Basal-cell carcinoma - Knowledge (XXG)

1402:(EDC, also known as curettage and cautery, simply curettage) is accomplished by using a round knife, or curette, to scrape away the soft cancer. The skin is then burned with an electric current. This further softens the skin, allowing for the knife to cut more deeply with the next layer of curettage. The cycle is repeated, with a safety margin of curettage of normal skin around the visible tumor. This cycle is repeated 3 to 5 times, and the free skin margin treated is usually 4 to 6 mm. Cure rate is very much user-dependent and depends also on the size and type of tumor. Infiltrative or morpheaform BCCs can be difficult to eradicate with EDC. Generally, this method is used on cosmetically unimportant areas like the trunk (torso). Some physicians believe that it is acceptable to utilize EDC on the face of elderly patients over the age of 70. However, with increasing life expectancy, such an objective criterion cannot be supported. The cure rate can vary, depending on the aggressiveness of the EDC and the free margin treated. Some advocate curettage alone without electrodesiccation, and with the same cure rate. 1172: 1018: 1181: 1234: 1118: 908: 708: 645: 1050: 1006: 435: 1220: 1034: 994: 1100: 469: 742: 1152: 1300: 1202: 728: 1514:

visits to as many as 25 visits. Usually, the more visits scheduled for therapy, the less complication or damage is done to the normal tissue supporting the tumor. Radiotherapy can also be useful if surgical excision has been done incompletely or if the pathology report following surgery suggests a high risk of recurrence, for example if nerve involvement has been demonstrated. Cure rate can be as high as 95% for small tumor, or as low as 80% for large tumors. A variation of an external

805: 423: 1135: 411: 597: 854: 833: 787: 1391:, excision, or electrodesiccation and curettage so that no conclusion can be made whether cryosurgery is as efficacious as other methods. Also, there is no evidence on whether curetting the lesions before cryosurgery affects the efficacy of treatment. Several textbooks are published on the therapy, and a few physicians still apply the treatment to selected patients. 60: 399: 721:

present, especially in long-standing lesions. Mitotic activity is usually not so evident, but a high mitotic rate may be present in more aggressive lesions. Adenoidal BCC can be classified as a variant of NBCC, characterized by basaloid cells with a reticulated configuration extending into the dermis.

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30. However, a Cochrane review examining the effect of solar protection (sunscreen only) in preventing the development of basal-cell carcinoma or cutaneous squamous cell carcinoma found that there was insufficient evidence to demonstrate whether sunscreen was effective for the prevention of either of

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of cells and one or more typical clefts. Such clefts are caused by shrinkage of mucin during tissue fixation and staining. Central necrosis with eosinophilic, granular features may be also present, as well as mucin. The heavy aggregates of mucin determine a cystic structure. Calcification may be also

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is approved by EU as a photosensitizer since 2001. This therapy is also used in other skin cancer types. A 2008 study reported that PDT was a good treatment option for primary superficial BCCs and reasonable for primary low-risk nodular BCCs, but was a "relatively poor" option for high-risk lesions.

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For basal cell carcinoma excisions on the lower lip the wound can be covered with a keystone flap. A keystone flap is achieved by creating a flap below the defect and pulling it superiorly to cover the wound. This can be performed if there is enough skin laxity to cover the defect and adequate blood

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Squamous-cell carcinoma of the skin is generally distinguishable by for example relatively more cytoplasm, horn cyst formation and absence of palisading and cleft formations. Yet, a high prevalence means a relatively high incidence of borderline cases, such as basal-cell carcinoma with squamous cell

1335:, which means that the entire surgical margin (both edges and deep) is examined. During the surgery, after each removal of tissue and while the patient waits, the tissue is examined for cancer cells. That examination dictates the decision for additional tissue removal. Mohs surgery is also used for 3374:

Ad Hoc Task Force, Connolly SM, Baker DR, Coldiron BM (2012). "AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American

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closer to the equator or at higher altitude. It is very common among elderly people over the age of 80. There are approximately 800,000 new cases yearly in the United States alone. Up to 30% of white people develop basal-cell carcinomas in their lifetime. In Canada, the most common skin cancer is

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instruments, it can result in very good cure rate. Disadvantages include lack of margin control, tissue necrosis, over or under treatment of the tumor, and long recovery time. Overall, there are sufficient data to consider cryosurgery as a reasonable treatment for BCC. There are no good studies,

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Rims of collagen bundles, calcification, follicular/sebaceous/infundibular differentiation and cut artefacts. Cytokeratin (CK)20+, p75+, Pleckstrin homology-like domain family A member 1 + (PHLDA1+), common acute lymphoblastic leukemiaantigen + (CD10+) in tumor stroma, CK 6-, Ki-67- and Androgen

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is generally used in older patients who are not candidates for surgery, it is also used in cases where surgical excision will be disfiguring or difficult to reconstruct (especially on the tip of the nose, and the nostril rims). Radiation treatment with external radiation often takes as few as 5

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Surgery to remove the basal-cell carcinoma affected area and the surrounding skin is thought to be the most effective treatment. A disadvantage with standard surgical excision is a reported higher recurrence rate of basal-cell cancers of the face, especially around the eyelids, nose, and facial

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can prevent the development of skin cancer. It is usually recommended to individuals with extensive sun damage, history of multiple skin cancers, or rudimentary forms of cancer (i.e., solar keratosis). It is often repeated every 2 to 3 years to further decrease the risk of skin cancer.

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is that the Mohs surgeon performs the surgery and personally reviews the Mohs pathology slides. Most standard excisions done in an office setting are sent to an outside laboratory for standard bread loafing method of processing. With this method, it is likely that less than 5% of the

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Nodular basal-cell carcinoma (also known as "classic basal-cell carcinoma") accounts for 50% of all BCC. It most commonly occurs on the sun-exposed areas of the head and neck. Histopathology shows aggregates of basaloid cells with well-defined borders, showing a peripheral

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these keratinocyte-derived cancers. The review did ultimately state that the certainty of these results was low, so future evidence could very well alter this conclusion. One-third occur in non-sun-exposed areas; thus, the pathogenesis is more complex than UV exposure as

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Usually, recurrent tumors after radiation are treated with surgery, and not with radiation. Further radiation treatment will further damage normal tissue, and the tumor might be resistant to further radiation. Radiation therapy may be contraindicated for treatment of

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basal-cell carcinoma (as much as one third of all cancer diagnoses), affecting 1 in 7 individuals over a lifetime. This tumor accounts for approximately 70% of non-melanoma skin cancers. In 80 percent of all cases, basal-cell carcinoma affects head or neck skin.

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The major source of ultraviolet radiation is solar radiation or sunlight. However, exposure to artificial sources particularly through tanning salons is becoming more important in terms of human health effects, as use of these facilities by young people,

451: 1447:, traditionally an anti-fungal medication, has also garnered recent attention for its potential use in the treatment of BCC, especially those that cannot be removed surgically. Possessing anti-Hedgehog pathway activity, there is clinical evidence that 4115: 4099: 1565:

is excellent if the appropriate method of treatment is used in early primary basal-cell cancers. Recurrent cancers are much harder to cure, with a higher recurrence rate with any methods of treatment. Although basal-cell carcinoma rarely

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Superficial basal-cell carcinoma, formerly referred to in-situ basal-cell carcinoma, is characterized by a superficial proliferation of neoplastic basal-cells. This tumor is generally responsive to topic chemotherapy, such as

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Most sporadic BCC arises in small numbers on sun-exposed skin of people over age 50, although younger people may also be affected. The development of multiple basal-cell cancer at an early age could be indicative of

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or chemotherapy to make sure the surgical wound has adequately healed. Some people advocate the use of curettage (see EDC below) first, followed by chemotherapy. These experimental procedures are not standard care.

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Basal-cell carcinoma is a common skin cancer and occurs mainly in fair-skinned patients with a family history of this cancer. Sunlight is a factor in about two-thirds of these cancers; therefore, doctors recommend

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Cells arranged in a diffuse, trabecular and/or nested pattern, involving also the subcutis. Mouse Anti-Cytokeratin (CAM) 5.2+, CK20+, S100-, human leukocyte common antigen- ( LCA-), thyroid transcription factor 1-

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agent. One can expect a great deal of inflammation with this treatment. Chemotherapy often follows Mohs surgery to eliminate the residual superficial basal-cell carcinoma after the invasive portion is removed.

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For many new (primary) and all recurrent forms of basal cell carcinoma after previous surgery, especially on the head, neck, hands, feet, genitalia and anterior legs (shins), Mohs surgery should be considered.

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Lubeek SF, van Vugt LJ, Aben KK, van de Kerkhof PC, Gerritsen MP (2017). "The epidemiology and clinicopathological features of basal cell carcinoma in patients 80 years and older: a systematic review".

1818:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015" 2396:

Epstein EH, Shepard JA, Flotte TJ (January 2008). "Case records of the Massachusetts General Hospital. Case 3-2008. An 80-year-old woman with cutaneous basal-cell carcinomas and cysts of the jaws".

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Laffay L, Depaepe L, d'Hombres A, Balme B, Thomas L, De Bari B (2012). "Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature".

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appearance of the cancer cells under the microscope. Nevertheless, not all basal-cell carcinomas actually originate within the basal layer. Basal-cell carcinomas are thought to develop from the

4235: 1574:. The vast majority of cases can be successfully treated before serious complications occur. The recurrence rate for the above treatment options ranges from 50 percent to 1 percent or less. 1237:

Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.

3725:"Imiquimod 5% cream as adjunctive therapy for primary, solitary, nodular nasal basal-cell carcinomas before Mohs micrographic surgery: a randomized, double blind, vehicle-controlled study" 636:. Exfoliative cytology methods have high sensitivity and specificity for confirming the diagnosis of basal cell carcinoma when clinical suspicion is high but unclear usefulness otherwise. 1426:

Removing the residual superficial tumor with surgery alone can result in large and difficult to repair surgical defects. One often waits a month or more after surgery before starting the

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East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, et al. (2016). "Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration".

1570:, it grows locally with invasion and destruction of local tissues. The cancer can impinge on vital structures like nerves and result in loss of sensation or loss of function or rarely 684:, although surgical treatment is better able to ensure complete removal and confirm that there is not an underlying more aggressive subtype that was not sampled in the initial biopsy. 3780: 698:

Nodular basal-cell carcinoma includes most of the remaining categories of basal-cell cancer. It is not unusual to encounter heterogeneous morphologic features within the same tumor.

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is examined, as each slice of tissue is only 6 micrometres thick, about 3 to 4 serial slices are obtained per section, and only about 3 to 4 sections are obtained per specimen.

1534:. A 2008 study reported that radiation therapy is appropriate for primary BCCs and recurrent BCCs, but not for BCCs that have recurred following previous radiation treatment. 1171: 2849:

Krynitz B, Olsson H, Lundh Rozell B, Lindelöf B, Edgren G, Smedby K (2016). "Risk of basal cell carcinoma in Swedish organ transplant recipients: a population-based study".

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Farhi D, Dupin N, Palangié A, Carlotti A, Avril MF (October 2007). "Incomplete excision of basal cell carcinoma: rate and associated factors among 362 consecutive cases".

