36:
416:
ConA has proven useful in applications requiring solid-phase immobilization of glycoenzymes, especially those that have proved difficult to immobilize by traditional covalent coupling. Using ConA-couple matrices, such enzymes may be immobilized in high quantities without a concurrent loss of activity
258:
ConA binds specifically Ξ±-D-mannosyl and Ξ±-D-glucosyl residues (two hexoses differing only in the alcohol on carbon 2) in terminal position of ramified structures from B-Glycans (rich in Ξ±-mannose, or hybrid and bi-antennary glycan complexes). It has 4 binding sites, corresponding to the 4 sub-units.
293:
whereby the N-terminal half of the conA precursor is swapped to become the C-terminal half in the mature form; all other known circular permutations occur at the genetic level. ConA circular permutation is carried out by jack bean asparaginyl endopeptidase, a versatile enzyme capable of cleaving and
420:
A report from Taiwan (2009) demonstrated potent therapeutic effect of ConA against experimental hepatoma (liver cancer); in the study by Lei and Chang, ConA was found to be sequestered more by hepatic tumor cells, in preference to surrounding normal hepatocytes. Internalization of ConA occurs
421:
preferentially to the mitochondria after binding to cell membrane glycoproteins, which triggers an autophagic cell death. ConA was found to partially inhibit tumor nodule growth independent of its lymphocyte activation; the eradication of the tumor in the murine
417:
or stability. Such noncovalent ConA-glycoenzyme couplings may be relatively easily reversed by competition with sugars or at acidic pH. If necessary for certain applications, these couplings can be converted to covalent bindings by chemical manipulation.
425:
hepatoma model in this study was additionally attributed to the mitogenic/lymphoproliferative action of ConA that may have activated a CD8+ T-cell-mediated, as well as NK- and NK-T cell-mediated, immune response in the liver.
1807:
Yu M, Sato H, Seiki M, Thompson EW (August 1995). "Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells".
294:
ligating peptide substrates at a single active site. To convert conA to the mature form, jack bean asparaginyl endopeptidase cleaves the precursor of conA in the middle and ligates the two original termini.
1951:
Tikhonovich MV, Erdiakov AK, Gavrilova SA (August 2018). "Nonsteroid anti-inflammatory therapy suppresses the development of proliferative vitreoretinopathy more effectively than a steroid one".
672:
1445:
Capo C, Garrouste F, Benoliel AM, Bongrand P, Ryter A, Bell GI (August 1982). "Concanavalin-A-mediated thymocyte agglutination: a model for a quantitative study of cell adhesion".
1277:
Sela BA, Lis H, Sharon N, Sachs L (December 1971). "Quantitation of N-acetyl-D-galactosamine-like sites on the surface membrane of normal and transformed mammalian cells".
1183:
Becker FF, Shurgin A (October 1975). "Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide".
1615:
Kanellopoulos JM, De Petris S, Leca G, Crumpton MJ (May 1985). "The mitogenic lectin from
Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes".
1156:
Kakizoe T, Komatsu H, Niijima T, Kawachi T, Sugimura T (June 1980). "Increased agglutinability of bladder cells by concanavalin A after administration of carcinogens".
332:-treated normal cells do not agglutinate at 4 Β°C, thereby suggesting that there is a temperature-sensitive step involved in ConA-mediated agglutination.
1349:"Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures"
274:
ConA can also initiate cell division (mitogenesis), primarily acting on T-lymphocytes, by stimulating their energy metabolism within seconds of exposure.
247:
symmetry. Its tertiary structure has been elucidated, as have the molecular basis of its interactions with metals as well as its affinity for the sugars
202:; a subset of human suppressor T-cells is also sensitive to ConA. ConA was the first lectin to be available on a commercial basis, and is widely used in
70:
1113:
Betton GR (November 1976). "Agglutination reactions of spontaneous canine tumour cells, induced by concanavalin A, demonstrated by an isotopic assay".
