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520:. The recommendations, which include development of inorganic, organic and biochemistry coursework that is more geared toward the chemistry of bioorganic functional groups, have been further refined in academic journals. Brenner's contribution to this area was recognized by the 2016 ASBMB Award for Exemplary Contributions to Education.
474:, summarizing it as "an influential source of misinformation on longevity, featuring counterfactual claims about longevity genes being conserved between yeast and humans, the existence of supposed activators of these genes, and claimed successful age reversal in mice based on partial reprogramming." Brenner published a major review of
2993:
Pirinen, E; Auranen, M; Khan, NA; Brilhante, V; Urho, N; Pessia, A; Hakkarainen, A; Kuula, J; Heinonen, U; Schmidt, MS; Haimilahti, K; Piirilä, P; Lundbom, N; Taskinen, MR; Brenner, C; Velagapudi, V; Pietiläinen, KH; Suomalainen, A (2 June 2020). "Niacin Cures
Systemic NAD(+) Deficiency and Improves
307:
as the inaugural Alfred E Mann Family
Foundation Chair in Diabetes and Cancer Metabolism. City of Hope created the position and the associated Department of Diabetes & Cancer Metabolism to focus on underlying metabolism and the intersection of metabolic disturbances with diseases such as cancer
446:
Examining rodents and their offspring, Brenner has showed that rodent postpartum mothers are under severe metabolic stress to their NAD system. Supplementing rodent mothers with NR increases maternal weight loss, advances juvenile development and provides long lasting neurodevelopmental advantages
2932:
Covarrubias, AJ; Kale, A; Perrone, R; Lopez-Dominguez, JA; Pisco, AO; Kasler, HG; Schmidt, MS; Heckenbach, I; Kwok, R; Wiley, CD; Wong, HS; Gibbs, E; Iyer, SS; Basisty, N; Wu, Q; Kim, IJ; Silva, E; Vitangcol, K; Shin, KO; Lee, YM; Riley, R; Ben-Sahra, I; Ott, M; Schilling, B; Scheibye-Knudsen, M;
412:, inflammation, mitochondrial myopathy pellagra, and infections such as coronavirus infection Brenner's work included the first human trial of NR in 2016, which demonstrated safe oral availability as an NAD+ precursor. Though Brenner was the first to show that NR increases
2048:
392:
Brenner has developed targeted, quantitative analysis of the NAD+ metabolome and made fundamental contributions to NAD metabolism including discovery of nicotinic acid riboside-dependent NAD synthesis, elucidating the mechanism of synthesis of
240:
and nucleosidase pathways to NAD. Brenner's work includes the first human trial of NR, which demonstrated safe oral availability as an NAD+ precursor. He has characterized ways in which NAD is disrupted by diseases and metabolic stress.
2749:
Diguet, N; Trammell, SAJ; Tannous, C; Deloux, R; Piquereau, J; Mougenot, N; Gouge, A; Gressette, M; Manoury, B; Blanc, J; Breton, M; Decaux, JF; Lavery, GG; Baczkó, I; Zoll, J; Garnier, A; Li, Z; Brenner, C; Mericskay, M (22 May 2018).
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416:
activity, improves gene silencing, and can extend yeast lifespan, his work has not emphasized sirtuins or nonspecific anti-aging claims and instead emphasizes how NR repairs metabolic stresses that dysregulate NAD+ and
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Fons, NR; Sundaram, RK; Breuer, GA; Peng, S; McLean, RL; Kalathil, AN; Schmidt, MS; Carvalho, DM; Mackay, A; Jones, C; Carcaboso, ÁM; Nazarian, J; Berens, ME; Brenner, C; Bindra, RS (22 August 2019).
3803:
3705:
Chemical
Sciences, Roundtable; Board on Chemical Sciences and Technology; Division on Earth and Life Studies; National Research Council (24 March 2014). "Chapter 1: Introduction and Overview".
1852:
1414:
Trapasso, F; Krakowiak, A; Cesari, R; Arkles, J; Yendamuri, S; Ishii, H; Vecchione, A; Kuroki, T; Bieganowski, P; Pace, HC; Huebner, K; Croce, CM; Brenner, C; et al. (18 February 2003).
2020:
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296:(UI) as Professor and Departmental Executive Officer (DEO) of Biochemistry. In 2010 he became the Roy J. Carver Chair of Biochemistry at UI, holding that position until 2020.
558:
93:
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Brenner, C (12 August 2022). "Longevity lessons
Methuselah's Zoo: What Nature Can Teach Us About Living Longer, Healthier Lives Steven N. Austad MIT Press, 2022. 320 pp".
400:
Brenner is active in translating NR technologies to treat and prevent human conditions that disturb the NAD system including cancer diabetic and chemotherapeutic
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2049:"Humanitarian Grant Awarded for Preclinical Study on the Impact of NAD Precursor Vitamins on Milk Bioactive Production and Brain Development in Rodents"
3318:
Ear, PH; Chadda, A; Gumusoglu, SB; Schmidt, MS; Vogeler, S; Malicoat, J; Kadel, J; Moore, MM; Migaud, ME; Stevens, HE; Brenner, C (22 January 2019).
