393:, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.
461:, another TH2 cytokine, primes eosinophilic exit from the bone marrow by lining vessel walls with adhesion molecules such as VCAM-1 and ICAM-1. When eosinophils are activated, they undergo cytolysis, where the breaking of the cell releases eosinophilic granules found in extracellular DNA traps. High concentrations of these DNA traps are known to cause cellular damage, as the granules they contain are responsible for the ligand-induced secretion of eosinophilic toxins which cause structural damage. There is evidence to suggest that eosinophil granule protein expression is regulated by the non-coding RNA
925:
474:
819:
values are more informative than mean values for determining normal levels. Few large-scale studies have reported median blood eosinophil counts, with the median for healthy individuals being 100 cells/μL and the 95th percentile at 420 cells/μL. Thus, it is now evident that the normal median blood eosinophil count in healthy adults is around 100 cells/μL, with counts above 400 cells/μL considered outside the normal range. Current cutoffs such as 150 or 300 cells/μL used in asthma or COPD management fall within the normal range.
40:
402:
52:
3721:
1025:, thereby inhibiting its function and reducing the number of developing eosinophils as well as the number of eosinophils leading to inflammation through antibody-dependent cell-mediated cytotoxicity and eosinophilic apoptosis. Lysosomotropic agents are an efficient means to target the lysosome-like eosinophil granules inducing eosinophil apoptosis.
3733:
424:
controls the development of eosinophils in the bone marrow, as they differentiate from myeloid precursor cells. Their lineage fate is determined by transcription factors, including GATA and C/EBP. Eosinophils produce and store many secondary granule proteins prior to their exit from the bone marrow.
935:
Eosinophils play an important role in asthma as the number of accumulated eosinophils corresponds to the severity of asthmatic reaction. Eosinophilia in mice models are shown to be associated with high interleukin-5 levels. Furthermore, mucosal bronchial biopsies conducted on patients with diseases
691:
Eosinophils are responsible for tissue damage and inflammation in many diseases, including asthma. High levels of interleukin-5 has been observed to up regulate the expression of adhesion molecules, which then facilitate the adhesion of eosinophils to endothelial cells, thereby causing inflammation
818:
Strong evidence indicates that blood eosinophil counts can predict the effectiveness of specific anti-inflammatory drugs. Despite their increasing use in clinical practice, data on "normal" blood eosinophil counts remain insufficient. Due to the right-skewed distribution of these counts, median
939:
Eosinophils can also cause tissue damage in the lungs of asthmatic patients. High concentrations of eosinophil major basic protein and eosinophil-derived neurotoxin that approach cytotoxic levels are observed at degranulation sites in the lungs as well as in the asthmatic sputum.
936:
such as asthma have been found to have higher levels of interleukin-5 leading to higher levels of eosinophils. The infiltration of eosinophils at these high concentrations causes an inflammatory reaction. This ultimately leads to airway remodelling and difficulty of breathing.
1544:
Metcalf D, Burgess AW, Johnson GR, Nicola NA, Nice EC, DeLamarter J, Thatcher DR, Mermod JJ (September 1986). "In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in
Escherichia coli: comparison with purified native GM-CSF".
2286:
Venge P, Byström J, Carlson M, Hâkansson L, Karawacjzyk M, Peterson C, Sevéus L, Trulson A (September 1999). "Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease".
1012:
target IL-13 and its receptor, which reduces eosinophilic inflammation in patients with asthma due to lowering the number of adhesion molecules present for eosinophils to bind to, thereby decreasing inflammation.
711:
Following activation by an immune stimulus, eosinophils degranulate to release an array of cytotoxic granule cationic proteins that are capable of inducing tissue damage and dysfunction. These include:
446:
2190:
Morgan RK, Costello RW, Durcan N, Kingham PJ, Gleich GJ, McLean WG, Walsh MT (August 2005). "Diverse effects of eosinophil cationic granule proteins on IMR-32 nerve cell signaling and survival".
2387:
Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G (June 2013).
1931:
Horiuchi T, Weller PF (July 1997). "Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5".
2701:
1816:
Saito K, Nagata M, Kikuchi I, Sakamoto Y (December 2004). "Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin".
1517:
Metcalf D, Begley CG, Nicola NA, Johnson GR (March 1987). "Quantitative responsiveness of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3)".
664:(worm) colonization and may be slightly elevated in the presence of certain parasites. Eosinophils are also involved in many other biological processes, including postpubertal
3290:
1120:
761:
remodelling. Eosinophil cationic protein creates toxic pores in the membranes of target cells, allowing potential entry of other cytotoxic molecules to the cell, can inhibit
1892:
Kato Y, Fujisawa T, Nishimori H, Katsumata H, Atsuta J, Iguchi K, Kamiya H (2005). "Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils".
2428:
Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG (September 2011).
1738:
Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, Kay AB, Rothenberg ME (May 2008). "Eosinophils: biological properties and role in health and disease".
2669:
176:
2694:
3208:
2821:
741:
Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues. Eosinophil cationic protein and eosinophil-derived
986:
3283:
2687:
2469:
Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, Busse WW, Wenzel S, Wu Y, Datta V, Kolbeck R, Molfino NA (November 2013).
1073:
response, the TH2 response becomes suppressed, showing that mice without TH2 cytokines are significantly less likely to express asthma symptoms.
1452:
1305:
874:
2518:
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P (September 2014).
1688:"The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications"
3276:
578:
2602:"CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue"
1139:
2068:
2569:
Vraila, Marianthi; Asp, Elin; Melo, Fabio Rabelo; Grujic, Mirjana; Rollman, Ola; Pejler, Gunnar; Lampinen, Maria (November 2023).
3622:
928:
183:
924:
345:
in size with bilobed nuclei. While eosinophils are released into the bloodstream, they reside in tissue. They are found in the
2235:
Young JD, Peterson CG, Venge P, Cohn ZA (1986). "Mechanism of membrane damage mediated by human eosinophil cationic protein".
473:
3617:
1169:
2601:
3560:
1110:
914:
734:
171:
3711:
3091:
2899:
1201:"Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma"
854:
274:-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to
962:
909:. But, perhaps the most common cause for eosinophilia is an allergic condition such as asthma. In 1989, contaminated
722:
1637:
Wagner LA, Christensen CJ, Dunn DM, Spangrude GJ, Georgelas A, Kelley L, Esplin MS, Weiss RB, Gleich GJ (June 2007).
2663:
790:
3446:
2674:
846:
1590:"Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors"
758:
629:
There are also eosinophils that play a role in fighting viral infections, which is evident from the abundance of
3153:
1100:
898:
866:
159:
147:
425:
After maturation, eosinophils circulate in blood and migrate to inflammatory sites in tissues, or to sites of
2143:"Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins"
833:
An increase in eosinophils, i.e., the presence of more than 500 eosinophils/microlitre of blood is called an
3626:
3384:
3255:
3174:
3043:
786:
495:
2094:"Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein"
3648:
3366:
3302:
2199:
1115:
1022:
299:
3758:
3753:
3595:
3451:
3429:
862:
728:
515:
307:
279:
164:
3763:
3612:
3545:
3456:
3380:
3250:
2244:
1781:
Lacy P (September 2005). "The role of Rho GTPases and SNAREs in mediator release from granulocytes".
