108:. The middle T antigen is not required for replication and it acts to enhance transcription by binding host proteins which interact with the late promoter. On the other hand, the large T antigen is required and it acts to initiate replication directly. It binds the viral origin of replication and recruits
116:
such that once its concentration is great enough it blocks the transcription of early genes and initiates genome replication. It also acts to cause the entry of the host cell into S phase.
420:
415:
472:
1000:
995:
990:
985:
947:
942:
1322:
980:
975:
451:
446:
441:
165:
1703:
1466:
278:
1436:
1370:
597:
1064:
732:
88:
In some, simpler viruses, this pattern of expression is clearly defined, while in those with more complex genomes, such as the
1583:
1837:
1057:
1052:
158:
1685:
1620:
1292:
1268:
1075:
960:
866:
792:
717:
612:
496:
431:
351:
317:
268:
361:
288:
253:
62:
but these are not as a result of two stages of transcription surrounding replication but by the production of the
1243:
1047:
248:
1742:
1630:
1556:
1494:
1446:
1398:
1350:
1302:
1181:
1030:
925:
686:
592:
572:
555:
405:
293:
228:
85:, commonly encoding non-structural proteins, initiates replication of the genome and expression of late genes.
151:
395:
1805:
1641:
1526:
366:
1775:
1666:
1546:
1418:
1278:
66:
which is required for the export of the transcripts of the second set of proteins transcribed form the
1577:
1515:
1202:
646:
637:
559:
506:
327:
218:
1248:
642:
632:
551:
113:
1770:
1647:
1222:
970:
909:
674:
78:
43:
1484:
1090:
827:
822:
817:
812:
807:
802:
781:
1714:
1171:
1161:
914:
101:
59:
1788:
1671:
1216:
1041:
936:
542:
462:
109:
1831:
1737:
1388:
849:
486:
203:
174:
36:
1457:
1409:
1361:
1313:
1234:
1019:
855:
532:
341:
208:
182:
105:
67:
51:
143:
1797:
1340:
660:
623:
89:
74:
100:
An example of early gene expression is the expression of the small, middle and
1679:
1611:
1208:
1014:
845:
841:
133:
1725:
1720:
1661:
1655:
899:
776:
766:
754:
527:
191:
63:
55:
54:
proteins, this definition of these terms is commonly reserved for class I
17:
307:
28:
1567:
1505:
1253:
1192:
1085:
583:
239:
40:
1138:
1128:
1123:
1113:
1108:
1103:
1098:
705:
700:
695:
1690:
1521:
1133:
1118:
547:
283:
147:
1751:
1747:
1730:
876:
727:
47:
1796:
1787:
1764:
1701:
1628:
1619:
1610:
1566:
1554:
1545:
1504:
1492:
1483:
1456:
1444:
1435:
1408:
1396:
1387:
1360:
1348:
1339:
1312:
1300:
1291:
1266:
1233:
1191:
1179:
1170:
1155:
1073:
1028:
1013:
958:
923:
908:
893:
864:
840:
790:
775:
762:
753:
715:
684:
673:
622:
610:
582:
570:
541:
523:
494:
485:
460:
429:
403:
394:
383:
349:
340:
315:
306:
266:
238:
226:
217:
199:
190:
159:
8:
73:Early proteins are those produced following
1793:
1784:
1625:
1616:
1563:
1551:
1501:
1489:
1453:
1441:
1405:
1393:
1357:
1345:
1309:
1297:
1188:
1176:
1167:
1025:
920:
905:
861:
787:
772:
759:
681:
619:
579:
567:
538:
491:
400:
391:
346:
312:
235:
223:
214:
196:
166:
152:
144:
1323:Parainfluenza hemagglutinin-neuraminidase
50:) are described as expressing early and
125:
1467:Respiratory syncytial virus G protein
7:
92:, these expression periods overlap.
