455:
431:
411:
443:
29:
41:
286:
By inhibiting the transporter, thiazide diuretics increase the gradient potential for Na. This increases the activity of the basolateral Na/Ca antiport and causes the increase in calcium reclamation associated with thiazide diuretics.
257:
regulation by reabsorbing Ca in response to parathyroid hormone. PTH effect is mediated through phosphorylation of regulatory proteins and enhancing the synthesis of all transporters within the distal convoluted
226:. Aldosterone increases sodium reabsorption. Sodium and chloride (salt) reabsorption is also mediated by a group of kinases called WNK kinases. There are 4 different WNK kinases,
430:
470:
542:
454:
90:
1005:
299:(PCT). The lumen appears larger in the PCT than the DCT lumen because the PCT has a brush border (microvilli). DCT can be recognized by its numerous
1000:
280:
169:
535:
192:
Ca transporter. The basolateral ATP dependent Na/K pump produces the gradient for Na to be absorbed from the apical surface via the Na/Cl
410:
219:
Sodium and potassium levels are controlled by secreting K and absorbing Na. Sodium absorption by the distal tubule is mediated by the
802:
1042:
812:
807:
528:
261:
969:
894:
774:
670:
700:
85:
754:
660:
303:(even though it is not as much as PCT), basal enfoldings and lateral membrane interdigitations with neighboring cells.
1012:
792:
421:
325:
296:
987:
964:
871:
488:
318:. It has tightly packed columnar cells which display reversed polarity and may monitor the osmolarity of blood.
61:
1080:
695:
629:
920:
824:
607:
442:
173:
97:
1022:
675:
492:
884:
1047:
992:
749:
744:
680:
665:
436:
Transverse section of pyramidal substance of kidney of pig, the bloodvessels of which are injected.
417:
189:
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715:
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134:
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784:
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655:
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388:
348:
315:
307:
300:
361:
196:, and for Ca to be reclaimed into the blood by the Na/Ca basolateral antiporter.
33:
Kidney nephron ("1st proximal convoluted tubule", "2nd distal convoluted tubule")
856:
851:
614:
520:
223:
213:
201:
181:
295:
The DCT is lined with simple cuboidal cells that are shorter than those of the
690:
619:
185:
56:
889:
769:
374:
321:
193:
146:
28:
759:
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273:
103:
979:
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634:
254:
220:
154:
126:
912:
560:
209:
205:
150:
123:
184:
surface (peritubular capillary side) there is an ATP-dependent Na/K
40:
177:
73:
524:
324:, cells of the DCT can be differentiated from cells of the
158:
279:
inhibit Na/Cl reabsorption from the DCT by blocking the
517: – Histology Learning System at Boston University
511: – Histology Learning System at Boston University
978:
929:
911:
870:
783:
735:
726:
643:
568:
559:
471:
List of distinct cell types in the adult human body
188:pump, a secondary active Na/Ca transporter, and an
84:
72:
67:
55:
50:
21:
145:It is partly responsible for the regulation of
460:Diagram outlining movement of ions in nephron.
168:surface (lumen side), cells of the DCT have a
536:
8:
732:
565:
543:
529:
521:
39:
27:
330:
481:
406:
208:(H) into the filtrate, or by absorbing
281:thiazide-sensitive Na-Cl cotransporter
170:thiazide-sensitive Na-Cl cotransporter
101:
18:
7:
45:Section of cortex of human kidney.
14:
306:The point where DCT contacts the
453:
441:
429:
409:
262:Arginine vasopressin receptor 2
895:Extraglomerular mesangial cell
775:Intraglomerular mesangial cell
1:
264:is also expressed in the DCT.
200:It regulates pH by absorbing
755:Glomerular basement membrane
493:mech/cases/case24/kidney.htm
310:thick ascending limb of the
1097:
793:Proximal convoluted tubule
326:proximal convoluted tubule
297:proximal convoluted tubule
79:tubulus contortus distalis
988:Internal urethral orifice
965:Median umbilical ligament
872:Juxtaglomerular apparatus
515:Histology image: 16007loa
509:Histology image: 16004loa
96:
38:
26:
16:Feature of kidney anatomy
820:Distal convoluted tubule
253:It also participates in
116:distal convoluted tubule
62:Metanephrogenic blastema
22:Distal convoluted tubule
696:Peritubular capillaries
921:Ureteropelvic junction
825:Collecting duct system
608:medullary interstitium
98:Anatomical terminology
885:Juxtaglomerular cells
269:Clinical significance
387:Readily discernible
1048:Lacunae of Morgagni
993:Urethral sphincters
216:into the filtrate.