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This technique uses the body's immune system to kill cancer cells. Improvement of the immune system works its way out up to the cancerous cells and treat the skin cancer.

2268: 531:(differential diagnosis can be challenging). It has been suggested that lesions diagnosed as 'trichoblastic carcinoma' may actually themselves be basal-cell carcinoma. 5966: 1649: 1308:

structures. There is no clear approach, nor a clear research comparing the effectiveness of Mohs micrographic surgery versus surgical excision for BCC of the eye.

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has received FDA approval, and topical IMQ is approved by the European Medicines Agency for treatment of small superficial basal-cell carcinoma. Off label use of

569:, or Gorlin Syndrome, which is also characterized by keratocystic odontogenic tumors of the jaw, palmar or plantar (sole of the foot) pits, calcification of the 6501: 6406: 4742: 434: 1582:

Basal-cell cancer is a very common skin cancer. It is much more common in fair-skinned individuals with a family history of basal-cell cancer and increases in

318:, about 80% are basal-cell cancers. In the United States, about 35% of white males and 25% of white females are affected by BCC at some point in their lives. 6162: 2735: 2510: 6198: 2060: 616:. Most nodular basal-cell cancers can be diagnosed clinically; however, other variants can be very difficult to distinguish from benign lesions such as 1095:

Peripheral sections may look like nests, but do not display atypia, nuclei are smaller, and serial sections will reveal the rest of the hair follicle.

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in the 1930s, in which the tumor is surgically excised and then immediately examined under a microscope. It is a form of pathology processing called

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affects the risk of basal-cell cancer. Treatment is typically by surgical removal. This can be by simple excision if the cancer is small; otherwise,

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is a term used to describe a rare and potentially aggressive malignancy that is also thought to arise from trichoblasts and may resemble a benign

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has some efficacy either alone or when combined with vismodegib/sonidegib for primary and recurrent BCC. There is one case report of efficacy in

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Lack of basaloid cells disposed in peripheral palisades; adenoid-cystic lesion without connection to the epidermis; absence of artefactual clefts

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metaplasia (H&E stain at left in image). BerEP4 staining helps in such cases, staining only basal-cell carcinoma cells (right in image).

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on invasive basal-cell carcinoma has been reported. Imiquimod may be used prior to surgery in order to reduce the size of the carcinoma.

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basal-cell cancer, is more difficult to treat with conservative methods, given its tendency to penetrate into deeper layers of the skin.

457: 1775: 1490:, a common garden weed, may be effective. Australian biopharmaceutical company Peplin is developing this as topical treatment for BCC. 398: 6107: 5374: 5323: 4831: 6039: 6034: 4732: 3628:

Barlow JO, Zalla MJ, Kyle A, DiCaudo DJ, Lim KK, Yiannias JA (June 2006). "Treatment of basal cell carcinoma with curettage alone".

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cream (IMQ), with five applications per week for six weeks has a reported 70–90% success rate at reducing, even removing, the BCC .

3042:"Chemoprevention of Basal and Squamous Cell Carcinoma With a Single Course of Fluorouracil, 5%, Cream: A Randomized Clinical Trial" 4026: 3664: 6411: 6102: 6069: 6019: 5855: 4841: 1399: 280: 644: 6426: 6167: 6097: 5952: 5859: 5692: 1348: 3512:

Kokoszka A, Scheinfeld N (June 2003). "Evidence-based review of the use of cryosurgery in treatment of basal-cell carcinoma".

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to the target area. When these molecules are activated by light, they become toxic, therefore destroying the target cells.

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Ip KH, McKerrow K (2021). "Itraconazole in the treatment of basal cell carcinoma: A case-based review of the literature".

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Morpheaform basal-cell carcinoma (also known as "cicatricial basal-cell carcinoma", and "morphoeic basal-cell carcinoma")

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Fusco N, Lopez G, Gianelli U (September 2015). "Basal-Cell Carcinoma and Seborrheic Keratosis: When Opposites Attract".

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Boettler MA, Shahwan KT, Abidi NY, Carr DR (2022). "Trichoblastic carcinoma: a comprehensive review of the literature".

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Lane JE, Kent DE (2005). "Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery".

1359:, and multiple other skin cancers; usually with cure rates higher than for other surgical and non-surgical treatments. 1219: 6024: 5844: 5761: 5394: 4910: 4441: 4396: 727: 542:

removes most UV-induced damage, not all crosslinks are excised. There is, therefore, cumulative DNA damage leading to

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have become another common source of ultraviolet radiation. Diagnosis often depends on skin examination, confirmed by

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Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, et al. (July 2016).

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is an old modality for the treatment of many skin cancers. When accurately utilized with a temperature probe and

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Fibroepitheliomatous pattern (anastomosing basaloid epithelial strands enclosing round islands of fibrous stroma)

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Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, et al. (December 2018).

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Cakir BÖ, Adamson P, Cingi C (November 2012). "Epidemiology and economic burden of nonmelanoma skin cancer".

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Peng Q, Juzeniene A, Chen J, Svaasand LO, Warloe T, Giercksky KE, et al. (2008). "Lasers in medicine".

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Some advocate the use of imiquimod prior to Mohs surgery to remove the superficial component of the cancer.

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Basal-cell carcinoma cells appear similar to epidermal basal cells, and are usually well differentiated.

573:(in the center line of the brain) and rib abnormalities. The cause of this syndrome is a mutation in the 6208: 6183: 5929: 5653: 5170: 5097: 4785: 4319: 4299: 2262: 1352: 1263: 1209: 577: 1545:(PDT) is a new modality for treatment of basal-cell carcinoma, which is administered by application of 1441:

are drugs approved for specially treating BCC, but are expensive and cannot be used in pregnant women.

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Telfer NR, Colver GB, Morton CA (July 2008). "Guidelines for the management of basal-cell carcinoma".

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is a term sometimes used to refer to a rare type of aggressive skin cancer that may resemble a benign

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Ackerman AB, Kerl H, Sánchez J, Guo Y (2000). "Basal-cell carcinoma: integration unifying concept".

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Weinstock MA, Thwin SS, Siegel JA, Marcolivio K, Means AD, Leader NF, et al. (February 2018).

2944:"Microcystic adnexal carcinoma of the cheek – a case report with dermatoscopy and dermatopathology" 3166:"Basal cell carcinoma of the eyelid. Risk of recurrence according to adequacy of surgical margins" 1201: 692: 303:, a topical immune-activating medication. In the rare cases in which distant spread has occurred, 6511: 6193: 6134: 5726: 5558: 5521: 5399: 5087: 4951: 4836: 4795: 4669: 4664: 4659: 4486: 3930: 3886: 3754: 3705: 3610: 3230: 2874: 2781: 2375: 2307: 2215: 2031: 1164:

Bland keratinocytes, keratin cysts, ductal differentiation. BerEp4- (in 60% of cases), CEA+, EMA+

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Superficial basal-cell carcinoma (also known as "superficial multicentric basal-cell carcinoma")

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Basal-cell cancer accounts for at least 32% of all cancers globally. Of skin cancers other than

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Cribier B (2018). "From basal cell carcinoma to trichoblastic tumors: a diagnostic challenge".

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There are mainly three patterns of aggressiveness, based mainly the cohesion of cancer cells:

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Basal-cell carcinoma can broadly be divided into three groups, based on the growth patterns.

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Castellucci P, Savoia F, Farina A, Lima GM, Patrizi A, Baraldi C, et al. (2020-11-02).

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Basal-cell carcinomas can often come in association with other lesions of the skin, such as

308: 257: 233:. Basal-cell cancer grows slowly and can damage the tissue around it, but it is unlikely to 17: 2462:"Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults" 1690:

Gandhi SA, Kampp J (November 2015). "Skin Cancer Epidemiology, Detection, and Management".

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and especially complex localisations or structures (e.g. earlobe) as well as the genitals.

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Basal cell carcinoma on the left upper back, nodular and micronodular, marked for biopsy

6476: 6154: 5526: 5455: 5288: 5278: 5195: 4737: 4565: 4135: 4018: 3838: 3662: 3330:"Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology" 3274: 3249: 3115: 3090: 3066: 3041: 3017: 2992: 2968: 2943: 2918: 2893: 2825: 2800: 2623: 2596: 2560: 2534:"The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma" 2533: 2486: 2461: 1842: 1817: 1411: 1275: 1125: 1090: 867: 625: 528: 350: 226: 94: 3995: 3970: 3525: 3182: 3165: 3089:

Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ (November 17, 2020).

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Ulcerated basal-cell carcinoma affecting the skin of the nose in an elderly individual

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List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer

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in form of the Rhenium-SCT). It is used in accordance to the general indications for

1515: 1506: 1427: 547: 535: 506: 369:. Infiltrative or morpheaform basal-cell cancers can present as a skin thickening or 330: 296: 265: 4124: 3758: 3614: 3234: 2878: 2785: 2327:

A clinical atlas of 101 common skin diseases : with histopathologic correlation

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Absence of any apparent carcinogenic factor, and occurring in odd sites such as the

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can be used, having a high sensitivity and specificity in detecting only BCC cells.

565:. In a small proportion of cases, basal-cell carcinoma also develops as a result of 361:

Individuals with a basal-cell carcinoma typically present with a shiny, pearly skin

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The following methods are employed in the treatment of basal-cell carcinoma (BCC):

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Mansouri B, Bicknell LM, Hill D, Walker GD, Fiala K, Housewright C (2017-08-01).

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Narrow strands and nests of basaloid cells. "Cicatricial" or "morphoeic" pattern.

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Narrow strands and nests of basaloid cells, surrounded by dense sclerotic stroma.

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gene, which is also on the hedgehog pathway, also causes basal-cell carcinoma.

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tissue – making diagnosis difficult without using tactile sensation and a skin

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Desmoplastic tricoepithelioma is particularly similar to basal-cell carcinoma.

1567: 1452: 1434: 585: 539: 472: 234: 225:. It often appears as a painless raised area of skin, which may be shiny with 110: 3986: 3813: 2894:"Dermoscopic Description of Fibroepithelioma of Pinkus with Negative Network" 2736:"Which histologic findings are characteristic of basal cell carcinoma (BCC)?" 2511:"Which histologic findings are characteristic of basal cell carcinoma (BCC)?" 2363: 1955:

Gallagher RP, Lee TK, Bajdik CD, Borugian M (2010). "Ultraviolet radiation".

6231: 5994: 5979: 5685: 5621: 5361: 5357: 5258: 5208: 4972: 4559: 4531: 4436: 4271: 4199: 3947: 3346: 3329: 1968: 1562: 1475: 1471: 1467: 1438: 1279: 1259: 677: 629: 621: 498: 476: 326: 300: 272: 175: 160: 4004: 3926: 3847: 3750: 3701: 3649: 3606: 3533: 3473: 3438: 3396: 3355: 3283: 3226: 3124: 3075: 3026: 2977: 2927: 2870: 2834: 2777: 2632: 2569: 2550: 2495: 2417: 2409: 2371: 2303: 2254: 2211: 2103: 2027: 2018: 2001: 1976: 1941: 1851: 1711: 546:. Apart from the mutagenesis, overexposure to sunlight depresses the local 3314: 3191: 5283: 4905: 4885: 4821: 4775: 4717: 4654: 4596: 4416: 4365: 4294: 2993:"Sun protection for preventing basal-cell and squamous cell skin cancers" 2740: 1761:

Nutrition for Healthy Skin: Strategies for Clinical and Cosmetic Practice

1340: 954: 543: 315: 156: 81: 3415:"Mohs Micrographic Surgery for the Management of Cutaneous Malignancies" 2959: 2909: 1387:

however, comparing cryosurgery with other modalities, particularly with

1327:(or Mohs micrographic surgery) is an outpatient procedure, developed by 5643: 5450: 5422: 5082: 4936: 4846: 4765: 4752: 4702: 4631: 4355: 4350: 4345: 2246: 1130:

Absence of cleft, rudimentary hair germs, papillary mesenchymal bodies.