1104:
886:
850:
681:
3268:
2204:
3672:
3607:
3590:
3424:
3342:
3038:
3013:
1420:
1403:
991:
931:
of white blood cells, comparing eosinophil granulocyte amount (shown in light red) with other cells
716:
327:
259:
before migrating into blood, after which they are terminally differentiated and do not multiply.
39:
3492:
3184:
2570:
2312:
2268:
2172:
2123:
2033:
1913:
1763:
1717:
1570:
1363:
918:
894:
842:
762:
1588:
Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K (January 1988).
341:
In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17
1251:
Rosenberg HF, Phipps S, Foster PS (June 2007). "Eosinophil trafficking in allergy and asthma".
3540:
3306:
3048:
2631:
2551:
2500:
2471:"Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia"
2451:
2410:
2369:
2351:
2304:
2260:
2217:
2164:
2115:
2074:
2064:
2025:
1990:
1948:
1905:
1874:
1833:
1798:
1755:
1709:
1668:
1639:"EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression"
1619:
1562:
1526:
1499:
1448:
1425:
1355:
1301:
1278:
1230:
1094:
782:
750:
700:
346:
315:
1986:
3660:
3600:
3572:
3567:
3535:
3522:
3512:
3125:
3028:
2843:
2621:
2613:
2582:
2541:
2531:
2490:
2482:
2441:
2400:
2359:
2343:
2296:
2252:
2209:
2154:
2105:
2056:
2017:
1982:
1940:
1897:
1864:
1825:
1790:
1747:
1699:
1658:
1650:
1609:
1601:
1554:
1489:
1481:
1415:
1347:
1268:
1260:
1220:
1212:
948:
Treatments used to combat autoimmune diseases and conditions caused by eosinophils include:
870:
794:
555:
511:
358:
350:
295:
212:
84:
3737:
3555:
3074:
2863:
2795:
1147:
952:
485:
Following activation, eosinophils effector functions include production of the following:
2364:
2331:
2248:
3725:
3582:
3527:
3468:
3388:
3361:
3140:
3120:
3069:
2913:
2858:
2838:
2833:
2755:
2719:
2626:
2495:
2470:
1663:
1638:
1614:
1589:
1494:
1469:
1225:
1200:
1058:
1034:
890:
619:
570:
544:
537:
530:
458:
454:
263:
61:
51:
2060:
2051:
Gleich GJ, Adolphson CR (1986). "The eosinophilic leukocyte: structure and function".
1829:
3747:
3550:
3439:
3220:
3130:
2775:
2300:
1794:
1751:
1704:
1687:
1070:
1066:
1062:
982:
974:
897:(in which eosinophils will be found in the squamous epithelium of the esophagus) and
669:
665:
615:
611:
607:
603:
599:
595:
591:
551:
490:
421:
420:, which promotes the production of TH2 cytokines, including the interleukins (ILs).
409:
331:
252:
216:
135:
2316:
2176:
2127:
2037:
1917:
1767:
1721:
481:, characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm.
401:
3517:
3502:
3497:
3434:
3332:
3245:
3179:
3148:
3008:
2873:
2765:
2728:
2711:
2272:
1367:
1088:
1018:
1009:
978:
910:
834:
828:
746:
696:
657:
638:
450:
311:
275:
267:
130:
1574:
2679:
2600:
Bolus WR, Gutierrez DA, Kennedy AJ, Anderson-Baucum EK, Hasty AH (October 2015).
1654:
152:
2922:
2805:
2639:
2159:
2142:
2110:
2093:
1082:
1014:
966:
526:
499:
462:
378:
323:
256:
248:
3720:
2586:
2486:
1264:
3640:
3393:
3299:
3033:
3023:
3003:
2995:
2940:
2930:
2868:
2760:
1046:
970:
906:
902:
882:
742:
646:
522:
503:
478:
430:
342:
228:
57:
2617:
2355:
2213:
2008:
Shi HZ (September 2004). "Eosinophils function as antigen-presenting cells".
1944:
1485:
1216:
1097:, extreme increase (>1,500 cells per microliter) in eosinophil blood count
3698:
3403:
3240:
3086:
3018:
2969:
2935:
2800:
2780:
2770:
2675:"What is an eosinophil?" at the Cincinnati Center for Eosinophilic Disorders
1869:
1852:
1005:
956:
858:
838:
798:
778:
677:
673:
642:
623:
587:
390:
303:
236:
232:
224:
2635:
2555:
2519:
2504:
2455:
2414:
2373:
2308:
2221:
2029:
1994:
1909:
1878:
1837:
1802:
1759:
1713:
1672:
1558:
1503:
1359:
1282:
1234:
1057:
from a high fat diet. Mouse models of eosinophilia from mice infected with
17:
2536:
2446:
2429:
2405:
2388:
2264:
2168:
2119:
2078:
1952:
1623:
1566:
1530:
1429:
1053:
expression. Furthermore, this effect was exaggerated when the mice became
3688:
3473:
3461:
3419:
3373:
3337:
3213:
3107:
2986:
2974:
2950:
2945:
2733:
2330:
Lommatzsch, Marek; Nair, Parameswaran; Virchow, Johann
Christian (2024).
1605:
1140:"eosinophil - Definition of eosinophil in English by Oxford Dictionaries"
1050:
997:
802:
770:
754:
661:
574:
565:
507:
426:
374:
283:
220:
65:
2021:
3693:
3507:
3356:
3327:
3115:
2962:
2571:"Monensin induces secretory granule-mediated cell death in eosinophils"
2546:
1054:
650:
240:
2347:
1901:
1853:"The cellular biology of eosinophil eicosanoid formation and function"
1686:
Trulson A, Byström J, Engström A, Larsson R, Venge P (February 2007).
1273:
837:, and is typically seen in people with a parasitic infestation of the
189:
3665:
3653:
3398:
3349:
3203:
3079:
2743:
2256:
774:
766:
685:
654:
634:
442:
417:
370:
366:
354:
319:
244:
1351:
2520:"Mepolizumab treatment in patients with severe eosinophilic asthma"
1338:
Lambrecht BN, Hammad H (January 2015). "The immunology of asthma".
1091:, increase (>500 cells per microliter) in eosinophil blood count
1045:, there is an increased number of eosinophils, greater alternative
3158:
1042:
923:
630:
438:
434:
400:
362:
335:
287:
1021:
are other treatment options that target the alpha subunit of the
282:, it is this affinity that causes them to appear brick-red after
2389:"Dupilumab in persistent asthma with elevated eosinophil levels"
2092:
Slifman NR, Loegering DA, McKean DJ, Gleich GJ (November 1986).