198:, and is known for its ability to stimulate mouse T-cell subsets giving rise to four functionally distinct T cell populations, including precursors to
289:
ConA and its variants (found in closely related plants) are the only proteins known to undergo a post-translational sequence arrangement known as
2019:
669:
510:
529:
Sumner JB, GralΓ«n N, Eriksson-Quensel IB (April 1938). "The
Molecular Weights of Urease, Canavalin, Concanavalin a and Concanavalin B".
2066:
1760:"Identification of concanavalin A receptors and galactose-binding proteins in purified plasma membranes of Dictyostelium discoideum"
1658:
Ofek I, Mirelman D, Sharon N (February 1977). "Adherence of
Escherichia coli to human mucosal cells mediated by mannose receptors".
813:
Carrington DM, Auffret A, Hanke DE (1985). "Polypeptide ligation occurs during post-translational modification of concanavalin A".
290:
239:
430:
377:(PHA), it is a selective T cell mitogen relative to its effects on B cells. PHA and ConA bind and cross-link components of the
214:
and other sugar-containing entities on the surface of various cells. It is also used to purify glycosylated macromolecules in
2186:
278:
215:
2252:
2102:
356:
2028:
909:"Structural and biochemical analyses of concanavalin A circular permutation by jack bean asparaginyl endopeptidase"
1835:
Saleemuddin M, Husain Q (April 1991). "Concanavalin A: a useful ligand for glycoenzyme immobilization--a review".
1312:
Gartner TK, Podleski TR (December 1975). "Evidence that a membrane bound lectin mediates fusion of L6 myoblasts".
2130:
410:
2010:
2000:
1531:
Cuatrecasas P (March 1973). "Interaction of wheat germ agglutinin and concanavalin A with isolated fat cells".
1007:"Insulin-like activity of concanavalin A and wheat germ agglutinin--direct interactions with insulin receptors"
402:
314:
2352:
623:"Ultrastructural visualization of surface carbohydrate structures on mycoplasma membranes by concanavalin A"
194:
and Ξ±-D-glucosyl groups. Its physiological function in plants, however, is still unknown. ConA is a plant
328:
irrespective of blood-group, and various cancerous cells. It was demonstrated that transformed cells and
2117:
2059:
577:
20:
907:
Nonis SG, Haywood J, Schmidberger JW, Mackie ER, Soares da Costa TP, Bond CS, Mylne JS (August 2021).
1667:
1489:
1223:
1018:
822:
538:
302:
Concanavalin A interacts with diverse receptors containing mannose carbohydrates, notably rhodopsin,
2006:
1567:
2304:
2016:
1568:"Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene"
1480:
Weiser MM (August 1972). "Concanavalin A agglutination of intestinal cells from the human fetus".
1976:
1691:
1640:
1597:
1513:
1241:
1138:
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889:
846:
374:
45:
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1968:
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987:
938:
881:
838:
795:
754:
719:
652:
603:
554:
506:
499:"Isolation, physicochemical characterization, and carbohydrate-binding specificity of lectins"
479:
452:
396:
268:
199:
89:
498:
462:
Hardman KD, Ainsworth CF (December 1972). "Structure of concanavalin A at 2.4-A resolution".
2347:
2309:
2124:
2052:
1960:
1896:
1886:
1844:
1779:
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1675:
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830:
785:
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709:
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642:
634:
593:
546:
471:
390:
260:
381:, and their ability to activate T cells is dependent on expression of the T cell receptor.
2023:
1996:
676:
378:
125:
1671:
1493:
1227:
1212:"A specific metabolic activity on the surface membrane in malignant cell-transformation"
1074:"Interaction of human plasma low density lipoprotein with concanavalin A and with ricin"
1022:
826:
690:"Non-glycosylated recombinant pro-concanavalin A is active without polypeptide cleavage"
542:
44:
concanavalin A (the monomers are colored cyan, green, red, and magenta respectively).
1901:
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1759:
1422:
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877:
175:
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1601:
1517:
1142:
893:
638:
2242:
2171:
1980:
1695:
1398:"The relationship of concanavalin A binding to lectin-initiated cell agglutination"
850:
737:
Loris R, Hamelryck T, Bouckaert J, Wyns L (March 1998). "Legume lectin structure".
