Knowledge (XXG)

Committed dose

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situation. If the radioactive material is necessary, it can be ingested orally via stable isotopes of specific elements. This is only suggested to those that have a lack of these elements however, because radioactive material can go from healthy to harmful with very small amounts. The most harmful way to absorb radiation is that of absorption because it is almost impossible to control how much will enter the body.
502:(CEDE) as defined in Title 10, Section 20.1003, of the Code of Federal Regulations of the USA the CEDE dose (HE,50) is the sum of the products of the committed dose equivalents for each of the body organs or tissues that are irradiated multiplied by the weighting factors (WT) applicable to each of those organs or tissues. 428:
radiotherapy method where a radioisotope is used as a drug (usually a liquid or pill). A review of this topic was published in 1999. Because the radioactive material becomes intimately mixed with the affected object it is often difficult to decontaminate the object or person in a case where internal
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has proposed a model whereby the incidence of cancers increases linearly with effective dose at a rate of 5.5% per sievert. This model is widely accepted for external radiation, but its application to internal contamination has been disputed. This model fails to account for the low rates of cancer in
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Since irradiation increases with proximity to the source of radiation, and as it is impossible to distance or shield an internal source, radioactive materials inside the body can deliver much higher doses to the host organs than they normally would from outside the body. This is particularly true for
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is the integration time in years following the intake. The commitment period is taken to be 50 years for adults, and to age 70 years for children. This refers specifically to the dose to the whole body, in the similar way to external effective dose. The committed effective dose is used to demonstrate
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The ICRP states "Radionuclides incorporated in the human body irradiate the tissues over time periods determined by their physical half-life and their biological retention within the body. Thus they may give rise to doses to body tissues for many months or years after the intake. The need to regulate
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is the time integral of the equivalent dose rate in a particular tissue or organ that will be received by an individual following intake of radioactive material into the body by a Reference Person, where t is the integration time in years. This refers specifically to the dose in a specific tissue or
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is usually much more hazardous than the internal dose. Normally, the greatest concern with internal exposure is that the radioactive material may stay in the body for an extended period of time, "committing" the subject to accumulating dose long after the initial exposure has ceased. Over a hundred
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Other radioisotopes have an affinity for particular tissues, such as plutonium into bone, and may be retained there for years in spite of their foreign nature. In summary, not all radiation is harmful. The radiation can be absorbed through multiple pathways, varying due to the circumstances of the
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The ICRP further states "For internal exposure, committed effective doses are generally determined from an assessment of the intakes of radionuclides from bioassay measurements or other quantities (e.g., activity retained in the body or in daily excreta). The radiation dose is determined from the
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Confusion between US and ICRP dose quantity systems can arise because the use of the term "dose equivalent" has been used within the ICRP system since 1991 only for quantities calculated using the value of Q (Linear energy transfer - LET), which the ICRP calls "operational quantities". However
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Analysis of blood samples, urine samples, fecal samples, and biopsies can provide more exact information about the chemical and isotopic nature of the contaminant, its distribution in the body, and the rate of elimination. Urine samples are the standard way to measure tritium intake, while fecal
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If the nature and quantity of radioactive materials taken into the body is known, and a reliable biochemical model of this material is available, this can be sufficient to determine committed dose. In occupational or accident scenarios, approximate estimates can be based on measurements of the
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of the material, may range from hours for medical radioisotopes to decades for transuranic waste. Committed dose is the integral of this decaying dose rate over the presumed remaining lifespan of the organism. Most regulations require this integral to be taken over 50 years for uptakes during
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might be attributable to cell's tendency to absorb transuranic metals into the cellular nucleus where they would be in very close proximity to the genome, though an elevated effectiveness can also be observed for external alpha radiation in cellular studies. As in the calculations for
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both of these produce closely spaced ionizing radiation. This concept is described as a binary system using two separate components for the therapy of cancer. Each component in itself is relatively harmless to the cells, but when combined for treatment they produce a highly cytocidal
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within the US NRC system "dose equivalent" is still used to name quantities which are calculated with tissue and radiation weighting factors, which in the ICRP system are now known as the "protection quantities" which are called "effective dose" and "equivalent dose".
