328:, resulted in the identification of NRAS, a new human oncogene. Subsequent work from his laboratory showed that NRAS has important roles in leukaemia and others demonstrated the role of NRAS in melanoma. Following the identification of NRAS, Marshall concentrated on studying how NRAS and the two other RAS genes, HRAS and KRAS, act in cancer. His work in the field of cell signalling showed how RAS and other signalling proteins are involved in transmitting signals from outside of the cell all the way to the cell nucleus. His work laid the foundation for studies that showed the importance of the
36:
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Futreal, P. Andrew; Stratton, Michael R.; Wooster, Richard; Marshall, Christopher J.; Marais, Richard; Paterson, Hugh; Darrow, Timothy L.; Seigler, Hilliard F.; Weber, Barbara L.; Yuen, Siu T.; Leung, Suet Y.; Ho, Judy W. C.; Nicholson, Andrew; Flanagan, Adrienne; Cossu, Antonio; Palmieri, Giuseppe;
779:
Bigner, Darell D.; Riggins, Gregory J.; Chenevix-Trench, Georgia; Maitland, Norman; Pritchard-Jones, Katherine; Hargrave, Darren; Shipley, Janet; Cooper, Colin; Gusterson, Barry A.; Jayatilake, Hiran; Wilson, Rebecca; Hooper, Steven; Watt, Stephen; et al. (June 2002).
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At the time of his death, Marshall's laboratory studied the cell signalling mechanisms that allow cancer cells to disseminate through the body. In particular, these studies were focused on signal transduction pathways regulated by Ras and Rho family of small GTPases.
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Hall, A; Marshall, CJ; Spurr, NK; Weiss, RA (1983). "Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1".
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Several post-doctoral fellows and graduate students who trained in
Professor Marshall's laboratory have gone on to prestigious positions:
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257:. Marshall was distinguished for research in the field of tumour cell signalling. His track record includes the discovery of the
253:(19 January 1949 – 8 August 2015) was a British scientist who worked as director of the Division for Cancer Biology at the
731:"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation"
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in London, and began studies to identify human cancer genes. This work, in collaboration with his colleague
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272:. These findings have led to therapeutic development of inhibitors of Ras farnesylation, MEK and B-Raf.
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Dr Faraz
Mardakheh, Group Leader, Barts Cancer Institute, Queen Mary University of London, London, UK.
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Professor John
Hancock, IBP Chair and Professor, University of Texas Medical School, USA.
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FRS, CRUK Chief
Scientist and Group Leader at the Francis Crick Institute, London, UK.
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619:"Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein"
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682:"From RAS to RHO: The making of the great cell biologist Alan Hall (1952–2015)"
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578:"All ras proteins are polyisoprenylated but only some are palmitoylated"
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Professor Erik Sahai, Group Leader, Francis Crick
Institute, London, UK.
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The Walter
Huppert lecture (British Association for Cancer Research)
300:. His graduate studies were followed by post-doctoral work at the
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of Ras proteins, and the discovery that Ras signals through the
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479:"ICR mourns loss of Research Director Professor Chris Marshall"
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The CH Li
Memorial Lecture (University of California, Berkeley)
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Hancock, JF; Magee, AI; Childs, JE; Marshall, CJ (June 1989).
29:
1276:
Fellows of the
Academy of Medical Sciences (United Kingdom)
365:, Professor of Cell Biology, University College London, UK.
372:, Head of Cancer Research UK Manchester Institute, UK.
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Professor Mike Olson, Beatson
Institute, Glasgow, UK.
856:"Institute Professor Wins Prestigious Science Award"
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People educated at King Henry VIII School, Coventry
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Health professionals from
Birmingham, West Midlands
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60:. Unsourced material may be challenged and removed.
502:. Cancer Research UK. 8 June 2016. Archived from
427:The Sterling Lecture (University of Pennsylvania)
191:Member of European Molecular Biology Organisation
882:"Chris Marshall wins Lifetime Achievement Award"
197:Sterling Medal of the University of Pennsylvania
858:. Institute of Cancer Research. Archived from
832:. Institute of Cancer Research. Archived from
457:Lifetime Achievement in Cancer Research Award.
199:Cancer Research UK Life Time Achievement Award
919:
8:
781:"Mutations of the BRAF gene in human cancer"
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617:Leevers, SJ; Marshall, CJ (February 1992).