1038:
878:
582:
413:
386:
382:
271:
3272:
2683:
2141:
Zheutlin LM, Ackerman SJ, Gleich GJ, Thomas LL (October 1984).
893:
production (corticosteroids suppress blood eosinophil levels);
1065:
in mice spleen. Mouse models of asthma from OVA show a higher
291:
90:
447:
5-hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid
1170:"What is an Eosinophil? | Definition & Function | CCED"
108:
93:
2192:
American
Journal of Respiratory Cell and Molecular Biology
2055:. Advances in Immunology. Vol. 39. pp. 177–253.
1933:
American
Journal of Respiratory Cell and Molecular Biology
913:
supplements caused a deadly form of eosinophilia known as
660:
and are associated with disease severity. They also fight
1470:"Eosinophil survival and apoptosis in health and disease"
1069:
response. When mice are administered IL-12 to induce the
1000:(STI571) – inhibits PDGF-BB in hypereosinophilic leukemia
114:
102:
56:
Eosinophil under the microscope (400×) from a peripheral
781:, and stimulate fibroblast cells to secrete mucus and
3709:
959:. Numbers of eosinophils in blood are rapidly reduced
111:
105:
99:
87:
753:
activity. Major basic protein induces mast cell and
117:
3681:
3639:
3581:
3482:
3412:
3320:
3313:
3233:
3193:
3167:
3139:
3106:
3059:
2994:
2985:
2921:
2912:
2892:
2820:
2742:
2727:
2718:
1851:Bandeira-Melo C, Bozza PT, Weller PF (March 2002).
1121:
List of distinct cell types in the adult human body
330:. These mediators are released by a process called
219:components responsible for combating multicellular
170:
158:
146:
141:
129:
96:
78:
73:
32:
1973:Rothenberg ME, Hogan SP (2006). "The eosinophil".
306:, which contain many chemical mediators, such as
1894:International Archives of Allergy and Immunology
334:following activation of the eosinophil, and are
699:is considered a major diagnostic criterion for
489:Cationic granule proteins and their release by
239:, they also control mechanisms associated with
2475:The Journal of Allergy and Clinical Immunology
2430:"Lebrikizumab treatment in adults with asthma"
1857:The Journal of Allergy and Clinical Immunology
1443:Young B, Lowe JS, Stevens A, Heath JW (2006).
1421:10.1182/blood.V79.12.3101.bloodjournal79123101
1296:Young B, Lowe jo, Stevens A, Heath JW (2006).
1253:The Journal of Allergy and Clinical Immunology
3284:
2695:
1968:
1966:
1964:
1962:
8:
1397:
1049:activation, and a propensity towards type 2
416:cells both express the transcription factor
1395:
1393:
1391:
1389:
1387:
1385:
1383:
1381:
1379:
1377:
1333:
1331:
1329:
1327:
1325:
1323:
1321:
1319:
1317:
633:they contain within their granules, and in
3317:
3291:
3277:
3269:
2991:
2918:
2826:
2748:
2739:
2724:
2702:
2688:
2680:
2666:- BioWeb at University of Wisconsin System
2575:Journal of Allergy and Clinical Immunology
2332:"Normal Blood Eosinophil Counts in Humans"
1818:Annals of Allergy, Asthma & Immunology
1103:, presence of a premalignant or malignant
50:
38:
2625:
2545:
2535:
2494:
2445:
2404:
2363:
2203:
2158:
2109:
1868:
1703:
1662:
1613:
1493:
1474:Allergy, Asthma & Immunology Research
1419:
1404:"Interleukin-5, Eosinophils, and Disease"
1272:
1224:
1205:Allergy, Asthma & Immunology Research
1987:10.1146/annurev.immunol.24.021605.090720
1733:
1731:
1246:
1244:
472:
298:. The staining is concentrated in small
3716:
3209:Megakaryocyte–erythroid progenitor cell
1199:Uhm TG, Kim BS, Chung IY (March 2012).
1131:
1107:of eosinophils in bone marrow and blood
985:, which eliminates eosinophils through
695:An accumulation of eosinophils in the
514:, which is preferentially produced by
187:
29:
1194:
1192:
1190:
994:of leukotriene synthesis or receptors
797:in the target, causing cell death by
7:
1594:The Journal of Experimental Medicine
1085:, decrease in eosinophil blood count
875:lymphocyte-variant hypereosinophilia
757:degranulation, and is implicated in
680:. They have also been implicated in
2524:The New England Journal of Medicine
2434:The New England Journal of Medicine
2393:The New England Journal of Medicine
338:to both parasite and host tissues.
1468:Park YM, Bochner BS (April 2010).
1447:(5th ed.). Elsevier Limited.
1300:(5th ed.). Elsevier Limited.
977:, prevents eosinophilopoiesis, or
477:Histology of an eosinophil within
25:
2289:Clinical and Experimental Allergy
1740:Clinical and Experimental Allergy
1692:Clinical and Experimental Allergy
3731:
3719:
2301:10.1046/j.1365-2222.1999.00542.x
2053:Advances in Immunology Volume 39
1795:10.1016/j.pharmthera.2005.03.008
1752:10.1111/j.1365-2222.2008.02958.x
1705:10.1111/j.1365-2222.2007.02644.x
929:Reference ranges for blood tests
184:Anatomical terms of microanatomy
83:
1896:. 137. 137 Suppl 1 (1): 17–20.
1783:Pharmacology & Therapeutics
917:, which was reminiscent of the
791:reactive nitrogen intermediates
785:. Eosinophil peroxidase forms
3618:Immunoglobulin class switching
1547:Journal of Cellular Physiology
1445:Wheater's Functional Histology
1298:Wheater's Functional Histology
1004:Monoclonal antibodies such as
901:; and with the use of certain
881:diseases (such as exfoliative
1:
2061:10.1016/S0065-2776(08)60351-X
1830:10.1016/S1081-1206(10)61269-0
1144:Oxford Dictionaries - English
1111:Chronic eosinophilic leukemia
915:eosinophilia-myalgia syndrome
735:eosinophil-derived neurotoxin
649:, are important mediators of
349:and the junction between the
64:surround the eosinophil, two
2900:Extramedullary hematopoiesis
2606:Journal of Leukocyte Biology
2010:Journal of Leukocyte Biology
1655:10.1182/blood-2006-06-027987
855:Systemic lupus erythematosus
27:Variety of white blood cells
2160:10.4049/jimmunol.133.4.2180
2111:10.4049/jimmunol.137.9.2913
1975:Annual Review of Immunology
1259:(6): 1303–10, quiz 1311–2.