946: 782:

Morphologically characterized by dome-shaped, blue-gray cystic nodules.

608:

is performed for histopathologic analyses. The most common method is a

377:. It is often difficult to visually distinguish basal-cell cancer from 253: 122: 4091: 3693: 2892:

Yonan Y, Maly C, DiCaudo D, Mangold A, Pittelkow M, Swanson D (2019).

2862: 1816:

GBD 2015 Mortality and Causes of Death Collaborators (October 2016).

59: 5920: 5713: 5507: 5340: 4694: 4639: 4406: 4401: 4375: 4284: 4103: 4049:

Neurocutaneous Disorders Phakomatoses and Hamartoneoplastic Syndromes

1332: 1246: 958: 660: 374: 366: 67:

An ulcerated basal cell carcinoma near the ear of a 75-year-old male

4047:

Gorlin RJ (2008). "Nevoid Basal Cell Carcinoma (Gorlin) Syndrome".

32:"Rodent ulcer" redirects here. For the skin condition in cats, see 6437: 5441: 4360: 2082:

Dubas LE, Ingraffea A (February 2013). "Nonmelanoma skin cancer".

1571: 1519: 1298: 950: 706: 643: 595: 574: 467: 230: 148: 98: 260:. Exposure to UV light during childhood is particularly harmful. 6335: 6327: 4941: 4460: 4279: 4147: 4108: 2847:

From the "Glas classification" or "Sabbatsberg classification":

861:

Pigmented basal-cell carcinoma exhibits increased melanization.

378: 370: 5948: 5312: 4231: 550:, possibly decreasing immune surveillance for new tumor cells. 2595:

Paolino G, Donati M, Didona D, Mercuri S, Cantisani C (2017).

1984: 757:

Other more specific subtypes of basal-cell carcinoma include:

483:(peripheral palisading, myxoid stroma, artefactual clefting). 3818:

European Journal of Nuclear Medicine and Molecular Imaging

3580: 3578: 3576: 3574: 3572: 687:

Infiltrative basal-cell carcinoma, which also encompasses

3793: 900:

Anastomosing epithelial strands in a fenestrated pattern

1410:

Some superficial cancers respond to local therapy with

353:, and can also closely resemble basal cell carcinoma). 2527: 2525: 2002:"UV protection and sunscreens: what to tell patients" 648:

High-magnification micrograph of basal-cell carcinoma

4081: 3091:"Interventions for basal cell carcinoma of the skin" 2589: 2587: 2585: 2583: 2581: 2579: 1303:

Basal cell carcinoma, right cheek, marked for biopsy

845:

Occurs most commonly on the trunk and appears as an

93:

Painless raised area of skin that may be shiny with

6469: 6435: 6374: 6367: 6326: 6293: 6230: 6221: 6176: 6153: 6085: 6002: 5993: 5986: 5919: 5892: 5869: 5830: 5819: 5783: 5735: 5712: 5701: 5666: 5609: 5572: 5544: 5463: 5449: 5440: 5408: 5356: 5347: 5227: 5194: 5138: 5123: 5114: 5071: 5042: 5021: 5012: 4965: 4924: 4893: 4882: 4875: 4864: 4809: 4751: 4693: 4630: 4550: 4479: 4468: 4459: 4374: 4338: 4270: 4263: 4179: 4085: 2711:

Andrews' Diseases of the Skin: clinical Dermatology

2656: 2654: 2652: 2650: 2648: 2646: 2644: 2642: 2597:"Histology of Non-Melanoma Skin Cancers: An Update" 192: 184: 174: 166: 142: 132: 104: 87: 71: 49: 44: 3248:Narayanan K, Hadid OH, Barnes EA (December 2014). 1241:In suspected but uncertain BCC cells close to the 4258:Diseases of the skin and appendages by morphology 1795:. World Health Organization. 2014. Chapter 5.14. 1518:is the epidermal radioisotope therapy (e.g. with 580:located in chromosome 9q22.3, which inhibits the 870:are pigmented while this subtype is uncommon in 279:is generally recommended. Other options include 3419:Facial Plastic Surgery Clinics of North America 2704: 2702: 2700: 2698: 2118:"Basal Cell Carcinoma Warning Signs and Images" 2084:Facial Plastic Surgery Clinics of North America 1922:Facial Plastic Surgery Clinics of North America 456:The majority of basal-cell carcinomas occur on 53:Basal-cell skin cancer, basalioma, rodent ulcer 3723:Butler DF, Parekh PK, Lenis A (January 2009). 3630:Journal of the American Academy of Dermatology 2696: 2694: 2692: 2690: 2688: 2686: 2684: 2682: 2680: 2678: 1636: 1634: 1632: 534:Overexposure to sun leads to the formation of 6407:Inflammatory linear verrucous epidermal nevus 5960: 5324: 4743:Pityriasis lichenoides et varioliformis acuta 4243: 3969:Wong CS, Strange RC, Lear JT (October 2003). 3548:"Understanding Actinic Keratosis – Treatment" 3328:Bichakjian CK, Olencki T, Olencki SZ (2016). 2662:Fitzpatrick's Dermatology in General Medicine 2267:: CS1 maint: DOI inactive as of March 2024 ( 1723: 1721: 8: 4397:Dermatofibroma (benign fibrous histiocytoma) 3948:Skin Cancer Foundation: Basal-Cell Carcinoma 2047: 2045: 2000:Jou PC, Feldman RJ, Tomecki KJ (June 2012). 1892:"Basal Cell Carcinoma (Rodent Ulcer or BCC)" 1274:The use of a chemotherapeutic agent such as 935:Resembles an enlarged pore or stellate pit. 229:. It may also present as a raised area with 6163:Aggressive digital papillary adenocarcinoma 3421:. Facial Reconstruction Post-Mohs Surgery. 3254:The Cochrane Database of Systematic Reviews 3095:The Cochrane Database of Systematic Reviews 2997:The Cochrane Database of Systematic Reviews 2466:The Cochrane Database of Systematic Reviews 2352:International Journal of Surgical Pathology 6371: 6227: 6199:Primary cutaneous adenoid cystic carcinoma 5999: 5990: 5967: 5953: 5945: 5827: 5709: 5460: 5446: 5353: 5331: 5317: 5309: 5120: 5018: 4890: 4879: 4872: 4476: 4465: 4267: 4250: 4236: 4228: 4082: 3773:"Peplin's skin cancer gel trial a success" 3164:Sigurdsson H, Agnarsson BA (August 1998). 58: 41: 3994: 3964: 3962: 3837: 3740: 3487:Maloney ME, Torres A, Hoffman TJ (1999). 3345: 3273: 3181: 3140:Basal Cell and Squamous Cell Skin Cancers 3114: 3065: 3016: 2967: 2917: 2824: 2709:James WD, Berger TG, et al. (2006). 2622: 2612: 2559: 2549: 2485: 2017: 1915: 1913: 1841: 1787: 1785: 1509:(mostly internal radiotherapy). Although 866:About 80% of all basal-cell carcinoma in 711:Basal-cell carcinoma with nodular pattern 440:Dermoscopy showing telangiectatic vessels 6417:Pigmented hairy epidermal nevus syndrome 2758:The American Journal of Dermatopathology 1896:Newcastle Hospitals NHS Foundation Trust 1685: 1683: 1681: 1679: 1677: 1675: 1673: 1671: 1669: 1667: 1232: 1068: 974: 759: 321:Basal-cell carcinoma is named after the 6456:Unilateral palmoplantar verrucous nevus 2799:Haddock ES, Cohen PR (September 2016). 2532:Sunjaya AP, Sunjaya AF, Tan ST (2017). 2173:"Basal Cell Carcinoma - Skin Disorders" 1628: 1608: 1484:Research suggests that treatment using 1167: 1045: 1029: 989: 903:Most commonly occurs on the lower back. 723: 394: 188:~30% of white people at some point (US) 6461:Zosteriform speckled lentiginous nevus 6308:Keratoacanthoma centrifugum marginatum 5050:Disseminated intravascular coagulation 2948:Dermatology Practical & Conceptual 2898:Dermatology Practical & Conceptual 2801:"Fibroepithelioma of Pinkus Revisited" 2260: 2167: 2165: 497:that populate the lowest layer of the 404:Basal cell carcinoma on patient's back 3408: 3406: 3369: 3367: 3365: 2391: 2389: 2139: 2137: 604:To diagnose basal-cell carcinomas, a 7: 6502:Epidermal nevi, neoplasms, and cysts 6077:Nevoid basal-cell carcinoma syndrome 2932:Creative Commons Attribution License 2006:Cleveland Clinic Journal of Medicine 1692:The Medical Clinics of North America 1593:nevoid basal-cell carcinoma syndrome 1532:nevoid basal-cell carcinoma syndrome 329:. It is thought to develop from the 5806:Papillary serous cystadenocarcinoma 3682:Australasian Journal of Dermatology 2398:The New England Journal of Medicine 1108:Squamous-cell carcinoma of the skin 227:small blood vessels running over it 5375:Combined small-cell lung carcinoma 4832:Postinflammatory hyperpigmentation 3783:from the original on 16 June 2006. 3587:The British Journal of Dermatology 823:Micronodular basal-cell carcinoma 812:Infiltrative basal-cell carcinoma 325:that form the lowest layer of the 95:small blood vessel running over it 25: 4733:Transient acantholytic dermatosis 3526:10.1046/j.1524-4725.2003.291511.x 3183:10.1034/j.1600-0420.1998.760416.x 3170:Acta Ophthalmologica Scandinavica 240:Risk factors include exposure to 6412:Linear verrucous epidermal nevus 4842:Idiopathic guttate hypomelanosis 3742:10.1111/j.1524-4725.2008.34378.x 3599:10.1111/j.1365-2133.2008.08666.x 3219:10.1111/j.1524-4725.2007.33255.x 2063:from the original on 4 July 2017 1778:from the original on 2017-09-10. 1739:from the original on 4 July 2017 1652:from the original on 5 July 2014 1400:Electrodesiccation and curettage 1395:Electrodesiccation and curettage 1218: 1200: 1179: 1170: 1150: 1133: 1116: 1098: 1048: 1032: 1016: 1004: 992: 906: 852: 831: 803: 785: 740: 726: 433: 421: 409: 397: 281:electrodesiccation and curettage 6517:Dermal and subcutaneous growths 6427:Phakomatosis pigmentokeratotica 5693:Syringocystadenoma papilliferum 4852:Hypopigmented mycosis fungoides 4029:from the original on 2011-05-14 3558:from the original on 2007-08-11 2442:from the original on 2009-03-01 1349:dermatofibrosarcoma protuberans 930:Pore-like basal-cell carcinoma 885:Nodular, with central necrosis. 826:Small and closely spaced nests. 27:Most common type of skin cancer 5481:Familial adenomatous polyposis 5093:Lichen sclerosis et atrophicus 4801:Subcorneal pustular dermatosis 4427:Infantile digital fibromatosis 3919:10.1001/jamadermatol.2016.3628 3863:Reports on Progress in Physics 3266:10.1002/14651858.CD007041.pub4 3107:10.1002/14651858.CD003412.pub3 3058:10.1001/jamadermatol.2017.3631 3009:10.1002/14651858.CD011161.pub2 2851:British Journal of Dermatology 1758:Krutmann J, Humbert P (2010). 1642:"Skin Cancer Treatment (PDQ®)" 940:Aberrant basal-cell carcinoma 915:Polypoid basal-cell carcinoma 538:, a form of DNA damage. While 1: 6189:Microcystic adnexal carcinoma 5856:Paget's disease of the breast 5798:Pancreatic serous cystadenoma 4685:Epidermolysis bullosa simplex 4522:Langerhans cell histiocytosis 4019:"Epidemiology of Skin Cancer" 3883:10.1088/0034-4885/71/5/056701 2329:. New York: Ardor Scribendi. 2296:10.1016/S0151-9638(18)31254-7 1834:10.1016/s0140-6736(16)31012-1 1357:microcystic adnexal carcinoma 1249:can highlight the BCC cells. 1160:Microcystic adnexal carcinoma 981:Moderately aggressive pattern 479:, showing the characteristic 221:, is the most common type of 6422:Systematized epidermal nevus 6168:Extramammary Paget's disease 5860:Extramammary Paget's disease 5587:Multiple endocrine neoplasia 5161:Systemic lupus erythematosus 4916:Systemic lupus erythematosus 4607:Systemic lupus erythematosus 4057:10.1007/978-3-211-69500-5_45 3466:10.1016/j.cursur.2005.01.003 2770:10.1097/DAD.0000000000000541 1245:, immunohistochemistry with 978:Low-level aggressive pattern 925:Generally on head and neck. 777:Cystic basal-cell carcinoma 703:Nodular basal-cell carcinoma 18:Classic basal cell carcinoma 5845:Pancreatic ductal carcinoma 5762:Mucinous cystadenocarcinoma 5395:Transitional cell carcinoma 4442:Lymphangioma circumscriptum 3375:Society for Mohs Surgery". 2614:10.3390/biomedicines5040071 2432:"What Is Basal Cell Cancer" 2177:MSD Manual Consumer Version 1501:can be delivered either as 1423:has received FDA approval. 897:Fibroepithelioma of Pinkus 517:germinative cells known as 271:It remains unclear whether 258:poor immune-system function 6533: 6395:Nevus comedonicus syndrome 6030:Fibroepithelioma of Pinkus 5902:Medullary breast carcinoma 5884:Invasive lobular carcinoma 5794:Ovarian serous cystadenoma 5745:Signet ring cell carcinoma 5264:Mucous membrane pemphigoid 3830:10.1007/s00259-020-05088-z 3642:10.1016/j.jaad.2006.01.041 3491:. Blackwell. p. 113. 3389:10.1016/j.jaad.2012.06.009 2942:Inskip M, Magee J (2015). 