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353:; and, knowledge of form is important because it graphically represents the laws according to which the processes of life take place. Form influences the manifestation of the vital properties of organized life substances. Knowledge of form must be extended to its extreme if (one) wants to reap the greatest possible benefits.
270:
Excerpt from a letter written by the Rector G. Cantoni, dated 18 October 1865: "In seguito al felice esito da lei sortito negli esami (...) per un posto di studio allâestero, il Regio
Ministero dellâIstruzione pubblica (...) le ha aggiudicato un sussidio di lire 2400 per un anno, affinchè ella possa
344:
Sertoli was a modest man of strong character, a man untarnished by lust for personal recognition. He was a philosopher. His lecture at the opening ceremony of the academic year in 1872 at the Royal School of
Veterinary Medicine in Milan stated that life includes the concept of form because life is
135:
On June 6, 1842, Enrico
Sertoli was born into a noble family living in Sondrio, a pleasant, northern Italian town located in the Orobic Alps. His father was Giuseppe Sertoli, the architectural engineer who designed and supervised the renovation of Sts. Gervaso and Protasio Church. Enrico spent his
172:
Sertoli graduated from the
University of Pavia Medical School in 1865 when he was 23 years old. That same year, his most important paper reported his histologic discoveries regarding the seminiferous tubules. The paper was titled, âDellâesistenza di particolari cellule ramificate nei canalicoli
33:
372:
After 37 years of scientific study and didactic activity in Milan he ended his career and retired in
Sondrio in 1907. He was not married, and he had no children. He died on January 28, 1910. Although Enrico Sertoli did not have the
417:
and they are located near the base of the âtrunckâ of
Sertoliâs tree-like cells. As the germinal cell's differentiate, they are moved away from the base and into the branches of the âtreesâ and by doing so they become
136:
childhood and adolescence in
Sondrio, the second of five brothers. He received a classical undergraduate education in Sondrio. When he was 18 years old, he matriculated in the Department of Medicine and Surgery of the
208:
muscles that have regular and parallel fibers, he produced the first myogram. He was the first to demonstrate objectively the duration of the excitability and heat sensibility of the tested muscular fibers.
195:
He explained that he only described the morphologic characteristics of the branched cells, because he did not understand their nature and function. Later, however, after having subsequently examined the
539:
Sertoli E. "Discorso inaugurale di apertura dellâanno scolastico 1872â73 della R. Scuola
Superiore di Veterinaria di Milano." Milan, Archivio della Regia Scuola Superiore di Veterinaria di Milano, 1872
384:: the forerunner of antisepsis, he was rejected and forgotten by the scientific community of his time, only to gain his well-deserved place among the great names of medicine after his death.
84:
282:
He returned to Italy for military service and was placed under the command of
Colonel Guicciardi; he fought to resist Austria's efforts to invade northern Italy through the
192:. The branching parts of the newly discovered, tree-like cells were cytoplasmic structures. Sertoli named the cells he had discovered âcellule ramificateâ (branched cells).
364:
of his time, he said: âTake courage, young scholars! Donât be deterred by the difficulties you will encounter in studying such an important part of medical knowledgeâ.
592:
148:, noted for his studies of dermal structure. From Oehl, Sertoli acquired knowledge of biologic and microscopic techniques, working alongside such individuals as
274:
However Enrico probably received only a part of the 2400 lire bursary he had been awarded because he hastily returned to Italy the next year.
271:
perfezionarsi in Vienna nella scienza della
Fisiologia e Istologia. (...) I sussidi saranno pagati in dodici rate mensili eguali posticipate".
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was called, he received a short military leave in Sondrio before being sent with the 68th Regiment of the Infantry to mitigate a rebellion in
762:
377:
to discover the function of his âcellule ramificate,â given the right tools, he would likely have described their physiologic purpose.
173:
seminiferi del testicolo umanoâ (About the existence of special, branched cells in the seminiferous tubules of the human testis).
757:
606:
Sertoli, Enrico (1865). "Dell'esistenza di particolari cellule ramificate nei canalicoli seminiferi del testicolo umano".
201:
777:
309:
After leaving the military in 1867, Sertoli obtained an appointment as an assistant in the Laboratory of Physiology in
333:
Sertoli was appointed Professor of Physiology in the Department of Anatomy and Physiology of the Secondary School of
252:
402:
450:
Discorso inaugurale di apertura dellâanno scolastico 1872â73 della R. Scuola Superiore di Veterinaria di Milano.