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The US Nuclear Regulatory commission defines some non-SI quantities for the calculation of committed dose for use only within the US regulatory system. They carry different names to those used within the International ICRP radiation protection system, thus:
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environment that people were exposed to, but this cannot take into account factors such as breathing rate and adherence to hygiene practices. Exact information about the intake and its biochemical impact is usually only available in medical situations where
496:(CDE) is the equivalent dose received by a particular organ or tissue from an internal source, without weighting for tissue sensitivity. This is essentially an intermediate calculation result that cannot be directly compared to final dosimetry quantities 368:. While there is no doubt that internal contamination was the cause of ARS in these cases, there is not enough data to establish what quantities of committed dose might cause ARS symptoms. In most scenarios where ARS is a concern, the external 330:
report endorses the ICRP approaches to the estimation of doses and risks from internal emitters and agrees with CERRIE conclusions that these should be best estimates and that associated uncertainties should receive more attention.
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matrix might never be able to truly become part of an organism, it is normal to consider such particles in the lungs and digestive tract as a form of internal contamination which results in internal exposure.
936:"The confusing world of radiation dosimetry" - M.A. Boyd, Waste Management conference paper 2009, U.S. Environmental Protection Agency. An account of differences between USA and ICRP dosimetry systems. 111:
compliance with dose limits and is entered into the "dose of record" for occupational exposures used for recording, reporting and retrospective demonstration of compliance with regulatory dose limits.
1274: 381:, have received committed doses in excess of 10 Gy and went on to die of cancer or natural causes, whereas the same amount of acute external dose would invariably cause an earlier death by ARS. 479:) effect which is lethal (within a limited range of 5-9 micrometers or approximately one cell diameter). Clinical trials, with promising results, are currently carried out in Finland and Japan. 976:- "The confusing world of radiation dosimetry" - M.A. Boyd, 2009, U.S. Environmental Protection Agency. An account of chronological differences between USA and ICRP dosimetry systems. 455:
to the neutron energy spectrum suitable for BNCT treatment. The tumor is selectively bombarded with these neutrons. The neutrons quickly slow down in the body to become low energy
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accounting, the entire committed dose is conservatively assigned to the year of uptake, even though it may take many years for the tissues to actually accumulate this dose.
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are chemically identical to natural isotopes needed by the body, and may be more readily absorbed if the individual has a deficit of that element. For instance,
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The Response of the National Radiological Protection Board to the Report of the Committee Examining Radiation Risks of Internal Emitters (CERRIE), HPA, UK, 2005
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Internal exposure of the public is controlled by regulatory limits on the radioactive content of food and water. These limits are typically expressed in
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have failed to find any increase in thyroid cancer, even though there is linear increase in thyroid cancer risk with I-131 absorption at moderate doses.
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exposures to radionuclides and the accumulation of radiation dose over extended periods of time has led to the definition of committed dose quantities".
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taken into the body of an adult worker by inhalation or ingestion in a year. ALI is the intake of a given radionuclide in a year that would result in:
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tissues that would otherwise become cancerous as a result of the radiation. Most studies of very-high-dose I-131 for treatment of
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Limitation of Exposure to Ionizing Radiation (Report No. 116). National Council on Radiation Protection and Measurements (NCRP).
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Intake of radioactive materials into the body tends to increase the risk of cancer, and possibly other stochastic effects. The
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is the sum of the products of the committed organ or tissue equivalent doses and the appropriate tissue weighting factors
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Whole body counting (WBC) is the most direct approach, but has some limitations: it cannot detect beta emitters such as
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health risk due to an intake of radioactive material into the human body. Stochastic in this context is defined as the
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is notable in that high doses of the isotope are sometimes less dangerous than low doses, since they tend to kill
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carries a 5.5% chance of developing cancer. Such a risk is the sum of both internal and external radiation dose.
