243:, an anti-IgE monoclonal antibody, marketed as Xolair by Genentech, can significantly mitigate allergic reactions in individuals with severe food allergies. These studies led to his role at Genentech, as Principal Medical Director and Global Development Lead, where he led efforts that culminated in a successful Phase 3 study (a collaboration between Genentech and the NIH) and subsequent FDA approval of omalizumab for food allergy in 2024.
186:
as the Prince Turki Bin Abdul Aziz al Saud
Professor of Pediatrics and conducted NIH-funded laboratory research for over two decades. His roles included Treasurer of the Society for Mucosal Immunology from 2007 to 2011, a member of the editorial board of
246:
In 2004, Umetsu led a team that developed vaccines that reduced or eliminated dogs' allergic reactions to peanuts, milk, and wheat. Umetsu's approach, using heat-killed
Listeria mixed with allergens, targets the hygiene hypothesis.
525:
204:
In 2013, Umetsu transitioned from academia to the role of
Principal Medical Director in Respiratory and Allergic Diseases and Global Development Lead for Xolair at Genentech.
194:
236:
gene family. He has published over 200 manuscripts, holds nine patents, and has been working in translational medicine in asthma and food allergies.
561:
281:
589:
197:
from 2002 to 2007, as a member of the
Allergenic Products Advisory Committee at CBER FDA from 1998 to 2002, and as a Study Section chair with the
137:
113:
311:
544:
584:
475:
Schneider, Lynda C.; Rachid, Rima; LeBovidge, Jennifer; Blood, Emily; Mittal, Mudita; Umetsu, Dale T. (December 21, 2013).
169:
105:
198:
189:
562:
https://www.seattlepi.com/lifestyle/health/article/Promising-vaccine-could-cure-common-food-allergies-1159403.php
282:
https://www.seattlepi.com/lifestyle/health/article/promising-vaccine-could-cure-common-food-allergies-1159403.php
132:
physician, immunologist and pharmaceutical executive, who currently serves as clinical professor of medicine at
526:"FDA Approves First Medication to Help Reduce Allergic Reactions to Multiple Foods After Accidental Exposure"
477:"A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients"
579:
339:
183:
141:
101:
91:
221:
229:
176:
165:
161:
133:
109:
63:
54:
409:
67:
506:
328:
140:. Previously, he served as the Prince Turki bin Abdul Aziz al-Saud Professor of Pediatrics at
496:
488:
439:
391:
153:
58:
315:
501:
476:
264:
193:
since 2008, and associate editor from 2009 onwards. He also served on the board of the
573:
293:
213:
362:
157:
457:
492:
240:
87:
225:
510:
427:
379:
179:
as a professor, where he also served as the director of the Asthma Center.
129:
410:"New treatment may desensitize kids with milk allergies, study suggests"
443:
395:
340:
https://www.npr.org/transcripts/5286340?storyId=5286340?storyId=5286340
233:
217:
265:"Meet Our Team | Giving to Broad Institute of MIT and Harvard"
144:
and as a tenured professor of pediatrics at
Stanford University.
71:
37:
Academic physician, immunologist and pharmaceutical executive
164:, followed by an MD and PhD in medicine and immunology from
329:
https://hms.harvard.edu/news/new-treatment-peanut-allergies
97:
83:
78:
50:
45:
33:
25:
18:
524:Commissioner, Office of the (August 9, 2024).
481:The Journal of Allergy and Clinical Immunology
8:
136:and clinical professor of pediatrics at the
212:Umetsu's research primarily focuses on the
195:American Academy of Allergy and Immunology
172:, affiliated with Harvard Medical School.
15:
500:
312:"Immunology Faculty Member - Dale Umetsu"
374:
372:
256:
138:University of California, San Francisco
114:University of California, San Francisco
543:Pallarito, Karen (November 12, 2004).
357:
355:
353:
351:
349:
347:
220:, focusing on subsets of CD4 T cells,
458:"Umetsu DT - Search Results - PubMed"
7:
545:"Vaccine Stops Food Allergy in Dogs"
175:Umetsu began his academic career at
314:. December 7, 2013. Archived from
14:
239:Umetsu's research has shown that
168:. He completed his residency at
590:Harvard Medical School faculty
1:
199:Center for Scientific Review
446:– via www.nature.com.
438:(3): 170–171. May 1, 2008.
390:(3): 170–171. May 1, 2008.