1354:"Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans"
3828:"ChromaDex Chief Scientific Advisor Dr. Charles Brenner Receives 2020 National Scientific Achievement Award from the American Society for Nutrition"
580:
2155:
Sreenivas, S; Krishnaiah, SM; Govindappa, N; Basavaraju, Y; Kanojia, K; Mallikarjun, N; Natarajan, J; Chatterjee, A; Sastry, KN (January 2015).
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258:
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Tempel, W; Rabeh, WM; Bogan, KL; Belenky, P; Wojcik, M; Seidle, HF; Nedyalkova, L; Yang, T; Sauve, AA; Park, HW; Brenner, C (2 October 2007).
3724:
568:
799:
Trammell, SAJ; Schmidt, MS; Weidemann, BJ; Redpath, P; Jaksch, F; Dellinger, RW; Li, Z; Abel, ED; Migaud, ME; Brenner, C (10 October 2016).
209:(born October 30, 1961) is the inaugural Alfred E Mann Family Foundation Chair of the Department of Diabetes & Cancer Metabolism at the
384:
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214:
120:
2207:"Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap(3)A Elucidates Its Inhibitory Action on Translation"
1162:
Tempel, W; Rabeh, WM; Bogan, KL; Belenky, P; Wojcik, M; Seidle, HF; Nedyalkova, L; Yang, T; Sauve, AA; Park, HW; Brenner, C (2007-10-02).
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Heer, CD; Sanderson, DJ; Voth, LS; Alhammad, YMO; Schmidt, MS; Trammell, SAJ; Perlman, S; Cohen, MS; Fehr, AR; Brenner, C (2020-10-13).
590:
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Brenner is both cautious and critical of research that promotes claims of anti-aging and longevity. After writing a favorable review of
339:
Brenner has made multiple contributions to molecular biology and biochemistry, beginning with purification and characterization of the
2425:
316:
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3320:"Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring"
1614:
381:, 2007) reported another pathway which turns NR into NAM through the action of nucleosidases Urh1/Pnp1/Meu1 and is Nrk1 independent.
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1582:"Leading Biochemist Charles Brenner, PhD, Joins City of Hope as Chair of First Department Focused on Diabetes and Cancer Metabolism"
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Trammell, SAJ; Weidemann, BJ; Chadda, A; Yorek, MS; Holmes, A; Coppey, LJ; Obrosov, A; Kardon, RH; Yorek, MA; Brenner, C (2016).
2629:"Interleukin-8 drives CD38 to form NAADP from NADP(+) and NAAD in the endolysosomes to mobilize Ca(2+) and effect cell migration"
1033:
850:
Trammell, SAJ; Weidemann, BJ; Chadda, A; Yorek, MS; Holmes, A; Coppey, LJ; Obrosov, A; Kardon, RH; Yorek, MA; Brenner, C (2016).
1123:"Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD + Precursor Vitamins in Human Nutrition"
284:, where he worked from 1996-2003, becoming Director of the Structural Biology & Bioinformatics Program in 2000. He moved to
373:(NR) to make NAD+. Bieganowski and Brenner (2004) found that NR is converted to NAD+ through the action of nicotinamide ribose
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546:
509:
2157:"Enhancement in production of recombinant two-chain Insulin Glargine by over-expression of Kex2 protease in Pichia pastoris"
320:
3128:"Manipulating biosynthesis pathways may hold promise for preventing chemotherapy-induced pain | Carver College of Medicine"
508:
In 2012, Brenner and Dagmar Ringe developed pre-medical curriculum recommendations that would be consistent with a revised
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2156:
604:
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3778:"Sirtris Pharmaceuticals, Inc. offering of common stock, Filed Pursuant to Rule 424(b)(4) Registration No.: 333-140979"
1514:"Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease"
2101:"Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins"
713:"Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity"
324:
281:
132:
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Vaur, P; Brugg, B; Mericskay, M; Li, Z; Schmidt, M S.; Vivien, D; Orset, C; Jacotot, E; Brenner, C (December 2017).
756:
Vaur, P; Brugg, B; Mericskay, M; Li, Z; Schmidt, M S.; Vivien, D; Orset, C; Jacotot, E; Brenner, C (December 2017).
210:
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1615:"Brenner stepping down as chair of Department of Biochemistry | Department of Biochemistry and Molecular Biology"
3214:"Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+"
1998:
1311:"Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+"
991:"Changes in Chemistry and Biochemistry Education: Creative Responses to MCAT Revisions in the Age of the Genome"
285:
128:
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Brenner is an author of more than 200 peer-reviewed publications. He was the senior editor of the 2004 book,
1416:"Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding"
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574:
529:
289:
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2882:"Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration"
758:"Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration"
1853:"ChromaDex To Host Key Opinion Leader Webinar on the Transforming Benefits of Nicotinamide Riboside (NR)"
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81:
2935:"Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages"
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217:. Brenner previously held the Roy J. Carver Chair in Biochemistry and was head of biochemistry at the
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Syeda, F; Fagan, RL; Wean, M; Avvakumov, GV; Walker, JR; Xue, S; Dhe-Paganon, S; Brenner, C (2011).
