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307:(NWTS) were specific for particular cancers. In 2000, the four pediatric groups merged to create the Children's Oncology Group. Since then, its researchers have published well over one thousand research manuscripts in peer-reviewed scientific journals. COG has enrolled more children with cancer on clinical trials than any other organization in the world.
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The COG is primarily funded by the NCI, the primary or Chair's grant supports research operations and funds personnel at member institutions conducting research, and the statistics and data center grant supports these essential research functions. Other key grants include the COG Phase 1 Consortium
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The group, with more than 7,500 experts worldwide, has nearly 100 active clinical-translational trials open at any given time. These trials include treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and
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Almost all centers that treat children with cancer in the US and Canada are part of the COG, with more than 200 centers in the United States, Canada, Switzerland, the
Netherlands, Australia, and New Zealand. The member institutions have multidisciplinary teams consisting of physicians, research
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The cooperative group system for clinical research began in 1955 with a consortium focused on childhood cancer research. By the mid-1990s, there were nine groups funded by the NCI to conduct research in adults with cancer, and four focused on childhood cancer research. Two groups, the
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grant, supporting 21 COG institutions charged with early phase clinical trials, and the
Community Cancer Oncology Program (CCOP) grant. There is additional funding from other granting agencies and from philanthropic sources.
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emerging treatments, supportive care, and survivorship. More than 90% of 13,500 children and adolescents diagnosed with cancer each year in the United States are cared for at COG member institutions.
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The group's research studies encompass hematologic malignancies, solid tumors, central nervous system tumors, and rare cancers.
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Reaman, GH (2004). "Pediatric cancer research from past successes through collaboration to future transdisciplinary research".
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266:(NCI), is the world's largest organization devoted exclusively to pediatric cancer research. The COG conducts a spectrum of
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Bleyer, WA (1997). "The U.S. pediatric cancer clinical trials programmes: international implications and the way forward".
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387:. The large multi-site structure of COG also allows it to conduct research into very rare childhood cancer including
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482:"Progress in Childhood Cancer: 50 Years of Research Collaboration, a Report from the Children's Oncology Group"
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Schilsky RL, McIntyre OR, Holland JF, Frei E (2006). "A concise history of the cancer and leukemia group B".
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In addition to disease specific research, COG conducts studies in developmental therapeutics (new cancer
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are the second most common form of childhood cancer. COG conducts research in children with
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O'Leary, M; Krailo M; Anderson JR; Reaman GH (2008).
710:"Community Clinical Oncology program Research Base"
156:. Unsourced material may be challenged and removed.
755:Cancer organizations based in the United States
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262:), a clinical trials group supported by the
61:Learn how and when to remove these messages
319:include the most common childhood cancer,
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642:Nass, SJ; Balogh E; Mendelsohn J (2011).
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276:adolescents, and young adults with cancer
234:Learn how and when to remove this message
216:Learn how and when to remove this message
698:. NCI Cancer Therapy Evaluation Program.
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365:Central nervous system (brain) tumors
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154:adding citations to reliable sources
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18:Children's Cancer Study Group
42:This article has multiple issues.
498:10.1053/j.seminoncol.2008.07.008
305:National Wilms Tumor Study Group
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765:Pediatrics in the United States
141:needs additional citations for
50:or discuss these issues on the
274:trials for infants, children,
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714:NCI Funded Research Portfolio
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543:10.1016/S0959-8049(97)00249-9
297:Children's Cancer Study Group
760:Clinical trial organizations
660:10.1097/MJT.0b013e3181ff7e23
321:acute lymphoblastic leukemia
165:"Children's Oncology Group"
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770:Children's Oncology Group
696:National Cancer Institute
408:stem cell transplantation
351:), tumors of the kidney (
264:National Cancer Institute
256:Children's Oncology Group
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613:10.1177/1043454204264406
572:(11 Pt 2): 3553s–3555s.
317:Hematologic malignancies
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325:acute myeloid leukemia
272:translational research
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601:J Pediatr Oncol Nurs
486:Seminars in Oncology
402:), supportive care,
395:, and other tumors.
361:soft tissue sarcomas
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445:NCI Cancer Bulletin
412:behavioral sciences
107:independent sources
414:and survivorship.
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453:. Retrieved
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92:and may be
83:reads like
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427:References
373:ependymoma
359:and other
176:newspapers
47:improve it
648:Am J Ther
206:June 2020
53:talk page
678:21326081
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105:and add
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418:Funding
381:gliomas
290:History
190:scholar
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270:and
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169:news
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