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gene promoter to drive Cre expression to be limited within innate-like T cells. There is a cell type specific function in innate-like T cells based on the distal
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148:"T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages"
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Further research at the late stage of thymocyte development reveals that distal Lck promoter with driven Cre will result in the distal
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Roeder RG (November 1991). "The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly".
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promoters. The generated environment of a Lck-PROX mice when approached with proximal promoter demonstrates maximal
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T-cell development and activation is controlled by complementary placement of proximal and distal
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protein and normal thymic development, while distal promoters lead to deficient
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Promoter-Driven Cre Shows Cell Type-Specific
Function in Innate-like T Cells"
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53:) and the intervening DNA bends such that the bound proteins contact the
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Figueroa MG, Parker LM, Krol K, Zhao M (September 2021).
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41:(decreasing expression). They act by binding
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26:that can be many kilobases distant from the
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81:protein and unnormal thymic levels.
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146:Chiang YJ, Hodes RJ (October 2016).
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264:. You can help Knowledge (XXG) by
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217:10.4049/immunohorizons.2100079
152:European Journal of Immunology
113:Trends in Biochemical Sciences
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125:10.1016/0968-0004(91)90164-Q
37:(increasing expression) or
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24:regulatory DNA sequences
16:Regulatory DNA sequences
92:promoter - driven Cre.
164:10.1002/eji.201646440
65:In T-cell development
51:transcription factors
30:that they regulate.
33:They can either be
316:Biochemistry stubs
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39:silencers
35:enhancers
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