:
1790:
1786:
1782:
1774:
1769:
1767:
1762:
1760:
1755:
1754:
1751:
1738:
1734:
1733:
1729:
1727:
1723:
1722:
1718:
1717:
1714:
1709:
1705:
1698:
1689:
1685:
1681:
1677:
1672:
1667:
1663:
1659:
1655:
1648:
1645:
1640:
1634:
1630:
1629:
1621:
1618:
1613:
1609:
1605:
1601:
1597:
1593:
1586:
1583:
1578:
1574:
1570:
1566:
1562:
1558:
1551:
1548:
1543:
1539:
1534:
1529:
1525:
1521:
1517:
1513:
1509:
1502:
1499:
1494:
1490:
1485:
1480:
1475:
1470:
1466:
1462:
1458:
1451:
1448:
1443:
1439:
1434:
1429:
1425:
1421:
1417:
1413:
1409:
1402:
1399:
1394:
1390:
1385:
1380:
1375:
1370:
1366:
1362:
1358:
1351:
1348:
1343:
1339:
1334:
1329:
1325:
1321:
1317:
1313:
1309:
1302:
1299:
1288:
1284:
1278:
1275:
1270:
1266:
1261:
1256:
1252:
1248:
1244:
1240:
1236:
1229:
1226:
1221:
1217:
1212:
1207:
1203:
1199:
1195:
1191:
1187:
1180:
1177:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1136:
1133:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1093:
1090:
1085:
1079:
1075:
1074:
1066:
1063:
1058:
1054:
1049:
1044:
1039:
1034:
1030:
1026:
1022:
1015:
1012:
1007:
1003:
999:
995:
991:
987:
980:
977:
972:
968:
964:
960:
956:
952:
945:
942:
937:
933:
929:
925:
921:
917:
910:
907:
902:
898:
893:
888:
883:
878:
874:
870:
866:
859:
856:
851:
847:
843:
839:
835:
831:
823:
820:
815:
811:
806:
801:
797:
793:
789:
785:
781:
774:
771:
759:
755:
749:
746:
741:
735:
731:
730:
722:
719:
714:
708:
704:
703:
695:
692:
687:
683:
679:
675:
671:
667:
659:
656:
651:
647:
642:
637:
633:
629:
625:
621:
617:
613:
609:
602:
599:
594:
590:
585:
580:
576:
572:
568:
564:
560:
553:
550:
545:
541:
536:
531:
526:
521:
517:
513:
509:
502:
499:
494:
490:
485:
480:
476:
472:
468:
464:
460:
453:
450:
443:
437:
430:
425:
421:
420:H&E stain
417:
411:
406:
401:
399:
392:
390:
388:
382:
380:
376:
368:
366:
359:
357:
350:
348:
345:
342:
340:
336:
331:
324:
322:
320:
314:
311:
309:
305:
301:
293:
292:H&E stain
289:
285:
284:
281:
275:
270:
262:
260:
258:
254:
250:
242:
240:
238:
234:
230:
225:
223:
219:
215:
211:
207:
202:
200:
192:
190:
187:
185:
181:
177:
174:
171:
167:
159:
157:
155:
151:
146:
144:
140:
135:
133:
129:
125:
121:
117:
113:
110:Primary SRCC
108:
106:
102:
98:
95:
91:
87:
83:
73:
67:
64:
62:
58:
54:
50:
45:
41:
36:
31:
19:
2873:
2855:
2831:
2813:
2784:
2766:
2736:
2649:
2615:
2589:hyperplastic
2578:
2571:Colon/rectum
2477:
2184:
2121:Hidrocystoma
2115:
2041:HĂĽrthle cell
2022:Prolactinoma
1927:
1912:
1730:
1719:
1664:(1): 43–53.