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ECRR is not a formal scientific advisory committee to the European Commission or to the European Parliament
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2010 recommendations of the ECRR : the health effects of exposure to low doses of ionizing radiation
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of cancer induction and genetic damage, due to low levels of radiation. The SI unit of measure is the
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The true relationship between committed dose and cancer is almost certainly non-linear. For example,
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who were exposed to plutonium dust, and the high rates of thyroid cancer in children following the
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There is no direct way to measure committed dose. Estimates can be made by analyzing the data from
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A committed dose from an internal source represents the same effective risk as the same amount of
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emitters that are easily shielded by skin and clothing. Some have hypothesized that alpha's high
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are captured by the injected boron-10, forming excited (boron-11) which breaks down into
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in the event of an accident or attack at a nuclear power plant, or the detonation of a
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The 2007 Recommendations of the International Commission on Radiological Protection
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applied uniformly to the whole body from an external source, or the same amount of
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applied to part of the body. The committed dose is not intended as a measure for
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European Committee on Radiation Risk (2010). Busby, Chris; et al. (eds.).
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tagged chemical that preferentially binds to tumor cells. Neutrons from a
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The exposure to the ingestion of a soluble radioactive substance, such as
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Annual limit on intake (ALI) is the derived limit for the amount of
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The intake of radioactive material can occur through four pathways:
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The ICRP defines two dose quantities for individual committed dose.
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exposure is occurring. While some very insoluble materials such as
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The dose rate from a single uptake decays over time due to both
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Intake of very large amounts of radioactive material can cause
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Rivkees, Scott A.; Sklar, Charles; Freemark, Michael (1998).
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adulthood or over 70 years for uptakes during childhood. In
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A person who is being treated for cancer by means of an
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organ, in the similar way to external equivalent dose.
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Below are a series of examples of internal exposure.
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ICRP publication 103 - paragraph B225 and glossary.
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International Commission on Radiological Protection
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International Commission on Radiological Protection
