89:, who was administering a cooperative research project involving fourteen hospitals, asked Gleason to develop a standardized pathological testing system to measure the development of prostate cancer. At the time, no single system existed to measure the speed at which prostate cancer spreads, nor was there a single system to describe the architecture of prostate cancer cells as seen under a microscope. While many classifications existed, but they were in practice difficult to apply, and pathologists would invent their own. This lack of a single standard led to confusion in patients' treatment and difficulties in evaluation of potential new treatments.
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Gleason rose to become chief of pathology at the medical center, and also taught at the
University of Minnesota, with which the center is affiliated. He retired in 1986. In 2001, he received both the American Urological Association's Presidential Citation Award and an Outstanding Achievement Award
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Dr. Akhouri Sinha, a colleague of
Gleason's for forty years, described the scoring system as "comprehensive, yet simple so that the grading system can be used by pathologists, clinicians and scientists throughout the world". The scoring was adopted slowly until 1987, when several leading experts in
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in 1966, focused on two details of the architecture of the cancer cells, and assigned a score of one to five to each attribute. Thus, any given patient could have a score of between two and ten——the higher the score, the more aggressive the cancer, and the lower the chance of survival. Gleason
112:, "Every prostate cancer patient knows his Gleason score." Roth noted that it was remarkable that the Gleason score remained the standard in the profession, despite millions of dollars spent on attempting to develop molecular standards in an attempt to displace it.
65:, where his father, Fred Gleason, ran a hardware store, and his mother, Ethel, was a schoolteacher. He attended the University of Minnesota, and received his bachelor's degree, M.D., and Ph.D. from that institution. He entered the
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the field recommended its use in all scientific publications regarding prostate cancer. The test became even more widely utilized following a surge in prostate cancers identified through a blood test, the
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found the score directly related to survival rates in a study of 270 patients, which was the basis of his journal report. Subsequently, a study of 4,000 patients confirmed the relationship.
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Gleason, Donald F; Mellinger George T (Feb 2002). "Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. 1974".
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Phillips, John L; Sinha
Akhouri A (Sep 2009). "Patterns, art, and context: Donald Floyd Gleason and the development of the Gleason grading system".
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in patients. He was a former chief of pathology at the
Minneapolis VA Medical Center, and received three degrees from and taught at the
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Filosa, Alessandra; Fabiani Andrea (Apr 2009). "Dr. Donald Floyd
Gleason's historic, immense contribution to urologic pathology".
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and was survived by his wife, Nancy (to whom he was married for 62 years) and three daughters, Donna, Sue, and Ginger.
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and training as a resident in pathology at the VA hospital in
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33:(November 20, 1920 – December 28, 2008) was an American physician and
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Gleason remained at the
Minneapolis VA Medical Center after
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As of 2009, according to Dr Bruce Roth, a professor at
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Gleason's technique, which he published in the journal
160:"Donald F. Gleason, 88, dies; devised prostate test"
128:. He died of a heart attack on December 28, 2008 in
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365:United States Army personnel of World War II
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193:Dr. Donald Gleason, physician, researcher
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390:Military personnel from Minnesota
375:People from Litchfield, Minnesota
71:University of Maryland, Baltimore
380:People from Richfield, Minnesota
190:Cohen, Ben (December 31, 2008),
69:, serving an internship at the
37:, best known for devising the "
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302:10.1016/S0022-5347(02)80309-3
269:10.1016/j.urology.2009.01.012
385:Military personnel from Iowa
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77:Career and test development
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218:Anal. Quant. Cytol. Histol
370:People from Spencer, Iowa
296:: 953–8, discussion 959.
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120:Personal and later life
67:U.S. Army Medical Corps
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47:University of Minnesota
355:American pathologists
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63:Litchfield, Minnesota
126:Richfield, Minnesota
57:Gleason was born in
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31:Donald F. Gleason
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340:2008 deaths
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263:: 497–503.
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35:pathologist
329:Categories
292:(2 Pt 2).
136:References
53:Early life
310:0022-5347
234:0884-6812
228:: 123–4.
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277:19376571
242:19402390
252:Urology
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