288:
in 2003, serving as
Associate Director for Basic Sciences at Norris Cotton Cancer Center (now named
3910:
2270:
Syeda, F; Fagan, RL; Wean, M; Avvakumov, GV; Walker, JR; Xue, S; Dhe-Paganon S; Brenner, C (2011).
1215:
Robu, ME; Larson, JD; Nasevicius, A; Beiraghi, S; Brenner, C; Farber, SA; Ekker, SC (25 May 2007).
536:, and serves as member of the scientific advisory board and chief scientific advisor to ChromaDex.
266:
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3753:"Brenner recognized for devotion to 'cutting-edge education' and serving the biomedical community"
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2812:"PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma"
2272:"The Replication Focus Targeting Sequence (RFTS) Domain is a DNA-Competitive Inhibitor of Dnmt1"
1078:"The Replication Focus Targeting Sequence (RFTS) Domain is a DNA-Competitive Inhibitor of Dnmt1"
315:, the Burroughs Wellcome Fund, the Beckman Foundation, the Lung Cancer Research Foundation, the
2323:"Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation"
2074:
1878:
1732:"Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations"
903:"Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation"
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170:
2752:"Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy"
265:, receiving his Ph.D. in Cancer Biology in 1993. Brenner conducted post-doctoral research at
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253:
with a bachelor's degree in biology in 1983. After working for the biotechnology companies
157:
56:
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1138:
517:
397:, and discovering multiple conditions in which NAD metabolism is dysregulated in disease.
355:
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2421:"The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism"
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3155:"Biological and Exploitable Crossroads for the Immune Response in Cancer and COVID-19"
2933:
Ishihara, K; Quake, SR; Newman, J; Brenner, C; Campisi, J; Verdin, E (November 2020).
2767:
2627:
Nam, TS; Park, DR; Rah, SY; Woo, TG; Chung, HT; Brenner, C; Kim, UH (September 2020).
2521:"Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites"
1469:"Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates"
1450:
1415:
1370:
1353:
438:“Combating Postpartum Metabolic Stress/Cell Reports, Jan. 22, 2019 (Vol. 22, Issue 4)”
3924:
3557:
3212:
Belenky, P; Racette, FG; Bogan, KL; McClure, JM; Smith, JS; Brenner, C (4 May 2007).
3106:
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2730:
2256:
2191:
1709:
1548:
1513:
1309:
Belenky, P; Racette, FG; Bogan, KL; McClure, JM; Smith, JS; Brenner, C (4 May 2007).
703:
405:
146:
Specificity and
Activity of the Kex2 Protease: From Yeast Genetics to Enzyme Kinetics
3444:"Why you shouldn't get too excited at claims scientists have reversed ageing... yet"
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1068:
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1387:
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1268:
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409:
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229:
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2205:
Herzog, D; Jansen, J; Mißun, M; Diederichs, K; Stengel, F; Marx, A (18 May 2022).
946:"Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1"
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1962:
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3213:
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Vitali, L; Merlini, A; Galvagno, F; Proment, A; Sangiolo, D (19 October 2022).
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2835:
2696:
2487:
1747:
1420:
Proceedings of the
National Academy of Sciences of the United States of America
1327:
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1293:
1034:"Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015"
669:
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500:“Charles Brenner: ASBMB Award for Exemplary Contributions to Education Lecture”
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1930:
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801:"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans"
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3872:"William E. M. Lands Lectureship | Biological Chemistry | Michigan Medicine"
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1800:"Nicotinamide Riboside-The Current State of Research and Therapeutic Uses"
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944:
Fagan, RL; Cryderman, DE; Kopelovich, L; Wallrath, LL; Brenner, C (2013).
228:(NAD) metabolism and has developed targeted, quantitative methods for NAD
2472:"Cross-talk in NAD(+) metabolism: insights from Saccharomyces cerevisiae"
2222:
475:
145:
3016:
2438:
2372:"Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule"
824:
3685:"Response to the New MCAT: ASBMB Premedical Curriculum Recommendations"
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3286:
3263:"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice"
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1007:
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852:"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice"
2570:"Nicotinamide riboside kinase structures reveal new pathways to NAD+"
1905:"Brenner Named Head of Biochemistry at UI Carver College of Medicine"
1164:"Nicotinamide riboside kinase structures reveal new pathways to NAD+"
237:
139:
2100:
3716:
3500:
Longevity.Technology - Latest News, Opinions, Analysis and
Research
3368:"Supplement makes (mouse) moms' milk better; pups benefit for life"
3573:"A science-based review of the world's best-selling book on aging"
3055:
Lautrup, S; Sinclair, DA; Mattson, MP; Fang, EF (1 October 2019).
532:. He was a co-founder of ProHeathspan prior to its acquisition by
418:
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including Nrk1 (yeast and human) and Nrk2 (human). Belenky et al (
346:
at
Stanford. Significant research projects include the role of Ap
257:
and DNAX Research
Institute, Brenner attended graduate school at
3496:"Charles Brenner: longevity is not a simple engineering problem"
413:
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Brenner is a former member of the Scientific Advisory Board of
478:
in 2022 entitled "Sirtuins are not conserved longevity genes".