705:
Discorso inaugurale di apertura dellâanno scolastico 1872â73 della R. Scuola Superiore di Veterinaria di Milano
525:
Sertoli E. "Dellâesistenza di particolari cellule ramificate nei canalicoli seminiferi del testicolo umano."
462:"Sulla struttura dei canalicoli seiminiferi del testicolo studiata in rapporto allo sviluppo dei nemaspermi,"
266:
Excerpt from a letter written by the Rector G. Cantoni announcing the achievement of a scholarship for Vienna.
413:. During the earliest stages of sperm development in the spermatic tubules, the germinal cells are called
586:
772:
767:
244:
577:
Hess, Franca, RA., LSR. (2005). "History of the Sertoli cell discovery. In: Sertoli cell biology".
380:
Thinking of how a remarkable intuition can fade into oblivion brings to mind sadder cases, such as
334:
145:
137:
120:
435:"Dell'esistenza di particolari cellule ramificate nei canalicoli seminiferi del testicolo umano,"
733:
Sertoli, Enrico (1871). "Osservazioni sulla struttura dei canalicoli seminiferi del testicolo".
625:
Sertoli, Enrico (1871). "Osservazioni sulla struttura dei canalicoli seminiferi del testicolo".
180:
and unique, cellular dyeing techniques, he demonstrated previously unseen, branching, tree-like
140:, where he became a resident student under the supervision of the physiologist and histologist
243:
After graduating from medical school, Sertoli was awarded a grant to conduct research at the
381:
184:
with the bases of their âtrunksâ abutting the inner wall of the seminiferous tubules. Their
149:
542:
Sertoli E. "Ăber die Bindung der Kohlensaure im Blute und ihre Ausscheidung in der Lunge."
227:
Sertoli concluded that the branched cells functioned to support and nourish the developing
483:
Barateli Giorgio M., Lanzani Alessandro, Russel N. Sacco, "Biography of Enrico Sertoli,"
88:
Sertoli's idealised drawing illustrating a cross section of a seminiferous tubule. (1878)
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181:
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322:
318:
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in a sterile goat: the goatâs testes had âbranched cellsâ but lacked germinal cells.
213:
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157:
116:
423:
398:
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185:
141:
100:
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were pale staining, oval to pyramidal shaped, and contained one or two prominent
469:"Ăber die Bindung der Kohlensaure im Blute und ihre Ausscheidung in der Lunge."
310:
262:
161:
104:
676:
U Ě ber die Bindung der Kohlensaure im Blute und ihre Ausscheidung in der Lunge
374:
177:
419:
357:
287:
228:
189:
112:
108:
32:
648:. Rendiconti dellâIstituto Lombardo di Scienze e Lettere. pp. 567â579.
115:, teacher, and inventor. He is remembered for his discovery regarding the
511:
Patriarca P. "Storia della medicina e della sanitĂ , in Valtellina," in:
455:"Osservazioni sulla struttura dei canalicoli seiminiferi del testicolo,"
361:
350:
299:
255:, one of the most famous biologists of the time. War between Austria and
153:
314:
303:
291:
248:
96:
490:
Hess R.A., Franca L.S.R., "History of the Sertoli cell discovery," in
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Enrico Sertoli concluded his talk by exhorting his listeners to study
406:
346:
295:
197:
497:
Patriarca C., Colecchia M., Clerici C.A., "Morphology Is Function,"
452:
Archivio della Regia Scuola Superiore di Veterinaria di Milano, 1872
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338:
261:
256:
218:
83:
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of horses, bears, sheep, goats, rabbits, and mice. Using penile
663:(in Italian). Archivio Medicina Veterinaria. pp. 1: 22â31.
397:
Sertoli is remembered for his 1865 discovery of the eponymous
707:. Archivio della Regia Scuola Superiore di Veterinaria. 1872.
235:â in honour of the Italian student who first described them.
678:. Medizinisch-chemische Untersuchungen. pp. 2: 350â353.
231:
and to phagocytose damaged cells.The cells were then named â
223:
Drawing of Sertoli cells. (From Sertoli E. Il Morgagni 1865)
532:
Sertoli E. "Di uno pseudo-ermafroditismo in una capra."
513:
Dalla peste nera alla seconda guerra mondiale (1348â1945)
646:
Contribuzioni alla fisiologia generale dei muscoli lisci
409:, and provide nourishment and support for developing
74:
66:
54:
39:
23:
691:Storia della Medicina e della SanitĂ in Valtellina
259:ended his research time in Vienna 1 year later.
556:Zanobio B. "Sertoli Enrico," in Gillipsie C.C.