179:Work on RAS and RHO family of small GTPases
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302:Imperial Cancer Research Fund laboratories
288:. He then studied Natural Sciences at the
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416:Fellow of the Academy of Medical Sciences
304:at Lincoln's Inn Fields (now part of the
195:Novartis Medal of the Biochemical Society
189:Fellow of the Academy of Medical Sciences
120:Learn how and when to remove this message
467:
7:
884:. Cancer Research UK. Archived from
58:adding citations to reliable sources
423:European Academy of Cancer Sciences
635:10.1002/j.1460-2075.1992.tb05088.x
69:"Christopher Marshall" doctor
25:
286:King Henry VIII School, Coventry
34:
1109:Jeremy David Pickett-Heaps
320:In 1980, Marshall moved to The
45:needs additional citations for
1139:Ian William Murison Smith
1067:Christopher John Marshall
1:
729:Marshall, CJ (January 1995).
1261:Fellows of the Royal Society
1024:Jonathan Charles Howard
748:10.1016/0092-8674(95)90401-8
595:10.1016/0092-8674(89)90054-8
322:Institute of Cancer Research
310:Dana–Farber Cancer Institute
255:Institute of Cancer Research
233:Institute of Cancer Research
193:Royal Society Buchanan Award
686:The Journal of Cell Biology
667:"Chris Marshall, 1949-2015"
187:Fellow of the Royal Society
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830:"Professor Chris Marshall"
284:, UK, and educated at the
1222:Salome Gluecksohn-Waelsch
245:Christopher John Marshall
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203:
148:Christopher John Marshall
18:Christopher John Marshall
1097:Geoffrey James Pert
680:Marshall, Chris (2015).
264:, the identification of
306:Francis Crick Institute
296:in cell biology at the
290:University of Cambridge
1240:John Archibald Wheeler
1133:Robert Malcolm Simmons
1036:Jack Henri Kaplan
1055:Frank Matthews Leslie
698:10.1083/jcb.201505049
280:Marshall was born in
1228:Rita Levi-Montalcini
450:of the Royal Society
383:Victoria Sanz-Moreno
308:) in London and the
298:University of Oxford
54:improve this article
1169:Shirley M. Tilghman
1163:Richard Taylor
1151:Laszlo Solymar
1061:Robin Marshall
836:on 31 December 2013
800:10.1038/nature00766
539:1983Natur.303..396H
442:Biochemical Society
343:Students and alumni
1115:Richard J. Roberts
1085:Richard Alan North
1000:Richard Ellis
994:Graham Dixon-Lewis
964:Iain Campbell
455:Cancer Research UK
393:Awards and honours
229:Cancer Research UK
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1216:Gertrude B. Elion
1103:Keith Peters
958:Martin A. Bennett
888:on 1 January 2014
794:(6892): 949–954.
669:. 19 August 2015.
533:(5916): 396–400.
316:Oncogene research
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205:Scientific career
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27:British scientist
16:(Redirected from
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862:on 11 June 2011
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43:This article
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1234:Calvin Quate
1157:Roger Tayler
1145:Peter Sneath
1079:David Miller
1066:
1042:Gurdev Khush
976:Keith Chater
970:Johnson Cann
890:. Retrieved
886:the original
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860:the original
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504:the original
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363:Alison Lloyd
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225:Institutions
219:Cell biology
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161:(2015-08-08)
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52:Please help
47:verification
44:
1271:2015 deaths
1266:1949 births
982:Ed Corrigan
892:27 February
840:27 February
510:27 February
399:EMBO Member
333:cancer gene
312:in Boston.
168:Nationality
1255:Categories
1091:Tim Pedley
866:28 January
462:References
414:Elected a
403:Elected a
381:Professor
368:Professor
361:Professor
351:Professor
282:Birmingham
276:Early life
110:March 2024
80:newspapers
484:10 August
418:(FMedSci)
326:Alan Hall
1210:Ugo Fano
941:elected
808:12068308
716:25979981
262:oncogene
1202:Foreign
950:Fellows
943:in 1995
937:of the
935:Fellows
816:3071547
765:8995643
757:7834738
707:4442819
653:1371463
604:2661017
563:4372475
555:6304521
535:Bibcode
440:of the
407:of the
251:FMedSci
171:British
94:scholar
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527:Nature
405:Fellow
215:Cancer
211:Fields
184:Awards
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812:S2CID
784:(PDF)
761:S2CID
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453:2011
446:2008
436:1999
411:(FRS)
294:DPhil
260:N-Ras
101:JSTOR
87:books
894:2013
868:2009
842:2013
804:PMID
753:PMID
735:Cell
712:PMID
649:PMID
600:PMID
582:Cell
551:PMID
512:2013
486:2015
331:BRAF
156:Died
144:Born
73:news
796:doi
792:417
743:doi
702:PMC
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631:doi
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