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267:
Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons. ... internalization of EAAT3 triggered by amphetamine increases glutamatergic signaling and thus contributes to the effects of amphetamine on
415:
In addition, RT-PCR and
Western blot analysis revealed the expression of GLAST and GLT-1, astrocytic high-affinity glutamate transporters, in M5076 cells. Thus, theanine was shown to competitively inhibit the glutamate uptake by acting on these glutamate
179:
Dunlop J, McIlvain HB, Carrick TA, et al. (October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2".
1166:
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Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC (May 2011).
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Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T (2001). "Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin".
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251:"SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [ Homo sapiens (human) ]"
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282:"Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons"
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332:"TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity"
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Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG (July 2014).
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is a selective noncompetitive reuptake inhibitor of presynaptic
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229:. Springer Science & Business Media. p. 200.
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J. Storm-Mathisen; O.P. Ottersen (3 November 2000).
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84:(via transporter endocytosis) in dopamine neurons.
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91:is reported to competitively inhibit reuptake at
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257:. National Center for Biotechnology Information
1547:Tooltip Glutamine aminohydrolase (glutaminase)
76:, a non-selective blocker of all five EAATs.
1884:
1160:
458:
8:
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223:Susan Napier; Matilda Bingham (5 May 2009).
1891:
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1826:Metabotropic glutamate receptor modulators
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1208:Tooltip Excitatory amino acid transporters
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663:
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1910:Excitatory amino acid reuptake inhibitors
437:Excitatory amino acid reuptake inhibitors
365:
355:
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134:Excitatory amino acid receptor antagonist
1830:GABA metabolism and transport modulators
1822:Ionotropic glutamate receptor modulators
1365:Tooltip Vesicular glutamate transporters
18:excitatory amino acid reuptake inhibitor
144:
129:Excitatory amino acid receptor agonist
1402:Amido black 10B (naphthol blue black)
7:
1845:
1843:
1863:. You can help Knowledge (XXG) by
1580:Tooltip Aspartate aminotransferase
1072:Angiotensin II receptor antagonist
1016:Endocannabinoid reuptake inhibitor
48:excitatory amino acid transporters
14:
963:Acetylcholine receptor antagonist
725:Norepinephrine reuptake inhibitor
226:Transporters as Targets for Drugs
1847:
1627:Tooltip Alanine aminotransferase
430:
1773:Tooltip Glutamate decarboxylase
1667:Tooltip Glutamate dehydrogenase
1091:Vasopressin receptor antagonist
1005:Cannabinoid receptor antagonist
46:by blocking one or more of the
1758:Phosphinothricin (glufosinate)
1077:Endothelin receptor antagonist
941:Acetylcholine receptor agonist
700:Adrenergic receptor antagonist
1:
1818:Receptor/signaling modulators
909:Glutamate receptor antagonist
825:Serotonin receptor antagonist
778:Histamine receptor antagonist
553:Negative allosteric modulator
547:Positive allosteric modulator
403:10.1016/s0378-4274(01)00317-4
1735:Tooltip Glutamine synthetase
1066:Adenosine reuptake inhibitor
1000:Cannabinoid receptor agonist
919:Glutamate reuptake inhibitor
838:Serotonin reuptake inhibitor
749:Dopamine receptor antagonist
336:Proc. Natl. Acad. Sci. U.S.A
298:10.1016/j.neuron.2014.05.043
754:Dopamine reuptake inhibitor
676:Adrenergic receptor agonist
53:Examples of EAARIs include
1931:
1842:
1045:Opioid receptor antagonist
899:Glutamate receptor agonist
820:Serotonin receptor agonist
773:Histamine receptor agonist
124:Glycine reuptake inhibitor
1811:
1461:Glutamic acid (glutamate)
1427:Aspartic acid (aspartate)
1282:-CCG-III ((2S,3S,4R)-CCG)
1239:Glutamic acid (glutamate)
1221:Aspartic acid (aspartate)
744:Dopamine receptor agonist
1781:3-Mercaptopropionic acid
1290:-Serine-O-sulphate (SOS)
1010:Endocannabinoid enhancer
956:Cholinesterase inhibitor
875:GABA receptor antagonist
158:. Elsevier. p. 49.
61:, selective blockers of
1588:2-Amino-3-butenoic acid
1382:6-(4'-Phenylstyryl)-QDC
1266:-3-Hydroxyaspartic acid
1050:Enkephalinase inhibitor
1040:Opioid receptor agonist
880:GABA reuptake inhibitor
585:♦ Miscellaneous:
357:10.1073/pnas.1103029108
119:GABA reuptake inhibitor
1859:-related article is a
1753:Methionine sulfoximine
1340:-3-Methylglutamic acid
633:Ion channel modulators
194:10.1124/mol.105.012005
870:GABA receptor agonist
1607:-Methylene-aspartate
439:at Wikimedia Commons
1720:Pyridoxal phosphate
1422:Chicago sky blue 6B
1387:6-Biphenyl-4-yl-QDC
1086:receptor antagonist
348:2011PNAS..108.8485R
28:which inhibits the
1915:Pharmacology stubs
1743:2-Aminoadipic acid
1612:Hydrazinosuccinate
474:Pharmacomodulation
268:neurotransmission.
109:Reuptake inhibitor
55:dihydrokainic acid
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342:(20): 8485–8490.
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416:transporters.
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408:
404:
400:
396:
392:
391:Toxicol. Lett
385:
382:
377:
373:
368:
363:
358:
353:
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341:
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333:
325:
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317:
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308:
303:
299:
295:
292:(2): 404–16.