227:
211:
207:
183:
159:
35:
1726:
774:"Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism"
1501:
2034:
1584:
958:"Plant asparaginyl endopeptidases and their structural determinants of function"
739:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
550:
325:
318:
303:
135:
1216:
Proceedings of the
National Academy of Sciences of the United States of America
1011:
Proceedings of the
National Academy of Sciences of the United States of America
2277:
1964:
367:
348:
340:
235:
187:
101:
924:
335:
ConA-mediated agglutination of other cell types has been reported, including
16:
Lectin (carbohydrate-binding protein) originally extracted from the jack-bean
2112:
2037:
1891:
1236:
360:
352:
306:
238:, heavily glycated) binds a metallic atom (usually Mn and a Ca). It has the
167:
49:
41:
1972:
1937:
1910:
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1126:
991:
942:
885:
799:
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1431:
1382:
1333:
1298:
1263:
1169:
1058:
1031:
842:
758:
723:
656:
607:
582:"The use of concanavalin A to study the immunoregulation of human T cells"
503:
The
Lectins Properties, Functions and Applications in Biology and Medicine
483:
2257:
2247:
2237:
2221:
2216:
2151:
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2141:
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106:
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973:
475:
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2211:
2206:
2201:
2196:
2191:
2075:
1924:
Erdiakov AK, Tikhonovich MV, Rzhavina EM, Gavrilova SA (May 2015). "".
1711:"Interaction of concanavalin A with the cell wall of Bacillus subtilis"
385:
370:
329:
252:
248:
203:
195:
191:
163:
456:
94:
2321:
2163:
2079:
1679:
1245:
1040:
834:
178:
family. It binds specifically to certain structures found in various
155:
2044:
501:. In Liener, Irvin E.; Sharon, Nathan; Goldstein, Irwin J. (eds.).
2287:
2282:
2107:
179:
218:, as well as to study immune regulation by various immune cells.
2181:
2176:
1875:"Lectin of Concanavalin A as an anti-hepatoma therapeutic agent"
1566:
Weiss A, Shields R, Newton M, Manger B, Imboden J (April 1987).
2048:
621:
Schiefer HG, Krauss H, Brunner H, Gerhardt U (December 1975).
264:
231:
52:
429:
ConA intravitreal injection can be used in the modeling of
1926:
2270:
2230:
2162:
2093:
2086:
1314:
778:
Biochimica et
Biophysica Acta (BBA) - Bioenergetics
131:
121:
116:
100:
88:
80:
65:
60:
28:
2041:con A in complex with methyl alpha1-2 mannobioside
1279:Biochimica et Biophysica Acta (BBA) - Biomembranes
409:It has also been shown as a stimulator of several
388:residues of many microbes, including the bacteria
1210:Inbar M, Ben-Bassat H, Sachs L (November 1971).
1868:
1866:
670:GE Healthcare Life Sciences, Immobilized lectin
497:Goldstein, Irwin J.; Poretz, Ronald D. (2012).
190:, mainly internal and nonreducing terminal Ξ±-D-
864:Hendrix RW (April 1991). "Protein carpentry".
772:Krauss S, Buttgereit F, Brand MD (June 1999).
2060:
572:
570:
568:
524:
522:
447:
445:
8:
956:Nonis SG, Haywood J, Mylne JS (April 2021).
40:Crystallographic structure of a tetramer of
19:"ConA" redirects here. For other uses, see
2090:
2067:
2053:
2045:
113:
34:
2009:at the U.S. National Library of Medicine
1999:at the U.S. National Library of Medicine
1900:
1890:
1783:
1734:
1583:
1421:
1372:
1253:
1235:
1089:
1048:
1030:
981:
932:
789:
713:
646:
597:
1005:Cuatrecasas P, Tell GP (February 1973).
1709:Doyle RJ, Birdsell DC (February 1972).
1072:Harmony JA, Cordes EH (November 1975).
688:Min W, Dunn AJ, Jones DH (April 1992).
441:
25:
1396:Noonan KD, Burger MM (October 1973).
