178:(ALL). It was the first time CRISPR was used on a human HIV patient. 19 months later, the patient's ALL was in complete remission. Their research demonstrated the safety of CRISPR for humans, although the therapy was not effective for curing AIDS as only 5% to 8% of the patient's
135:(HSC) therapy. He treated more than 40,000 patients and performed over 3,200 HSC transplants, improving the survival rate from nearly 0% at the beginning to 65%. In 2015, his research on the treatment of
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116:. He later served as Director of the Beijing Hematopoietic Stem Cell Therapy Laboratory and Director of the PLA Institute of Hematopoietic Stem Cell Research at the Fifth Medical Center (formerly the
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researcher. He served as
Director of the PLA Institute of Hematopoietic Stem Cell Research and the Beijing Hematopoietic Stem Cell Therapy Laboratory. Known for his research on
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On 24 July 2019, Chen Hu died from a sudden heart attack in
Beijing, aged 57. At the time of his death he was a candidate for election to the
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Xu, Lei; Wang, Jun; Liu, Yulin; Xie, Liangfu; Su, Bin; Mou, Danlei; Wang, Longteng; Liu, Tingting; Wang, Xiaobao (11 September 2019).
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resistance to the animals. They subsequently used the technique to treat an AIDS patient who suffered from
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cells carried the edited CCR5 gene, much lower than the ideal 100%. Their research was published in
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290:"CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia"
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After graduation, Chen became a physician at the
Affiliated Hospital of the
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49:; 17 February 1962 – 24 July 2019) was a Chinese military physician and
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365:"Chinese scientists use CRISPR tool on HIV patient for the first time"
426:"In a CRISPR first, therapy aiming to cure HIV patient appears safe"
109:(now Army Medical University). He earned both a Ph.D. and an M.D.
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Chinese military physician and stem cell researcher (1962–2019)
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Chen spent more than 30 years researching treatment for
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Julie Zaugg and
Serenitie Wang (13 September 2019).
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105:(PLA) in September 1979 and enrolled at the
530:Burials at Babaoshan Revolutionary Cemetery
145:State Science and Technology Progress Award
63:State Science and Technology Progress Award
331:"Resistance to HIV Engineered Via CRISPR"
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166:to transplant human HSCs with the edited
122:People's Liberation Army General Hospital
188:in September 2019, after Chen had died.
147:(First Class). A year later, he won the
467:from the original on 22 September 2019.
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436:from the original on 13 September 2019
405:from the original on 22 September 2019
375:from the original on 13 September 2019
266:from the original on 22 September 2019
230:from the original on 22 September 2019
341:from the original on 8 September 2018
151:for Science and Technology Progress.
89:Chen Hu was born 17 February 1962 in
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424:Begley, Sharon (11 September 2019).
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154:In 2017, Chen and his collaborator,
114:Academy of Military Medical Sciences
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185:The New England Journal of Medicine
455:Zhang Wenkang 张文康 (28 July 2019).
329:Azvolinsky, Anna (3 August 2017).
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107:Third Military Medical University
500:21st-century Chinese physicians
495:20th-century Chinese physicians
294:New England Journal of Medicine
395:"CRISPR编辑干细胞治疗HIV和急性淋巴细胞白血病患者"
254:Yue, Huairang (26 July 2019).
224:Jiankang Shibao (Health Times)
65:(First Class) in 2015 and the
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176:acute lymphoblastic leukemia
170:gene to mice, and conferred
515:Chinese medical researchers
193:Chinese Academy of Sciences
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457:"院士候选人陈虎去世！生前正研究基因编辑治疗艾滋病"
256:"解放军总医院第五医学中心教授陈虎逝世，享年57岁"
220:"痛惜！全军造血干细胞研究所所长陈虎离世，仅57岁"
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505:Biologists from Chongqing
73:engineered resistance to
69:in 2016. In 2017, he and
520:Chinese military doctors
103:People's Liberation Army
133:hematopoietic stem cell
55:hematopoietic stem cell
335:The Scientist Magazine
525:Stem cell researchers
401:. 12 September 2019.
307:10.1056/NEJMoa1817426
149:Ho Leung Ho Lee Prize
101:. He enlisted in the
67:Ho Leung Ho Lee Prize
61:, he was awarded the
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79:CRISPR gene editing
510:Cancer researchers
131:, with a focus on
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156:Deng Hongkui
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124:in Beijing.
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71:Deng Hongkui
57:therapy for
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23:Chinese name
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490:2019 deaths
485:1962 births
180:bone marrow
27:family name
479:Categories
399:Sciencenet
199:References
260:The Paper
120:) of the
91:Chongqing
85:Biography
51:stem cell
465:Archived
434:Archived
403:Archived
373:Archived
339:Archived
316:31509667
264:Archived
228:Archived
143:won the
129:leukemia
59:leukemia
21:In this
162:, used
95:Luoyang
43:Chinese
39:Chen Hu
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139:using
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25:, the
99:Henan
461:Sina
442:2019
430:STAT
411:2019
381:2019
347:2019
312:PMID
272:2019
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168:CCR5
32:Chen
369:CNN
302:doi
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172:HIV
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75:HIV
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