1174:www.cincinnatichildrens.org
1061:showed an increase in IL-5
963:monoclonal antibody therapy
723:eosinophil cationic protein
3780:
3447:Polyclonal B cell response
2587:10.1016/j.jaci.2023.07.012
2487:10.1016/j.jaci.2013.05.020
1265:10.1016/j.jaci.2007.03.048
826:
777:, induce degranulation by
641:. Eosinophils, along with
44:3D rendering of eosinophil
3066:Antigen-presenting cells
2854:
2829:
2791:
2751:
1402:Sanderson, Colin (1992).
847:collagen vascular disease
521:Lipid mediators like the
429:infection in response to
182:
49:
37:
3154:Nucleated red blood cell
2710:Myeloid blood cells and
2618:10.1189/jlb.3HI0115-018R
2214:10.1165/rcmb.2005-0056OC
1945:10.1165/ajrcmb.17.1.2796
1486:10.4168/aair.2010.2.2.87
1217:10.4168/aair.2012.4.2.68
1101:Clonal hypereosinophilia
899:eosinophilic esophagitis
889:and other causes of low
867:clonal hypereosinophilia
3256:Hematopoietic stem cell
3175:Leukocyte extravasation
3044:Foreign-body giant cell
1870:10.1067/mai.2002.121529
1519:Experimental Hematology
787:reactive oxygen species
496:Reactive oxygen species
68:at the top left corner.
3561:Tolerance in pregnancy
3303:adaptive immune system
1559:10.1002/jcp.1041280311
1116:Acidophile (histology)
932:
482:
406:
3596:Somatic hypermutation
3430:Polyclonal antibodies
3425:Monoclonal antibodies
2670:Histology at ucsf.edu
2537:10.1056/nejmoa1403290
2447:10.1056/nejmoa1106469
2406:10.1056/nejmoa1304048
2147:Journal of Immunology
2098:Journal of Immunology
927:
863:eosinophilic leukemia
809:Clinical significance
729:eosinophil peroxidase
516:eosinophil peroxidase
476:
404:
308:eosinophil peroxidase
3613:Junctional diversity
3381:Antigen presentation
3251:Hematopoietic system
3039:Langhans giant cells
1606:10.1084/jem.167.1.43
851:rheumatoid arthritis
682:antigen presentation
357:, and, in the lower
302:within the cellular
251:that develop during
3608:V(D)J recombination
3591:Affinity maturation
3343:Antigenic variation
3014:Alveolar macrophage
2581:(5): 1312–1320.e3.
2481:(5): 1086–1096.e5.
2249:1986Natur.321..613Y
2022:10.1189/jlb.0404228
717:major basic protein
703:(nasal allergies).
692:and tissue damage.
457:(LTB4) and MCP1/4.
441:(eotaxin-2), CCL5 (
353:and medulla of the
328:major basic protein
211:, are a variety of
207:or, less commonly,
203:, sometimes called
3185:Intrinsic immunity
3049:Touton giant cells
1150:on 8 February 2018
933:
921:in Spain in 1981.
919:toxic oil syndrome
895:reflux esophagitis
783:glycosaminoglycans
651:allergic responses
483:
407:
405:Blood cell lineage
316:deoxyribonucleases
165:H2.00.04.1.02017
3707:
3706:
3635:
3634:
3385:professional APCs
3266:
3265:
3229:
3228:
3102:
3101:
3029:Epithelioid cells
2908:
2907:
2888:
2887:
2884:
2883:
2816:
2815:
2348:10.1159/000537833
1902:10.1159/000085427
1454:978-0-443-06850-8
1414:(12): 3101–3109.
1340:Nature Immunology
1307:978-0-443-06850-8
1095:Hypereosinophilia
887:Addison's disease
861:diseases such as
701:allergic rhinitis
564:Enzymes, such as
381:, but not in the
296:Romanowsky method
213:white blood cells
198:
197:
193:
16:(Redirected from
3771:
3736:
3735:
3734:
3724:
3723:
3715:
3601:Clonal selection
3573:Immune privilege
3568:Immunodeficiency
3523:Cross-reactivity
3513:Hypersensitivity
3318:
3293:
3286:
3279:
3270:
3200:Precursor cells
3126:Promegakaryocyte
2992:
2919:
2844:Promegakaryocyte
2827:
2749:
2740:
2725:
2704:
2697:
2690:
2681:
2652:
2651:
2649:
2647:
2638:. Archived from
2629:
2597:
2591:
2590:
2566:
2560:
2559:
2549:
2539:
2530:(13): 1198–207.
2515:
2509:
2508:
2498:
2466:
2460:
2459:
2449:
2425:
2419:
2418:
2408:
2384:
2378:
2377:
2367:
2327:
2321:
2320:
2283:
2277:
2276:
2257:10.1038/321613a0
2232:
2226:
2225:
2207:
2187:
2181:
2180:
2162:
2138:
2132:
2131:
2113:
2089:
2083:
2082:
2048:
2042:
2041:
2005:
1999:
1998:
1970:
1957:
1956:
1928:
1922:
1921:
1889:
1883:
1882:
1872:
1848:
1842:
1841:
1813:
1807:
1806:
1778:
1772:
1771:
1735:
1726:
1725:
1707:
1683:
1677:
1676:
1666:
1634:
1628:
1627:
1617:
1585:
1579:
1578:
1541:
1535:
1534:
1514:
1508:
1507:
1497:
1465:
1459:
1458:
1440:
1434:
1433:
1423:
1399:
1372:
1371:
1335:
1312:
1311:
1293:
1287:
1286:
1276:
1248:
1239:
1238:
1228:
1196:
1185:
1184:
1182:
1180:
1166:
1160:
1159:
1157:
1155:
1146:. Archived from
1136:
1033:Within the fat (
871:Hodgkin lymphoma
795:oxidative stress
759:peripheral nerve
707:Granule proteins
512:hypobromous acid
359:gastrointestinal
190:edit on Wikidata
124:
123:
120:
119:
116:
113:
110:
107:
104:
101:
98:
95:
92:
89:
54:
42:
30:
21:
3779:
3778:
3774:
3773:
3772:
3770:
3769:
3768:
3744:
3743:
3742:
3732:
3730:
3718:
3710:
3708:
3703:
3677:
3631:
3577:
3556:Clonal deletion
3484:
3478:
3408:
3309:
3297:
3267:
3262:
3225:
3189:
3168:Immune response
3163:
3141:Red blood cells
3135:
3098:
3075:Langerhans cell
3070:Dendritic cells
3055:
2981:
2904:
2880:
2864:Proerythroblast
2850:
2812:
2796:Monocytopoiesis
2787:
2731:
2714:
2708:
2660:
2655:
2645:
2643:
2599:
2598:
2594:
2568:
2567:
2563:
2517:
2516:
2512:
2468:
2467:
2463:
2440:(12): 1088–98.
2427:
2426:
2422:
2399:(26): 2455–66.
2386:
2385:
2381:
2329:
2328:
2324:
2285:
2284:
2280:
2243:(6070): 613–6.
