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Cold pressor test

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is present, they let the researcher know. Once the pain is unbearable, the participant removes their hand. This provides a measure of threshold (first feeling pain) and tolerance (total time minus threshold). This method is the most frequently used application of the cold pressor task. Comparable
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excitability. Some research suggests that the outcome of the cold pressor test can help to predict hypertension in patients; however other studies have failed to confirm this.
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Harlan WR, Osborne RK, Graybiel A (May 1964). "Prognostic value of the cold pressor test and the basal blood pressure: Based on an eighteen-year follow-up study".
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Lowery D, Fillingim RB, Wright RA (March–April 2003). "Sex differences and incentive effects on perceptual and cardiovascular responses to cold pressor pain".
77:, the equivalent to the cold pressor using hot water. The hot water immersion test (HIT) is equally capable of triggering a pain response without the 454:
Lafleche AB, Pannier BM, Laloux B, Safar ME (August 1998). "Arterial response during cold pressor test in borderline hypertension".
208:"The cold pressor test for measuring the reactibility of the blood pressure: Data concerning 571 normal and hypertensive subjects" 698: 658: 819: 505: 625: 924: 591: 888: 41:
test performed by immersing the hand into an ice water container, usually for one minute, and measuring changes in
68:. This is done by requiring a participant to place their hand in the cold pressor for as long as they can. Once 857: 74: 359:
Brown JL, Sheffield D, Leary MR, Robinson ME (March–April 2003). "Social support and experimental pain".
903: 791: 620: 404:"Differential physiological effects during tonic painful hand immersion tests using hot and ice water" 207: 929: 814: 338: 568: 498: 431: 384: 319: 893: 873: 471: 423: 376: 311: 276: 247:"Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans" 227: 188: 153: 731: 581: 463: 415: 368: 303: 266: 258: 219: 180: 143: 94: 834: 801: 786: 878: 781: 648: 372: 307: 271: 246: 98: 65: 61: 42: 38: 223: 918: 776: 741: 693: 653: 491: 467: 184: 106: 102: 435: 388: 323: 93:
Sensory afferent nerves trigger a systemic sympathetic activation leading to marked
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American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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release. This increased pressure fills the ventricle to a greater extent, but
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Other measures can also be obtained from the cold pressor such as
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Keller-Ross ML, Cunningham HA, Carter JR (September 2020).
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Wood DL, Sheps SG, Elveback LR, Schirger A (1984-05-01).
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congenital insensitivity to pain with partial anhidrosis
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Streff A, Kuehl LK, Michaux G, Anton F (March 2010).