2664:. (6th ed.). McGraw-Hill. 2660:Freedberg, et al. (2003). 2204:10.1007/s00403-021-02241-y 2122:The Skin Cancer Foundation 1957:Chronic Diseases in Canada 1704:10.1016/j.mcna.2015.06.002 1503:external beam radiotherapy 1466:Topical treatment with 5% 1295:Standard surgical excision 984:Highly aggressive pattern 582:hedgehog signaling pathway 449: 31: 5879:Lobular carcinoma in situ 5802:Serous cystadenocarcinoma 5639:Clear-cell adenocarcinoma 5428:Bartholin gland carcinoma 5339:Glandular and epithelial 3779:. Melbourne. 1 May 2006. 3489:Surgical Dermatopathology 3431:10.1016/j.fsc.2017.03.002 2817:10.1007/s13555-016-0123-8 2478:10.1002/14651858.cd013187 2149:National Cancer Institute 2145:"Genetics of Skin Cancer" 2096:10.1016/j.fsc.2012.10.003 2057:National Cancer Institute 1934:10.1016/j.fsc.2012.07.004 1733:National Cancer Institute 1074:of basal cell carcinoma: 567:basal-cell nevus syndrome 481:histomorphologic features 341:germinative cells called 66: 57: 6390:Schimmelpenning syndrome 6385:Epidermal nevus syndrome 6140:Erythroplasia of Queyrat 5907:Medullary thyroid cancer 5840:Mammary ductal carcinoma 5775:Mucoepidermoid carcinoma 5629:Adenoid cystic carcinoma 5596:Adrenocortical carcinoma 5536:Hepatocellular carcinoma 5029:Thrombocytopenic purpura 4675:Dermatitis herpetiformis 4660:Acute contact dermatitis 4612:Pityriasis rubra pilaris 4537:Wiskott–Aldrich syndrome 4507:Lichen simplex chronicus 4387:Epidermal inclusion cyst 3987:10.1136/bmj.327.7418.794 2364:10.1177/1066896915593802 1793:World Cancer Report 2014 1764:. Springer. p. 31. 1362:An essential aspect of 1143:Adenoid cystic carcinoma 252:, long-term exposure to 138:Examination, skin biopsy 5385:Squamous-cell carcinoma 5294:Squamous-cell carcinoma 5289:Systemic histoplasmosis 4680:Porphyria cutanea tarda 4310:Squamous-cell carcinoma 3347:10.6004/jnccn.2016.0065 2805:Dermatology and Therapy 2593:Initially copied from: 2249:(inactive 2024-03-13). 2053:"Skin Cancer Treatment" 1969:10.24095/hpcdp.29.S1.04 1729:"Skin Cancer Treatment" 1337:squamous-cell carcinoma 968:Aggressiveness patterns 892:with central necrosis. 563:squamous cell carcinoma 524:Trichoblastic carcinoma 347:trichoblastic carcinoma 235:spread to distant areas 6270:Pilar sheath acanthoma 5768:Pseudomyxoma peritonei 5592:Adrenocortical adenoma 5532:Hepatocellular adenoma 5269:Cicatricial pemphigoid 5186:Acne keloidalis nuchae 5181:Folliculitis decalvans 3971:"Basal cell carcinoma" 3799:June 14, 2008, at the 3334:J Natl Compr Canc Netw 2538:Journal of Skin Cancer 2410:10.1056/NEJMcpc0707893 2019:10.3949/ccjm.79a.11110 1866:"Basal Cell Carcinoma" 1551:Methyl aminolevulinate 1345:atypical fibroxanthoma 1304: 1238: 1079:Differential diagnosis 1072:differential diagnoses 1065:Differential diagnoses 712: 649: 601: 487: 144:Differential diagnosis 34:Eosinophilic granuloma 6209:Malignant mixed tumor 6184:Merkel-cell carcinoma 5930:Acinic cell carcinoma 5654:Papillary hidradenoma 5171:Loose anagen syndrome 5098:Necrobiosis lipoidica 5034:Actinic/solar purpura 4708:Insect bite reactions 4497:Seborrheic dermatitis 4320:Merkel-cell carcinoma 4300:Molluscum contagiosum 2746:Updated: Feb 21, 2019 2713:. Saunders Elsevier. 2519:Updated: Feb 21, 2019 2290:(Suppl 5): VS3–VS11. 2284:Ann Dermatol Venereol 1353:Merkel cell carcinoma 1302: 1236: 1210:Merkel cell carcinoma 1082:Pathological Features 769:Other characteristics 710: 647: 634:hypertrophic scarring 599: 578:tumor suppressor gene 471: 6303:Generalized eruptive 6280:Seborrheic keratosis 5758:Mucinous cystadenoma 5617:Neuroendocrine tumor 5554:Renal cell carcinoma 5390:Basal-cell carcinoma 5370:Small-cell carcinoma 4994:Annulare centrifugum 4517:Glucagonoma syndrome 4315:Basal-cell carcinoma 4290:Seborrheic keratosis 4216:Basal-cell carcinoma 3729:Dermatologic Surgery 3514:Dermatologic Surgery 3207:Dermatologic Surgery 2551:10.1155/2017/2692604 1988:] has increased. 1828:(10053): 1459–1544. 1543:Photodynamic therapy 1538:Photodynamic therapy 1312:supply to the flap. 657:immunohistochemistry 655:In uncertain cases, 584:. A mutation in the 559:seborrheic keratosis 491:Basal-cell carcinoma 416:Basal-cell carcinoma 293:photodynamic therapy 289:topical chemotherapy 237:or result in death. 203:Basal-cell carcinoma 153:seborrheic keratosis 127:poor immune function 45:Basal-cell carcinoma 6446:Nevus unius lateris 6204:Verrucous carcinoma 5894:Medullary carcinoma 5380:Verrucous carcinoma 5239:Aphthous stomatitis 5176:Lichen planopilaris 5151:Androgenic alopecia 4957:Fixed drug eruption 4532:Pemphigus foliaceus 4432:Granular cell tumor 4051:. pp. 669–94. 3875:2008RPPh...71e6701P 3315:10.24296/jomi/290.6 2960:10.5826/dpc.0501a07 2910:10.5826/dpc.0903a23 1075: 918:Exophytic nodules ( 493:is named after the 460:areas of the body. 6194:Mucinous carcinoma 6135:Bowenoid papulosis 5727:Cystadenocarcinoma 5559:Endometrioid tumor 5522:Cholangiocarcinoma 5410:Complex epithelial 5400:Inverted papilloma 5259:Pemphigus vulgaris 5088:Granuloma annulare 4952:Carcinoid syndrome 4837:Tuberous sclerosis 4796:Coccidioidomycosis 4670:Bullous pemphigoid 4665:Pemphigus vulgaris 4597:Secondary syphilis 4487:Contact dermatitis 4180:External resources 3953:2006-06-19 at the 3667:2009-05-20 at the 3377:J Am Acad Dermatol 3297:Hallock G (2020). 2247:10.1700/1088.11948 1963:(Suppl 1): 51–68. 1305: 1239: 1070:Main histological 1069: 888:Generally a large 815:Deep infiltration. 713: 650: 618:intradermal naevus 602: 488: 357:Signs and symptoms 6489: 6488: 6485: 6484: 6402:Nevus comedonicus 6363: 6362: 6359: 6358: 6285:Warty dyskeratoma 6217: 6216: 6145:Actinic keratosis 5942: 5941: 5938: 5937: 5915: 5914: 5871:Lobular carcinoma 5815: 5814: 5662: 5661: 5436: 5435: 5306: 5305: 5302: 5301: 5146:Telogen effluvium 5110: 5109: 5106: 5105: 5067: 5066: 5063: 5062: 5008: 5007: 4860: 4859: 4728:Lichen spinulosus 4723:Keratosis pilaris 4602:Mycosis fungoides 4502:Stasis dermatitis 4492:Atopic dermatitis 4455: 4454: 4330:Trichoepithelioma 4305:Actinic keratosis 4225: 4224: 4066:978-3-211-21396-4 3694:10.1111/ajd.13655 3498:978-0-86542-299-5 2863:10.1111/bjd.14153 2720:978-0-7216-2921-6 2336:978-1-893357-10-5 2192:Arch Dermatol Res 1898:. 31 October 2022 1872:. 26 October 2023 1802:978-92-832-0429-9 1771:978-3-642-12264-4 1499:Radiation therapy 1243:resection margins 1226: 1225: 1192:Trichoepithelioma 1062: 1061: 1039:Moderate cohesion 965: 964: 922:-like structures) 555:actinic keratosis 383:actinic elastosis 250:radiation therapy 242:ultraviolet light 211:basal-cell cancer 209:), also known as 200: 199: 134:Diagnostic method 119:radiation therapy 115:ultraviolet light 39:Medical condition 16:(Redirected from 6524: 6451:Patch blue nevus 6372: 6336:Verruca vulgaris 6228: 6125:Marjolin's ulcer 6113:Signet-ring-cell 6000: 5991: 5969: 5962: 5955: 5946: 5862: 5832:Ductal carcinoma 5828: 5808: 5764: 5750:Krukenberg tumor 5710: 5564:Renal oncocytoma 5476:Linitis plastica 5465:Gastrointestinal 5461: 5447: 5354: 5333: 5326: 5319: 5310: 5244:Oral candidiasis 5121: 5019: 4947:Erythema nodosum 4891: 4880: 4873: 4817:Tinea versicolor 4655:Bullous impetigo 4592:Pityriasis rosea 4527:Lichen sclerosus 4512:Darier's disease 4477: 4466: 4422:Kaposi's sarcoma 4268: 4252: 4245: 4238: 4229: 4083: 4071: 4070: 4044: 4038: 4037: 4035: 4034: 4023:BC Cancer Agency 4015: 4009: 4008: 3998: 3981:(7418): 794–98. 3966: 3957: 3945: 3939: 3938: 3901: 3895: 3894: 3858: 3852: 3851: 3841: 3809: 3803: 3791: 3785: 3784: 3769: 3763: 3762: 3744: 3720: 3714: 3713: 3677: 3671: 3660: 3654: 3653: 3625: 3619: 3618: 3582: 3567: 3566: 3564: 3563: 3544: 3538: 3537: 3509: 3503: 3502: 3484: 3478: 3477: 3449: 3443: 3442: 3410: 3401: 3400: 3371: 3360: 3359: 3349: 3340:(May): 574–597. 3325: 3319: 3318: 3294: 3288: 3287: 3277: 3260:(12): CD007041. 3245: 3239: 3238: 3202: 3196: 3195: 3185: 3161: 3155: 3154: 3152: 3145: 3135: 3129: 3128: 3118: 3101:(12): CD003412. 3086: 3080: 3079: 3069: 3046:JAMA Dermatology 3037: 3031: 3030: 3020: 2988: 2982: 2981: 2971: 2939: 2933: 2931: 2921: 2889: 2883: 2882: 2845: 2839: 2838: 2828: 2796: 2790: 2789: 2753: 2747: 2745: 2734:Robert S Bader. 2731: 2725: 2724: 2706: 2673: 2658: 2637: 2636: 2626: 2616: 2591: 2574: 2573: 2563: 2553: 2529: 2520: 2518: 2509:Robert S Bader. 2506: 2500: 2499: 2489: 2472:(12): CD013187. 2457: 2451: 2450: 2448: 2447: 2428: 2422: 2421: 2393: 2384: 2383: 2347: 2341: 2340: 2322: 2316: 2315: 2279: 2273: 2272: 2266: 2258: 2230: 2224: 2223: 2187: 2181: 2180: 2169: 2160: 2159: 2157: 2156: 2141: 2132: 2131: 2129: 2128: 2114: 2108: 2107: 2079: 2073: 2072: 2070: 2068: 2059:. 21 June 2017. 2049: 2040: 2039: 2021: 1997: 1991: 1990: 1952: 1946: 1945: 1917: 1908: 1907: 1905: 1903: 1888: 1882: 1881: 1879: 1877: 1862: 1856: 1855: 1845: 1813: 1807: 1806: 1789: 1780: 1779: 1755: 1749: 1748: 1746: 1744: 1735:. 