2681:"NAD(+) metabolism, stemness, the immune response, and cancer"
65:
573:
1998-2001, New Investigator in the Pharmacological Sciences,
1668:
Katsyuba, E; Romani, M; Hofer, D; Auwerx, J (January 2020).
1467:
Draganescu, A; Hodawadekar, SC; Gee, KR; Brenner, C (2000).
551:
2016, ASBMB Award for Exemplary Contributions to Education,
2994:
Muscle Performance in Adult-Onset Mitochondrial Myopathy".
354:
tumor suppressor gene, characterization and inhibition of
3850:
American Association for the Advancement of Science (AAAS)
3899:
3711:. Washington, D.C.: National Academies Press. p. 1.
2021:"2008 - Dartmouth Medical School - Charles Brenner, PhD"
195:
3057:"NAD(+) in Brain Aging and Neurodegenerative Disorders"
553:
American Society for Biochemistry and Molecular Biology
514:
American Society for Biochemistry and Molecular Biology
1907:. News-releases.uiowa.edu. May 5, 2009. Archived from
512:(MCAT), following a request from the President of the
3708:
Undergraduate Chemistry Education: A Workshop Summary
1644:"Awards for Regev and Gierasch; new job for Brenner"
2370:Elhassan, YS; Philp, AA; Lavery, GG (1 July 2017).
559:
American Association for the Advancement of Science
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American Association for the Advancement of Science
88:
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3132:Carver College of Medicine, The University of Iowa
1730:Cercillieux, A; Ciarlo, E; Canto, C (2022-08-02).
1276:Belenky, P; Bogan, KL; Brenner, C (January 2007).
545:2020, Mary Swartz Rose Senior Investigator Award,
311:Brenner has been funded by agencies including the
1798:Mehmel, M; Jovanović, N; Spitz, U (31 May 2020).
365:Notably, the Brenner laboratory discovered that
1963:"Curriculum Vitae | Charles Brenner Laboratory"
467:Lifespan: Why We Age – and Why We Don't Have To
224:Brenner is a major contributor in the field of
3470:"Unpacking Longevity: The Myths of Anti-Aging"
3417:Brenner, Charles; Duggan, David, eds. (2004).
452:Oncogenomics: Molecular Approaches to Cancer.
3951:Stanford University School of Medicine alumni
2470:James Theoga Raj, C; Lin, SJ (October 2019).
395:nicotinic acid adenine dinucleotide phosphate
8:
3630:"Sirtuins are not conserved longevity genes"
3419:Oncogenomics: Molecular approaches to cancer
1397:Oncogenomics: Molecular approaches to cancer
995:Biochemistry and Molecular Biology Education
605:"Sirtuins are not conserved longevity genes"
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1670:"NAD(+) homeostasis in health and disease"
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1217:"p53 Activation by Knockdown Technologies"
15:
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3683:Brenner, Charles; Ringe, Dagmar (2012).
2685:Signal Transduction and Targeted Therapy
2679:Navas, LE; Carnero, A (1 January 2021).
2674:
2672:
2211:Journal of the American Chemical Society
2043:
2041:
1793:
1791:
1789:
1787:
1785:
1783:
654:"Viral infection as an NAD+ battlefield"
292:) from 2003-2009. In 2009 he joined the
1570:
1278:"NAD+ metabolism in health and disease"
1121:Bogan, KL; Brenner, C (1 August 2008).
581:March of Dimes Birth Defects Foundation
388:NRK1/2 mediated pathway from NR to NAD+
3577:Archives of Gerontology and Geriatrics
2164:Applied Microbiology and Biotechnology
1638:
1636:
485:
423:
259:Stanford University School of Medicine
182:Peter A. Belenky, Samuel A.J. Trammell
3751:Sengupta, Samarpita (March 1, 2016).
2988:
2986:
2927:
2925:
2875:
2873:
2871:
2805:
2803:
2744:
2742:
2740:
1957:
1955:
1953:
1951:
1139:10.1146/annurev.nutr.28.061807.155443
569:University of Michigan Medical School
7:
3966:City of Hope National Medical Center
1736:Cellular and Molecular Life Sciences
1395:Brenner, C; Duggan, D, eds. (2004).
301:City of Hope National Medical Center
215:City of Hope National Medical Center
121:City of Hope National Medical Center
3442:Ritchie, Stuart (24 January 2023).
1995:Arnold and Mabel Beckman Foundation
1879:"Vital Signs: Investigator Insight"
1352:Bieganowski, P; Brenner, C (2004).
591:Arnold and Mabel Beckman Foundation
579:1998-2000, Basil O'Connor Scholar,
317:Bill & Melinda Gates Foundation
280:Brenner then joined the faculty at
3494:Garth, Eleanor (2 November 2022).
2519:Trammell, SAJ; Brenner, C (2013).
2426:Journal of Molecular Endocrinology
350:A bindings in the function of the
80:Discovery and characterization of
14:
3846:"AAAS Members Elected as Fellows"
3694:. No. March. pp. 12–14.
