61:
37:
1114:
1099:
1190:
1183:
118:
Complement deficiency has historically been associated with early, severe bacterial infections among children. Infection susceptibility is frequently observed.
1176:
1408:
1256:
1445:
746:
Pickering, M.C.; Botto, M.; Taylor, P.R.; Lachmann, P.J.; Walport, M.J. (2001). "Systemic Lupus
Erythematosus, Complement Deficiency, and Apoptosis".
978:
Cole, F. Sessions; Whitehead, Alexander S.; Auerbach, Harvey S.; Lint, Thomas; Zeitz, Howard J.; Kilbridge, Peter; Colten, Harvey R. (July 4, 1985).
1572:
573:
1274:
765:
422:
377:
343:
1577:
1129:
1512:
1429:
1340:
831:"Deficiency of the second component of complement associated with anaphylactoid purpura and presence of mycoplasma in the serum"
223:
1603:
1582:
1452:
1324:
572:
Jönsson, Göran; Truedsson, Lennart; Sturfelt, Gunnar; Oxelius, Vivi-Anne; Braconier, Jean Henrik; Sjöholm, Anders G. (2005).
231:
219:
208:
146:
1319:
251:
211:
can occur. Renal and neuropsychiatric disease, on the other hand, is thought to be uncommon in these SLE patients.
112:
92:
1432:
1284:
1251:
133:
levels, which could contribute to raised infection susceptibility. More than half of 40 C2D patients in a study had
278:"Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency"
1398:
1418:
1313:
1308:
1303:
1298:
1293:
1228:
804:
277:
1467:
1215:
134:
1168:
1567:
1552:
404:
1037:
207:
patients with C2D, skin and joint involvement are common, and severe persistent cutaneous and/or subacute
150:
78:
1542:
1522:
1243:
256:
200:
186:
108:
74:
1562:
1266:
466:
182:
104:
60:
1118:
1414:
1289:
428:
308:
215:
190:
178:
630:"Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy"
1383:
1374:
1359:
1203:
1140:
1065:
1057:
1007:
999:
953:
945:
899:
891:
852:
779:
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761:
728:
710:
669:
651:
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554:
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492:
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418:
373:
367:
339:
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49:
335:
1481:
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1393:
1207:
1199:
1049:
991:
979:
937:
883:
842:
753:
718:
700:
659:
641:
585:
544:
526:
474:
410:
292:
239:
926:"Subacute cutaneous lupus erythematosus in multiple members of a family with C2 deficiency"
1504:
227:
941:
980:"The Molecular Basis for Genetic Deficiency of the Second Component of Human Complement"
470:
1557:
1457:
1279:
847:
830:
723:
688:
664:
629:
122:
1123:
757:
590:
549:
514:
1597:
887:
479:
454:
432:
328:
1533:
1345:
870:
Leddy, John P.; Griggs, Robert C.; Klemperer, Martin R.; Frank, Michael M. (1975).
403:
Sturfelt, Gunnar; Truedsson, Lennart (2020). "Complement
Component C2 Deficiency".
312:
235:
161:
In roughly 10% of patients, a C2 deficiency is linked to an illness that resembles
36:
1053:
1036:
Sjöholm, A.G.; Jönsson, G.; Braconier, J.H.; Sturfelt, G.; Truedsson, L. (2006).
414:
995:
1538:
1499:
1145:
1108:
296:
142:
138:
54:
1061:
1003:
949:
895:
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655:
599:
540:
488:
1151:
747:
174:
85:
1069:
925:
871:
783:
732:
673:
607:
496:
304:
1011:
957:
903:
856:
558:
1489:
1224:
646:
1091:
531:
77:
caused by any one of several different alterations in the structure of
199:
associated with C2D is regarded as less severe when compared to other
1364:
1233:
1103:
829:
Sussman, M.; Jones, J. H.; Almeida, June D.; Lachmann, P. J. (1973).
398:
396:
924:
JP, Callen; SJ, Hodge; KB, Kulick; G, Stelzer; JJ, Buchino (1987).
453:
Pettigrew, H. David; Teuber, Suzanne S.; Gershwin, M. Eric (2009).
1156:
705:
508:
506:
196:
166:
162:
1134:
326:
Sherwood L. Gorbach; John G. Bartlett; Neil R. Blacklow (2004).
170:
130:
126:
1172:
699:(Suppl 3). Springer Science and Business Media LLC: S279–S293.
204:
515:"Infectious diseases associated with complement deficiencies"
153:
are two other infections commonly seen in C2D patients.