7:
586:Clinical and Experimental Immunology
2029:World of Lectin, Gateway to lectins
1078:The Journal of Biological Chemistry
706:10.1002/j.1460-2075.1992.tb05174.x
14:
1873:Lei HY, Chang CP (January 2009).
271:(pI) is in the range of 4.5β5.5.
1758:West CM, McMahon D (July 1977).
962:Biochemical Society Transactions
384:ConA interacts with the surface
291:Circular permutation in proteins
166:) originally extracted from the
1837:Enzyme and Microbial Technology
1115:International Journal of Cancer
639:10.1128/JB.124.3.1598-1600.1975
431:proliferative vitreoretinopathy
277:For biotechnological uses, see
55:(grey) are depicted as spheres.
2187:Myelin-associated glycoprotein
1617:European Journal of Immunology
355:, human fetal (but not adult)
317:(CEA). It also interacts with
279:Fluorescent glucose biosensors
216:lectin affinity chromatography
1:
1879:Journal of Biomedical Science
1727:10.1128/JB.109.2.652-658.1972
1091:10.1016/S0021-9258(19)40714-X
791:10.1016/S0005-2728(99)00058-4
751:10.1016/S0167-4838(97)00182-9
580:, Johnson C (November 1981).
505:. Elsevier. pp. 33β247.
226:Like most lectins, ConA is a
2253:N-Acetylglucosamine receptor
1849:10.1016/0141-0229(91)90146-2
1502:10.1126/science.177.4048.525
1326:10.1016/0006-291X(75)90770-6
1291:10.1016/0005-2736(71)90132-5
878:10.1016/0960-9822(91)90280-a
2103:Asialoglycoprotein receptor
1953:International Ophthalmology
1764:The Journal of Cell Biology
1585:10.4049/jimmunol.138.7.2169
1402:The Journal of Cell Biology
1353:The Journal of Cell Biology
551:10.1126/science.87.2261.395
357:intestinal epithelial cells
324:ConA strongly agglutinates
2369:
1347:de Petris S (April 1975).
315:carcino-embryonary antigen
276:
18:
2131:proteochondroitin sulfate
1965:10.1007/s10792-017-0594-3
411:matrix metalloproteinases
309:, insulin receptors, the
174:). It is a member of the
112:
33:
2017:Concanavalin A structure
2011:Medical Subject Headings
2007:Concanavalin+A+Receptors
2001:Medical Subject Headings
403:Dictyostelium discoideum
222:Structure and properties
1892:10.1186/1423-0127-16-10
1715:Journal of Bacteriology
1447:Journal of Cell Science
1237:10.1073/pnas.68.11.2748
627:Journal of Bacteriology
1629:10.1002/eji.1830150512
1127:10.1002/ijc.2910180518
925:10.1093/plcell/koab130
2118:Mannan-binding lectin
1572:Journal of Immunology
1032:10.1073/pnas.70.2.485
230:: each sub-unit (26.5
1776:10.1083/jcb.74.1.264
1414:10.1083/jcb.59.1.134
1365:10.1083/jcb.65.1.123
172:Canavalia ensiformis
72:Canavalia ensiformis
2305:Phytohaemagglutinin
1672:1977Natur.265..623O
1545:10.1021/bi00731a011
1494:1972Sci...177..525W
1459:10.1242/jcs.56.1.21
1228:1971PNAS...68.2748I
1023:1973PNAS...70..485C
974:10.1042/BST20200908
827:1985Natur.313...64C
543:1938Sci....87..395S
476:10.1021/bi00776a006
298:Biological activity
2022:2008-08-20 at the
675:2012-03-03 at the
375:phytohemagglutinin
285:Maturation process
200:regulatory T cells
2330:
2329:
2266:
2265:
1816:(15): 3272β3277.
1666:(5595): 623β625.
1488:(4048): 525β526.
1222:(11): 2748β2751.
1191:(10): 2879β2883.
1084:(22): 8614β8617.
537:(2261): 395β396.
512:978-0-323-14444-5
470:(26): 4910β4919.