39:depends on their relationship with
25:
1371:Mumps hemagglutinin-neuraminidase
733:Hepatitis B virus DNA polymerase
77:into the host cell but prior to
564:(non-enveloped circular ds-DNA)
46:. While many viruses (such as
1:
1584:Vesiculovirus matrix proteins
27:The classification of viral
1621:Structure and genome of HIV
678:(circular partially ds-DNA)
1854:
254:Herpesvirus glycoprotein B
249:HHV capsid portal protein
58:. (HIV has two stages of
1244:Influenza hemagglutinin
134:"DNA Virus Replication"
1806:Gag-onc fusion protein
1776:murine leukemia virus
1667:Reverse transcriptase
1547:Indiana vesiculovirus
1419:Measles hemagglutinin
81:. The expression of
507:Early 35 kDa protein
1838:Viral protein class
114:DNA-binding protein
1771:Rous sarcoma virus
60:protein expression
1825:
1824:
1821:
1820:
1817:
1816:
1813:
1812:
1760:
1759:
1606:
1605:
1602:
1601:
1598:
1597:
1594:
1593:
1541:
1540:
1537:
1536:
1479:
1478:
1475:
1474:
1431:
1430:
1427:
1426:
1383:
1382:
1379:
1378:
1335:
1334:
1331:
1330:
1287:
1286:
1262:
1261:
1151:
1150:
1147:
1146:
1009:
1008:
889:
888:
885:
884:
836:
835:
749:
748:
745:
744:
741:
740:
669:
668:
656:
655:
606:
605:
519:
518:
515:
514:
481:
480:
379:
378:
375:
374:
336:
335:
302:
301:
262:
261:
16:(Redirected from
1845:
1794:
1785:
1626:
1617:
1564:
1552:
1502:
1490:
1485:Zaire ebolavirus
1454:
1442:
1406:
1394:
1358:
1346:
1310:
1298:
1189:
1177:
1168:
1091:3C-like protease
1026:
921:
906:
862:
788:
782:Duplornaviricota
773:
760:
682:
620:
580:
568:
539:
492:
401:
392:
347:
313:
236:
224:
215:
197:
168:
161:
154:
145:
138:
137:
130:
21:
1853:
1852:
1848:
1847:
1846:
1844:
1843:
1842:
1828:
1827:
1826:
1809:
1756:
1715:transactivators
1697:
1590:
1533:
1471:
1423:
1375:
1327:
1283:
1258:
1229:
1172:Influenza virus
1162:Negarnaviricota
1159:
1157:
1143:
1069:
1017:
1005:
954:
915:Kitrinoviricota
912:
897:
895:
881:
853:
832:
779:
764:
737:
711:
677:
665:
652:
602:
563:
545:
531:
525:
511:
477:
456:
425:
387:
386:(Duplodnaviria,
385:
384:circular ds-DNA
371:
332:
298:
258:
207:
201:
186:
172:
142:
141:
132:
131:
127:
122:
104:encoded by the
102:large T antigen
98:
23:
22:
15:
12:
11:
5:
1851:
1849:
1841:
1840:
1830:
1829:
1823:
1822:
1819:
1818:
1815:
1814:
1811:
1810:
1808:
1803:
1801:
1791:
1789:Fusion protein
1782:
1781:
1780:
1779:
1778:
1773:
1762:
1761:
1758:
1757:
1755:
1754:
1745:
1740:
1735:
1734:
1733:
1728:
1723:
1710:
1708:
1699:
1698:
1696:
1695:
1694:
1693:
1688:
1676:
1675:
1674:
1672:HIV-1 protease
1669:
1664:
1652:
1651:
1650:
1637:
1635:
1623:
1614:
1608:
1607:
1604:
1603:
1600:
1599:
1596:
1595:
1592:
1591:
1589:
1588:
1587:
1586:
1578:matrix protein
1573:
1571:
1561:
1549:
1543:
1542:
1539:
1538:
1535:
1534:
1532:
1531:
1530:
1529:
1524:
1516:matrix protein
1511:
1509:
1499:
1487:
1481:
1480:
1477:
1476:
1473:
1472:
1470:
1469:
1463:
1461:
1451:
1439:
1433:
1432:
1429:
1428:
1425:
1424:
1422:
1421:
1415:
1413:
1403:
1391:
1385:
1384:
1381:
1380:
1377:
1376:
1374:
1373:
1367:
1365:
1355:
1343:
1337:
1336:
1333:
1332:
1329:
1328:
1326:
1325:
1319:
1317:
1307:
1295:
1289:
1288:
1285:
1284:
1282:
1281:
1275:
1273:
1264:
1263:
1260:
1259:
1257:
1256:
1251:
1246:
1240:
1238:
1231:
1230:
1228:
1227:
1226:
1225:
1217:viral envelope
1213:
1212:
1211:
1203:matrix protein
1198:
1196:
1186:
1174:
1165:
1158:negative-sense
1153:
1152:
1149:
1148:
1145:
1144:
1142:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1095:
1094:
1082:
1080:
1071:
1070:
1068:
1067:
1062:
1061:
1060:
1055:
1050:
1042:viral envelope
1037:
1035:
1023:
1011:
1010:
1007:
1006:
1004:
1003:
998:
993:
988:
983:
978:
973:
967:
965:
956:
955:
953:
952:
951:
950:
945:
937:viral envelope
932:
930:
918:
903:
896:positive-sense
891:
890:
887:
886:
883:
882:
880:
879:
873:
871:
859:
838:
837:
834:
833:
831:
830:
825:
820:
815:
810:
805:
799:
797:
785:
770:
757:
751:
750:
747:
746:
743:
742:
739:
738:
736:
735:
730:
724:
722:
713:
712:
710:
709:
708:
698:
693:
691:
679:
671:
670:
667:
666:
664:
663:
657:
654:
653:
651:
650:
640:
635:
629:
627:
617:
608:
607:
604:
603:
601:
600:
595:
589:
587:
577:
565:
543:Polyomaviridae
536:
521:
520:
517:
516:
513:
512:
510:
509:
503:
501:
489:
483:
482:
479:
478:
476:
475:
469:
467:
458:
457:
455:
454:
449:
444:
438:
436:
427:
426:
424:
423:
418:
412:
410:
398:
389:
388:Varidnaviria?)
381:
380:
377:
376:
373:
372:
370:
369:
364:
358:
356:
344:
338:
337:
334:
333:
331:
330:
324:
322:
310:
304:
303:
300:
299:
297:
296:
291:
286:
281:
275:
273:
264:
263:
260:
259:
257:
256:
251:
245:
243:
233:
221:
219:Herpes simplex
212:
194:
188:
187:
175:Viral proteins
173:
171:
170:
163:
156:
148:
140:
139:
124:
123:
121:
118:
110:DNA polymerase
97:
94:
33:early proteins
24:
14:
13:
10:
9:
6:
4:
3:
2:
1850:
1839:
1836:
1835:
1833:
1807:
1804:
1802:
1799:
1795:
1792:
1790:
1786:
1783:
1777:
1774:
1772:
1769:
1768:
1767:
1766:
1763:
1753:
1749:
1746:
1744:
1741:
1739:
1736:
1732:
1729:
1727:
1724:
1722:
1719:
1718:
1717:
1716:
1712:
1711:
1709:
1707:
1705:
1700:
1692:
1689:
1687:
1684:
1683:
1682:
1681:
1677:
1673:
1670:
1668:
1665:
1663:
1660:
1659:
1658:
1657:
1653:
1649:
1646:
1645:
1644:
1643:
1639:
1638:
1636:
1634:
1632:
1627:
1624:
1622:
1618:
1615:
1613:
1609:
1585:
1582:
1581:
1580:
1579:
1575:
1574:
1572:
1569:
1565:
1562:
1560:
1558:
1553:
1550:
1548:
1544:
1528:
1525:
1523:
1520:
1519:
1518:
1517:
1513:
1512:
1510:
1507:
1503:
1500:
1498:
1496:
1491:
1488:
1486:
1482:
1468:
1465:
1464:
1462:
1459:
1455:
1452:
1450:
1448:
1443:
1440:
1438:
1434:
1420:
1417:
1416:
1414:
1411:
1407:
1404:
1402:
1400:
1395:
1392:
1390:
1386:
1372:
1369:
1368:
1366:
1363:
1359:
1356:
1354:
1352:
1347:
1344:
1342:
1338:
1324:
1321:
1320:
1318:
1315:
1311:
1308:
1306:
1304:
1299:
1296:
1294:
1293:Parainfluenza
1290:
1280:
1277:
1276:
1274:
1272:
1270:
1265:
1255:
1252:
1250:
1249:Neuraminidase
1247:
1245:
1242:
1241:
1239:
1236:
1232:
1224:
1221:
1220:
1219:
1218:
1214:
1210:
1207:
1206:
1205:
1204:
1200:
1199:
1197:
1194:
1190:
1187:
1185:
1183:
1178:
1175:
1173:
1169:
1166:
1163:
1154:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1092:
1089:
1088:
1087:
1084:
1083:
1081:
1079:
1077:
1072:
1066:
1063:
1059:
1056:
1054:
1051:
1049:
1046:
1045:
1044:
1043:
1039:
1038:
1036:
1034:
1032:
1027:
1024:
1021:
1016:
1012:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
968:
966:
964:
962:
957:
949:
946:
944:
941:
940:
939:
938:
934:
933:
931:
929:
927:
922:
919:
916:
911:
907:
904:
901:
892:
878:
875:
874:
872:
870:
868:
863:
860:
857:
851:
847:
843:
839:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
800:
798:
796:
794:
789:
786:
783:
778:
774:
771:
768:
761:
758:
756:
752:
734:
731:
729:
726:
725:
723:
721:
719:
714:
707:
704:
703:
702:
699:
697:
694:
692:
690:
688:
683:
680:
676:
672:
662:
659:
658:
648:
644:
641:
639:
636:
634:
631:
630:
628:
625:
621:
618:
616:
614:
609:
599:
596:
594:
591:
590:
588:
585:
581:
578:
576:
574:
569:
566:
561:
557:
553:
549:
544:
540:
537:
534:
529:
522:
508:
505:
504:
502:
500:
498:
493:
490:
488:
487:Baculoviridae
484:
474:
471:
470:
468:
466:
464:
459:
453:
450:
448:
445:
443:
440:
439:
437:
435:
433:
428:
422:
419:
417:
414:
413:
411:
409:
407:
402:
399:
397:
393:
390:
382:
368:
365:
363:
360:
359:
357:
355:
353:
348:
345:
343:
339:
329:
326:
325:
323:
321:
319:
314:
311:
309:
305:
295:
292:
290:
287:
285:
282:
280:
277:
276:
274:
272:
270:
265:
255:
252:
250:
247:
246:
244:
241:
237:
234:
232:
230:
225:
222:
220:
216:
213:
210:
205:
204:Duplodnaviria
200:linear ds-DNA
198:
195:
193:
189:
184:
180:
176:
169:
164:
162:
157:
155:
150:
149:
146:
135:
129:
126:
119:
117:
115:
111:
107:
103:
95:
93:
91:
90:herpesviruses
86:
84:
80:
76:
71:
69:
65:
61:
57:
53:
49:
45:
42:
38:
37:late proteins
34:
30:
19:
1713:
1702:
1678:
1654:
1640:
1629:
1576:
1555:
1514:
1493:
1458:glycoprotein
1445:
1410:glycoprotein
1397:
1362:glycoprotein
1349:
1314:glycoprotein
1301:
1267:
1235:glycoprotein
1215:
1201:
1180:
1074:
1065:Nucleocapsid
1040:
1029:
1020:Pisuviricota
959:
935:
924:
865:
856:Pisuviricota
791:
716:
685:
611:
571:
533:Monodnaviria
495:
461:
430:
404:
396:Epstein–Barr
350:
342:Adenoviridae
316:
267:
227:
209:Varidnaviria
178:
128:
106:polyomavirus
99:
87:
82:
72:
68:cell nucleus
32:
26:
1798:oncoprotein
910:Hepatitis C
675:Hepatitis B
661:Agnoprotein
624:oncoprotein
598:VP2 and VP3
83:early genes
79:replication
64:Rev protein
56:DNA viruses
44:replication
1223:M2 protein
1209:M1 protein
1015:SARS-CoV-2
120:References
18:Early gene
1765:Multiple
1662:Integrase
900:Riboviria
777:Rotavirus
767:Riboviria
528:Riboviria
1832:Category
1058:Membrane
1053:Envelope
647:SV40 Tag
308:Vaccinia
112:and s/s
29:proteins
1389:Measles
842:Rhinov.