2768:10.1161/CIRCULATIONAHA.116.026099
1588:. MJH Life Sciences. Aug 27, 2020
587:Beckman Young Investigators Award
360:nicotinamide adenine dinucleotide
226:nicotinamide adenine dinucleotide
3902:Brenner web page at City of Hope
2376:Journal of the Endocrine Society
1885:. Vol. 28, no. 4. 2004
494:
432:
358:, and discovery of new steps in
232:. Brenner discovered eukaryotic
2419:Fletcher RS, Lavery GG (2018).
2099:Nakayama, K (1 November 1997).
2025:Lung Cancer Research Foundation
1512:Brenner, C; Fuller, RS (1992).
717:Journal of Biological Chemistry
321:Leukemia & Lymphoma Society
3468:Colbert, Chris (13 May 2022).
1282:Trends in Biochemical Sciences
547:American Society for Nutrition
510:Medical College Admission Test
1:
3941:American molecular biologists
3589:10.1016/j.archger.2022.104825
3421:. Hoboken, N.J.: Wiley-Liss.
1399:. Hoboken, N.J.: Wiley-Liss.
1371:10.1016/S0092-8674(04)00416-7
329:National Institutes of Health
261:. At Stanford he worked with
3337:10.1016/j.celrep.2019.01.007
3172:10.3390/biomedicines10102628
2587:10.1371/journal.pbio.0050263
2339:10.1016/j.celrep.2014.10.063
2321:Wu, B-K; Brenner, C (2014).
1234:10.1371/journal.pgen.0030078
1181:10.1371/journal.pbio.0050263
919:10.1016/j.celrep.2014.10.063
901:Wu, B-K; Brenner, C (2014).
167:Other academic advisors
3571:Brenner, C (January 2023).
1883:Dartmouth Medicine Magazine
652:Brenner, C (January 2022).
325:National Science Foundation
282:Thomas Jefferson University
133:Thomas Jefferson University
3982:
3961:University of Iowa faculty
3956:Brandeis University alumni
3946:Wesleyan University alumni
3231:10.1016/j.cell.2007.03.024
3073:10.1016/j.cmet.2019.09.001
3008:10.1016/j.cmet.2020.04.008
2951:10.1038/s42255-020-00305-3
2836:10.1038/s41467-019-11732-6
2697:10.1038/s41392-020-00354-w
2525:Comput Struct Biotechnol J
2488:10.1007/s00294-019-00972-0
1748:10.1007/s00018-022-04499-5
1328:10.1016/j.cell.2007.03.024
1294:10.1016/j.tibs.2006.11.006
1127:Annual Review of Nutrition
670:10.1038/s42255-021-00507-3
211:Beckman Research Institute
3628:Brenner, C (2022-09-22).
2176:10.1007/s00253-014-6052-5
2075:"@author Charles Brenner"
1686:10.1038/s42255-019-0161-5
603:Brenner, C (2022-09-22).
524:Industrial collaborations
493:
482:Educational contributions
431:
186:
99:
3643:10.1093/lifemeta/loac025
730:10.1074/jbc.RA120.015138
618:10.1093/lifemeta/loac025
299:In 2020, Brenner joined
286:Dartmouth Medical School
129:Dartmouth Medical School
3911:Interviews and podcasts
3906:Brenner twitter profile
3804:"Charles Brenner Ph.D."
3534:10.1126/science.add9130
2289:10.1074/jbc.M110.209882
2105:The Biochemical Journal
2053:GlobeNewswire News Room
1441:10.1073/pnas.0437915100
1095:10.1074/jbc.M110.209882
963:10.1074/jbc.M113.480517
575:Burroughs Wellcome Fund
530:Sirtris Pharmaceuticals
290:Dartmouth Cancer Center
249:Brenner graduated from
2899:10.1096/fj.201700221RR
2537:10.5936/csbj.201301012
1486:10.1074/jbc.275.7.4555
775:10.1096/fj.201700221RR
389:
335:Research contributions
2816:Nature Communications
2646:10.1096/fj.202001249R
2388:10.1210/js.2017-00092
1539:10.1073/pnas.89.3.922
1518:Proc. Natl. Acad. Sci
805:Nature Communications
597:Selected publications
402:peripheral neuropathy
387:
371:nicotinamide riboside
344:proprotein convertase
234:nicotinamide riboside
82:nicotinamide riboside
3876:Biological Chemistry
2223:10.1021/jacs.2c00815
245:Education and career
3279:2016NatSR...626933T
3002:(6): 1078–1090.e5.
2828:2019NatCo..10.3790F
2439:10.1530/JME-18-0085
2282:(17): 15344–15351.
1530:1992PNAS...89..922B
1432:2003PNAS..100.1592T
1088:(17): 15344–15351.
1053:2013JChEd..90..807B
1032:Brenner, C (2013).
989:Brenner, C (2013).
956:(33): 23858–23867.
868:2016NatSR...626933T
825:10.1038/ncomms12948
817:2016NatCo...712948T
723:(52): 17986–17996.
267:Brandeis University
251:Wesleyan University
71:Brandeis University
62:Stanford University
53:Wesleyan University
3852:. 30 November 2012
3397:scholar.google.com
3267:Scientific Reports
2639:(9): 12565–12576.