2234:
2233:
2229:
2205:10.1.1.335.4162
2189:
2188:
2184:
2140:
2139:
2135:
2091:
2090:
2086:
2071:
2050:
2049:
2045:
2007:
2006:
2002:
1972:
1971:
1960:
1930:
1929:
1925:
1891:
1890:
1886:
1850:
1849:
1845:
1815:
1814:
1810:
1780:
1779:
1775:
1737:
1736:
1729:
1685:
1684:
1680:
1636:
1635:
1631:
1587:
1586:
1582:
1543:
1542:
1538:
1516:
1515:
1511:
1467:
1466:
1462:
1455:
1442:
1441:
1437:
1401:
1400:
1375:
1352:10.1038/ni.3049
1337:
1336:
1315:
1308:
1295:
1294:
1290:
1250:
1249:
1242:
1198:
1197:
1188:
1178:
1176:
1168:
1167:
1163:
1153:
1151:
1138:
1137:
1133:
1129:
1079:
1031:
953:corticosteroids
946:
831:
825:
816:
811:
709:
670:oestrus cycling
637:removal during
559:
548:
541:
534:
471:
399:
215:and one of the
194:
86:
82:
69:
62:Red blood cells
45:
28:
23:
22:
15:
12:
11:
5:
3777:
3775:
3767:
3766:
3761:
3756:
3746:
3745:
3741:
3740:
3728:
3705:
3704:
3702:
3701:
3696:
3691:
3685:
3683:
3679:
3678:
3676:
3675:
3670:
3669:
3668:
3658:
3657:
3656:
3645:
3643:
3637:
3636:
3633:
3632:
3630:
3629:
3620:
3615:
3610:
3605:
3604:
3603:
3598:
3587:
3585:
3583:Immunogenetics
3579:
3578:
3576:
3575:
3570:
3565:
3564:
3563:
3558:
3553:
3548:
3543:
3531:
3530:
3528:Co-stimulation
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3488:
3486:
3480:
3479:
3477:
3476:
3471:
3469:Immune complex
3465:
3464:
3459:
3454:
3449:
3444:
3443:
3442:
3437:
3432:
3427:
3416:
3414:
3410:
3409:
3407:
3406:
3401:
3396:
3391:
3389:Dendritic cell
3377:
3376:
3371:
3370:
3369:
3367:Conformational
3364:
3353:
3352:
3347:
3346:
3345:
3340:
3335:
3324:
3322:
3315:
3311:
3310:
3298:
3296:
3295:
3288:
3281:
3273:
3264:
3263:
3261:
3260:
3259:
3258:
3248:
3243:
3237:
3235:
3231:
3230:
3227:
3226:
3224:
3223:
3218:
3217:
3216:
3211:
3206:
3197:
3195:
3191:
3190:
3188:
3187:
3182:
3177:
3171:
3169:
3165:
3164:
3162:
3161:
3156:
3151:
3145:
3143:
3137:
3136:
3134:
3133:
3128:
3123:
3121:Megakaryoblast
3118:
3112:
3110:
3104:
3103:
3100:
3099:
3097:
3096:
3095:
3094:
3084:
3083:
3082:
3077:
3072:
3063:
3061:
3057:
3056:
3054:
3053:
3052:
3051:
3046:
3041:
3031:
3026:
3021:
3016:
3011:
3006:
3000:
2998:
2989:
2983:
2982:
2980:
2979:
2978:
2977:
2967:
2966:
2965:
2955:
2954:
2953:
2943:
2938:
2933:
2927:
2925:
2916:
2914:Myeloid tissue
2910:
2909:
2906:
2905:
2903:
2902:
2896:
2894:
2890:
2889:
2886:
2885:
2882:
2881:
2879:
2878:
2877:
2876:
2871:
2866:
2859:Erythropoiesis
2855:
2852:
2851:
2849:
2848:
2847:
2846:
2841:
2839:Megakaryoblast
2834:Thrombopoiesis
2830:
2824:
2818:
2817:
2814:
2813:
2811:
2810:
2809:
2808:
2803:
2792:
2789:
2788:
2786:
2785:
2784:
2783:
2778:
2773:
2768:
2763:
2756:Granulopoiesis
2752:
2746:
2737:
2722:
2716:
2715:
2709:
2707:
2706:
2699:
2692:
2684:
2678:
2677:
2672:
2667:
2659:
2658:External links
2656:
2654:
2653:
2592:
2561:
2510:
2461:
2420:
2379:
2342:(4): 214–216.
2322:
2295:(9): 1172–86.
2278:
2227:
2182:
2133:
2084:
2069:
2043:
2000:
1958:
1923:
1884:
1863:(3): 393–400.
1843:
1824:(6): 594–600.
1808:
1773:
1727:
1678:
1649:(12): 5191–8.
1629:
1580:
1536:
1509:
1460:
1453:
1435:
1373:
1313:
1306:
1288:
1240:
1186:
1161:
1130:
1128:
1125:
1124:
1123:
1118:
1113:
1108:
1098:
1092:
1086:
1078:
1075:
1030:
1029:Animal studies
1027:
1002:
1001:
995:
989:
960:
945:
942:
891:corticosteroid
827:Main article:
824:
821:
815:
812:
810:
807:
773:production by
739:
738:
732:
726:
720:
708:
705:
676:rejection and
627:
626:
585:
571:Growth factors
568:
562:
557:
546:
539:
532:
519:
493:
470:
467:
459:Interleukin-13
455:leukotriene B4
449:, and certain
398:
395:
196:
195:
186:
180:
179:
174:
168:
167:
162:
156:
155:
150:
144:
143:
139:
138:
133:
127:
126:
80:
76:
75:
71:
70:
55:
47:
46:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3776:
3765:
3762:
3760:
3757:
3755:
3752:
3751:
3749:
3739:
3729:
3727:
3722:
3717:
3713:
3700:
3697:
3695:
3692:
3690:
3687:
3686:
3684:
3680:
3674:
3671:
3667:
3664:
3663:
3662:
3659:
3655:
3652:
3651:
3650:
3647:
3646:
3644:
3642:
3638:
3628:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3602:
3599:
3597:
3594:
3593:
3592:
3589:
3588:
3586:
3584:
3580:
3574:
3571:
3569:
3566:
3562:
3559:
3557:
3554:
3552:
3551:Clonal anergy
3549:
3547:
3544:
3542:
3539:
3538:
3537:
3533:
3532:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3490:
3489:
3487:
3481:
3475:
3472:
3470:
3467:
3466:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3441:
3440:Microantibody
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3422:
3421:
3418:
3417:
3415:
3411:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3386:
3382:
3379:
3378:
3375:
3372:
3368:
3365:
3363:
3360:
3359:
3358:
3355:
3354:
3351:
3348:
3344:
3341:
3339:
3336:
3334:
3331:
3330:
3329:
3326:
3325:
3323:
3319:
3316:
3312:
3308:
3304:
3301:
3294:
3289:
3287:
3282:
3280:
3275:
3274:
3271:
3257:
3254:
3253:
3252:
3249:
3247:
3244:
3242:
3239:
3238:
3236:
3232:
3222:
3221:Myelomonocyte
3219:
3215:
3212:
3210:
3207:
3205:
3202:
3201:
3199:
3198:
3196:
3192:
3186:
3183:
3181:
3178:
3176:
3173:
3172:
3170:
3166:
3160:
3157:
3155:
3152:
3150:
3147:
3146:
3144:
3142:
3138:
3132:
3131:Megakaryocyte
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3113:
3111:
3109:
3105:
3093:
3090:
3089:
3088:
3085:
3081:
3078:
3076:
3073:
3071:
3068:
3067:
3065:
3064:
3062:
3058:
3050:
3047:
3045:
3042:
3040:
3037:
3036:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3009:Kupffer cells
3007:
3005:
3002:
3001:
2999:
2997:
2993:
2990:
2988:
2984:
2976:
2973:
2972:
2971:
2968:
2964:
2961:
2960:
2959:
2956:
2952:
2949:
2948:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2928:
2926:
2924:
2920:
2917:
2915:
2911:
2901:
2898:
2897:
2895:
2891:
2875:
2872:
2870:
2867:
2865:
2862:
2861:
2860:
2857:
2856:
2853:
2845:
2842:
2840:
2837:
2836:
2835:
2832:
2831:
2828:
2825:
2823:
2819:
2807:
2804:
2802:
2799:
2798:
2797:
2794:
2793:
2790:
2782:
2779:
2777:
2776:Metamyelocyte
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2758:
2757:
2754:
2753:
2750:
2747:
2745:
2741:
2738:
2735:
2730:
2726:
2723:
2721:
2720:Hematopoiesis
2717:
2713:
2705:
2700:
2698:
2693:
2691:
2686:
2685:
2682:
2676:
2673:
2671:
2668:
2665:
2662:
2661:
2657:
2642:on 9 May 2017
2641:
2637:
2633:
2628:
2623:
2619:
2615:
2612:(4): 467–77.
2611:
2607:
2603:
2596:
2593:
2588:
2584:
2580:
2576:
2572:
2565:
2562:
2557:
2553:
2548:
2543:
2538:
2533:
2529:
2525:
2521:
2514:
2511:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2465:
2462:
2457:
2453:
2448:
2443:
2439:
2435:
2431:
2424:
2421:
2416:
2412:
2407:
2402:
2398:
2394:
2390:
2383:
2380:
2375:
2371:
2366:
2361:
2357:
2353:
2349:
2345:
2341:
2337:
2333:
2326:
2323:
2318:
2314:
2310:
2306:
2302:
2298:
2294:
2290:
2282:
2279:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2228:
2223:
2219:
2215:
2211:
2206:
2201:
2198:(2): 169–77.
2197:
2193:
2186:
2183:
2178:
2174:
2170:
2166:
2161:
2156:
2153:(4): 2180–5.
2152:
2148:
2144:
2137:
2134:
2129:
2125:
2121:
2117:
2112:
2107:
2104:(9): 2913–7.
2103:
2099:
2095:
2088:
2085:
2080:
2076:
2072:
2070:9780120224395
2066:
2062:
2058:
2054:
2047:
2044:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2004:
2001:
1996:
1992:
1988:
1984:
1981:(1): 147–74.
1980:
1976:
1969:
1967:
1965:
1963:
1959:
1954:
1950:
1946:
1942:
1938:
1934:
1927:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1895:
1888:
1885:
1880:
1876:
1871:
1866:
1862:
1858:
1854:
1847:
1844:
1839:
1835:
1831:
1827:
1823:
1819:
1812:
1809:
1804:
1800:
1796:
1792:
1789:(3): 358–76.
1788:
1784:
1777:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1746:(5): 709–50.
1745:
1741:
1734:
1732:
1728:
1723:
1719:
1715:
1711:
1706:
1701:
1698:(2): 208–18.
1697:
1693:
1689:
1682:
1679:
1674:
1670:
1665:
1660:
1656:
1652:
1648:
1644:
1640:
1633:
1630:
1625:
1621:
1616:
1611:
1607:
1603:
1599:
1595:
1591:
1584:
1581:
1576:
1572:
1568:
1564:
1560:
1556:
1553:(3): 421–31.
1552:
1548:
1540:
1537:
1532:
1528:
1525:(3): 288–95.
1524:
1520:
1513:
1510:
1505:
1501:
1496:
1491:
1487:
1483:
1480:(2): 87–101.
1479:
1475:
1471:
1464:
1461:
1456:
1450:
1446:
1439:
1436:
1431:
1427:
1422:
1417:
1413:
1409:
1405:
1398:
1396:
1394:
1392:
1390:
1388:
1386:
1384:
1382:
1380:
1378:
1374:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1334:
1332:
1330:
1328:
1326:
1324:
1322:
1320:
1318:
1314:
1309:
1303:
1299:
1292:
1289:
1284:
1280:
1275:
1270:
1266:
1262:
1258:
1254:
1247:
1245:
1241:
1236:
1232:
1227:
1222:
1218:
1214:
1210:
1206:
1202:
1195:
1193:
1191:
1187:
1175:
1171:
1165:
1162:
1149:
1145:
1141:
1135:
1132:
1126:
1122:
1119:
1117:
1114:
1112:
1109:
1106:
1102:
1099:
1096:
1093:
1090:
1087:
1084:
1081:
1080:
1076:
1074:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1028:
1026:
1024:
1023:IL-5 receptor
1020:
1016:
1011:
1007:
999:
996:
993:
990:
988:
984:
983:IL-5 receptor
980:
976:
972:
968:
964:
961:
958:
954:
951:
950:
949:
943:
941:
937:
930:
926:
922:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
868:
864:
860:
856:
852:
848:
844:
840:
836:
830:
822:
820:
813:
808:
806:
804:
800:
796:
793:that promote
792:
788:
784:
780:
776:
772:
768:
764:
763:proliferation
760:
756:
752:
748:
747:ribonucleases
744:
736:
733:
730:
727:
724:
721:
718:
715:
714:
713:
706:
704:
702:
698:
693:
689:
687:
683:
679:
675:
671:
668:development,
667:
666:mammary gland
663:
659:
656:
652:
648:
644:
640:
636:
632:
625:
621:
617:
613:
609:
605:
601:
597:
593:
589:
586:
584:
580:
576:
572:
569:
567:
563:
560:
553:
552:prostaglandin
549:
542:
535:
528:
524:
520:
517:
513:
509:
505:
501:
497:
494:
492:
491:degranulation
488:
487:
486:
480:
475:
468:
466:
464:
460:
456:
452:
448:
444:
440:
437:(eotaxin-1),
436:
432:
428:
423:
419:
415:
411:
403:
396:
394:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
339:
337:
333:
332:degranulation
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
276:coal tar dyes
273:
269:
265:
260:
258:
254:
253:hematopoiesis
250:
246:
242:
238:
234:
231:. Along with
230:
226:
222:
218:
217:immune system
214:
210:
206:
202:
191:
185:
181:
178:
175:
173:
169:
166:
163:
161:
157:
154:
151:
149:
145:
140:
137:
136:Immune system
134:
132:
128:
122:
81:
79:Pronunciation
77:
72:
67:
63:
59:
53:
48:
41:
36:
31:
19:
3759:Granulocytes
3754:Cell biology
3518:Inflammation
3503:Alloimmunity
3498:Autoimmunity
3483:Immunity vs.