872:"Hereditary complement (C2) deficiency with dermatomyositis"
165:. Clinical manifestations of this SLE-like illness include
276:
Alper CA, Xu J, Cosmopoulos K, et al. (July 2003).
193:
will be present in approximately 50% of the population.
584:(1). Ovid Technologies (Wolters Kluwer Health): 23–34.
30:
C2 deficiency, Complement component 2 deficiency, C2D.
409:. New York, NY: Springer New York. pp. 207–213.
1081:
628:
Ram, Sanjay; Lewis, Lisa A.; Rice, Peter A. (2010).
1521:
1498:
1480:
1428:
1358:
1333:
1265:
1242:
1223:
1214:
1085:
48:
26:
21:
455:"Clinical Significance of Complement Deficiencies"
327:
640:(4). American Society for Microbiology: 740–780.
525:(3). American Society for Microbiology: 359–395.
1038:"Complement deficiency and disease: An update"
334:. Lippincott Williams & Wilkins. pp.
1184:
689:"Complement and systemic lupus erythematosus"
8:
752:. Vol. 76. Elsevier. pp. 227–324.
990:(1). Massachusetts Medical Society: 11–16.
111:bacterial infections, as well as a risk of
84:It has been associated with an increase in
1409:Purine nucleoside phosphorylase deficiency
1257:Transient hypogammaglobulinemia of infancy
1239:
1220:
1191:
1177:
1169:
1082:
459:Annals of the New York Academy of Sciences
59:
35:
18:
846:
722:
704:
663:
645:
589:
548:
530:
478:
369:Textbook of Microbiology & Immunology
121:C2D is linked to abnormalities in serum
841:(4). Oxford University Press: 531–539.
268:
137:-related invasive infection, primarily
1573:Terminal complement pathway deficiency
214:C2 deficiency has also been linked to
7:
942:10.1001/archderm.1987.01660250072021
835:Clinical and Experimental Immunology
574:"Hereditary C2 Deficiency in Sweden"
1578:Paroxysmal nocturnal hemoglobinuria
187:Anti-double-stranded DNA antibodies
406:Encyclopedia of Medical Immunology
14:
591:10.1097/01.md.0000152371.22747.1e
513:Figueroa, J E; Densen, P (1991).
372:. Elsevier India. pp. 125–.
1341:Common variable immunodeficiency
876:The American Journal of Medicine
480:10.1111/j.1749-6632.2009.04633.x
1513:Idiopathic CD4+ lymphocytopenia
984:New England Journal of Medicine
1583:Complement receptor deficiency
1453:Adenosine deaminase deficiency
1:
758:10.1016/s0065-2776(01)76021-x
634:Clinical Microbiology Reviews
519:Clinical Microbiology Reviews
209:cutaneous lupus erythematosus
1054:10.1016/j.molimm.2005.06.025
888:10.1016/0002-9343(75)90537-9
415:10.1007/978-1-4614-8678-7_10
252:Systemic Lupus Erythematosus
147:Haemophilus influenza type b
113:Systemic Lupus Erythematosus
93:systemic lupus erythematosus
91:It can present similarly to
1252:X-linked agammaglobulinemia
1048:(1–2). Elsevier BV: 78–85.
996:10.1056/nejm198507043130103
936:(1). Arch Dermatol: 66–70.
220:membrane glomerulonephritis
115:(SLE) or SLE-like disease.
44:Structure of the C2 protein
1620:
882:(1). Elsevier BV: 83–91.
43:
34:
1468:Bare lymphocyte syndrome
1320:Wiskott–Aldrich syndrome
687:Walport, Mark J (2002).
224:Henoch-Schonlein purpura
135:Streptococcus pneumoniae
1568:Complement 3 deficiency
1553:Complement 4 deficiency
1549:Complement 2 deficiency
930:Archives of Dermatology
297:10.1023/A:1024540917593
242:have also been linked.
201:complement deficiencies
71:Complement 2 deficiency
22:Complement 2 deficiency
749:Advances in Immunology
125:levels, such as lower
79:complement component 2
1604:Complement deficiency
1543:Hereditary angioedema
1399:Ataxia–telangiectasia
1244:Hypogammaglobulinemia
465:(1). Wiley: 108–123.
366:Parija (2009-01-01).
