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The spotted or lazarine leprosy was first described by
Ladislao de la Pascua in 1844. Lucio and Alvarado published a description of the disease with the same names in 1852. Latapí re-described it in 1938 and reported it as 'spotted' leprosy of Lucio in 1948. It was named the diffuse leprosy of Lucio
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The underlying pathology was explained by Chévez-Zamora as a diffuse generalised cutaneous infiltration. He named it pure and primitive diffuse lepromatosis, upon which necrotising lesions develop. He proposed the name Fenómeno de Lucio or erythema necrotisans for these lesions.
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Lucio's phenomenon consists of well-shaped erythematous spots which later become necrotic with scabs, ulcerations and scars. These lesions are usually located on the lower extremities and may be extensive. They are frequently painful and rarely fatal.
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The likely pathogenesis is endothelial cell injury due to colonization/invasion followed by proliferation, angiogenesis, thrombosis and vessel ectasia.
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Kasper DL, Braunwald E, Fauci AS, et al. Harrison's
Principles of Internal Medicine. 16th edition. McGraw-Hill. 2005. Vol I. p.971.
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endothelial proliferation and marked thickening of vessel walls to the point of obliteration
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Saúl A; Novales J (1983). "Lucio-Latapí leprosy and the Lucio phenomenon".
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a diffuse infiltration of all the skin which never transforms into nodule
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a complete alopecia of eyebrows and eyelashes and body hair
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thrombosis of the superficial and mid-dermal blood vessels
214:"Diffuse leprosy of Lucio and Latapí: a histologic study"
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Lucio's phenomenon is treated by anti-leprosy therapy (
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colonisation of endothelial cells by acid-fast bacilli
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The main pathological features of this disease are a
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131:There are by five characteristic features:
50:and Alvarado in 1852 and re-identified by
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104:a peculiar type of lepra reaction named
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27:Clinical variety of lepromatous leprosy
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83:This condition is characterized by:
32:diffuse leprosy of Lucio and Latapí
62:and very rare in other countries.
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128:affecting all cutaneous vessels.
71:and Latapí in 1963 by Frenken.
58:(23% of leprosy cases) and in
1:
46:. It was first described by
42:, is a clinical variety of
36:diffuse lepromatous leprosy
18:Diffuse lepromatous leprosy
319:
54:in 1936. It is common in
212:Vargas-Ocampo F (2007).
231:10.47276/lr.78.3.248
190:exchange transfusion
180:, and treatment for
44:lepromatous leprosy
188:. In severe cases
106:Lucio's phenomenon
101:zones of the skin
79:Clinical features
16:(Redirected from
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255:Acta Leprologica
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192:may be helpful.
40:"pretty leprosy"
34:, also known as
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261:(3): 115–132.
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224:(3): 248–260.
218:Leprosy Review
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142:angiogenesis
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108:or necrotic
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186:antibiotics
176:), optimal
174:clofazimine
99:dysesthesic
285:0071477608
196:References
184:including
182:bacteremia
178:wound care
126:vasculitis
95:anhydrotic
60:Costa Rica
160:Treatment
146:vascular
120:Pathology
297:Category
240:18035776
170:rifampin
110:erythema
303:Leprosy
267:6359800
166:dapsone
148:ectasia
66:History
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238:
172:, and
56:Mexico
52:Latapí
48:Lucio
281:ISBN
263:PMID
236:PMID
97:and
30:The
226:doi
93:an
38:or
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222:78
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204:^
168:,
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259:1
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20:)
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