101:) were limited by the applicator system of the clip. However, by 1988, an easy to use applicator delivery system was developed, and a functional reloadable endoclip system was described. This consisted of a stainless steel clip (of size approximately 6 mm long and 1.2 mm wide at the prongs) with a metal deployment device (that could be used to insert the clip into the endoscopic camera, and deployed outside the camera) enclosed in a plastic sheath. These clips were initially reloadable.
205:
19:
90:
253:
Endoclips have been seen to dislodge between 1 and 3 weeks from deployment, although lengthy clip retention intervals of as high as 26 months have been reported. Endoclips are believed to be safe and no major complications (such as perforation or impaction) have been reported with them, although
72:
474:
675:
Sung JJ, Chan FK, Lau JY, Yung MY, Leung WK, Wu JC, Ng EK, Chung SC (2003). "The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison".
108:) have been described and used for various applications. Rotatable clips have been devised to improve localization of deployment. Also, clips that open and close (as opposed to single-deployment) have also been developed (Resolution Clip,
436:
Yoshikane H, Hidano H, Sakakibara A, Niwa Y, Goto H (2000). "Feasibility study on endoscopic suture with the combination of a distal attachment and a rotatable clip for complications of endoscopic resection in the large intestine".
63:. Many forms of endoclips exist of different shapes and sizes, including two and three prong devices, which can be administered using single use and reloadable systems, and may or may not open and close to facilitate placement.
216:
Endoclips have also found an application in preventing bleeding when performing complicated endoscopic procedures. For example, prophylactic clipping of the base of a polyp has been found to be useful in preventing
760:
Cipolletta L, Bianco MA, Marmo R, Rotondano G, Piscopo R, Vingiani AM, Meucci C (2001). "Endoclips versus heater probe in preventing early recurrent bleeding from peptic ulcer: a prospective and randomized trial".
42:
in gross surgical applications, as it is used to join together two disjointed surfaces, but, can be applied through the channel of an endoscope under direct visualization. Endoclips have found use in treating
478:
97:
The endoclip was first described by
Hayashi and Kudoh in 1975, and was termed the "staunch clip". Initial attempts to incorporate the clip into applications in endoscopy (such as clipping bleeding
119:(such as a bleeding vessel), an endoclip can be inserted through the channel of the endoscope until the sheathed clip is visible on the endoscopic image, and the handle for deployment handed to the
917:
Shimizu Y, Kato M, Yamamoto J, Nakagawa S, Komatsu Y, Tsukagoshi H, Fujita M, Hosokawa M, Asaka M (2004). "Endoscopic clip application for closure of esophageal perforations caused by EMR".
796:
Lin HJ, Hsieh YH, Tseng GY, Perng CL, Chang FY, Lee SD (2002). "A prospective, randomized trial of endoscopic hemoclip versus heater probe thermocoagulation for peptic ulcer bleeding".
993:"Endoscopic clip-assisted biliary cannulation: externalization and fixation of the major papilla from within a duodenal diverticulum using the endoscopic clip fixing device"
499:
Jensen DM, Machicado GA, Hirabayashi K (2006). "Randomized controlled study of 3 different types of hemoclips for hemostasis of bleeding canine acute gastric ulcers".
176:. Bleeding peptic ulcers require endoscopic treatment if they show evidence of high risk stigmata of re-bleeding, such as evidence of active bleeding or oozing on
534:
Yamaguchi Y, Yamato T, Katsumi N, Morozumi K, Abe T, Ishida H, Takahashi S (2001). "Endoscopic hemoclipping for upper GI bleeding due to
Mallory-Weiss syndrome".
242:
1032:
Binmoeller KF, Grimm H, Soehendra N (1993). "Endoscopic closure of a perforation using metallic clips after snare excision of a gastric leiomyoma".
180:
or the presence of a visible blood vessel around the ulcer. The alternatives to endoscopic clipping of peptic ulcers are thermal therapy (such as
188:
to constrict the blood vessel. Comparative studies between endoclips and thermal therapy make the point that endoclips cause less trauma to the
393:
Lin HJ, Lo WC, Cheng YC, Perng CL (2007). "Endoscopic hemoclip versus triclip placement in patients with high-risk peptic ulcer bleeding".
83:
613:
Cheng AW, Chiu PW, Chan PC, Lam SH (2004). "Endoscopic hemostasis for bleeding gastric stromal tumors by application of hemoclip".