291:
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246:
243:
238:
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228:
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216:
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188:(4): 974–82.
187:
183:
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167:
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157:
156:
148:
145:
139:
135:
132:
130:
127:
125:
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120:
117:
115:
114:Glutamatergic
112:
110:
107:
106:
102:
100:
98:
94:
90:
83:
79:
75:
73:
65:(GLT-1), and
64:
60:
56:
51:
49:
45:
41:
38:
35:
31:
27:
23:
19:
1865:expanding it
1857:pharmacology
1854:
1839:
1814:
1813:
1647:-Cycloserine
1501:
1397:Acid red 114
1373:4-Methylene-
1337:
1299:
1263:
1226:
1126:
1114:
918:
812:Serotonergic
736:Dopaminergic
615:
414:
397:(2): 89–96.
394:
390:
384:
339:
335:
324:
289:
285:
275:
266:
259:. Retrieved
254:
245:
225:
218:
185:
181:
174:
154:
147:
95:(GLAST) and
71:
52:
21:
17:
15:
1685:Chloroquine
1514:Valinomycin
1509:Trypan blue
1491:Rose bengal
1476:NPPB (N144)
1350:WAY-213,613
1254:Kainic acid
1216:Amphetamine
1194:Transporter
1128:Amino acids
1027:Opioidergic
933:Cholinergic
646:transporter
626:Ion channel
562:Transporter
506:Ion channel
261:11 November
78:Amphetamine
59:WAY-213,613
1904:Categories
1748:JFD01307SC
1481:Ponceau SS
1456:Furosemide
1451:Evans blue
1417:Bumetamide
1377:-glutamate
1186:modulators
1179:metabolism
976:Ganglionic
967:Muscarinic
945:Muscarinic
668:Adrenergic
537:Antagonist
140:References
57:(DHK) and
34:excitatory
1815:See also:
1680:Bithionol
1635:β-Chloro-
1471:Nigericin
1183:transport
1176:Glutamate
1123:Precursor
972:Nicotinic
950:Nicotinic
862:GABAergic
587:Precursor
572:Inhibitor
498:Inhibitor
255:NCBI Gene
155:Glutamate
99:(GLT-1).
89:-Theanine
50:(EAATs).
44:aspartate
40:glutamate
1639:-alanine
1345:UCPH-101
1332:Theanine
1327:TFB-TBOA
1317:SYM-2081
1302:-2,4-PDC
1111:Cofactor
981:Muscular
641:Receptor
592:Cofactor
578:Releaser
566:Enhancer
560:♦
523:Receptor
521:♦
504:♦
487:♦
411:11325559
376:21525407
316:25033183
210:24207924
202:16014807
103:See also
74:-2,4-PDC
30:reuptake
1068:(AdoRI)
1018:(eCBRI)
601:Classes
527:Agonist
515:Blocker
493:Inducer
367:3101002
344:Bibcode
307:4159050
32:of the
1700:GW5074
1560:CB-839
1533:Enzyme
1361:vGluTs
1012:(eCBE)
609:Enzyme
510:Opener
489:Enzyme
409:
374:
364:
314:
304:
286:Neuron
233:
208:
200:
162:
1855:This
1555:BPTES
1504:-ACDP
1502:trans
1392:7-CKA
1338:threo
1300:trans
1264:threo
1262:-(-)-
1249:HIP-B
1244:HIP-A
1229:-ACBD
1204:EAATs
1125:(see
1113:(see
1059:Other
882:(GRI)
840:(SRI)
756:(DRI)
727:(NRI)
643:&
555:(NAM)
549:(PAM)
481:Types
206:S2CID
97:EAAT2
93:EAAT1
82:EAAT3
72:trans
63:EAAT2
22:EAARI
1861:stub
1786:AAOA
1690:EGCG
1675:AAOA
1593:AAOA
1496:SITS
1432:DIDS
1322:TBOA
1307:MPDC
1274:-αAA
1234:DHKA
1181:and
913:NMDA
903:AMPA
829:5-HT
631:See
614:see
580:(RA)
574:(RI)
568:(RE)
407:PMID
372:PMID
312:PMID
263:2014
231:ISBN
198:PMID
160:ISBN
42:and
26:drug
1769:GAD
1695:GTP
1663:GDH
1623:ALT
1598:AMB
1576:AST
1565:DON
1543:GAH
1227:cis
399:doi
395:121
362:PMC
352:doi
340:108
302:PMC
294:doi
190:doi
16:An
1906::
1828:•
1824:•
1820:•
1731:GS
1605:DL
1603:β-
1082:NK
983:))
952:)
853:AA
696:))
655:BA
564::
525::
508::
491::
413:.
405:.
393:.
370:.
360:.
350:.
338:.
334:.
310:.
300:.
290:83
288:.
284:.
265:.
253:.
204:.
196:.
186:68
184:.
1892:e
1885:t
1878:v
1867:.
1792:L
1645:L
1637:L
1444:L
1375:L
1298:-
1296:L
1288:L
1280:L
1272:L
1260:L
1168:e
1161:t
1154:v
1131:)
1119:)
1084:1
974:(
965:(
943:(
915:)
911:(
905:)
901:(
834:)
831:3
827:(
803:)
800:3
798:H
792:2
790:H
784:1
782:H
780:(
721:)
719:β
715:)
713:2
708:1
706:(
704:α
702:(
694:2
689:1
687:(
685:β
680:α
678:(
659:M
657:/
466:e
459:t
452:v
401::
378:.
354::
346::
318:.
296::
239:.
212:.
192::
168:.
87:L
70:-
68:L
20:(
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