51:. The need for chemosterilants is a direct consequence of the limitations of insecticides. Insecticides are most effective in regions in which there is high vector density in conjunction with endemic transmission, and this may not always be the case. Additionally, the insects themselves will develop a resistance to the insecticide either on the target protein level or through avoidance of the insecticide in what is called a behavioral resistance. If an insect that has been treated with a chemosterilant mates with a fertile insect, no offspring will be produced. The intention is to keep the percent of sterile insects within a population constant, such that with each generation, there will be fewer offspring.
173:, as not enough is known about the aggression displayed by free-roaming dogs, and thus, researchers were unable to objectively make a decision on this front. Using GPS technology to track the movement of the free-roaming male dogs, it was found that chemical sterilization in comparison to surgical sterilization did not have a significant impact on the range of their roaming around the city. Much more detailed studies need to be performed in this area, since this study was the first of its kind and had relatively short sample sizes along with the examination of behavior not spanning a long enough time period.
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with using chemosterilants on an operational scale due to difficulties in finding the ideal small molecule. The molecule used as a chemosterilant must satisfy a certain criteria. Firstly, the molecule must be available at a low cost. The molecule must result in permanent sterility upon exposure through topical application or immersion of larvae into water. Additionally, the survivability of the sterile males must not be affected, and the chemosterilant should not be toxic to humans or the environment. The two promising agents in the beginning were
217:. This chemosterilant was provided to sparrows by impregnating canary seeds, and this was used as a food source for a group of sparrows. There was a control group that was fed canary seeds without the ornitrol, and these birds laid almost twice as many eggs as group that was given ornitrol. It was deemed an effective chemosterilant in the study; however, after the removal of the chemosterilant from the diet, the birds were able to lay viable eggs as soon as 1–2 weeks later.
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144:-inducing agents, has been studied. If cells are signaled to perform apoptosis rather than being eliminated by a foreign substance, this will result in no inflammation in the area. Experiments were tested using mice in vitro and ex vivo that have proved this. Using an apoptosis-inducing agent known as
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in an organism. Chemosterilants are particularly useful in controlling the population of species that are known to cause disease, such as insects, or species that are, in general, economically damaging. The sterility induced by chemosterilants can have temporary or permanent effects. Chemosterilants
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is through surgical means. However, surgical intervention poses ethical concerns. Through the formulation of a non-surgical castration technique, animals would not have to undergo anesthesia, and would not have to experience post-surgical bleeding or infection of the area that has been operated on.
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Research on chemosterilants began in the 1960s–1970s, but the effort was abandoned due to concerns regarding toxicity. However, with great advancements made in genetics and analysis of vectors, the search for safer chemosterilants has resumed in the 21st century. Initially, there were many concerns
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Chemosterilants can be useful to developing countries due to the fact that they have less resources and funds that can be allocated towards castration of their free-roaming animals. Additionally, the culture opposes the removal of testes. This study, performed in 2015, was unable to conclude the
136:, which is the degeneration of the sperm cells normally found in the semen. If no sperm cells are present, reproduction can no longer occur. There is, however, one complication that results from the use of necrosis-inducing agents. Many animals generally exhibit an
152:, and injecting it into mice, testicular cell death was observed. Inflammation was not observed in this case; however, more research still needs to be conducted with these materials, as the long-term impacts are unknown.
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Pagseesing, S.; Yostawonkul, J.; Surassmo, S.; Boonrungsiman, S.; Namdee, K.; Khongkow, M.; Boonthum, C.; Iempridee, T.; Ruktanonchai, U. R.; Saengkrit, N.; Chatdarong, K.; Ponglowhapan, S.; Yata, T. (28 April 2021).
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Garde, E.; Pérez, G.E.; Vanderstichel, R; Dalla Villa, P.F.; Serpell, J.A. (2016). "Effects of surgical and chemical sterilization on the behavior of free-roaming male dogs in Puerto
Natales, Chile".
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and zinc gluconate is through a transvaginal injection of the chemical into the ovaries, and visualization is achieved through the use of an ultrasound. One group of cattle was only treated with CaCl
120:-inducing agents, which result in the degeneration of cells in the testes, resulting in infertility. These kinds of chemicals are generally injected into male reproductive organs, such as the
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seems to be most promising, as the ovarian mass of the female cattle upon slaughter was less than cattle treated with zinc gluconate or the combination. The goal of treatment with CaCl
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was another compound of interest since it is not toxic to humans, but it would not be possible to induce sterility in larvae due to the fact that it exists as a
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and tries to incorporate them in its normal building processes. The fit of the chemical is not exactly right and the metabolic process comes to a halt.
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directly after the injection. To avoid the pain and discomfort associated with necrosis-inducing agents, another form of sterilization, known as
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Mitchell, Carl J.; Hayes, Richard O.; Hughes, T. B. (28 April 2021). "Effects of the
Chemosterilant Ornitrol on House Sparrow Reproduction".
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can be used to target one or both sexes, and it prevents the organism from advancing to be sexually functional. They may be used to control
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There are many regions in which there is a population of cats and dogs that freely roam on the streets. The most conventional approach to
403:"Formulation, physical, in vitro and ex vivo evaluation of nanomedicine-based chemosterilant for non-surgical castration of male animals"
485:"Examination of the use of intraovarian administration of CaCl 2 and zinc gluconate as potential chemosterilants in Bos indicus heifers"
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Effect of chemosterilants on the behavior of wandering male dogs in Puerto
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Use of chemosterilants for non-surgical castration (dogs and cats)
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Another chemosterilant found to be effective is known as
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controlling reproductive rates in companion animals
225:Two types of chemosterilants are commonly used:
305:Hayes, Wayland J. Jr; Laws, Edward R. (1991).
209:Ornitrol in controlling the sparrow population
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282:"chemosterilant | pesticide | Britannica"
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343:Baxter, Richard H. G. (2016-10-26).
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116:. These are specifically known as
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307:Handbook of pesticide toxicology
532:The American Midland Naturalist
483:Cavalieri, J; Hayes, L (2017).
454:10.1016/j.prevetmed.2015.11.011
442:Preventive Veterinary Medicine
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489:Australian Veterinary Journal
221:Commonly used chemosterilants
132:. When injected, they induce
181:and zinc gluconate in cattle
159:Structure of Zinc Gluconate
91:Examples of chemosterilants
55:Early research and concerns
47:populations by sterilizing
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27:Class of chemical compound
63:Structure of pyriproxyfen
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244:chromosomes
177:Use of CaCl
146:doxorubicin
134:azoospermia
586:Categories
291:2022-04-22
263:References
234:metabolite
130:epididymis
70:aziridines
462:0167-5877
369:2673-2424
325:899003092
142:apoptosis
85:larvicide
40:sterility
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251:See also
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49:males
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458:ISSN
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365:ISSN
321:OCLC
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112:and
107:CaCl
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