104:
Endoclips in use today have a variety of additional shapes and sizes than the original. Clips with two and three prongs (TriClip,
52:
123:
assistant. The clip is unsheathed by retraction at the handle, positioned, and "fired" by the assistant to treat the lesion.
169:
1078:
226:
60:
48:
1073:
192:
around the ulcer than electrocautery, but no definitive advantage to either approach has reached consensus by
721:"Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers"
719:
Lau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, Chan FK, Ng EK, You JH, Lee CW, Chan AC, Chung SC (2000).
325:
Binmoeller KF, Thonke F, Soehendra N (1993). "Endoscopic hemoclip treatment for gastrointestinal bleeding".
233:, or by the endoscopic procedure itself. Clips have also been used to secure the placement of endoscopic
212:(left) with a visible vessel suggesting recent bleeding is successfully closed with two endoclips (right)
165:
152:) gastrointestinal tract. Many bleeding lesions have been successfully clipped, including bleeding
439:
327:
1083:
864:
821:
701:
418:
352:
287:
254:
concern has been raised about blocking the outflow of the bile duct if clips are deployed in the
193:
157:
954:"Endoscopic placement of jejunal feeding tubes by using the Resolution clip: report of 2 cases"
1049:
1014:
973:
934:
899:
856:
813:
778:
742:
693:
657:
630:
595:
551:
516:
456:
410:
344:
307:
109:
1041:
1004:
965:
926:
891:
848:
805:
770:
732:
689:
685:
622:
585:
543:
508:
448:
402:
336:
299:
882:
Friedland S, Soetikno R (2006). "Colonoscopy with polypectomy in anticoagulated patients".
39:
35:
181:
1045:
930:
370:
204:
1067:
809:
590:
573:
406:
222:
153:
75:
868:
705:
356:
825:
422:
234:
229:
that may have been caused by complicated therapeutic endoscopy procedures, such as
105:
98:
737:
720:
230:
218:
209:
185:
173:
149:
145:
79:
56:
1009:
992:
969:
895:
852:
512:
303:
137:
71:
18:
626:
774:
547:
238:
177:
161:
141:
116:
31:
1018:
977:
938:
903:
860:
817:
782:
746:
697:
661:
634:
555:
520:
460:
414:
340:
311:
1053:
599:
348:
89:
255:
44:
34:
in order to close two mucosal surfaces without the need for surgery and
839:
Kovacs TO, Jensen DM (2007). "Endoscopic treatment of ulcer bleeding".
452:
615:
189:
953:
203:
120:
88:
70:
17:
574:"Dieulafoy's disease treated by endoscopic haemostatic clipping"
112:), and also facilitate the appropriate location of deployment.
55:), in preventing bleeding after therapeutic procedures such as
221:
bleeding, especially in high-risk patients or patients on
184:
to burn the vessel causing the bleeding), or injection of
93:
Successful closure of the gastric ulcer with an endoclip
225:
medications. In addition, clips can be used to close
648:
Letard JC, Kaffy F, Rousseau D, Nivet JM (2001). "".
290:(1999). "Endoclip: closing the surgical gap".
243:endoscopic retrograde cholangiopancreatography
136:Endoclips have found a primary application in
841:Current Treatment Options in Gastroenterology
8:
22:A single-use rotatable endoclip in packaging
245:, a procedure used to image to bile duct.
1008:
736:
589:
388:
386:
281:
279:
277:
275:
273:
271:
115:When a treatable lesion is identified on
30:is a metallic mechanical device used in
690:10.7326/0003-4819-139-4-200308190-00005
267:
567:
565:
140:(or the stopping of bleeding) during
7:
371:"TriClip Endoscopic Clipping Device"
991:Scotiniotis I, Ginsberg GG (1999).
14:
84:upper gastrointestinal hemorrhage
810:10.1111/j.1572-0241.2002.05978.x
591:10.1111/j.1440-1746.1998.01547.x
407:10.1111/j.1572-0241.2006.00962.x
38:. Its function is similar to a
1:
1046:10.1016/S0016-5107(93)70060-7
952:Frizzell E, Darwin P (2006).
931:10.1016/S0016-5107(04)01960-1
227:gastrointestinal perforations
61:gastrointestinal perforations
738:10.1056/NEJM200008033430501
1100:
650:Gastroenterol. Clin. Biol.