397:Bacillus subtilis
343:(through surface
269:isoelectric point
145:
144:
141:
140:
2360:
2310:Pokeweed mitogen
2125:Mannose receptor
2091:
2069:
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1985:
1984:
1959:(4): 1365β1378.
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1680:10.1038/265623a0
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1648:
1612:
1606:
1605:
1587:
1578:(7): 2169β2176.
1563:
1557:
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1539:(7): 1312β1323.
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1164:(6): 2006β2009.
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919:(8): 2794β2811.
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835:10.1038/313064a0
810:
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728:
727:
717:
700:(4): 1303β1307.
694:The EMBO Journal
685:
679:
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661:
660:
650:
633:(3): 1598β1600.
618:
612:
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562:
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516:
494:
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400:and the protist
261:molecular weight
255:are well known.
210:to characterize
114:
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38:
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2024:Wayback Machine
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858:
821:(5997): 64β67.
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311:immunoglobulins
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2353:Legume lectins
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2300:Concanavalin A
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2095:C-type lectins
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2072:
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2064:
2057:
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2031:
2026:
2014:
2004:
1997:Concanavalin+A
1992:
1991:External links
1989:
1987:
1986:
1943:
1932:(5): 572β585.
1916:
1862:
1843:(4): 290β295.
1827:
1799:
1770:(1): 264β273.
1750:
1721:(2): 652β658.
1701:
1650:
1623:(5): 479β486.
1607:
1558:
1523:
1472:
1437:
1408:(1): 134β142.
1388:
1359:(1): 123β146.
1339:
1320:(3): 972β978.
1304:
1285:(2): 564β568.
1269:
1202:
1175:
1148:
1121:(5): 687β696.
1105:
1064:
1017:(2): 485β489.
997:
968:(2): 965β976.
948:
913:The Plant Cell
899:
856:
805:
784:(2): 129β138.
764:
729:
680:
662:
613:
592:(2): 237β249.
564:
518:
511:
489:
440:
438:
435:
373:. Similar to
299:
296:
286:
283:
243:
223:
220:
148:Concanavalin A
143:
142:
139:
138:
133:
129:
128:
123:
119:
118:
110:
109:
104:
98:
97:
92:
86:
85:
82:
78:
77:
67:
63:
62:
58:
57:
39:
31:
30:
29:Concanavalin A
15:
13:
10:
9:
6:
4:
3:
2:
2365:
2354:
2351:
2349:
2346:
2344:
2341:
2340:
2338:
2323:
2320:
2318:
2317:Legume lectin
2315:
2311:
2308:
2306:
2303:
2301:
2298:
2297:
2296:
2293:
2289:
2286:
2284:
2281:
2280:
2279:
2276:
2275:
2273:
2269:
2259:
2256:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2236:
2235:
2233:
2229:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2169:
2167:
2165:
2161:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2135:
2134:
2133:
2132:
2128:
2126:
2123:
2119:
2116:
2115:
2114:
2111:
2109:
2106:
2104:
2101:
2100:
2098:
2096:
2092:
2089:
2085:
2081:
2077:
2070:
2065:
2063:
2058:
2056:
2051:
2050:
2047:
2040:
2039:
2036:
2032:
2030:
2027:
2025:
2021:
2018:
2015:
2012:
2008:
2005:
2002:
1998:
1995:
1994:
1990:
1982:
1978:
1974:
1970:
1966:
1962:
1958:
1954:
1947:
1944:
1939:
1935:
1931:
1927:
1920:
1917:
1912:
1908:
1903:
1898:
1893:
1888:
1884:
1880:
1876:
1869:
1867:
1863:
1858:
1854:
1850:
1846:
1842:
1838:
1831:
1828:
1823:
1819:
1815:
1811:
1803:
1800:
1795:
1791:
1786:
1781:
1777:
1773:
1769:
1765:
1761:
1754:
1751:
1746:
1742:
1737:
1732:
1728:
1724:
1720:
1716:
1712:
1705:
1702:
1697:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1654:
1651:
1646:
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1611:
1608:
1603:
1599:
1595:
1591:
1586:
1581:
1577:
1573:
1569:
1562:
1559:
1554:
1550:
1546:
1542:
1538:
1534:
1527:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1473:
1468:
1464:
1460:
1456:
1452:
1448:
1441:
1438:
1433:
1429:
1424:
1419:
1415:
1411:
1407:
1403:
1399:
1392:
1389:
1384:
1380:
1375:
1370:
1366:
1362:
1358:
1354:
1350:
1343:
1340:
1335:
1331:
1327:
1323:
1319:
1315:
1308:
1305:
1300:
1296:
1292:
1288:
1284:
1280:
1273:
1270:
1265:
1261:
1256:
1251:
1247:
1243:
1238:
1233:
1229:
1225:
1221:
1217:
1213:
1206:
1203:
1198:
1194:
1190:
1186:
1179:
1176:
1171:
1167:
1163:
1159:
1152:
1149:
1144:
1140:
1136:
1132:
1128:
1124:
1120:
1116:
1109:
1106:
1101:
1097:
1092:
1087:
1083:
1079:
1075:
1068:
1065:
1060:
1056:
1051:
1046:
1042:
1038:
1033:
1028:
1024:
1020:
1016:
1012:
1008:
1001:
998:
993:
989:
984:
979:
975:
971:
967:
963:
959:
952:
949:
944:
940:
935:
930:
926:
922:
918:
914:
910:
903:
900:
895:
891:
887:
883:
879:
875:
871:
867:
860:
857:
852:
848:
844:
840:
836:
832:
828:
824:
820:
816:
809:
806:
801:
797:
792:
787:
783:
779:
775:
768:
765:
760:
756:
752:
748:
744:
740:
733:
730:
725:
721:
716:
711:
707:
703:
699:
695:
691:
684:
681:
678:
674:
671:
666:
663:
658:
654:
649:
644:
640:
636:
632:
628:
624:
617:
614:
609:
605:
600:
595:
591:
587:
583:
579:
573:
571:
569:
565:
560:
556:
552:
548:
544:
540:
536:
532:
525:
523:
519:
514:
508:
504:
500:
493:
490:
485:
481:
477:
473:
469:
465:
458:
454:
448:
446:
442:
436:
434:
432:
427:
424:
418:
414:
412:
407:
405:
404:
399:
398:
393:
392:
387:
382:
380:
376:
372:
369:
364:
362:
358:
354:
350:
346:
342:
338:
333:
331:
327:
322:
320:
316:
312:
308:
305:
297:
295:
292:
284:
280:
275:
272:
270:
266:
262:
256:
254:
250:
246:
242:
237:
233:
229:
221:
219:
217:
213:
212:glycoproteins
209:
205:
201:
197:
193:
189:
185:
184:glycoproteins
181:
177:
176:legume lectin
173:
169:
165:
161:
157:
153:
149:
137:
134:
130:
127:
124:
120:
115:
111:
108:
105:
103:
99:
96:
93:
91:
87:
83:
79:
75:
73:
68:
64:
59:
54:
51:
47:
43:
37:
32:
27:
22:
2299:
2243:Calreticulin
2172:Sialoadhesin
2129:
2033:
1956:
1952:
1946:
1929:
1925:
1919:
1882:
1878:
1840:
1836:
1830:
1813:
1809:
1802:
1767:
1763:
1753:
1718:
1714:
1704:
1663:
1659:
1653:
1620:
1616:
1610:
1575:
1571:
1561:
1536:
1533:Biochemistry
1532:
1526:
1485:
1481:
1475:
1450:
1446:
1440:
1405:
1401:
1391:
1356:
1352:
1342:
1317:
1313:
1307:
1282:
1278:
1272:
1219:
1215:
1205:
1188:
1184:
1178:
1161:
1157:
1151:
1118:
1114:
1108:
1081:
1077:
1067:
1014:
1010:
1000:
965:
961:
951:
916:
912:
902:
872:(2): 71β73.