3435:Autoantibody
3333:Superantigen
3180:Phagocytosis
3149:Reticulocyte
2957:
2923:Granulocytes
2874:Reticulocyte
2766:Promyelocyte
2729:Myelopoiesis
2644:. Retrieved
2640:the original
2609:
2605:
2595:
2578:
2574:
2564:
2527:
2523:
2513:
2478:
2474:
2464:
2437:
2433:
2423:
2396:
2392:
2382:
2339:
2335:
2325:
2292:
2288:
2281:
2240:
2236:
2230:
2195:
2191:
2185:
2150:
2146:
2136:
2101:
2097:
2087:
2052:
2046:
2016:(3): 520–7.
2013:
2009:
2003:
1978:
1974:
1936:
1932:
1926:
1893:
1887:
1860:
1856:
1846:
1821:
1817:
1811:
1786:
1782:
1776:
1743:
1739:
1695:
1691:
1681:
1646:
1642:
1632:
1600:(1): 43–56.
1597:
1593:
1583:
1550:
1546:
1539:
1522:
1518:
1512:
1477:
1473:
1463:
1444:
1438:
1411:
1407:
1346:(1): 45–56.
1343:
1339:
1297:
1291:
1256:
1252:
1211:(2): 68–79.
1208:
1204:
1177:. Retrieved
1173:
1164:
1152:. Retrieved
1148:the original
1143:
1134:
1089:Eosinophilia
1037:) tissue of
1032:
1019:benralizumab
1010:lebrikizumab
1003:
979:benralizumab
947:
938:
934:
911:L-tryptophan
877:; extensive
835:eosinophilia
832:
829:Eosinophilia
823:Eosinophilia
817:
740:
710:
697:nasal mucosa
694:
690:
658:pathogenesis
639:inflammation
628:
484:
451:leukotrienes
408:
340:
312:ribonuclease
294:, using the
278:: Normally
268:eosinophilic
261:
249:granulocytes
247:. They are
223:and certain
208:
205:eosinophiles
204:
200:
199:
3764:Human cells
3641:Lymphocytes
3300:Lymphocytic
3034:giant cells
3024:Osteoclasts
3004:Histiocytes
2996:Macrophages
2806:Promonocyte
2646:8 September
2547:2268/176693
2336:Respiration
1939:(1): 70–7.
1083:Eosinopenia
1015:Mepolizumab
992:antagonists
967:mepolizumab
814:Blood count
769:, suppress
527:leukotriene
523:eicosanoids
500:hypobromite
397:Development
379:lymph nodes
343:micrometres
324:plasminogen
280:transparent
257:bone marrow
229:vertebrates
201:Eosinophils
142:Identifiers
58:blood smear
18:Eosinophils
3748:Categories
3682:Substances
3546:Peripheral
3534:Inaction:
3413:Antibodies
3394:Macrophage
3307:complement
2958:Eosinophil
2941:Neutrophil
2931:Myeloblast
2869:Normoblast
2761:Myeloblast
2664:Eosinophil
1274:1885/30451
1127:References
1047:macrophage
1041:deficient
971:reslizumab
955:– promote
907:penicillin
883:dermatitis
843:autoimmune
839:intestines
779:mast cells
743:neurotoxin
647:mast cells
561:) families
504:superoxide
479:epithelium
431:chemokines
233:mast cells
225:infections
209:acidophils
33:Eosinophil
3699:Cytolysin
3689:Cytokines
3536:Tolerance
3485:tolerance
3404:Immunogen
3241:Phagocyte
3108:Platelets
3087:Monoblast
3019:Microglia
2987:Monocytes
2970:Mast cell
2936:Band cell
2801:Monoblast
2781:Band cell
2771:Myelocyte
2356:0025-7931
2200:CiteSeerX
1006:dupilumab
957:apoptosis
944:Treatment
859:malignant
849:(such as
799:apoptosis
751:antiviral
678:neoplasia
674:allograft
643:basophils
624:TNF alpha
588:Cytokines
525:from the
391:esophagus
318:(DNase),
314:(RNase),
304:cytoplasm
237:basophils
221:parasites
66:platelets
3738:Medicine
3649:Cellular
3493:Immunity
3491:Action:
3474:Paratope
3462:Idiotype
3452:Allotype
3420:Antibody
3374:Mimotope
3338:Allergen
3321:Antigens
3314:Lymphoid
3214:CFU-GEMM
2975:CFU-Mast
2951:CFU-Baso
2946:Basophil
2734:CFU-GEMM
2636:25934927
2556:25199059
2505:23866823
2456:21812663
2415:23688323
2374:38354723
2365:10997252
2317:11541968
2309:10469025
2222:15860794
2177:12043171
2128:33456907
2038:25152503
2030:15218055
1995:16551246
1918:23556551
1910:15947480
1879:11897981
1838:15609771
1803:15951020
1768:25254034
1760:18384431
1722:45301814
1714:17250693
1673:17351112
1504:20358022
1360:25521684
1283:17481712
1235:22379601
1154:27 March
1077:See also
1059:T. canis
1051:cytokine
998:imatinib
981:against
973:against
965:– e.g.,
905:such as
803:necrosis
771:antibody
755:basophil
662:helminth
590:such as
575:TGF beta
573:such as
566:elastase
508:peroxide
498:such as
469:Function
427:helminth
375:prostate
300:granules
290:, a red
284:staining
3726:Biology
3712:Portals
3694:Opsonin
3673:NK cell
3661:Humoral
3541:Central
3508:Allergy
3457:Isotype
3357:Epitope
3328:Antigen
3116:CFU-Meg
2963:CFU-Eos
2893:General
2627:4763864
2496:4172321
2273:4322838
2265:2423882
2245:Bibcode
2169:6206154
2120:3760576
2079:3538819
1953:9224211
1664:1890841
1624:3257253
1615:2188821
1567:3528176
1531:3493174
1495:2846745
1430:1596561
1368:5451867
1226:3283796