21 June 2017. 1725: 1716: 1715: 1687: 1662: 1661: 1659: 1657: 1638: 1616: 1613: 1595:, also known as 1547:photosensitizers 1487:Euphorbia peplus 1329:Frederic E. Mohs 1222: 1204: 1183: 1174: 1154: 1137: 1120: 1102: 1076: 1052: 1036: 1020: 1008: 999:Cohesive nodular 996: 975: 910: 856: 835: 807: 789: 760: 744: 730: 614:local anesthesia 475:of a basal-cell 437: 425: 413: 401: 309:targeted therapy 170:Surgical removal 62: 42: 21: 6532: 6531: 6527: 6526: 6525: 6523: 6522: 6521: 6492: 6491: 6490: 6481: 6465: 6431: 6375:Epidermal nevus 6355: 6351:Periungual wart 6322: 6295:Keratoacanthoma 6289: 6265:Melanoacanthoma 6223: 6213: 6172: 6149: 6130:Bowen's disease 6081: 5982: 5973: 5943: 5934: 5911: 5888: 5865: 5854: 5850:Comedocarcinoma 5823: 5821: 5811: 5792: 5779: 5756: 5731: 5705: 5703: 5697: 5668: 5658: 5605: 5568: 5540: 5513:Somatostatinoma 5456:adenocarcinomas 5454: 5432: 5418:Warthin's tumor 5404: 5343: 5337: 5307: 5298: 5230: 5223: 5190: 5156:Alopecia areata 5134: 5116: 5102: 5059: 5038: 5014: 5004: 4961: 4920: 4906:Viral exanthems 4884: 4868: 4866: 4856: 4827:Pityriasis alba 4805: 4747: 4689: 4626: 4546: 4542:Zinc deficiency 4472: 4470: 4451: 4379: 4370: 4334: 4325:Nevus sebaceous 4259: 4256: 4226: 4221: 4220: 4175: 4174: 4094: 4080: 4075: 4074: 4067: 4046: 4045: 4041: 4032: 4030: 4017: 4016: 4012: 3968: 3967: 3960: 3955:Wayback Machine 3946: 3942: 3903: 3902: 3898: 3860: 3859: 3855: 3811: 3810: 3806: 3801:Wayback Machine 3792: 3788: 3771: 3770: 3766: 3722: 3721: 3717: 3679: 3678: 3674: 3669:Wayback Machine 3661: 3657: 3627: 3626: 3622: 3584: 3583: 3570: 3561: 3559: 3546: 3545: 3541: 3511: 3510: 3506: 3499: 3486: 3485: 3481: 3454:Current Surgery 3451: 3450: 3446: 3412: 3411: 3404: 3373: 3372: 3363: 3327: 3326: 3322: 3296: 3295: 3291: 3247: 3246: 3242: 3213:(10): 1207–14. 3204: 3203: 3199: 3163: 3162: 3158: 3150: 3143: 3137: 3136: 3132: 3088: 3087: 3083: 3039: 3038: 3034: 3003:(9): CD011161. 2990: 2989: 2985: 2941: 2940: 2936: 2891: 2890: 2886: 2848: 2846: 2842: 2798: 2797: 2793: 2755: 2754: 2750: 2733: 2732: 2728: 2721: 2708: 2707: 2676: 2659: 2640: 2594: 2592: 2577: 2531: 2530: 2523: 2508: 2507: 2503: 2459: 2458: 2454: 2445: 2443: 2436:SkinCancerGuide 2430: 2429: 2425: 2395: 2394: 2387: 2349: 2348: 2344: 2337: 2324: 2323: 2319: 2281: 2280: 2276: 2259: 2232: 2231: 2227: 2189: 2188: 2184: 2171: 2170: 2163: 2154: 2152: 2143: 2142: 2135: 2126: 2124: 2116: 2115: 2111: 2081: 2080: 2076: 2066: 2064: 2051: 2050: 2043: 1999: 1998: 1994: 1954: 1953: 1949: 1919: 1918: 1911: 1901: 1899: 1890: 1889: 1885: 1875: 1873: 1864: 1863: 1859: 1815: 1814: 1810: 1803: 1791: 1790: 1783: 1772: 1757: 1756: 1752: 1742: 1740: 1727: 1726: 1719: 1689: 1688: 1665: 1655: 1653: 1640: 1639: 1630: 1625: 1620: 1619: 1614: 1610: 1605: 1597:Gorlin syndrome 1580: 1560: 1540: 1496: 1461: 1408: 1397: 1377: 1369:surgical margin 1318: 1297: 1289: 1255: 1231: 1184: 1175: 1067: 1056: 1053: 1040: 1037: 1024: 1021: 1012: 1009: 1000: 997: 970: 755: 748: 745: 736: 731: 705: 669: 642: 640:Characteristics 626:fibrous papules 594: 466: 464:Pathophysiology 454: 448: 441: 438: 429: 426: 417: 414: 405: 402: 387:cryodestruction 359: 40: 37: 28: 23: 22: 15: 12: 11: 5: 6530: 6528: 6520: 6519: 6514: 6509: 6507:Histopathology 6504: 6494: 6493: 6487: 6486: 6483: 6482: 6480: 6479: 6477:Cutaneous horn 6473: 6471: 6467: 6466: 6464: 6463: 6458: 6453: 6448: 6442: 6440: 6433: 6432: 6430: 6429: 6424: 6419: 6414: 6409: 6404: 6399: 6398: 6397: 6392: 6387: 6378: 6376: 6369: 6365: 6364: 6361: 6360: 6357: 6356: 6354: 6353: 6348: 6343: 6338: 6332: 6330: 6324: 6323: 6321: 6320: 6315: 6310: 6305: 6299: 6297: 6291: 6290: 6288: 6287: 6282: 6277: 6272: 6267: 6262: 6261: 6260: 6255: 6250: 6245: 6236: 6234: 6225: 6219: 6218: 6215: 6214: 6212: 6211: 6206: 6201: 6196: 6191: 6186: 6180: 6178: 6174: 6173: 6171: 6170: 6165: 6159: 6157: 6155:Adenocarcinoma 6151: 6150: 6148: 6147: 6142: 6137: 6132: 6127: 6122: 6121: 6120: 6115: 6110: 6105: 6100: 6091: 6089: 6083: 6082: 6080: 6079: 6074: 6073: 6072: 6067: 6062: 6057: 6052: 6047: 6042: 6037: 6032: 6027: 6022: 6017: 6008: 6006: 5997: 5988: 5984: 5983: 5974: 5972: 5971: 5964: 5957: 5949: 5940: 5939: 5936: 5935: 5933: 5932: 5926: 5924: 5917: 5916: 5913: 5912: 5910: 5909: 5904: 5898: 5896: 5890: 5889: 5887: 5886: 5881: 5875: 5873: 5867: 5866: 5864: 5863: 5852: 5847: 5842: 5836: 5834: 5825: 5817: 5816: 5813: 5812: 5810: 5809: 5789: 5787: 5781: 5780: 5778: 5777: 5772: 5771: 5770: 5754: 5753: 5752: 5741: 5739: 5733: 5732: 5730: 5729: 5719: 5717: 5707: 5699: 5698: 5696: 5695: 5690: 5689: 5688: 5683: 5672: 5670: 5669:skin appendage 5664: 5663: 5660: 5659: 5657: 5656: 5651: 5646: 5641: 5636: 5631: 5626: 5625: 5624: 5613: 5611: 5610:Other/multiple 5607: 5606: 5604: 5603: 5598: 5589: 5584: 5578: 5576: 5570: 5569: 5567: 5566: 5561: 5556: 5550: 5548: 5542: 5541: 5539: 5538: 5529: 5527:Klatskin tumor 5524: 5518: 5517: 5516: 5515: 5510: 5505: 5500: 5495: 5484: 5483: 5478: 5469: 5467: 5458: 5444: 5438: 5437: 5434: 5433: 5431: 5430: 5425: 5420: 5414: 5412: 5406: 5405: 5403: 5402: 5397: 5392: 5387: 5382: 5377: 5372: 5366: 5364: 5351: 5345: 5344: 5338: 5336: 5335: 5328: 5321: 5313: 5304: 5303: 5300: 5299: 5297: 5296: 5291: 5286: 5281: 5279:Coxsackievirus 5276: 5271: 5266: 5261: 5256: 5251: 5246: 5241: 5235: 5233: 5225: 5224: 5222: 5221: 5216: 5211: 5206: 5200: 5198: 5192: 5191: 5189: 5188: 5183: 5178: 5173: 5168: 5163: 5158: 5153: 5148: 5142: 5140: 5136: 5135: 5133: 5132: 5129: 5127: 5118: 5112: 5111: 5108: 5107: 5104: 5103: 5101: 5100: 5095: 5090: 5085: 5075: 5073: 5069: 5068: 5065: 5064: 5061: 5060: 5058: 5057: 5052: 5046: 5044: 5040: 5039: 5037: 5036: 5031: 5025: 5023: 5016: 5010: 5009: 5006: 5005: 5003: 5002: 4996: 4991: 4989:Gyratum repens 4986: 4981: 4975: 4969: 4967: 4963: 4962: 4960: 4959: 4954: 4949: 4944: 4939: 4934: 4928: 4926: 4922: 4921: 4919: 4918: 4913: 4911:Toxic erythema 4908: 4903: 4901:Drug eruptions 4897: 4895: 4888: 4877: 4870: 4862: 4861: 4858: 4857: 4855: 4854: 4849: 4844: 4839: 4834: 4829: 4824: 4819: 4813: 4811: 4807: 4806: 4804: 4803: 4798: 4793: 4788: 4783: 4778: 4773: 4768: 4763: 4757: 4755: 4749: 4748: 4746: 4745: 4740: 4738:Lichen nitidus 4735: 4730: 4725: 4720: 4715: 4710: 4705: 4699: 4697: 4691: 4690: 4688: 4687: 4682: 4677: 4672: 4667: 4662: 4657: 4652: 4647: 4642: 4640:Herpes simplex 4636: 4634: 4628: 4627: 4625: 4624: 4619: 4614: 4609: 4604: 4599: 4594: 4589: 4583: 4578: 4573: 4568: 4562: 4556: 4554: 4548: 4547: 4545: 4544: 4539: 4534: 4529: 4524: 4519: 4514: 4509: 4504: 4499: 4494: 4489: 4483: 4481: 4474: 4463: 4457: 4456: 4453: 4452: 4450: 4449: 4444: 4439: 4434: 4429: 4424: 4419: 4414: 4409: 4404: 4399: 4394: 4389: 4383: 4381: 4372: 4371: 4369: 4368: 4363: 4358: 4353: 4348: 4342: 4340: 4336: 4335: 4333: 4332: 4327: 4322: 4317: 4312: 4307: 4302: 4297: 4292: 4287: 4282: 4276: 4274: 4265: 4261: 4260: 4257: 4255: 4254: 4247: 4240: 4232: 4223: 4222: 4219: 4218: 4207: 4196: 4184: 4183: 4181: 4177: 4176: 4173: 4172: 4161: 4150: 4139: 4127: 4112: 4095: 4090: 4089: 4087: 4086:Classification 4079: 4078:External links 4076: 4073: 4072: 4065: 4039: 4010: 3958: 3940: 3896: 3853: 3824:(5): 1511–21. 3804: 3786: 3764: 3715: 3688:(3): 394–397. 3672: 3655: 3636:(6): 1039–45. 3620: 3568: 3539: 3504: 3497: 3479: 3444: 3425:(3): 291–301. 3402: 3383:(4): 531–550. 3361: 3320: 3289: 3240: 3197: 3156: 3153:on 2009-02-27. 3130: 3081: 3032: 2983: 2934: 2884: 2840: 2791: 2764:(10): 744–50. 2748: 2726: 2719: 2674: 2638: 2575: 2521: 2501: 2452: 2423: 2404:(4): 393–401. 2385: 2342: 2335: 2317: 2274: 2241:(2): 46e–49e. 2225: 2198:(5): 399–403. 2182: 2161: 2133: 2109: 2074: 2041: 1992: 1947: 1909: 1883: 1857: 1808: 1801: 1781: 1770: 1750: 1717: 1698:(6): 1323–35. 1663: 1648:. 2013-10-25. 