888:"Therapeutic Radiopharmaceuticals afrtin=2+3=9000" 823:Journal of Clinical Endocrinology & Metabolism 772:(Regulators' ed.). Aberystwyth: Green Audit. 62:of a health effect which is certain to happen. 360:(ARS) in rare instances. Examples include the 290:a committed effective dose equivalent of 0.02 69:(ICRP) predicts that an effective dose of one 1401: 995: 116:intake using recommended dose coefficients". 8: 301:(20 rems) to any individual organ or tissue, 128:inhalation of airborne contaminants such as 1161:Airborne radioactive particulate monitoring 148:injection of medical radioisotopes such as 1428: 1408: 1394: 1386: 1002: 988: 980: 861:Radium in Humans: A Review of U.S. Studies 945:US nuclear regulatory commission glossary 834: 294:(2 rems) for a "reference human body", or 886:Wynn, Volkert; Hoffman, Timothy (1999). 263:samples are the standard way to measure 175:which would release radioactive iodine. 558: 1749:Wireless electronic devices and health 718: 708: 683:. ICRP publication 103. Vol. 37. 644:: CS1 maint: archived copy as title ( 637: 328:National Radiological Protection Board 155:Some artificial radioisotopes such as 1326:Radiation Protection Convention, 1960 604:ICRP publication 103 - Paragraph 144. 7: 1775:List of civilian radiation accidents 1744:Wireless device radiation and health 1739:Biological dose units and quantities 1689:Electromagnetic radiation and health 950:Argonne national laboratory glossary 565:ICRP publication 103 - Paragraph 83. 659:ICPR: Draft report for consultation 500:Committed effective dose equivalent 297:a committed dose equivalent of 0.2 65:The radiation risk proposed by the 1724:Radioactivity in the life sciences 574:ICRP Publication 103 paragraph 140 14: 198:relative biological effectiveness 586:ICRP publication 103 - Glossary. 16:Measure of radiation health risk 537:Total effective dose equivalent 1093:Computed tomography dose index 362:Alexander Litvinenko poisoning 320:Los Alamos National Laboratory 305:whatever dose is the smaller. 141:absorption of vapours such as 1: 867:. Argonne National Laboratory 441:Boron neutron capture therapy 741:"Written answers: Radiation" 443:(BNCT) involves injecting a 277:radioisotope dose calibrator 1612:Cosmic background radiation 58:, which are defined as the 1902: 1841: 1699:Lasers and aviation safety 1357: 241: 1839: 1729:Radioactive contamination 1582:Electromagnetic radiation 1572: 1355: 1050:Radioactive contamination 547:Committed dose equivalent 494:Committed dose equivalent 97:Committed effective dose, 90:Committed equivalent dose 1881:Radiation health effects 1842:See also the categories 1780:1996 Costa Rica accident 1441:Acoustic radiation force 1358:See also the categories 1347:Radiation-induced cancer 1342:Acute radiation syndrome 370:effective radiation dose 366:Leide das Neves Ferreira 358:acute radiation syndrome 1754:Radiation heat-transfer 1607:Gravitational radiation 836:10.1210/jcem.83.11.5239 398:The exposure caused by 25:radiological protection 1795:1990 Zaragoza accident 1790:1984 Moroccan accident 1759:Linear energy transfer 1433:Non-ionizing radiation 1198:Semiconductor detector 1154:measurement techniques 970:Uk Govt CERRIE website 965:UK Govt COMARE website 858:Rowland, R.E. (1994). 145:oxide through the skin 1785:1987 Goiânia accident 1587:Synchrotron radiation 1577:Earth's energy budget 1559:Radioactive materials 1554:Particle accelerators 1217:Protection techniques 1181:Scintillation counter 1886:Radiation protection 1856:Radiation protection 1709:Radiation protection 1597:Black-body radiation 1504:Background radiation 1419:(physics and health) 1376:Radiation protection 1193:Radiation monitoring 1186:Proportional counter 1071:quantities and units 1025:Background radiation 1011:Radiation protection 284:radioactive material 279:prior to injection. 273:radiopharmaceuticals 223:biological half-life 27:is a measure of the 1826:Radiation hardening 1768:Radiation incidents 1704:Medical radiography 1663:Radiation syndrome 1617:Cherenkov radiation 1208:Whole-body counting 1118:Mean glandular dose 1055:Radioactive sources 697:on 16 November 2012 250:whole body counting 227:effective half-life 1821:Radioactive source 1642:Radiation exposure 1622:Askaryan radiation 1602:Particle radiation 1486:Ionizing radiation 1045:Internal dosimetry 1040:Ionizing radiation 664:2015-06-22 at the 527:Ionizing radiation 517:Internal dosimetry 484:Related quantities 373:people, including 324:Chernobyl accident 275:are measured in a 244:Internal dosimetry 169:radioactive iodine 56:radiation sickness 1863: 1862: 1844:Radiation effects 1714:Radiation therapy 1650: 1649: 1592:Thermal radiation 1529:Neutron