869:
865:
859:
818:
814:
808:
781:
777:
767:
742:
738:
732:
697:
693:
683:
665:
630:
626:
616:
589:
585:
534:
530:
502:
492:
467:
464:Biochemistry
463:
428:
422:
419:
415:
408:
401:
395:
389:
383:
365:
337:muscle cells
334:
326:erythrocytes
323:
319:lipoproteins
301:
288:
273:
257:
240:
228:homotetramer
225:
208:biochemistry
171:
160:carbohydrate
151:
147:
146:
71:
2278:Toxalbumins
2035:Proteopedia
745:(1): 9β36.
349:fibroblasts
341:lymphocytes
304:blood group
263:is 104β112
236:amino-acids
188:glycolipids
126:Swiss-model
61:Identifiers
48:(gold) and
2337:Categories
437:References
368:lymphocyte
366:ConA is a
361:adipocytes
353:thymocytes
122:Structures
117:Search for
74:(jackbean)
2113:Collectin
1885:(1): 10.
1453:: 21β48.
460:;
433:in rats.
168:jack-bean
162:-binding
50:manganese
42:jack bean
2343:Proteins
2295:Mitogens
2258:Selectin
2248:Galectin
2238:Calnexin
2222:SIGLEC12
2217:SIGLEC10
2152:Neurocan
2147:Brevican
2142:Versican
2137:Aggrecan
2020:Archived
1973:28639085
1938:26263683
1911:19272170
1645:21414006
1602:35173412
1518:23661797
1143:36612952
992:33666219
943:34235541
894:45963307
886:15336168
800:10393256
673:Archived
578:Dwyer JM
559:17746464
413:(MMPs).
313:and the
267:and the
192:mannosyl
136:InterPro
66:Organism
2348:Lectins
2212:SIGLEC9
2207:SIGLEC8
2202:SIGLEC7
2197:SIGLEC6
2192:SIGLEC5
2080:lectins
2076:Protein
1981:4017540
1902:2644972
1857:1367163
1822:7614461
1785:2109878
1745:4621684
1696:4223466
1668:Bibcode
1637:3873340
1594:3104454
1553:4696755
1510:5050484
1490:Bibcode
1482:Science
1467:7166565
1432:4201706
1423:2110924
1383:1092699
1374:2111157
1334:1201086
1299:4332414
1264:4330939
1224:Bibcode
1170:7371036
1059:4510292
1019:Bibcode
983:8106488
934:8408470
851:4359482
843:3965973
823:Bibcode
759:9546043
724:1563347
657:1104592
608:6461456
599:1536405
539:Bibcode
531:Science
484:4638345
423:in-situ
391:E. coli
386:mannose
371:mitogen
330:trypsin
307:markers
253:glucose
249:mannose
204:biology
196:mitogen
164:protein
154:) is a
132:Domains
102:UniProt
53:cations
46:Calcium
2322:BanLec
2164:SIGLEC
2087:Animal
2013:(MeSH)
2003:(MeSH)
1979:
1971:
1936:
1909:
1899:
1855:
1820:
1794:559679
1792:
1782:
1743:
1736:285189
1733:
1694:
1688:323718
1686:
1660:Nature
1643:
1635:
1600:
1592:
1551:
1516:
1508:
1465:
1430:
1420:
1381:
1371:
1332:
1297:
1262:
1255:389516
1252:
1244:
1197:168971
1195:
1168:
1141:
1135:992901
1133:
1100:171260
1098:
1057:
1050:433288
1047:
1039:
990:
980:
941:
931:
892:
884:
849:
841:
815:Nature
798:
757:
722:
715:556578
712:
655:
648:236075
645:
606:
596:
557:
509:
482:
394:, and
359:, and
351:, rat
234:, 235
186:, and
180:sugars
156:lectin
107:P81461
81:Symbol