866: 833: 800: 754: 719: 634: 590: 567: 528: 521: 23: 18: 132:"Cold pressor test as a predictor of hypertension" 704:congenital insensitivity to pain with anhidrosis 339:"Higher pain tolerance in males can't be bought" 499: 8: 525: 506: 492: 484: 270: 147: 122: 206:Hines Jr EA, Brown GE (January 1936). 15: 7: 73:in terms of pain elicitation is the 27:measuring changes in blood pressure 456:The American Journal of Physiology 373:10.1097/01.psy.0000030388.62434.46 308:10.1097/01.PSY.0000033127.11561.78 173:The American Journal of Cardiology 14: 699:Congenital insensitivity to pain 659:Paroxysmal extreme pain disorder 468:10.1152/ajpheart.1998.275.2.H409 109:decreases due to an increase in 1: 224:10.1016/S0002-8703(36)90370-8 420:10.1016/j.ejpain.2009.05.011 185:10.1016/0002-9149(64)90205-X 101:(normal is 40mm Hg), due to 97:. The result is an elevated 946: 263:10.1152/ajpregu.00045.2020 49:. These changes relate to 408:European Journal of Pain 75:hot water immersion test 820:Posteromarginal nucleus 755:Measurement and testing 361:Psychosomatic Medicine 296:Psychosomatic Medicine 212:American Heart Journal 149:10.1161/01.HYP.6.3.301 904:Drug-seeking behavior 792:Visual analogue scale 815:Anterolateral system 337:Staff (9 Apr 2003). 925:Vascular procedures 894:Philosophy of pain 569:Respiratory system 912: 911: 767:Cold pressor test 750: 749: 35:cold pressor test 31: 30: 19:Cold pressor test 937: 867:Related concepts 858:Pain eradication 616: 603: 554: 526: 522:By region/system 508: 501: 494: 485: 479: 440: 439: 399: 393: 392: 356: 350: 349: 347: 346: 334: 328: 327: 291: 285: 284: 274: 257:(3): R288–R295. 242: 236: 235: 203: 197: 196: 168: 162: 161: 151: 127: 95:vasoconstriction 16: 945: 944: 940: 939: 938: 936: 935: 934: 915: 914: 913: 908: 862: 829: 802:Pathophysiology 796: 787:Tail flick test 746: 715: 630: 614: 601: 592:Musculoskeletal 586: 563: 552: 517: 512: 482: 453: 449: 447:Further reading 444: 443: 401: 400: 396: 358: 357: 353: 344: 342: 336: 335: 331: 293: 292: 288: 244: 243: 239: 205: 204: 200: 170: 169: 165: 129: 128: 124: 119: 91: 12: 11: 5: 943: 941: 933: 932: 927: 917: 916: 910: 909: 907: 906: 901: 896: 891: 886: 881: 879:Pain tolerance 876: 874:Pain threshold 870: 868: 864: 863: 861: 860: 855: 850: 845: 839: 837: 831: 830: 828: 827: 822: 817: 812: 806: 804: 798: 797: 795: 794: 789: 784: 782:Hot plate test 779: 774: 769: 764: 758: 756: 752: 751: 748: 747: 745: 744: 739: 734: 729: 723: 721: 717: 716: 714: 713: 712: 711: 706: 696: 691: 686: 681: 676: 671: 666: 661: 656: 651: 649:Pain asymbolia 646: 640: 638: 632: 631: 629: 628: 623: 618: 610: 605: 596: 594: 588: 587: 585: 584: 579: 573: 571: 565: 564: 562: 561: 556: 548: 543: 538: 532: 530: 523: 519: 518: 513: 511: 510: 503: 496: 488: 481: 480: 462:(2): H409–15. 450: 448: 445: 442: 441: 414:(3): 266–272. 394: 367:(2): 276–283. 351: 329: 302:(2): 284–291. 286: 237: 198: 179:(5): 683–687. 163: 142:(3): 301–306. 121: 120: 118: 115: 99:pulse pressure 90: 87: 66:pain tolerance 62:pain threshold 43:blood pressure 39:cardiovascular 29: 28: 25: 21: 20: 13: 10: 9: 6: 4: 3: 2: 942: 931: 928: 926: 923: 922: 920: 905: 902: 900: 897: 895: 892: 890: 887: 885: 882: 880: 877: 875: 872: 871: 869: 865: 859: 856: 854: 851: 849: 846: 844: 841: 840: 838: 836: 832: 826: 823: 821: 818: 816: 813: 811: 808: 807: 805: 803: 799: 793: 790: 788: 785: 783: 780: 778: 777:Grimace scale 775: 773: 770: 768: 765: 763: 760: 759: 757: 753: 743: 742:Low back pain 740: 738: 735: 733: 730: 728: 