1967:University of Iowa
1817:10.3390/nu12061616
1619:University of Iowa
856:Scientific Reports
565:William E.M. Lands
390:
362:(NAD) metabolism.
305:Duarte, California
294:University of Iowa
255:Chiron Corporation
219:University of Iowa
125:University of Iowa
3726:978-0-309-29589-5
3393:"Charles Brenner"
3372:medicalxpress.com
3330:(4): 969–983.e4.
3287:10.1038/srep26933
3134:. October 8, 2018
2945:(11): 1265–1283.
2939:Nature Metabolism
2892:(12): 5440–5452.
2762:(21): 2256–2273.
2531:(5): e201301012.
2217:(19): 8613–8623.
2117:10.1042/bj3270625
1991:"Charles Brenner"
1674:Nature Metabolism
1061:10.1021/ed4002738
1008:10.1002/bmb.20653
876:10.1038/srep26933
768:(12): 5440–5452.
658:Nature Metabolism
506:
505:
472:David A. Sinclair
444:
443:
204:
203:
171:Gregory A. Petsko
101:Scientific career
3973:
3888:
3887:
3885:
3883:
3868:
3862:
3861:
3859:
3857:
3842:
3836:
3835:
3824:
3818:
3817:
3815:
3813:
3800:
3794:
3793:
3791:
3789:
3774:
3768:
3767:
3765:
3763:
3748:
3739:
3738:
3702:
3696:
3695:
3689:
3680:
3674:
3673:
3663:
3645:
3625:
3619:
3618:
3608:
3568:
3562:
3561:
3517:
3511:
3510:
3508:
3506:
3491:
3485:
3484:
3482:
3480:
3465:
3459:
3458:
3456:
3454:
3439:
3433:
3432:
3414:
3408:
3407:
3405:
3403:
3389:
3383:
3381:
3379:
3378:
3364:
3358:
3357:
3339:
3315:
3309:
3308:
3298:
3258:
3252:
3251:
3233:
3209:
3203:
3202:
3192:
3174:
3150:
3144:
3143:
3141:
3139:
3124:
3118:
3117:
3115:
3113:
3092:
3052:
3046:
3045:
3019:
2990:
2981:
2980:
2970:
2929:
2920:
2919:
2901:
2877:
2866:
2865:
2855:
2807:
2798:
2797:
2787:
2746:
2735:
2734:
2716:
2676:
2667:
2666:
2648:
2624:
2618:
2617:
2607:
2589:
2565:
2559:
2558:
2548:
2516:
2510:
2509:
2499:
2482:(5): 1113–1119.
2476:Current Genetics
2467:
2461:
2460:
2450:
2433:(1): R107–R121.
2416:
2410:
2409:
2399:
2367:
2361:
2360:
2350:
2333:(5): 1827–1840.
2318:
2312:
2311:
2301:
2291:
2267:
2261:
2260:
2242:
2202:
2196:
2195:
2161:
2152:
2146:
2145:
2143:
2141:
2128:
2096:
2090:
2089:
2087:
2085:
2071:
2065:
2064:
2062:
2060:
2055:. 7 October 2019
2045:
2036:
2035:
2033:
2031:
2017:
2011:
2010:
2008:
2006:
2001:on 2 August 2018
1997:. Archived from
1987:
1978:
1977:
1975:
1973:
1959:
1946:
1945:
1943:
1941:
1927:
1921:
1920:
1918:
1916:
1911:on July 20, 2011
1901:
1895:
1894:
1892:
1890:
1875:
1869:
1868:
1866:
1864:
1849:
1840:
1839:
1829:
1819:
1795:
1778:
1777:
1767:
1727:
1721:
1720:
1718:
1716:
1665:
1652:
1651:
1650:. July 20, 2020.
1640:
1631:
1630:
1628:
1626:
1611:
1598:
1597:
1595:
1593:
1578:
1561:
1551:
1541:
1508:
1498:
1488:
1479:(7): 4555–4560.
1463:
1453:
1443:
1410:
1391:
1373:
1348:
1330:
1305:
1272:
1254:
1236:
1211:
1201:
1183:
1158:
1117:
1107:
1097:
1072:
1038:
1028:
1010:
985:
975:
965:
940:
930:
913:(5): 1827–1840.
897:
887:
846:
836:
795:
777:
752:
742:
732:
707:
689:
648:
638:
620:
498:
497:
486:
462:Methuselah's Zoo
447:into adulthood.
436:
435:
424:
263:Robert S. Fuller
200:
197:
179:Notable students
162:Robert S. Fuller
158:Doctoral advisor
152:
36:October 30, 1961
35:
33:
16:
3981:
3980:
3976:
3975:
3974:
3972:
3971:
3970:
3921:
3920:
3900:The Brenner Lab
3896:
3891:
3881:
3879:
3878:. 22 March 2018
3870:
3869:
3865:
3855:
3853:
3844:
3843:
3839:
3834:. May 21, 2020.