2288:Ricin
2283:Abrin
2271:Plant
2231:Other
2108:KLRD1
1977:S2CID
1692:S2CID
1641:S2CID
1598:S2CID
1514:S2CID
1246:61219
1242:JSTOR
1139:S2CID
1041:62526
1037:JSTOR
890:S2CID
847:S2CID
2182:CD33
2177:CD22
2038:1bxh
1969:PMID
1934:PMID
1907:PMID
1853:PMID
1818:PMID
1790:PMID
1741:PMID
1684:PMID
1633:PMID
1590:PMID
1549:PMID
1506:PMID
1463:PMID
1428:PMID
1379:PMID
1330:PMID
1295:PMID
1260:PMID
1193:PMID
1166:PMID
1131:PMID
1096:PMID
1055:PMID
988:PMID
939:PMID
882:PMID
839:PMID
796:PMID
782:1412
755:PMID
743:1383
720:PMID
653:PMID
604:PMID
555:PMID
507:ISBN
480:PMID
457:3CNA
339:, B-
259:The
251:and
206:and
152:ConA
95:3CNA
84:ConA
21:Cona
1961:doi
1930:101
1897:PMC
1887:doi
1845:doi
1780:PMC
1772:doi
1731:PMC
1723:doi
1719:109
1676:doi
1664:265
1625:doi
1580:doi
1576:138
1541:doi
1498:doi
1486:177
1455:doi
1418:PMC
1410:doi
1369:PMC
1361:doi
1322:doi
1287:doi
1283:249
1250:PMC
1232:doi
1123:doi
1086:doi
1082:250
1045:PMC
1027:doi
978:PMC
970:doi
929:PMC
921:doi
874:doi
831:doi
819:313
786:doi
747:doi
710:PMC
702:doi
643:PMC
635:doi
631:124
594:PMC
547:doi
472:doi
453:PDB
347:),
265:kDa
232:kDa
90:PDB
2339::
2078::
1975:.
1967:.
1957:38
1955:.
1928:.
1905:.
1895:.
1883:16
1881:.
1877:.
1865:^
1851:.
1841:13
1839:.
1814:55
1812:.
1788:.
1778:.
1768:74
1766:.
1762:.
1739:.
1729:.
1717:.
1713:.
1690:.
1682:.
1674:.
1662:.
1639:.
1631:.
1621:15
1619:.
1596:.
1588:.
1574:.
1570:.
1547:.
1537:12
1535:.
1512:.
1504:.
1496:.
1484:.
1461:.
1451:56
1449:.
1426:.
1416:.
1406:59
1404:.
1400:.
1377:.
1367:.
1357:65
1355:.
1351:.
1328:.
1318:67
1316:.
1293:.
1281:.
1258:.
1248:.
1240:.
1230:.
1220:68
1218:.
1214:.
1189:35
1187:.
1162:40
1160:.
1137:.
1129:.
1119:18
1117:.
1094:.
1080:.
1076:.
1053:.
1043:.
1035:.
1025:.
1015:70
1013:.
1009:.
986:.
976:.
966:49
964:.
960:.
937:.
927:.
917:33
915:.
911:.
888:.
880:.
868:.
845:.
837:.
829:.
817:.
794:.
780:.
776:.
753:.
741:.
718:.
708:.
698:11
696:.
692:.
651:.
641:.
629:.
625:.
602:.
590:46
588:.
584:.
567:^
553:.
545:.
535:87
533:.
521:^
478:.
468:11
466:.
455::
444:^
406:.
363:.
321:.
182:,
2068:e
2061:t
2054:v
1983:.
1963::
1940:.
1913:.
1889::
1859:.
1847::
1824:.
1796:.
1774::
1747:.
1725::
1698:.
1678::
1670::
1647:.
1627::
1604:.
1582::
1555:.
1543::
1520:.
1500::
1492::
1469:.
1457::
1434:.
1412::
1385:.
1363::
1336:.
1324::
1301:.
1289::
1266:.
1234::
1226::
1199:.
1172:.
1145:.
1125::
1102:.
1088::
1061:.
1029::
1021::
994:.
972::
945:.
923::
896:.
876::
870:1
853:.
833::
825::
802:.
788::
761:.
749::
726:.
704::
659:.
637::
610:.
561:.
549::
541::
515:.
486:.
474::
281:.
244:2
241:D
170:(
158:(
150:(
23:.
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