360:. In somewhat bombastic tones, typical of the
515:, L'officina del Libro Editore, Sondrio, 1998
442:"Di uno pseudo-ermafroditismo di una capra,"
8:
693:(in Italian). Sondrio: LâOfficina del libro.
591:: CS1 maint: multiple names: authors list (
99:â January 28, 1910, Sondrio) was an Italian
560:. Charles Scribner's Sons, New York, 1978.
31:
20:
661:Di uno pseudo-ermafroditismo in una capra
549:Usuelli F. "Enrico Sentoli (1842â1910)."
569:
584:
204:muscles of various domestic animals,
7:
544:Medizinisch-chemische Untersuchungen
471:Medizinisch-chemische Untersuchungen
317:, where he studied the functions of
212:He also described a case of pseudo
558:Dictionary of Scientific Biography
14:
321:and the pulmonary elimination of
131:Birth, youth and university study
16:Italian physiologist (1842â1910)
504:Patriarca P. "Enrico Sertoli."
722:(in Italian). Milano: Adelphi.
1:
518:Pugliese A. "Henri Sertoli."
144:, an early proponent of the
345:not comprehensible without
794:
763:University of Pavia alumni
403:tubuli seminiferi contorti
534:Arch Medicina Veterinaria
494:, Elsevier, 1: 3â13, 2005
444:Arch Medicina Veterinaria
30:
735:Gazzetta Medica Lombarda
659:Sertoli, Enrico (1876).
644:Sertoli, Enrico (1882).
627:Gazzetta Medica Italiana
464:Gazzetta medica lombarda
457:Gazzetta medica lombarda
689:Patriarca, PL. (1998).
401:. These cells line the
302:there had him fighting
251:) in the laboratory of
466:, Milan, 401â403, 1875
459:, Milan, 413â415, 1871
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224:
89:
758:Italian physiologists
551:Ann Veterinaria Ital.
392:
265:
253:Professor E.W. Brucke
222:
121:seminiferous tubules.
87:
720:Il dottor Semmelweis
718:Cèline, LF. (1975).
674:Sertoli, E. (1867).
492:Sertoli Cell Biology
368:Retirement and death
245:University of Vienna
152:, the discoverer of
111:, biologic chemist,
778:People from Sondrio
335:Veterinary Medicine
306:instead of rebels.
146:experimental method
138:University of Pavia
78:University of Pavia
508:11(2): 47â50, 1995
268:
239:Research in Vienna
225:
90:
581:. Chapt. 1: 3â13.
553:12: 455â466, 1934
522:53: 161â169, 1910
473:2: 350â353, 1867.
150:Giulio Bizzozzero
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536:, 1: 22â31, 1876
529:, 7: 31â33, 1865
446:, 1: 22â31, 1876
439:, 7: 31â40, 1865
382:Ignaz Semmelweis
278:Military service
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58:January 28, 1910
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422:and ultimately
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329:Teaching career
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233:Sertoliâs cells
214:hermaphroditism
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95:(June 6, 1842,
75:Alma mater
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168:Main Discovery
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117:branched cells
93:Enrico Sertoli
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62:(aged 67)
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388:Contributions
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142:Eusebio Oehl
134:
101:physiologist
92:
91:
60:(1910-01-28)
50:June 6, 1842
18:
773:1910 deaths
768:1842 births
608:Il Morgagni
527:Il Morgagni
499:Pathologica
437:Il Morgagni
424:spermatozoa
341:at age 28.
286:. When an
162:Nobel Prize
160:, a future
105:histologist
67:Nationality
752:Categories
741:: 401â413.
478:References
420:spermatids
375:technology
229:germ cells
178:microscope
176:Using the
46:1842-06-06
565:Footnotes
358:histology
351:organisms
288:armistice
202:retractor
154:platelets
126:Biography
113:physician
109:anatomist
579:Elsevier
430:Writings
362:rhetoric
311:TĂźbingen
300:epidemic
190:nucleoli
164:winner.
485:Urology
405:of the
315:Germany
304:cholera
292:Palermo
249:Austria
97:Sondrio
70:Italian
633:: 413.
501:, 2019
487:, 2002
407:testis
347:organs
296:Sicily
206:smooth
198:testes
186:nuclei
156:, and
614:: 31.
411:sperm
339:Milan
298:. An
257:Italy
182:cells
593:link
349:and
55:Died
40:Born
337:in
119:of
754::
737:.
631:52
629:.
610:.
589:}}
585:{{
426:.
325:.
313:,
294:,
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44:(
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