122:) is a portion of
1068:
1067:
907:
906:
903:
902:
830:Connecting tubule
424:, 3 distal tubule
403:Additional images
400:
399:
135:collecting tubule
112:
111:
107:
1088:
942:Vesical arteries
765:Filtration slits
750:Bowman's capsule
733:
566:
545:
538:
531:
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331:
180:channel. On the
104:edit on Wikidata
43:
31:
19:
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1043:navicular fossa
974:
960:Detrusor muscle
925:
899:
866:
813:Thick ascending
779:
737:Renal corpuscle
722:
639:
625:Cortical lobule
555:
551:Anatomy of the
549:
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500:
499:
489:MedEd at Loyola
487:
483:
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461:
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448:Renal corpuscle
446:
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425:
422:proximal tubule
414:
405:
362:Eosinophilicity
353:Usually present
293:
271:
176:to Ca, via the
143:
108:
46:
34:
17:
12:
11:
5:
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1081:Kidney anatomy
1073:
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1062:
1060:Urinary meatus
1057:
1056:
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1053:urethral gland
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1016:
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990:
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952:Vaginal artery
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835:Papillary duct
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808:Thin ascending
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553:urinary system
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503:External links
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334:Characteristic
322:Histologically
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212:and secreting
204:and secreting
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1023:pre-prostatic
1021:
1020:
1019:Male urethra
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1007:
1004:
1002:
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947:Vesical veins
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847:Renal papilla
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842:Tubular fluid
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799:
798:Loop of Henle
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630:Medullary ray
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312:loop of Henle
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263:
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252:
249:
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236:
231:
230:
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190:ATP dependent
187:
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156:
152:
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140:
138:
136:
132:
131:loop of Henle
128:
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60:
58:
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49:
42:
37:
30:
25:
20:
1033:intermediate
938:Circulation
880:Macula densa
862:Renal pelvis
819:
785:Renal tubule
676:interlobular
656:Renal artery
491:
484:
469:
396:More likely
356:Not present
349:brush border
320:
316:macula densa
305:
301:mitochondria
294:
285:
272:
245:
239:
233:
227:
163:
144:
129:between the
119:
115:
113:
78:
857:Major calyx
852:Minor calyx
645:Circulation
393:Less likely
224:aldosterone
214:bicarbonate
202:bicarbonate
182:basolateral
68:Identifiers
803:Descending
745:Glomerulus
711:interlobar
701:Vasa recta
691:Renal vein
666:interlobar
476:References
418:Glomerulus
314:is called
186:antiporter
141:Physiology
1028:prostatic
997:External
890:Mesangium
770:Mesangium
661:segmental
652:Arteries
375:Cytoplasm
291:Histology
277:diuretics
194:symporter
174:permeable
147:potassium
57:Precursor
1075:Category
1013:Internal
954:(female)
760:Podocyte
716:efferent
681:afferent
603:pyramids
466:See also
308:cortical
274:Thiazide
172:and are
133:and the
980:Urethra
970:Trigone
931:Bladder
913:Ureters
728:Nephron
706:arcuate
671:arcuate
635:Nephron
598:Medulla
581:Capsule
561:Kidneys
258:tubule.
255:calcium
221:hormone
210:protons
206:protons
164:On its
155:calcium
127:nephron
51:Details
1038:spongy
1006:female
687:Veins
591:column
586:Cortex
576:Fascia
569:Layers
389:nuclei
346:Apical
244:, and
166:apical
157:, and
151:sodium
124:kidney
615:Sinus
382:Less
369:Less
178:TRPV5
102:[
91:17721
74:Latin
1001:male
620:Lobe
420:, 2
379:More
366:More
340:DCT
247:WNK4
241:WNK3
235:WNK2
229:WNK1
114:The
337:PCT
161:.
120:DCT
86:FMA
1077::
416:1
328::
283:.
238:,
232:,
159:pH
153:,
149:,
137:.
544:e
537:t
530:v
250:.
118:(
106:]
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