725: 724: 722: 718: 710: 707: 705: 702: 701: 700: 697: 695: 694:Referred pain 692: 690: 687: 685: 682: 680: 677: 675: 672: 670: 667: 665: 662: 660: 657: 655: 654:Pain disorder 652: 650: 647: 645: 642: 641: 639: 637: 633: 627: 626:Delayed-onset 624: 622: 619: 617: 611: 609: 606: 604: 598: 597: 595: 593: 589: 583: 580: 578: 575: 574: 572: 570: 566: 560: 557: 555: 549: 547: 544: 542: 539: 537: 534: 533: 531: 529:Head and neck 527: 524: 520: 516: 509: 504: 502: 497: 495: 490: 489: 486: 477: 473: 469: 465: 461: 457: 452: 451: 446: 437: 433: 429: 425: 421: 417: 413: 409: 405: 398: 395: 390: 386: 382: 378: 374: 370: 366: 362: 355: 352: 340: 333: 330: 325: 321: 317: 313: 309: 305: 301: 297: 290: 287: 282: 278: 273: 268: 264: 260: 256: 252: 248: 241: 238: 233: 229: 225: 221: 217: 213: 209: 202: 199: 194: 190: 186: 182: 178: 174: 167: 164: 159: 155: 150: 145: 141: 137: 133: 126: 123: 116: 114: 112: 108: 107:stroke volume 104: 103:catecholamine 100: 96: 88: 86: 84: 80: 76: 71: 67: 63: 58: 56: 53:response and 52: 48: 44: 40: 36: 26: 22: 17: 766: 689:Phantom pain 674:Hyperalgesia 669:Chronic pain 553:(swallowing) 551:Odynophagia 459: 455: 411: 407: 397: 364: 360: 354: 343:. 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Eurekalert 332: 299: 295: 289: 254: 250: 240: 215: 211: 201: 176: 172: 166: 139: 136:Hypertension 135: 125: 92: 85:activation. 59: 34: 32: 930:Pain scales 899:Cancer pain 825:Substance P 810:Nociception 772:Dolorimeter 727:Pelvic pain 684:Hyperpathia 679:Hypoalgesia 600:Arthralgia 582:Pleurodynia 577:Sore throat 79:confounding 919:Categories 848:Anesthesia 835:Management 762:Pain scale 732:Proctalgia 636:Neurologic 536:Eye strain 345:2008-12-02 218:(1): 1–9. 117:References 89:Physiology 83:baroreflex 47:heart rate 884:Suffering 853:Cordotomy 843:Analgesia 664:Allodynia 644:Neuralgia 608:Bone pain 559:Toothache 232:0002-8703 111:afterload 889:SOCRATES 615:(muscle) 613:Myalgia 541:Headache 436:16132640 428:19540783 389:21421297 381:12651995 324:21147595 316:12651996 281:32697654 193:14152011 51:vascular 602:(joint) 476:9683427 272:7509253 158:6735451 24:Purpose 474:  434:  426:  387:  379:  322:  314:  279:  269:  230:  191:  156:  720:Other 621:Acute 432:S2CID 385:S2CID 320:S2CID 55:pulse 37:is a 737:Back 546:Neck 515:Pain 472:PMID 424:PMID 377:PMID 312:PMID 277:PMID 228:ISSN 189:PMID 154:PMID 70:pain 64:and 45:and 33:The 464:doi 460:275 416:doi 369:doi 304:doi 267:PMC 259:doi 255:319 220:doi 181:doi 144:doi 81:of 921:: 470:. 458:. 430:. 422:. 412:14 410:. 406:. 383:. 375:. 365:65 363:. 318:. 310:. 300:65 298:. 275:. 265:. 253:. 249:. 226:. 216:11 214:. 210:. 187:. 177:13 175:. 152:. 138:. 134:. 113:. 507:e 500:t 493:v 478:. 466:: 438:. 418:: 391:. 371:: 348:. 326:. 306:: 283:. 261:: 234:. 222:: 195:. 183:: 160:. 146:: 140:6

Index

cardiovascular
blood pressure
heart rate
vascular
pulse
pain threshold
pain tolerance
pain
hot water immersion test
confounding
baroreflex
vasoconstriction
pulse pressure
catecholamine
stroke volume
afterload
"Cold pressor test as a predictor of hypertension"
doi
10.1161/01.HYP.6.3.301
PMID
6735451
doi
10.1016/0002-9149(64)90205-X
PMID
14152011
"The cold pressor test for measuring the reactibility of the blood pressure: Data concerning 571 normal and hypertensive subjects"
doi
10.1016/S0002-8703(36)90370-8
ISSN
0002-8703

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