606:
493:10.1016/j.jaci.2013.09.046
170:Boston Children's Hospital
106:Boston Children's Hospital
269:giving.broadinstitute.org
216:of allergic diseases and
119:
41:
428:"News & Highlights"
380:"News & Highlights"
182:In 2005, Umetsu joined
585:American immunologists
222:Natural killer T cells
184:Harvard Medical School
142:Harvard Medical School
102:Harvard Medical School
92:Translational medicine
230:innate lymphoid cells
201:from 1998 to 2000.
398:– via Nature.
177:Stanford University
166:New York University
162:Columbia University
134:Stanford University
110:Stanford University
64:New York University
55:Columbia University
46:Academic background
444:10.1038/mi.2008.10
432:Mucosal Immunology
396:10.1038/mi.2008.10
384:Mucosal Immunology
298:directory.ucsf.edu
190:Mucosal Immunology
549:www.healthday.com
123:
122:
597:
564:
559:
553:
552:
540:
534:
533:
521:
515:
514:
504:
487:(6): 1368–1374.
472:
466:
465:
454:
448:
447:
424:
418:
417:
406:
400:
399:
376:
367:
366:
359:
342:
337:
331:
326:
320:
319:
308:
302:
301:
294:"UCSF Directory"
290:
284:
279:
273:
272:
261:
154:Bachelor of Arts
152:Umetsu earned a
16:
605:
604:
600:
599:
598:
596:
595:
594:
570:
569:
568:
567:
560:
556:
542:
541:
537:
523:
522:
518:
474:
473:
469:
456:
455:
451:
426:
425:
421:
408:
407:
403:
378:
377:
370:
361:
360:
345:
338:
334:
327:
323:
310:
309:
305:
292:
291:
287:
280:
276:
263:
262:
258:
253:
210:
150:
128:is an American
112:
108:
104:
90:
62:
21:
12:
11:
5:
603:
601:
593:
592:
587:
582:
572:
571:
566:
565:
554:
535:
516:
467:
449:
419:
401:
368:
343:
332:
321:
318:on 2013-12-07.
303:
285:
274:
255:
254:
252:
249:
209:
206:
149:
146:
126:Dale T. Umetsu
121:
120:
117:
116:
99:
95:
94:
85:
81:
80:
76:
75:
52:
48:
47:
43:
42:
39:
38:
35:
31:
30:
27:
23:
22:
20:Dale T. Umetsu
19:
13:
10:
9:
6:
4:
3:
2:
602:
591:
588:
586:
583:
581:
580:Living people
578:
577:
575:
563:
558:
555:
550:
546:
539:
536:
531:
527:
520:
517:
512:
508:
503:
498:
494:
490:
486:
482:
478:
471:
468:
463:
459:
453:
450:
445:
441:
437:
433:
429:
423:
420:
415:
411:
405:
402:
397:
393:
389:
385:
381:
375:
373:
369:
364:
363:"Dale Umetsu"
358:
356:
354:
352:
350:
348:
344:
341:
336:
333:
330:
325:
322:
317:
313:
307:
304:
299:
295:
289:
286:
283:
278:
275:
270:
266:
260:
257:
250:
248:
244:
242:
237:
235:
231:
227:
223:
219:
215:
214:immunobiology
207:
205:
202:
200:
196:
192:
191:
185:
180:
178:
173:
171:
167:
163:
159:
155:
147:
145:
143:
139:
135:
131:
127:
118:
115:
111:
107:
103:
100:
96:
93:
89:
86:
82:
79:Academic work
77:
73:
69:
65:
60:
56:
53:
49:
44:
40:
36:
34:Occupation(s)
32:
28:
24:
17:
557:
548:
538:
529:
519:
484:
480:
470:
461:
452:
435:
431:
422:
414:ScienceDaily
413:
404:
387:
383:
335:
324:
316:the original
306:
297:
288:
277:
268:
259:
245:
238:
211:
203:
188:
181:
174:
158:biochemistry
151:
125:
124:
98:Institutions
26:Nationality
574:Categories
251:References
241:omalizumab
226:Treg cells
88:Immunology
84:Discipline
148:Biography
51:Education
511:24176117
232:and the
208:Research
130:academic
29:American
502:4405160
509:
499:
462:PubMed
218:asthma
160:from
507:PMID
70:and
530:FDA
497:PMC
489:doi
485:132
440:doi
392:doi
234:TIM
156:in
72:PhD
576::
547:.
528:.
505:.
495:.
483:.
479:.
460:.
434:.
430:.
412:.
386:.
382:.
371:^
346:^
296:.
267:.
228:,
224:,
68:MD
61:)
59:BA
551:.
532:.
513:.
491::
464:.
442::
436:1
416:.
394::
388:1
365:.
300:.
271:.
74:)
66:(
57:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.