257:Complement deficiency
75:complement deficiency
1563:Properdin deficiency
1384:Di George's syndrome
1267:Dysgammaglobulinemia
1042:Molecular Immunology
647:10.1128/cmr.00048-09
181:. With a low titer,
151:Neisseria meningitis
105:bacterial infections
532:10.1128/cmr.4.3.359
471:2009NYASA1173..108P
330:Infectious diseases
1415:Hyper IgM syndrome
1325:Hyper-IgE syndrome
1290:Hyper IgM syndrome
1206:disorders causing
693:Arthritis Research
240:Hodgkin's lymphoma
216:rheumatic diseases
191:Anti-Ro antibodies
179:glomerulonephritis
99:Signs and symptoms
1591:
1590:
1476:
1475:
1375:thymic hypoplasia
1360:T cell deficiency
1354:
1353:
1166:
1165:
767:978-0-12-022476-0
424:978-1-4614-8677-0
379:978-81-312-2163-1
345:978-0-7817-3371-7
185:may be positive.
103:C2D is linked to
68:
67:
16:Medical condition
1611:
1463:ZAP70 deficiency
1394:Nezelof syndrome
1240:
1221:
1208:immunodeficiency
1193:
1186:
1179:
1170:
1083:
1073:
1023:
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969:
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285:J. Clin. Immunol
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1524:
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1505:Lymphocytopenia
1503:
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1472:
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1435:
1424:
1380:hypoparathyroid
1362:
1350:
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1261:
1231:
1210:
1197:
1167:
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1080:
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1030:Further reading
1027:
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232:cutaneous lupus
228:dermatomyositis
159:
101:
58:
17:
12:
11:
5:
1617:
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1607:
1606:
1596:
1595:
1589:
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1585:
1580:
1575:
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1565:
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1558:MBL deficiency
1555:
1546:
1529:
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1519:
1518:
1516:
1515:
1509:
1507:
1496:
1495:
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1458:Omenn syndrome
1455:
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1423:
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1331:
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1328:
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1322:
1317:
1311:
1306:
1301:
1296:
1287:
1285:IgM deficiency
1282:
1280:IgG deficiency
1277:
1275:IgA deficiency
1271:
1269:
1263:
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1260:
1259:
1254:
1248:
1246:
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1086:Classification
1079:
1078:External links
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291:(4): 297–305.
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189:are uncommon.
158:
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123:immunoglobulin
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1390:euparathyroid
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157:Complications
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107:, especially
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73:is a type of
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53:
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42:
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29:
25:
20:
1548:
1534:C1-inhibitor
1532:
1449:
1442:
1405:
1404:
1389:
1379:
1373:
1346:ICF syndrome
1150:
1139:
1128:
1113:
1098:
1045:
1041:
1017:November 18,
1015:. Retrieved
987:
983:
973:
963:November 18,
961:. Retrieved
933:
929:
919:
909:November 18,
907:. Retrieved
879:
875:
865:
838:
834:
824:
814:November 19,
812:. Retrieved
808:
799:
789:November 18,
787:. Retrieved
748:
741:
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692:
682:
637:
633:
623:
613:November 18,
611:. Retrieved
581:
577:
567:
522:
518:
462:
458:
448:
438:November 18,
436:. Retrieved
405:
383:. Retrieved
368:
361:
349:. Retrieved
329:
321:
288:
284:
271:
236:polymyositis
213:
195:
160:
120:
117:
109:encapsulated
102:
90:
83:
70:
69:
1406:peripheral:
385:13 November
230:. Subacute
27:Other names
1539:Angioedema
1525:deficiency
1523:Complement
1500:Leukopenia
1450:autosomal:
1204:complement
1141:DiseasesDB
805:"UpToDate"
263:References
143:septicemia
139:meningitis
86:infections
55:Hematology
1443:x-linked:
1157:234599007
1152:SNOMED CT
1062:0161-5890
1004:0028-4793
950:0003-987X
896:0002-9343
776:0065-2776
715:1465-9905
656:0893-8512
600:0025-7974
541:0893-8512
489:0077-8923
433:243396344
175:arthritis
50:Specialty
1598:Category
1490:HIV/AIDS
1482:Acquired
1433:combined
1225:Antibody
1200:Lymphoid
1070:16026838
809:UpToDate
784:11079100
733:12110148
674:20930072
608:15643297
578:Medicine
497:19758139
305:12959222
246:See also
218:such as
1229:humoral
1216:Primary
1012:2582254
958:3467658
904:1090155
857:4583776
848:1553813
724:3240161
665:2952982
559:1889047
467:Bibcode
313:1198276
95:(SLE).
1446:X-SCID
1430:Severe
1135:217000
1068:
1060:
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1002:
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550:358203
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539:
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487:
431:
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