3826:
3825:
3821:
3811:
3809:
3802:
3801:
3797:
3787:
3785:
3776:
3775:
3771:
3761:
3759:
3750:
3749:
3742:
3727:
3704:
3703:
3699:
3687:
3682:
3681:
3677:
3634:Life Metabolism
3627:
3626:
3622:
3570:
3569:
3565:
3519:
3518:
3514:
3504:
3502:
3493:
3492:
3488:
3478:
3476:
3474:Private Medical
3467:
3466:
3462:
3452:
3450:
3441:
3440:
3436:
3429:
3416:
3415:
3411:
3401:
3399:
3391:
3390:
3386:
3376:
3374:
3366:
3365:
3361:
3317:
3316:
3312:
3260:
3259:
3255:
3211:
3210:
3206:
3152:
3151:
3147:
3137:
3135:
3126:
3125:
3121:
3111:
3109:
3061:Cell Metabolism
3054:
3053:
3049:
2996:Cell Metabolism
2992:
2991:
2984:
2931:
2930:
2923:
2879:
2878:
2869:
2809:
2808:
2801:
2748:
2747:
2738:
2678:
2677:
2670:
2626:
2625:
2621:
2567:
2566:
2562:
2518:
2517:
2513:
2469:
2468:
2464:
2418:
2417:
2413:
2369:
2368:
2364:
2320:
2319:
2315:
2269:
2268:
2264:
2204:
2203:
2199:
2159:
2154:
2153:
2149:
2139:
2137:
2098:
2097:
2093:
2083:
2081:
2073:
2072:
2068:
2058:
2056:
2047:
2046:
2039:
2029:
2027:
2019:
2018:
2014:
2004:
2002:
1989:
1988:
1981:
1971:
1969:
1961:
1960:
1949:
1939:
1937:
1929:
1928:
1924:
1914:
1912:
1903:
1902:
1898:
1888:
1886:
1877:
1876:
1872:
1862:
1860:
1851:
1850:
1843:
1797:
1796:
1781:
1729:
1728:
1724:
1714:
1712:
1667:
1666:
1655:
1642:
1641:
1634:
1624:
1622:
1613:
1612:
1601:
1591:
1589:
1580:
1579:
1572:
1568:
1511:
1466:
1413:
1407:
1394:
1351:
1308:
1275:
1214:
1161:
1120:
1075:
1036:
1031:
988:
943:
900:
849:
798:
755:
710:
651:
609:Life Metabolism
602:
599:
542:
526:
518:Suzanne Pfeffer
502:, May 25, 2016.
495:
489:External videos
484:
433:
427:External videos
356:DNA methylation
349:
337:
247:
207:Charles Brenner
194:
173:
150:
131:
127:
123:
111:
69:
60:
49:Alma mater
31:
29:
21:
20:Charles Brenner
12:
11:
5:
3979:
3977:
3969:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3923:
3922:
3919:
3918:
3916:Google scholar
3913:
3908:
3903:
3895:
3894:External links
3892:
3890:
3889:
3863:
3837:
3819:
3795:
3784:. May 22, 2007
3769:
3740:
3725:
3717:10.17226/18555
3697:
3675:
3636:(2): 122–133.
3620:
3563:
3512:
3486:
3460:
3434:
3427:
3409:
3384:
3359:
3310:
3253:
3204:
3145:
3119:
3067:(4): 630–655.
3047:
2982:
2921:
2867:
2799:
2736:
2668:
2619:
2560:
2511:
2462:
2411:
2382:(7): 816–835.
2362:
2313:
2262:
2197:
2147:
2091:
2066:
2037:
2012:
1979:
1947:
1922:
1896:
1870:
1859:. July 7, 2022
1841:
1779:
1722:
1653:
1632:
1621:. July 8, 2020
1599:
1569:
1567:
1564:
1563:
1562:
1524:(3): 922–926.
1509:
1464:
1411:
1405:
1392:
1364:(4): 495–502.
1349:
1306:
1273:
1212:
1159:
1133:(1): 115–130.
1118:
1073:
1047:(7): 807–812.
1029:
986:
941:
898:
847:
796:
753:
708:
649:
611:(2): 122–133.
598:
595:
594:
593:
583:
577:
571:
561:
557:2013, Fellow,
555:
549:
541:
538:
525:
522:
504:
503:
491:
490:
483:
480:
464:, he reviewed
442:
441:
429:
428:
347:
336:
333:
313:March of Dimes
308:and diabetes.
271:Gregory Petsko
246:
243:
202:
201:
192:
188:
187:
184:
183:
180:
176:
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163:
160:
154:
153:
142:
136:
135:
118:
114:
113:
108:
104:
103:
97:
96:
92:Fellow of the
90:
86:
85:
78:
77:Known for
74:
73:
50:
46:
45:
42:
38:
37:
27:
23:
22:
19:
13:
10:
9:
6:
4:
3:
2:
3978:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3931:Living people
3929:
3928:
3926:
3917:
3914:
3912:
3909:
3907:
3904:
3901:
3898:
3897:
3893:
3877:
3873:
3867:
3864:
3851:
3847:
3841:
3838:
3833:
3829:
3823:
3820:
3808:
3805:
3799:
3796:
3783:
3779:
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3758:
3754:
3747:
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3714:
3710:
3709:
3701:
3698:
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3644:
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3616:
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3602:
3598:
3594:
3590:
3586:
3582:
3578:
3574:
3567:
3564:
3559:
3555:
3551:
3547:
3543:
3539:
3535:
3531:
3528:(6607): 718.