1179:14 June
1035:adipose
775:B cells
767:T cells
686:T cells
554:(e.g.,
529:(e.g.,
363:ovaries
361:tract,
347:medulla
255:in the
241:allergy
153:D004804
74:Details
3666:B cell
3654:T cell
3399:B cell
3362:Linear
3350:Hapten
3246:Plasma
3204:CFU-GM
3080:CFU-DL
2744:CFU-GM
2712:plasma
2634:
2624:
2554:
2503:
2493:
2454:
2413:
2372:
2362:
2354:
2315:
2307:
2271:
2263:
2237:Nature
2220:
2202:
2175:
2167:
2126:
2118:
2077:
2067:
2036:
2028:
1993:
1951:
1916:
1908:
1877:
1836:
1801:
1766:
1758:
1720:
1712:
1671:
1661:
1622:
1612:
1575:515338
1573:
1565:
1529:
1502:
1492:
1451:
1428:
1366:
1358:
1304:
1281:
1233:
1223:
869:, and
853:) and
655:asthma
635:fibrin
631:RNases
622:, and
581:, and
550:) and
506:, and
443:RANTES
418:GATA-3
377:, and
371:spleen
367:uterus
355:thymus
351:cortex
326:, and
320:lipase
262:These
245:asthma
131:System
3234:Other
3194:Other
3159:CFU-E
3060:Other
2313:S2CID
2269:S2CID
2173:S2CID
2124:S2CID
2034:S2CID
1914:S2CID
1764:S2CID
1718:S2CID
1643:Blood
1571:S2CID
1408:Blood
1364:S2CID
1105:clone
1055:obese
903:drugs
749:with
737:(EDN)
731:(EPX)
725:(ECP)
719:(MBP)
620:IL-13
453:like
439:CCL24
435:CCL11
433:like
383:lungs
336:toxic
288:eosin
286:with
264:cells
188:[
177:62861
3305:and
2648:2016
2632:PMID
2552:PMID
2501:PMID
2452:PMID
2411:PMID
2370:PMID
2352:ISSN
2305:PMID
2261:PMID
2218:PMID
2165:PMID
2116:PMID
2075:PMID
2065:ISBN
2026:PMID
1991:PMID
1949:PMID
1906:PMID
1875:PMID
1834:PMID
1799:PMID
1756:PMID
1710:PMID
1669:PMID
1620:PMID
1563:PMID
1527:PMID
1500:PMID
1449:ISBN
1426:PMID
1356:PMID
1302:ISBN
1279:PMID
1231:PMID
1181:2018
1156:2018
1063:mRNA
1043:mice
1039:CCR2
1017:and
1008:and
987:ADCC
975:IL-5
879:skin
845:and
801:and
789:and
745:are
653:and
645:and
616:IL-9
612:IL-8
608:IL-6
604:IL-5
600:IL-4
596:IL-2
592:IL-1
583:PDGF
579:VEGF
463:EGOT
422:IL-5
414:ILC2
412:and
387:skin
272:acid
270:or "
266:are
243:and
235:and
148:MeSH
3627:HLA
3623:MHC
3092:MPS
2822:MEP
2622:PMC
2614:doi
2583:doi
2579:152
2542:hdl
2532:doi
2528:371
2491:PMC
2483:doi
2479:132
2442:doi
2438:365
2401:doi
2397:368
2360:PMC
2344:doi
2340:103
2297:doi
2253:doi
2241:321
2210:doi
2155:doi
2151:133
2106:doi
2102:137
2057:doi
2018:doi
1983:doi
1941:doi
1898:doi
1865:doi
1861:109
1826:doi
1791:doi
1787:107
1748:doi
1700:doi
1659:PMC
1651:doi
1647:109
1610:PMC
1602:doi
1598:167
1555:doi
1551:128
1490:PMC
1482:doi
1416:doi
1348:doi
1269:hdl
1261:doi
1257:119
1221:PMC
1213:doi
1071:TH1
1067:TH2
969:or
885:);
765:of
684:to
556:PGE
545:LTE
538:LTD
531:LTC
445:),
410:TH2
292:dye
227:in
172:FMA
3750::
3387::
2630:.
2620:.
2610:98
2608:.
2604:.
2577:.
2573:.
2550:.
2540:.
2526:.
2522:.
2499:.
2489:.
2477:.
2473:.
2450:.
2436:.
2432:.
2409:.
2395:.
2391:.
2368:.
2358:.
2350:.
2338:.
2334:.
2311:.
2303:.
2293:29
2291:.
2267:.
2259:.
2251:.
2239:.
2216:.
2208:.
2196:33
2194:.
2171:.
2163:.
2149:.
2145:.
2122:.
2114:.
2100:.
2096:.
2073:.
2063:.
2032:.
2024:.
2014:76
2012:.
1989:.
1979:24
1977:.
1961:^
1947:.
1937:17
1935:.
1912:.
1904:.
1873:.
1859:.
1855:.
1832:.
1822:93
1820:.
1797:.
1785:.
1762:.
1754:.
1744:38
1742:.
1730:^
1716:.
1708:.
1696:37
1694:.
1690:.
1667:.
1657:.
1645:.
1641:.
1618:.
1608:.
1596:.
1592:.
1569:.
1561:.
1549:.
1523:15
1521:.
1498:.
1488:.
1476:.
1472:.
1424:.
1412:79
1410:.
1406:.
1376:^
1362:.
1354:.
1344:16
1342:.
1316:^
1277:.
1267:.
1255:.
1243:^
1229:.
1219:.
1207:.
1203:.
1189:^
1172:.
1142:.
873:;
865:,
857:;
841:;
805:.
688:.
672:,
618:,
614:,
610:,
606:,
602:,
598:,
594:,
577:,
543:,
536:,
502:,
465:.
389:,
385:,
373:,
369:,
365:,
322:,
310:,
160:TH
94:oʊ
91:iː
60:.
3714::
3625:/
3383:/
3292:e
3285:t
3278:v
2736:)
2732:(
2703:e
2696:t
2689:v
2650:.
2616::
2589:.
2585::
2558:.
2544::
2534::
2507:.
2485::
2458:.
2444::
2417:.
2403::
2376:.
2346::
2319:.
2299::
2275:.
2255::
2247::
2224:.
2212::
2179:.
2157::
2130:.
2108::
2081:.
2059::
2040:.
2020::
1997:.
1985::
1955:.
1943::
1920:.
1900::
1881:.
1867::
1840:.
1828::
1805:.
1793::
1770:.
1750::
1724:.
1702::
1675:.
1653::
1626:.
1604::
1577:.
1557::
1533:.
1506:.
1484::
1478:2
1457:.
1432:.
1418::
1370:.
1350::
1310:.
1285:.
1271::
1263::
1237:.
1215::
1209:4
1183:.
1158:.
558:2
547:4
540:4
533:4
518:)
510:(
192:]
125:)
121:/
118:l
115:ɪ
112:f
109:ə
106:n
103:ɪ
100:s
97:ˈ
88:ˌ
85:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