1010:10.1053/ge.1999.v50.97369
970:10.1016/j.gie.2006.02.051
896:10.1016/j.gie.2006.02.030
853:10.1007/s11938-007-0066-3
578:J. Gastroenterol. Hepatol
513:10.1016/j.gie.2006.06.031
304:10.1053/ge.1999.v50.99616
132:Gastrointestinal bleeding
127:Applications of endoclips
45:gastrointestinal bleeding
627:10.1089/1092642041255522
572:Teo EK, Fock KM (1998).
78:with a red spot seen in
775:10.1067/mge.2001.111386
548:10.1067/mge.2001.111774
341:10.1055/s-2007-1010277
213:
144:of the upper (through
94:
86:
67:Structure and function
23:
207:
172:, and bleeding after
92:
74:
21:
1034:Gastrointest. Endosc
997:Gastrointest. Endosc
958:Gastrointest. Endosc
919:Gastrointest. Endosc
884:Gastrointest. Endosc
798:Am. J. Gastroenterol
763:Gastrointest. Endosc
536:Gastrointest. Endosc
501:Gastrointest. Endosc
395:Am. J. Gastroenterol
292:Gastrointest. Endosc
237:, and to orient the
208:An ulcer seen after
148:) or lower (through
1079:Implants (medicine)
194:gastroenterologists
166:Dieulafoy's lesions
158:Mallory-Weiss tears
453:10.1055/s-2000-648
214:
200:Other applications
95:
87:
82:of a patient with
24:
475:"Resolution Clip"
174:removal of polyps
110:Boston Scientific
59:, and in closing
1091:
1074:Gastroenterology
1058:
1057:
1029:
1023:
1022:
1012:
988:
982:
981:
949:
943:
942:
914:
908:
907:
879:
873:
872:
836:
830:
829:
793:
787:
786:
757:
751:
750:
740:
716:
710:
709:
678:Ann. Intern. Med
672:
666:
665:
645:
639:
638:
610:
604:
603:
593:
569:
560:
559:
531:
525:
524:
496:
490:
489:
487:
486:
477:. Archived from
471:
465:
464:
433:
427:
426:
390:
381:
380:
378:
377:
367:
361:
360:
322:
316:
315:
283:
1099:
1098:
1094:
1093:
1092:
1090:
1089:
1088:
1064:
1063:
1062:
1061:
1031:
1030:
1026:
990:
989:
985:
951:
950:
946:
916:
915:
911:
881:
880:
876:
838:
837:
833:
795:
794:
790:
759:
758:
754:
725:N. Engl. J. Med
718:
717:
713:
674:
673:
669:
647:
646:
642:
612:
611:
607:
571:
570:
563:
533:
532:
528:
498:
497:
493:
484:
482:
473:
472:
468:
435:
434:
430:
392:
391:
384:
375:
373:
369:
368:
364:
324:
323:
319:
285:
284:
269:
264:
251:
241:to assist with
202:
170:stomach tumours
134:
129:
69:
12:
11:
5:
1097:
1095:
1087:
1086:
1081:
1076:
1066:
1065:
1060:
1059:
1024:
983:
944:
909:
874:
831:
788:
752:
711:
667:
640:
605:
561:
526:
491:
466:
428:
382:
362:
317:
286:Devereaux CE,
266:
265:
263:
260:
250:
247:
201:
198:
182:electrocautery
133:
130:
128:
125:
68:
65:
53:lower GI tract
13:
10:
9:
6:
4:
3:
2:
1096:
1085:
1082:
1080:
1077:
1075:
1072:
1071:
1069:
1055:
1051:
1047:
1043:
1039:
1035:
1028:
1025:
1020:
1016:
1011:
1006:
1002:
998:
994:
987:
984:
979:
975:
971:
967:
963:
959:
955:
948:
945:
940:
936:
932:
928:
924:
920:
913:
910:
905:
901:
897:
893:
890:(1): 98–100.
889:
885:
878:
875:
870:
866:
862:
858:
854:
850:
846:
842:
835:
832:
827:
823:
819:
815:
811:
807:
804:(9): 2250–4.
803:
799:
792:
789:
784:
780:
776:
772:
769:(2): 147–51.
768:
764:
756:
753:
748:
744:
739:
734:
730:
726:
722:
715:
712:
707:
703:
699:
695:
691:
687:
684:(4): 237–43.
683:
679:
671:
668:
663:
659:
655:
652:(in French).