1627: 1626: 1624: 1621: 1618: 1617: 1607: 1606: 1604: 1601: 1579: 1576: 1559: 1556: 1539: 1536: 1495: 1492: 1460: 1457: 1421:5-fluorouracil 1412:5-fluorouracil 1407: 1404: 1396: 1393: 1376: 1373: 1317: 1314: 1296: 1293: 1288: 1285: 1276:5-Fluorouracil 1262:with at least 1254: 1251: 1230: 1227: 1224: 1223: 1216: 1212: 1206: 1205: 1198: 1197:Rceptor- (AR-) 1194: 1188: 1187: 1186: 1185: 1178: 1176: 1169: 1165: 1162: 1156: 1155: 1148: 1145: 1139: 1138: 1131: 1128: 1126:Trichoblastoma 1122: 1121: 1114: 1110: 1104: 1103: 1096: 1093: 1091:Hair follicles 1087: 1086: 1083: 1080: 1066: 1063: 1060: 1059: 1058: 1057: 1054: 1047: 1043: 1042: 1041: 1038: 1031: 1027: 1026: 1025: 1022: 1015: 1013: 1010: 1003: 1001: 998: 991: 986: 985: 982: 979: 969: 966: 963: 962: 957:, nipple, and 943: 941: 937: 936: 933: 931: 927: 926: 923: 916: 912: 911: 904: 901: 898: 894: 893: 886: 883: 876: 875: 864: 862: 858: 857: 850: 843: 841: 837: 836: 829: 827: 824: 820: 819: 816: 813: 809: 808: 801: 798: 795: 791: 790: 783: 780: 778: 774: 773: 770: 767: 766:Histopathology 764: 754: 753:Other subtypes 751: 750: 749: 746: 739: 737: 732: 725: 704: 701: 700: 699: 696: 685: 668: 665: 641: 638: 593: 590: 536:thymine dimers 529:trichoblastoma 465: 462: 447: 444: 443: 442: 439: 432: 430: 427: 420: 418: 415: 408: 406: 403: 396: 358: 355: 351:trichoblastoma 299:or the use of 198: 197: 194: 190: 189: 186: 182: 181: 178: 172: 171: 168: 164: 163: 146: 140: 139: 136: 130: 129: 108: 102: 101: 91: 85: 84: 75: 69: 68: 64: 63: 55: 54: 51: 47: 46: 38: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 6529: 6518: 6515: 6513: 6510: 6508: 6505: 6503: 6500: 6499: 6497: 6478: 6475: 6474: 6472: 6468: 6462: 6459: 6457: 6454: 6452: 6449: 6447: 6444: 6443: 6441: 6439: 6434: 6428: 6425: 6423: 6420: 6418: 6415: 6413: 6410: 6408: 6405: 6403: 6400: 6396: 6393: 6391: 6388: 6386: 6383: 6382: 6380: 6379: 6377: 6373: 6370: 6366: 6352: 6349: 6347: 6344: 6342: 6341:Verruca plana 6339: 6337: 6334: 6333: 6331: 6329: 6325: 6319: 6316: 6314: 6311: 6309: 6306: 6304: 6301: 6300: 6298: 6296: 6292: 6286: 6283: 6281: 6278: 6276: 6275:Seboacanthoma 6273: 6271: 6268: 6266: 6263: 6259: 6258:Epidermolytic 6256: 6254: 6251: 6249: 6246: 6244: 6241: 6240: 6238: 6237: 6235: 6233: 6229: 6226: 6220: 6210: 6207: 6205: 6202: 6200: 6197: 6195: 6192: 6190: 6187: 6185: 6182: 6181: 6179: 6175: 6169: 6166: 6164: 6161: 6160: 6158: 6156: 6152: 6146: 6143: 6141: 6138: 6136: 6133: 6131: 6128: 6126: 6123: 6119: 6116: 6114: 6111: 6109: 6106: 6104: 6101: 6099: 6096: 6095: 6093: 6092: 6090: 6088: 6084: 6078: 6075: 6071: 6068: 6066: 6063: 6061: 6058: 6056: 6053: 6051: 6048: 6046: 6043: 6041: 6038: 6036: 6033: 6031: 6028: 6026: 6023: 6021: 6018: 6016: 6013: 6012: 6010: 6009: 6007: 6005: 6001: 5998: 5996: 5992: 5989: 5985: 5981: 5977: 5970: 5965: 5963: 5958: 5956: 5951: 5950: 5947: 5931: 5928: 5927: 5925: 5922: 5918: 5908: 5905: 5903: 5900: 5899: 5897: 5895: 5891: 5885: 5882: 5880: 5877: 5876: 5874: 5872: 5868: 5861: 5857: 5853: 5851: 5848: 5846: 5843: 5841: 5838: 5837: 5835: 5833: 5829: 5826: 5824:and medullary 5818: 5807: 5803: 5799: 5795: 5791: 5790: 5788: 5786: 5782: 5776: 5773: 5769: 5766: 5765: 5763: 5759: 5755: 5751: 5748: 5747: 5746: 5743: 5742: 5740: 5738: 5734: 5728: 5724: 5721: 5720: 5718: 5715: 5711: 5708: 5700: 5694: 5691: 5687: 5684: 5682: 5679: 5678: 5677: 5674: 5673: 5671: 5665: 5655: 5652: 5650: 5647: 5645: 5642: 5640: 5637: 5635: 5632: 5630: 5627: 5623: 5620: 5619: 5618: 5615: 5614: 5612: 5608: 5602: 5599: 5597: 5593: 5590: 5588: 5585: 5583: 5580: 5579: 5577: 5575: 5571: 5565: 5562: 5560: 5557: 5555: 5552: 5551: 5549: 5547: 5543: 5537: 5533: 5530: 5528: 5525: 5523: 5520: 5519: 5514: 5511: 5509: 5506: 5504: 5501: 5499: 5496: 5494: 5491: 5490: 5489: 5486: 5485: 5482: 5479: 5477: 5474: 5471: 5470: 5468: 5466: 5462: 5459: 5457: 5452: 5448: 5445: 5443: 5439: 5429: 5426: 5424: 5421: 5419: 5416: 5415: 5413: 5411: 5407: 5401: 5398: 5396: 5393: 5391: 5388: 5386: 5383: 5381: 5378: 5376: 5373: 5371: 5368: 5367: 5365: 5363: 5359: 5355: 5352: 5350: 5346: 5342: 5334: 5329: 5327: 5322: 5320: 5315: 5314: 5311: 5295: 5292: 5290: 5287: 5285: 5282: 5280: 5277: 5275: 5272: 5270: 5267: 5265: 5262: 5260: 5257: 5255: 5252: 5250: 5249:Lichen planus 5247: 5245: 5242: 5240: 5237: 5236: 5234: 5232: 5226: 5220: 5217: 5215: 5212: 5210: 5207: 5205: 5204:Onychomycosis 5202: 5201: 5199: 5197: 5193: 5187: 5184: 5182: 5179: 5177: 5174: 5172: 5169: 5167: 5166:Tinea capitis 5164: 5162: 5159: 5157: 5154: 5152: 5149: 5147: 5144: 5143: 5141: 5137: 5131: 5130: 5128: 5126: 5122: 5119: 5115:Miscellaneous 5113: 5099: 5096: 5094: 5091: 5089: 5086: 5084: 5080: 5077: 5076: 5074: 5070: 5056: 5053: 5051: 5048: 5047: 5045: 5041: 5035: 5032: 5030: 5027: 5026: 5024: 5020: 5017: 5013:Nonblanchable 5011: 5000: 4997: 4995: 4992: 4990: 4987: 4985: 4982: 4980: 4976: 4974: 4971: 4970: 4968: 4964: 4958: 4955: 4953: 4950: 4948: 4945: 4943: 4940: 4938: 4935: 4933: 4930: 4929: 4927: 4923: 4917: 4914: 4912: 4909: 4907: 4904: 4902: 4899: 4898: 4896: 4892: 4889: 4887: 4881: 4878: 4874: 4871: 4863: 4853: 4850: 4848: 4845: 4843: 4840: 4838: 4835: 4833: 4830: 4828: 4825: 4823: 4820: 4818: 4815: 4814: 4812: 4810:Hypopigmented 4808: 4802: 4799: 4797: 4794: 4792: 4789: 4787: 4784: 4782: 4779: 4777: 4774: 4772: 4769: 4767: 4764: 4762: 4761:Acne vulgaris 4759: 4758: 4756: 4754: 4750: 4744: 4741: 4739: 4736: 4734: 4731: 4729: 4726: 4724: 4721: 4719: 4716: 4714: 4713:Lichen planus 4711: 4709: 4706: 4704: 4701: 4700: 4698: 4696: 4692: 4686: 4683: 4681: 4678: 4676: 4673: 4671: 4668: 4666: 4663: 4661: 4658: 4656: 4653: 4651: 4648: 4646: 4645:Herpes zoster 4643: 4641: 4638: 4637: 4635: 4633: 4629: 4623: 4620: 4618: 4617:Parapsoriasis 4615: 4613: 4610: 4608: 4605: 4603: 4600: 4598: 4595: 4593: 4590: 4587: 4584: 4582: 4579: 4577: 4574: 4572: 4569: 4567: 4563: 4561: 4558: 4557: 4555: 4553: 4549: 4543: 4540: 4538: 4535: 4533: 4530: 4528: 4525: 4523: 4520: 4518: 4515: 4513: 4510: 4508: 4505: 4503: 4500: 4498: 4495: 4493: 4490: 4488: 4485: 4484: 4482: 4478: 4475: 4467: 4464: 4462: 4458: 4448: 4445: 4443: 4440: 4438: 4435: 4433: 4430: 4428: 4425: 4423: 4420: 4418: 4415: 4413: 4410: 4408: 4405: 4403: 4400: 4398: 4395: 4393: 4390: 4388: 4385: 4384: 4382: 4377: 4373: 4367: 4364: 4362: 4359: 4357: 4354: 4352: 4349: 4347: 4344: 4343: 4341: 4337: 4331: 4328: 4326: 4323: 4321: 4318: 4316: 4313: 4311: 4308: 4306: 4303: 4301: 4298: 4296: 4293: 4291: 4288: 4286: 4283: 4281: 4278: 4277: 4275: 4273: 4269: 4266: 4262: 4253: 4248: 4246: 4241: 4239: 4234: 4233: 4230: 4217: 4213: 4212: 4208: 4206: 4202: 4201: 4197: 4195: 4191: 4190: 4186: 4185: 4182: 4178: 4171: 4167: 4166: 4162: 4160: 4156: 4155: 4151: 4149: 4145: 4144: 4140: 4137: 4133: 4132: 4128: 4126: 4122: 4121: 4117: 4113: 4110: 4106: 4105: 4101: 4097: 4096: 4093: 4088: 4084: 4077: 4068: 4062: 4058: 4054: 4050: 4043: 4040: 4028: 4024: 4020: 4014: 4011: 4006: 4002: 3997: 3992: 3988: 3984: 3980: 3976: 3972: 3965: 3963: 3959: 3956: 3952: 3949: 3944: 3941: 3936: 3932: 3928: 3924: 3920: 3916: 3912: 3908: 3907:JAMA Dermatol 3900: 3897: 3892: 3888: 3884: 3880: 3876: 3872: 3869:(5): 056701. 3868: 3864: 3857: 3854: 3849: 3845: 3840: 3835: 3831: 3827: 3823: 3819: 3815: 3808: 3805: 3802: 3798: 3795: 3790: 3787: 3782: 3778: 3774: 3768: 3765: 3760: 3756: 3752: 3748: 3743: 3738: 3734: 3730: 3726: 3719: 3716: 3711: 3707: 3703: 3699: 3695: 3691: 3687: 3683: 3676: 3673: 3670: 3666: 3663: 3659: 3656: 3651: 3647: 3643: 3639: 3635: 3631: 3624: 3621: 3616: 3612: 3608: 3604: 3600: 3596: 3592: 3588: 3581: 3579: 3577: 3575: 3573: 3569: 3557: 3553: 3549: 3543: 3540: 3535: 3531: 3527: 3523: 3520:(6): 566–71. 3519: 3515: 3508: 3505: 3500: 3494: 3490: 3483: 3480: 3475: 3471: 3467: 3463: 3460:(5): 518–26. 3459: 3455: 3448: 3445: 3440: 3436: 3432: 3428: 3424: 3420: 3416: 3409: 3407: 3403: 3398: 3394: 3390: 3386: 3382: 3378: 3370: 3368: 3366: 3362: 3357: 3353: 3348: 3343: 3339: 3335: 3331: 3324: 3321: 3316: 3312: 3308: 3304: 3300: 3293: 3290: 3285: 3281: 3276: 3271: 3267: 3263: 3259: 3255: 3251: 3244: 3241: 3236: 3232: 3228: 3224: 3220: 3216: 3212: 3208: 3201: 3198: 3193: 3189: 3184: 3179: 3176:(4): 477–80. 3175: 3171: 3167: 3160: 3157: 3149: 3142: 3141: 3134: 3131: 3126: 3122: 3117: 3112: 3108: 3104: 3100: 3096: 3092: 3085: 3082: 3077: 3073: 3068: 3063: 3059: 3055: 3052:(2): 167–74. 3051: 3047: 3043: 3036: 3033: 3028: 3024: 3019: 3014: 3010: 3006: 3002: 2998: 2994: 2987: 2984: 2979: 2975: 2970: 2965: 2961: 2957: 2953: 2949: 2945: 2938: 2935: 2929: 2925: 2920: 2915: 2911: 2907: 2903: 2899: 2895: 2888: 2885: 2880: 2876: 2872: 2868: 2864: 2860: 2857:(1): 95–103. 2856: 2852: 2844: 2841: 2836: 2832: 2827: 2822: 2818: 2814: 2811:(3): 347–62. 2810: 2806: 2802: 2795: 2792: 2787: 2783: 2779: 2775: 2771: 2767: 2763: 2759: 2752: 2749: 2743: 2742: 2737: 2730: 2727: 2722: 2716: 2712: 2705: 2703: 2701: 2699: 2697: 2695: 2693: 2691: 2689: 2687: 2685: 2683: 2681: 2679: 2675: 2671: 2670:0-07-138076-0 2667: 2663: 2657: 2655: 2653: 2651: 2649: 2647: 2645: 2643: 2639: 2634: 2630: 2625: 2620: 2615: 2610: 2606: 2602: 2598: 2590: 2588: 2586: 2584: 2582: 2580: 2576: 2571: 2567: 2562: 2557: 2552: 2547: 2543: 2539: 2535: 2528: 2526: 2522: 2516: 2512: 2505: 2502: 2497: 2493: 2488: 2483: 2479: 2475: 2471: 2467: 2463: 2456: 2453: 2441: 2437: 2433: 2427: 2424: 2419: 2415: 2411: 2407: 2403: 2399: 2392: 2390: 2386: 2381: 2377: 2373: 2369: 2365: 2361: 2357: 2353: 2346: 2343: 2338: 2332: 2328: 2321: 2318: 2313: 2309: 2305: 2301: 2297: 2293: 2289: 2286:(in French). 2285: 2278: 2275: 2270: 2264: 2256: 2252: 2248: 2244: 2240: 2236: 2229: 2226: 2221: 2217: 2213: 2209: 2205: 2201: 2197: 2193: 2186: 2183: 2178: 2174: 2168: 2166: 2162: 2150: 2146: 2140: 2138: 2134: 2123: 2119: 2113: 2110: 2105: 2101: 2097: 2093: 2089: 2085: 2078: 2075: 2062: 2058: 2054: 2048: 2046: 2042: 2037: 2033: 2029: 2025: 2020: 2015: 2012:(6): 427–36. 