1661:
1657:
1647:
1627:
1620:
1595:
1591:
1585:
1560:
1556:
1550:
1515:
1511:
1501:
1464:
1460:
1450:
1415:
1411:
1401:
1364:
1360:
1350:
1315:
1311:
1301:
1290:. Retrieved
1286:
1277:
1242:
1238:
1228:
1193:
1189:
1179:
1146:
1142:
1135:
1102:
1098:
1092:
1072:
1065:
1028:
1024:
1014:
989:
985:
979:
954:
950:
944:
919:
915:
909:
872:
868:
858:
833:
829:
822:
787:
783:
773:
762:. Retrieved
757:
748:
728:
721:
701:
694:
669:
665:
658:
615:
612:Case Reports
611:
601:
566:
562:
552:
518:(6): E1544.
515:
511:
501:
466:
462:
452:
396:
383:
372:
363:
354:
346:
343:
335:chemotherapy
332:
328:
315:
312:
300:signet rings
297:
278:
246:
226:
203:
196:
188:
173:glycoprotein
163:
147:
136:
109:
81:
80:
2833:gallbladder
2786:hyperplasia
2163:Cystadenoma
2116:sweat gland
2107:Adnexal and
1938:Glucagonoma
339:Gemcitabine
255:, creating
120:gallbladder
92:. It is an
2919:Peritoneum
2146:and serous
2089:Cylindroma
2074:Oncocytoma
1986:Urogenital
1943:Gastrinoma
1933:Insulinoma
1789:Epithelium
1467:: 915874.
1292:2016-04-20
764:2012-11-21
444:References
387:lymph node
369:Colorectal
249:peritoneum
243:Metastasis
176:E-cadherin
101:histologic
97:malignancy
94:epithelial
2878:neoplasms
2815:bile duct
2738:malignant
2720:Accessory
2650:Neoplasm:
2633:Gardner's
2556:Carcinoid
2442:Esophagus
2144:mucinous,
2126:Syringoma
2062:Carcinoid
2014:Endocrine
1802:carcinoma
1798:Papilloma
1127:206174013
1031:: 91–97.
632:1757-790X
325:Treatment
283:carcinoma
263:Histology
218:oncogenic
154:PET scans
61:Specialty
2952:Category
2848:Pancreas
2619:Juvenile
2593:juvenile
2548:Appendix
2424:GI tract
2262:lobular,
2177:Mucinous
1928:pancreas
1891:Adenomas
1680:23389081
1577:17693269
1542:25437572
1493:23738191
1442:23989057
1393:26523107
1342:26085880
1269:25436133
1220:23989057
1171:19107084
1163:23681075
1119:22991272
1057:25565869
971:25019985
936:25019985
901:26523107
686:15214826
650:24057330
593:25437572
544:32545410
206:adherens
184:APC gene
128:pancreas
66:Oncology
2585:adenoma
2465:Stomach
2260:Ductal,
2156:general
2142:Cystic,
2084:Apudoma
1863:Thymoma
1737:D018279
1726:M8490/3
1688:8262409
1612:7834113
1533:4254225
1484:3664482
1433:3888475
1384:4616218
1333:4455640
1260:4226827
1211:3888475
1048:4284042
1006:7228019
892:4616218
850:1338691
814:8797891
805:5921174
641:3794152
584:4254225
535:7352645
512:Cancers
493:9462273
416:Gastric
393:Stomach
360:Bladder
308:nucleus
288:stomach
286:of the
253:ovaries
233:HCC2998
182:of the
2875:cystic
2768:benign
2361:Acinar
2225:Serous
2154:Cystic
1948:VIPoma
1913:tract:
1882:Glands
1781:cancer
1686:
1678:
1635:
1610:
1575:
1540:
1530:
1491:
1481:
1440:
1430:
1391:
1381:
1340:
1330:
1267:
1257:
1218:
1208:
1169:
1161:
1125:
1117:
1080:
1055:
1045:
1004:
969:
934:
899:
889:
848:
812:
802:
736:
709:
684:
648:
638:
630:
591:
581:
542:
532:
491:
484:500272
481:
375:rectum
160:Causes
137:Among
126:, and
116:breast
112:tumors
68:
2729:Liver
2514:Lower
2433:Upper
1721:ICD-O
1684:S2CID
1167:S2CID
1123:S2CID
436:ileum
304:mucin
132:lungs
90:mucin
2673:Anus
2363:cell
1732:MeSH
1676:PMID
1633:ISBN
1608:PMID
1573:PMID
1538:PMID
1489:PMID
1465:2013
1438:PMID
1389:PMID
1338:PMID
1265:PMID
1216:PMID
1159:PMID
1115:PMID
1078:ISBN
1053:PMID
1002:PMID
967:PMID
932:PMID
897:PMID
846:PMID
810:PMID
734:ISBN
707:ISBN
682:PMID
646:PMID
628:ISSN
616:2013
589:PMID
540:PMID
489:PMID
237:PI3K
214:MUC4
208:and
166:CDH1
152:and
1666:doi
1600:doi
1565:doi
1561:194
1528:PMC
1520:doi
1479:PMC
1469:doi
1428:PMC
1420:doi
1416:258
1379:PMC
1369:doi
1328:PMC
1320:doi
1255:PMC
1247:doi
1206:PMC
1198:doi
1194:258
1151:doi
1107:doi
1103:107
1043:PMC
1033:doi
994:doi
959:doi
955:450
924:doi
920:450
887:PMC
877:doi
838:doi
800:PMC
792:doi
674:doi
670:128
636:PMC
620:doi
579:PMC
571:doi
530:PMC
520:doi
479:PMC
471:doi
2954::
2881::
2607:,
2603:,
2599:,
2595:,
2591:,
2587:,
2298:/
2244:/
2240:/
2236:/
2200:/
1735::
1724::
1682:.
1674:.
1662:17
1660:.
1656:.
1606:.
1594:.
1571:.
1559:.
1536:.
1526:.
1516:99
1514:.
1510:.
1487:.
1477:.
1463:.
1459:.
1436:.
1426:.
1414:.
1410:.
1387:.
1377:.
1365:21
1363:.
1359:.
1336:.
1326:.
1314:.
1310:.
1285:.
1263:.
1253:.
1241:.
1237:.
1214:.
1204:.
1192:.
1188:.
1165:.
1157:.
1147:37
1145:.
1121:.
1113:.
1101:.
1051:.
1041:.
1027:.
1023:.
1000:.
990:12
988:.
965:.
953:.
930:.
918:.
895:.
885:.
873:21
871:.
867:.
844:.
832:.
808:.
798:.
788:87
786:.
782:.
756:.
680:.
668:.
644:.
634:.
626:.
614:.
610:.
587:.
577:.
567:99
565:.
561:.
538:.
528:.
516:12
514:.
510:.
487:.
477:.
467:50
465:.
461:.
321:.
277:A
201:.
178:.
150:CT
122:,
118:,
107:.
47:A
2859::
2835::
2817::
2788::
2770::
2740::
2631:/
2582::
2408:e
2401:t
2394:v
2165:/
2034:/
1974:/
1893:/
1800:/
1772:e
1765:t
1758:v
1713:D
1690:.
1668::
1641:.
1614:.
1602::
1596:3
1579:.
1567::
1544:.
1522::
1495:.
1471::
1444:.
1422::
1395:.
1371::
1344:.
1322::
1316:9
1295:.
1271:.
1249::
1243:5
1222:.
1200::
1173:.
1153::
1129:.
1109::
1086:.
1059:.
1035::
1029:8
1008:.
996::
973:.
961::
938:.
926::
903:.
879::
852:.
840::
834:1
816:.
794::
767:.
742:.
715:.
688:.
676::
652:.
622::
595:.
573::
546:.
522::
495:.
473::
422:.
294:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
