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Farh K, Marson A, Zhu J, Kleinwietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJH, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA* Bernstein BE, *. Genetic and epigenetic fine mapping of causal variants
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In 1998, Hafler and Weiner co-founded a private biotech company called
Autoimmune Inc., a biopharmaceutical company developing orally administered pharmaceutical products for the treatment of autoimmune and other cell-mediated inflammatory diseases and conditions. The Company's products, which induce
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In 2015, Hafler was appointed to the newly created
Edgerly Professorship in Neurology at Yale. This endowed professorship was provided by William S. and Lois Stiles Edgerly who had long supported research in multiple sclerosis. In 2018 he was elected to membership in the National Academy of Medicine
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International
Multiple Sclerosis Genetic Consortium; Hafler, D.A., Compston, A., Sawcer, S., Lander, S., Daly, M.J., DeJager, P.L., de Bakker, P.I.W., Gabriel, S.B., Mirel, D.B., Ivinson, A.J., Pericak-Vance, M.A., Gregory, S.G., Rioux, J.D., McCauley, J.L., Haines, J.L., Barcellos, L.F., Cree, B.,
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with the citation "For seminal discoveries defining the pathogenesis of multiple sclerosis (MS), including identification of autoreactive T cells and mechanisms that underlie their dysregulation, and the discovery of susceptibility genes that lead to MS."
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Hafler, David A.; David A. Fox; Mary
Elizabeth Manning; Stuart F. Schlossman; Ellis L. Reinherz; Howard L. Weiner (1985). "In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis".
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Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells. Nature; 496(7446):518-22
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tissue-specific immunosuppression without toxicity, are based upon the principles of oral tolerance. The company went public in 1993 with Henri
Termeer and others on the Board of Directors.
198:, and began to work in his lab on multiple sclerosis. In 1984, he joined the faculty of Harvard Medical School in the department of Neurology. He stayed on in Weiner's laboratory, becoming a
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228:. It was awarded "for fundamental discoveries related to MS in fields such as immunology and genetics, and for bringing clinical importance to basic science findings."
220:, where he became the Glaser Professor and chairman of the department of Neurology. He was awarded the John Dystel Prize for Multiple Sclerosis Research in 2010 by the
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International
Multiple Sclerosis Genetics Consortium. Low frequency and rare coding variation contributes to multiple sclerosis risk. Cell, 2018
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115:. He became interested in immunology at a young age and began doing research in the field as a high school student. In 1974 he graduated from
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Baecher-Allan C, Brown JA, Freeman GJ, Hafler, DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 167(3): 1245-53 2004
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Ota K, Matsui M, Milford E, Weiner H, Hafler DA. T cell recognition of an immunodominant MBP epitope in MS. Nature 346, 183. 2001
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Viglietta V, Baecher-Allan C, Hafler DA, Loss of suppression by CD+CD25+ regulatory T cells in MS patients. J Exp Med 199:971.
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Bernstein, Sara (2010). "Dystel Prize winner Dr. David Hailer on the genetic roadmap to ending MS".
321:"Loss of functional suppression by CD+CD25+ regulatory T cells in patients with multiple sclerosis"
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581:(Press release). Yale University, Office of Public Affairs & Communications. 18 February 2015
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in New York City. In 1982, he was a guest investigator in the laboratory of the immunologist
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2010 John Dystel Prize for
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Human Trials: Scientists, Investors, And
Patients In The Quest For A Cure
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365:"Risk alleles for multiple sclerosis identified by a genomewide study"
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In 2009, Hafler and his laboratory moved to Yale
Medical School in
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From 1982 to 1984, he was a fellow in neurology and immunology at
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Multiple
Sclerosis: How Scientists Developed a Breakthrough Drug
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Immunobiology / Yale School of Medicine - David Hafler, MD, MSc
606:(Press release). National Academy of Medicine. 15 October 2018.
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and became the Breakstone Professor of Neurology at Harvard.
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Viglietta, V; Baecher-Allan C; Weiner HL; Hafler DA (2004).
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in biochemistry. His master's thesis was on fragments of
604:"National Academy of Medicine Elects 85 New Members"
557:"John Dystel Prize for Multiple Sclerosis Research"
194:. He was one of the first post-doctoral fellows of
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530:"AUTOIMMUNE INC - 10-K Annual Report - 12/31/1996"
620:. The American Society for Clinical Investigation
67:His work in the fields of immunity, genetics and
715:Yale School of Medicine / Neurology / Hafler Lab
269:2018 Elected to the National Academy of Medicine
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415:in autoimmune disease. Nature; 518(7539):337-43
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403:: CS1 maint: multiple names: authors list (
138:In 1978, he received his MD degree from the
765:Members of the National Academy of Medicine
750:Leonard M. Miller School of Medicine alumni
246:American Society for Clinical Investigation
475:"Curriculum vitae - David A. Hafler, M.D."
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252:Javits Neuroscience Investigator Award
140:University of Miami School of Medicine
559:. National Multiple Sclerosis Society
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325:The Journal of Experimental Medicine
642:. American Neurological Association
283:The New England Journal of Medicine
263:2015 Raymond D. Adams Lectureship,
226:National Multiple Sclerosis Society
442:. Perseus Publishing. p. 39.
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618:"Directory - David A. Hafler, MD"
265:American Neurological Association
99:. In 2018, he was elected to the
209:In 2000, he was appointed to an
760:Yale School of Medicine faculty
511:from the original on 2019-09-27
369:New England Journal of Medicine
640:"Raymond D. Adams Lectureship"
477:photobooks.com. Archived from
158:. From 1979 to 1982, he was a
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256:National Institutes of Health
241:1978 Elected into AOA Society
222:American Academy of Neurology
101:National Academy of Medicine
295:10.1056/NEJM198505303122201
111:Hafler was born in 1952 in
79:(born 1952) is an American
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740:American neuroscientists
107:Early life and education
745:Emory University alumni
85:Yale School of Medicine
35:Hafler in November 2020
218:New Haven, Connecticut
200:principal investigator
188:Harvard Medical School
176:Rockefeller University
152:Johns Hopkins Hospital
150:from 1978–1979 at the
735:American neurologists
436:Quinn, Susan (2002).
274:Selected publications
211:endowed professorship
192:Boston, Massachusetts
382:10.1056/NEJMoa073493
337:10.1084/jem.20031579
244:1993 Elected to The
162:in neurology at the
133:myelin basic protein
87:, where he works on
16:American neurologist
156:Baltimore, Maryland
125:Bachelor of Science
698:2016-03-04 at the
501:"Bloomberg - AIMM"
97:multiple sclerosis
69:multiple sclerosis
505:www.bloomberg.com
449:978-0-306-82091-5
289:(22): 1405–1411.
236:Awards and honors
129:Master of Science
127:in chemistry and
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123:with a combined
121:Atlanta, Georgia
117:Emory University
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146:. He was a
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59:Neurologist
724:Categories
646:4 December
624:4 December
539:2019-09-27
515:2019-09-27
423:References
56:Occupation
679:1940-3410
696:Archived
667:Momentum
509:Archived
391:17660530
355:15067033
160:resident
113:New York
93:genetics
89:immunity
346:2211881
303:2985995
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182:Career
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250:2004
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648:2018
626:2018
587:2015
565:2015
487:2015
444:ISBN
405:link
387:PMID
351:PMID
299:PMID
166:and
41:Born
377:doi
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341:PMC
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