651:
644:
641:
636:
632:
628:
624:
621:(3): 169–71.
620:
616:
609:
606:
601:
597:
592:
587:
583:
579:
575:
568:
566:
562:
557:
553:
549:
545:
542:(4): 427–30.
541:
537:
530:
527:
522:
518:
514:
510:
507:(5): 768–73.
506:
502:
495:
492:
481:on 2006-11-13
480:
476:
470:
467:
462:
458:
454:
450:
447:(6): 477–80.
446:
442:
441:
432:
429:
424:
420:
416:
412:
408:
404:
401:(3): 539–43.
400:
396:
389:
387:
383:
372:
366:
363:
358:
354:
350:
346:
342:
338:
335:(2): 167–70.
334:
330:
329:
321:
318:
313:
309:
305:
301:
297:
293:
289:
288:Binmoeller KF
282:
280:
278:
276:
274:
272:
268:
261:
259:
257:
248:
246:
244:
240:
236:
235:feeding tubes
232:
228:
224:
223:anticoagulant
220:
211:
206:
199:
197:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
154:peptic ulcers
151:
147:
143:
139:
131:
126:
124:
122:
118:
113:
111:
107:
102:
100:
99:blood vessels
91:
85:
81:
77:
76:Gastric ulcer
73:
66:
64:
62:
58:
54:
50:
47:(both in the
46:
41:
37:
33:
29:
20:
16:
1040:(2): 172–4.
1037:
1033:
1027:
1003:(3): 431–6.
1000:
996:
986:
964:(3): 454–6.
961:
957:
947:
925:(4): 636–9.
922:
918:
912:
887:
883:
877:
847:(2): 143–8.
844:
840:
834:
801:
797:
791:
766:
762:
755:
731:(5): 310–6.
728:
724:
714:
681:
677:
670:
656:(3): 323–4.
653:
649:
643:
618:
614:
608:
584:(3): 320–1.
581:
577:
539:
535:
529:
504:
500:
494:
483:. Retrieved
479:the original
469:
444:
438:
431:
398:
394:
374:. Retrieved
365:
332:
326:
320:
298:(3): 440–2.
295:
291:
252:
215:
135:
114:
106:Cook Medical
103:
96:
27:
25:
15:
231:polypectomy
219:polypectomy
210:polypectomy
186:epinephrine
150:colonoscopy
146:gastroscopy
80:gastroscopy
57:polypectomy
1068:Categories
485:2007-05-15
376:2007-05-15
262:References
138:hemostasis
1084:Endoscopy
440:Endoscopy
328:Endoscopy
239:bile duct
178:endoscopy
162:esophagus
142:endoscopy
117:endoscopy
32:endoscopy
1019:10462673
978:16923504
939:15472698
904:16813811
869:23784398
861:17391629
818:12358241
783:11174282
747:10922420
706:24699266
698:12965978
662:11395682
635:15245670
556:11275881
521:17055872
461:10863916
415:17100962
357:38706196
312:10462677
256:duodenum
36:suturing
28:endoclip
1054:8495838
826:1747162
600:9570248
423:7524541
349:8491134
160:of the
1052:
1017:
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937:
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781:
745:
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696:
660:
633:
598:
554:
519:
459:
421:
413:
355:
347:
310:
249:Safety
190:mucosa
40:suture
865:S2CID
822:S2CID
702:S2CID
419:S2CID
353:S2CID
217:post-
121:nurse
49:upper
1050:PMID
1015:PMID
974:PMID
935:PMID
900:PMID
857:PMID
814:PMID
779:PMID
743:PMID
694:PMID
658:PMID
631:PMID
596:PMID
552:PMID
517:PMID
457:PMID
411:PMID
345:PMID
308:PMID
51:and
1042:doi
1005:doi
966:doi
927:doi
892:doi
849:doi
806:doi
771:doi
733:doi
729:343
686:doi
682:139
623:doi
586:doi
544:doi
509:doi
449:doi
403:doi
399:102
337:doi
300:doi
26:An
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923:60
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898:.
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843:.
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800:.
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723:.
700:.
692:.
680:.
654:25
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619:14
617:.
594:.
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580:.
576:.
564:^
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540:53
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505:64
503:.
455:.
445:32
443:.
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409:.
397:.
385:^
351:.
343:.
333:25
331:.
306:.
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164:,
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1007::
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558:.
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