289:ICP34.5
96:Example
1568:capsid
1506:capsid
1254:HA-tag
1193:capsid
1156:ss-RNA
1086:ORF1ab
894:ss-RNA
854:etc. (
763:ds-RNA
584:capsid
452:EBNA-3
447:EBNA-2
442:EBNA-1
240:capsid
41:genome
1704:VRAPs
1686:gp120
1341:Mumps
1139:ORF9b
1129:ORF7b
1124:ORF7a
1114:ORF3d
1109:ORF3c
1104:ORF3b
1099:ORF3a
1093:(NS5)
1048:Spike
850:Hep A
846:Polio
706:HBeAg
701:HBcAg
696:HBsAg
560:HaPyV
556:MCPyV
524:other
463:ncRNA
421:LMP-2
416:LMP-1
294:ICP47
279:vmw65
179:early
75:entry
1691:gp41
1631:VSPs
1557:VSPs
1527:VP24
1522:VP40
1495:VSPs
1447:VSPs
1399:VSPs
1351:VSPs
1303:VSPs
1269:VNPs
1182:VSPs
1134:ORF8
1119:ORF6
1076:VNPs
1031:VSPs
1001:NS5B
996:NS5A
991:NS4B
986:NS4A
961:VNPs
926:VSPs
867:VNPs
828:NSP6
823:NSP5
818:NSP4
813:NSP3
808:NSP2
803:NSP1
793:VNPs
718:VNPs
687:VSPs
643:LTag
638:MTag
633:STag
613:VNPs
573:VSPs
552:MPyV
548:SV40
497:VNPs
473:EBER
432:VNPs
406:VSPs
352:VNPs
328:B13R
318:VNPs
284:ICP8
269:VNPs
229:VSPs
183:late
181:and
52:late
1752:Vpx
1750:or
1748:Vpu
1743:Vif
1738:Nef
1731:Vpr
1726:Rev
1721:Tat
1680:env
1656:pol
1648:p24
1642:gag
1437:RSV
1279:NS1
981:NS3
976:NS2
877:VPg
755:RNA
728:HBx
593:VP1
367:E1B
362:E1A
192:DNA
70:.)
48:HIV
35:or
31:as
1834::
1612:RT
971:P7
948:E2
943:E1
848:,
844:,
558:,
554:,
550:,
1800::
1706::
1633::
1570::
1559::
1508::
1497::
1460::
1449::
1412::
1401::
1364::
1353::
1316::
1305::
1271::
1237::
1195::
1184::
1164:)
1160:(
1078::
1033::
1022:)
1018:(
963::
928::
917:)
913:(
902:)
898:(
869::
858:)
852:,
795::
784:)
780:(
769:)
765:(
720::
689::
649:)
645:(
626::
615::
586::
575::
562:)
546:(
535:)
530:,
526:(
499::
465::
434::
408::
354::
320::
271::
242::
231::
211:)
206:,
202:(
185:)
177:(
167:e
160:t
153:v
136:.
20:)
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