radiation 1494:Radioactive decay 1383: 1382: 1364:Radiation effects 1335:Radiation effects 1098:Counts per minute 907:10.1021/cr9804386 779:978-1-897761-16-8 690:978-0-7020-3048-2 453:neutron moderator 402:present within a 318:early workers at 219:radioactive decay 173:nuclear explosive 54:effects, such as 1893: 1804:Related articles 1719:Radiation damage 1544:Nuclear reactors 1429: 1410: 1403: 1396: 1387: 1239:Radon mitigation 1234:Potassium iodide 1152:Instruments and 1004: 997: 990: 981: 937: 934: 928: 925: 919: 918: 895:Chemical Reviews 892: 883: 877: 876: 874: 872: 866: 855: 849: 848: 838: 814: 808: 805: 799: 798: 796: 794: 788: 782:. 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495: 492: 491: 490: 483: 478: 473: 470: 466: 462: 458: 454: 450: 446: 442: 439: 436: 432: 427: 423: 420: 416: 412: 408: 405: 401: 397: 395: 392: 391: 390: 384: 382: 380: 376: 371: 367: 363: 359: 354: 352: 347: 345: 341: 337: 332: 329: 325: 321: 316: 308: 306: 300: 296: 293: 289: 288: 287: 285: 280: 278: 274: 268: 266: 260: 258: 253: 251: 245: 237: 235: 233: 228: 225:, called the 224: 220: 212: 210: 208: 204: 199: 195: 191: 182: 180: 176: 174: 170: 166: 162: 158: 151: 147: 144: 140: 137: 134:ingestion of 133: 131: 127: 126: 125: 119: 117: 109: 102: 98: 95: 91: 88: 87: 86: 83: 76: 74: 72: 68: 63: 61: 57: 53: 52:deterministic 49: 45: 40: 38: 34: 30: 26: 22: 1852:Radiobiology 1734:Radiobiology 1694:Laser safety 1372:Radiobiology 1203:Survey meter 1123:Monitor unit 1087: 1069:Measurement 1060:Radiobiology 932: 927:NRC Glossary 923: 898: 894: 881: 869:. Retrieved 860: 853: 826: 822: 812: 803: 791:. Retrieved 784:the original 765: 758: 750: 744: 731: 699:. Retrieved 695:the original 679: 672: 654: 629:. Retrieved 622:the original 609: 600: 591: 570: 561: 505: 487: 460: 456: 425: 403: 400:Potassium-40 388: 379:radium girls 355: 348: 333: 312: 304: 281: 269: 261: 254: 247: 216: 186: 177: 154: 136:contaminated 123: 114: 107: 100: 96: 89: 84: 80: 64: 59: 41: 32: 20: 18: 1476:Ultraviolet 1471:Radio waves 1244:Respirators 1176:Ion chamber 265:transuranic 238:Measurement 120:Dose intake 33:probability 1870:Categories 1657:and health 1655:Radiation 1524:Cosmic ray 1304:Regulation 631:2014-10-31 553:References 394:Thorotrast 375:Eben Byers 336:iodine-131 242:See also: 157:iodine-131 29:stochastic 1811:Half-life 1684:Dosimetry 1519:Gamma ray 1466:Microwave 1456:Starlight 1417:Radiation 1316:NRC (USA) 1265:HPS (USA) 1166:Dosimeter 1083:Becquerel 1030:Dosimetry 721:ignored ( 711:cite book 477:cytotoxic 465:lithium-7 433:within a 351:becquerel 232:dosimetry 1461:Sunlight 1446:Infrared 1321:ONR (UK) 1311:IRR (UK) 1290:SRP (UK) 1229:Glovebox 1133:Roentgen 915:11749482 662:Archived 640:cite web 511:See also 469:helium-4 459:. These 445:boron-10 385:Examples 377:and the 267:intake. 213:Duration 106:, where 60:severity 1672:chronic 1295:UNSCEAR 1260:Euratom 1143:Sievert 845:9814445 746:Hansard 406:person. 340:thyroid 257:tritium 165:thyroid 143:tritium 71:sievert 37:sievert 1854:, and 1374:, and 913:  871:24 May 843:  793:18 May 776:  701:17 May 687:  467:and a 404:normal 1667:acute 1564:X-ray 1451:Light 891:(PDF) 865:(PDF) 787:(PDF) 770:(PDF) 625:(PDF) 618:(PDF) 190:alpha 130:radon 1285:IRPA 1280:ICRP 1275:ICRU 1270:IAEA 1113:Gray 911:PMID 873:2012 841:PMID 795:2012 774:ISBN 723:help 703:2012 685:ISBN 646:link 419:milk 415:cows 364:and 205:and 194:beta 192:and 19:The 1138:Rem 1128:Rad 903:doi 831:doi 413:in 23:in 1872:: 1850:, 1846:, 1370:, 1366:, 1362:, 909:. 899:99 897:. 893:. 839:. 827:83 825:. 821:. 749:. 743:. 715:: 713:}} 709:{{ 642:}} 638:{{ 579:^ 417:' 411:Sr 299:Sv 292:Sv 39:. 1409:e 1402:t 1395:v 1003:e 996:t 989:v 917:. 905:: 875:. 847:. 833:: 797:. 725:) 705:. 648:) 634:. 475:( 421:. 108:t 104:T 101:W

Index

radiological protection
stochastic
sievert
effective dose
equivalent dose
deterministic
radiation sickness
International Commission on Radiological Protection
sievert
radon
contaminated
tritium
technetium-99m
iodine-131
potassium iodide
thyroid
radioactive iodine
nuclear explosive
alpha
beta
relative biological effectiveness
equivalent dose
effective dose
radioactive decay
biological half-life
effective half-life
dosimetry
Internal dosimetry
whole body counting
tritium

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