3527:
3523:
3516:
3513:
3501:
3497:
3490:
3487:
3475:
3471:
3464:
3461:
3449:
3445:
3438:
3435:
3430:
3428:0-471-22592-4
3424:
3420:
3413:
3410:
3398:
3394:
3388:
3385:
3373:
3369:
3363:
3360:
3355:
3351:
3347:
3343:
3338:
3333:
3329:
3325:
3321:
3314:
3311:
3306:
3302:
3297:
3292:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3257:
3254:
3249:
3245:
3241:
3237:
3232:
3227:
3224:(3): 473–84.
3223:
3219:
3215:
3208:
3205:
3200:
3196:
3191:
3186:
3182:
3178:
3173:
3168:
3164:
3160:
3156:
3149:
3146:
3133:
3129:
3123:
3120:
3108:
3104:
3100:
3096:
3091:
3086:
3082:
3078:
3074:
3070:
3066:
3062:
3058:
3051:
3048:
3043:
3039:
3035:
3031:
3027:
3023:
3018:
3013:
3009:
3005:
3001:
2997:
2989:
2987:
2983:
2978:
2974:
2969:
2964:
2960:
2956:
2952:
2948:
2944:
2940:
2936:
2928:
2926:
2922:
2917:
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3880:. Retrieved
3875:
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3849:
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3806:
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3781:
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3756:
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3503:. Retrieved
3499:
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3473:
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3323:
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2577:
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2573:
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2327:Cell Reports
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2265:
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2163:
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2108:
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2094:
2082:. Retrieved
2078:
2069:
2057:. Retrieved
2052:
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2024:
2015:
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1999:the original
1994:
1970:. Retrieved
1966:
1938:. Retrieved
1934:
1925:
1913:. Retrieved
1909:the original
1899:
1887:. Retrieved
1882:
1873:
1861:. Retrieved
1857:BusinessWire
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1739:
1735:
1725:
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1677:
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1618:
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1285:
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1171:
1168:PLOS Biology
1167:
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811:(1): 12948.
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410:brain injury
399:
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298:
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275:Dagmar Ringe
248:
230:metabolomics
223:
206:
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174:Dagmar Ringe
144:
117:Institutions
100:
84:as a vitamin
3936:1961 births
3782:www.sec.gov
3757:ASBMB Today
3692:ASBMB Today
3448:inews.co.uk
2822:(1): 3790.
2756:Circulation
1935:Brenner Lab
1915:December 9,
1810:(6): 1616.
1680:(1): 9–31.
1648:ASBMB Today
41:Nationality
3925:Categories
3882:2 February
3856:2 February
3788:2 February
3762:2 February
3583:: 104825.
3505:3 February
3479:2 February
3453:3 February
3402:3 February
3377:2019-01-26
3138:6 February
3112:6 February
2140:6 February
2084:6 February
2059:6 February
2030:6 February
1972:2 February
1940:3 February
1889:2 February
1863:3 February
1742:(8): 463.
1715:6 February
1625:2 February
1592:3 February
1566:References
1227:(5): e78.
1001:(1): 1–4.
664:(1): 2–3.
408:, central
367:eukaryotes
327:. and the
196:brennerlab
112:Metabolism
110:Enzymology
32:1961-10-30
3807:Bloomberg
3652:2755-0230
3597:0167-4943
3558:251516708
3542:0036-8075
3346:2211-1247
3273:: 26933.
3181:2227-9059
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3081:1550-4131
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3026:1550-4131
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2844:2041-1723
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2731:229935354
2705:2059-3635
2655:1530-6860
2596:1545-7885
2257:248554359
2231:0002-7863
2192:253777642
1804:Nutrients
1756:1420-9071
1710:214277961
1694:2522-5812
1243:1553-7404
1190:1545-7885
1147:0199-9885
862:: 26933.
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704:245654307
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534:ChromaDex
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460:'s book
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3275:Bibcode
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3190:9599827
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2714:7775471
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1526:Bibcode
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1428:Bibcode
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1025:4659938
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864:Bibcode
834:5062546
813:Bibcode
740:7834058
563:2007,
375:kinases
323:, the
213:of the
191:Website
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540:Awards
319:, the
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151:(1993)
149:
140:Thesis
107:Fields
89:Awards
3688:(PDF)
3554:S2CID
3244:S2CID
3103:S2CID
3038:S2CID
2727:S2CID
2253:S2CID
2188:S2CID
2160:(PDF)
1706:S2CID
1549:48357
1384:S2CID
1341:S2CID
1265:S2CID
1065:S2CID
1037:(PDF)
1021:S2CID
700:S2CID
419:NADPH
269:with
236:(NR)
3884:2023
3858:2023
3814:2018
3790:2023
3764:2023
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379:Cell
369:use
352:FHIT
341:Kex2
273:and
198:.net
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