2011: 2007: 2003: 1996: 1993: 1989: 1987: 1986: 1978: 1974: 1970: 1966: 1962: 1958: 1951: 1948: 1943: 1939: 1935: 1931: 1928:(4): 419–22. 1927: 1923: 1916: 1914: 1910: 1897: 1893: 1887: 1884: 1871: 1870:dermnetnz.org 1867: 1861: 1858: 1853: 1849: 1844: 1839: 1835: 1831: 1827: 1823: 1819: 1812: 1809: 1804: 1798: 1794: 1788: 1786: 1782: 1777: 1773: 1767: 1763: 1762: 1754: 1751: 1738: 1734: 1730: 1724: 1722: 1718: 1713: 1709: 1705: 1701: 1697: 1693: 1686: 1684: 1682: 1680: 1678: 1676: 1674: 1672: 1670: 1668: 1664: 1651: 1647: 1643: 1637: 1635: 1633: 1629: 1622: 1612: 1609: 1602: 1600: 1598: 1594: 1588: 1585: 1577: 1575: 1573: 1569: 1564: 1557: 1555: 1552: 1548: 1544: 1537: 1535: 1533: 1527: 1525: 1524:brachytherapy 1521: 1517: 1516:brachytherapy 1512: 1508: 1507:brachytherapy 1504: 1500: 1493: 1491: 1489: 1488: 1482: 1479: 1477: 1473: 1469: 1464: 1459:Immunotherapy 1458: 1456: 1454: 1450: 1446: 1442: 1440: 1436: 1432: 1429: 1428:immunotherapy 1424: 1422: 1417: 1413: 1405: 1403: 1401: 1394: 1392: 1390: 1385: 1381: 1374: 1372: 1370: 1365: 1360: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1330: 1326: 1322: 1315: 1313: 1309: 1301: 1294: 1292: 1286: 1284: 1281: 1277: 1272: 1270: 1265: 1261: 1252: 1250: 1248: 1244: 1235: 1228: 1221: 1217: 1213: 1211: 1208: 1207: 1203: 1199: 1195: 1193: 1190: 1189: 1182: 1177: 1173: 1168: 1166: 1163: 1161: 1158: 1157: 1153: 1149: 1146: 1144: 1141: 1140: 1136: 1132: 1129: 1127: 1124: 1123: 1119: 1115: 1111: 1109: 1106: 1105: 1101: 1097: 1094: 1092: 1089: 1088: 1084: 1081: 1078: 1077: 1073: 1064: 1051: 1046: 1044: 1035: 1030: 1028: 1019: 1014: 1007: 1002: 995: 990: 988: 987: 983: 980: 977: 976: 973: 967: 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274: 269: 267: 266:tissue biopsy 263: 259: 255: 251: 247: 243: 238: 236: 232: 228: 224: 220: 216: 212: 208: 204: 195: 191: 187: 183: 179: 177: 173: 169: 165: 162: 158: 154: 150: 147: 145: 141: 137: 135: 131: 128: 124: 120: 116: 112: 109: 107: 103: 100: 96: 92: 90: 86: 83: 79: 76: 74: 70: 65: 61: 56: 52: 48: 43: 35: 30: 19: 6346:Plantar wart 6118:Spindle-cell 6065:Rodent ulcer 6040:Micronodular 6035:Infiltrative 6003: 5681:Hidrocystoma 5675: 5601:Hürthle cell 5582:Prolactinoma 5487: 5472: 5389: 5219:Ingrown nail 4791:Dermatophyte 4786:Gonococcemia 4771:Folliculitis 4412:Neurofibroma 4380:subcutaneous 4314: 4209: 4198: 4187: 4163: 4152: 4141: 4129: 4114: 4098: 4048: 4042: 4031:. Retrieved 4022: 4013: 3978: 3974: 3943: 3913:(1): 71–78. 3910: 3906: 3899: 3866: 3862: 3856: 3821: 3817: 3807: 3789: 3776: 3767: 3735:(1): 24–29. 3732: 3728: 3718: 3685: 3681: 3675: 3658: 3633: 3629: 3623: 3593:(1): 35–48. 3590: 3586: 3560:. Retrieved 3551: 3542: 3517: 3513: 3507: 3488: 3482: 3457: 3453: 3447: 3422: 3418: 3380: 3376: 3337: 3333: 3323: 3306: 3302: 3292: 3257: 3253: 3243: 3210: 3206: 3200: 3173: 3169: 3159: 3148:the original 3139: 3133: 3098: 3094: 3084: 3049: 3045: 3035: 3000: 2996: 2986: 2954:(1): 43–46. 2951: 2947: 2937: 2904:(3): 246–7. 2901: 2897: 2887: 2854: 2850: 2843: 2808: 2804: 2794: 2761: 2757: 2751: 2739: 2729: 2710: 2661: 2604: 2601:Biomedicines 2600: 2541: 2537: 2514: 2504: 2469: 2465: 2455: 2444:. Retrieved 2435: 2426: 2401: 2397: 2355: 2351: 2345: 2326: 2320: 2287: 2283: 2277: 2263:cite journal 2238: 2234: 2228: 2195: 2191: 2185: 2176: 2153:. Retrieved 2151:. 2009-07-29 2148: 2125:. Retrieved 2121: 2112: 2090:(1): 43–53. 2087: 2083: 2077: 2065:. Retrieved 2056: 2009: 2005: 1995: 1983: 1980: 1960: 1956: 1950: 1925: 1921: 1900:. Retrieved 1895: 1886: 1874:. Retrieved 1869: 1860: 1825: 1821: 1811: 1792: 1760: 1753: 1741:. Retrieved 1732: 1695: 1691: 1654:. Retrieved 1645: 1611: 1596: 1589: 1581: 1578:Epidemiology 1568:metastasizes 1561: 1541: 1528: 1511:radiotherapy 1497: 1485: 1483: 1480: 1465: 1462: 1449:itraconazole 1445:Itraconazole 1443: 1433: 1425: 1416:chemotherapy 1409: 1406:Chemotherapy 1398: 1389:Mohs surgery 1378: 1364:Mohs surgery 1361: 1325:Mohs surgery 1323: 1319: 1316:Mohs surgery 1310: 1306: 1290: 1273: 1268: 1256: 1240: 971: 872:white people 847:erythematous 756: 714: 693:micronodular 682:fluorouracil 670: 667:Main classes 654: 651: 610:shave biopsy 603: 571:falx cerebri 552: 533: 523: 522: 519:trichoblasts 518: 503:histological 490: 489: 455: 390:inflammation 360: 346: 343:trichoblasts 342: 320: 313: 305:chemotherapy 277:Mohs surgery 270: 262:Tanning beds 246:lighter skin 239: 219:rodent ulcer 218: 214: 210: 206: 202: 201: 106:Risk factors 29: 6070:Superficial 6020:Cicatricial 5976:Skin cancer 5723:Cystadenoma 5676:sweat gland 5667:Adnexal and 5498:Glucagonoma 5274:Herpesvirus 5254:Leukoplakia 5079:Scleroderma 4966:Specialized 4894:Generalized 4869:involvement 4781:Candidiasis 4473:involvement 4447:Myxoid cyst 4295:Acrochordon 4189:MedlinePlus 1902:12 November 1876:12 November 1384:cryotherapy 1380:Cryosurgery 1375:Cryosurgery 1011:Superficial 890:skin lesion 818:Aggressive 689:morpheaform 606:skin biopsy 501:due to the 495:basal cells 458:sun-exposed 323:basal cells 285:cryosurgery 223:skin cancer 78:Dermatology 50:Other names 6496:Categories 6381:Syndromes 6253:Clear-cell 6243:Large-cell 6108:Clear-cell 5706:and serous 5649:Cylindroma 5634:Oncocytoma 5546:Urogenital 5503:Gastrinoma 5493:Insulinoma 5349:Epithelium 5214:Paronychia 5055:Vasculitis 4979:Multiforme 4977:Erythema ( 4932:Cellulitis 4883:Blanchable 4632:Blistering 4622:Ichthyosis 4480:Eczematous 4392:Hemangioma 4211:Patient UK 4165:DiseasesDB 4033:2011-06-25 3562:2008-12-05 2446:2009-02-18 2358:(6): 464. 2155:2019-05-06 2127:2023-03-02 1982: [ 1623:References 1453:metastatic 1435:Vismodegib 1260:sunscreens 1253:Prevention 1229:Radicality 800:Aggressive 734:Palisading 718:palisading 630:acne scars 622:sebaceomas 540:DNA repair 473:Micrograph 450:See also: 345:(of note, 231:ulceration 111:Light skin 99:ulceration 6512:Carcinoma 6470:Ungrouped 6248:Fissuring 6232:Acanthoma 6177:Ungrouped 6060:Pore-like 6050:Pigmented 5995:Carcinoma 5980:epidermis 5704:mucinous, 5686:Syringoma 5622:Carcinoid 5574:Endocrine 5362:carcinoma 5358:Papilloma 5209:Psoriasis 5117:disorders 5072:Indurated 4973:Urticaria 4925:Localized 4867:epidermal 4650:Varicella 4560:Psoriasis 4471:epidermal 4437:Leiomyoma 4339:Pigmented 4272:Epidermal 4200:eMedicine 3891:119815301 3710:235608763 3303:J Med Ins 2607:(4): 71. 2380:206650583 2220:234598207 1584:incidence 1563:Prognosis 1558:Prognosis 1494:Radiation 1476:imiquimod 1472:Imiquimod 1468:Imiquimod 1439:sonidegib 1287:Treatment 1280:imiquimod 882:'s ulcer 678:imiquimod 592:Diagnosis 544:mutations 511:sebaceous 507:folliculo 499:epidermis 477:carcinoma 335:sebaceous 331:folliculo 327:epidermis 301:imiquimod 273:sunscreen 244:, having 215:basalioma 185:Frequency 176:Prognosis 167:Treatment 161:psoriasis 73:Specialty 6318:Solitary 6313:Multiple 6103:Basaloid 6055:Polypoid 6015:Aberrant 5822:lobular, 5737:Mucinous 5488:pancreas 5451:Adenomas 5284:Syphilis 5231:membrane 4886:Erythema 4822:Vitiligo 4776:Impetigo 4753:Pustular 4718:Miliaria 4566:Corporis 4417:Xanthoma 4366:Melanoma 4346:Freckles 4111:C44.L21) 4027:Archived 4005:14525881 3951:Archived 3927:27732698 3848:33140131 3797:Archived 3781:Archived 3759:45091789 3751:19018814 3702:34160824 3665:Archived 3650:16713459 3615:12365983 3607:18593385 3556:Archived 3534:12786697 3474:16125611 3439:28676157 3397:22959232 3356:27160235 3317:. 290.6. 3284:25503105 3235:19202086 3227:17903153 3125:33202063 3076:29299592 3027:27455163 2978:25692080 2928:31384511 2879:43844922 2871:26333521 2835:27329375 2786:44948030 2778:27043336 2741:Medscape 2633:29261131 2570:29464122 2544:: 1–10. 2515:Medscape 2496:30521689 2440:Archived 2418:18216361 2372:26135529 2312:81618758 2304:30477681 2255:22678003 2212:33993349 2104:23369588 2061:Archived 2036:44457153 2028:22660875 1977:21199599 1942:23084294 1852:27733281 1776:Archived 1737:Archived 1712:26476255 1650:Archived 1341:melanoma 955:perineum 628:, early 515:apocrine 339:apocrine 316:melanoma 157:melanoma 89:Symptoms 82:oncology 6098:Adenoid 6045:Nodular 5978:of the 5820:Ductal, 5716:general 5702:Cystic, 5644:Apudoma 5423:Thymoma 5083:morphea 5043:Papular 5022:Macular 5015:Purpura 4999:Ab igne 4984:Migrans 4937:Abscess 4865:Without 4847:Leprosy 4766:Rosacea 4703:Scabies 4695:Papular 4564:Tinea ( 4552:Scaling 4356:Melasma 4351:Lentigo 4264:Growths 4205:med/214 4159:D002280 4138:-8093/3 4136:M8090/3 4107:: C44 ( 3935:8964342 3871:Bibcode 3839:8113182 3777:The Age 3275:7390281 3192:9716337 3116:8164471 3067:5839275 3018:6457780 2969:4325690 2919:6659602 2826:4972729 2624:5744095 2561:5804366 2487:6517175 1843:5388903 1656:30 June 1271:cause. 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