165:
While he was there he was particularly involved in perfecting the new technique of using immunoflourescence to define autoantibodies in many diseases, providing much of the basis for modern diagnostics. With his colleagues, he was the first to describe smooth muscle reactive autoantibodies and this
887:
166:
led the way to important immunological discoveries in the fields of liver disease, viral infections and neoplasia. While there he made a point of developing activities for the children hospitalised through arthritis.
527:
Johnson, G.D.; Davidson, R.S.; McNamee, K.C.; Russell, G.; Goodwin, D.; Holborow, E.J. (17 December 1982). "Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy".
907:
892:
882:
912:
877:
207:(Oxford, Blackwell, 1965) which was regarded as a landmark text in the field and has been described as ‘a model of scientific writing’. He also wrote
150:
127:
103:
227:. Holborow was appointed the head of the Bone and Joint Research Unit and was given a professorial chair in immunopathology. He was a co-editor for
593:"T cell cytotoxicity to Epstein-Barr virus infected B cells: comparison of patients with rheumatoid arthritis and their HLA identical siblings"
242:
He married in 1943. Upon his death in 2009 he was survived by his widow, two sons, a daughter, six grandchildren, and two great-grandchildren.
154:
161:, Buckinghamshire. He eventually became the director of the Rheumatism Research Unit and worked there until the Unit was closed in 1976.
139:
107:(20 March 1918 – 3 February 2009) was a British physician, rheumatologist, and immunologist, known for his pioneering research on
902:
691:
220:
897:
196:
123:
484:
Unsworth, D. J.; Manuel, P. D.; Walker-Smith, J. A.; Campbell, C. A.; Johnson, G. D.; Holborow, E. J. (November 1981).
369:
Papamichail, M.; Brown, J.C.; Holborow, E.J. (16 October 1971). "Immunoglobulins on the surface of human lymphocytes".
91:
636:"Characterisation of the size and composition of circulating immune complexes in patients with rheumatoid arthritis"
709:
Johnson GD; Holborow EJ; Glynn LE (30 October 1965). "Antibody to smooth muscle in patients with liver disease".
180:
131:
119:
176:
718:
191:, he created a model centre for the scientific basis of investigating patients with rheumatic diseases.
171:
With
Leonard Glynn, he was one of the first scientists to explore the contribution of autoimmunity to
872:
867:
591:
Winrow, V. R.; Norton, J.; Holborow, E. J.; Stierle, H. E.; Young, A.; Sachs, J. A. (April 1988).
143:
768:
665:
634:
Mageed, R. A.; Kirwan, J. R.; Thompson, P. W.; McCarthy, D. A.; Holborow, E. J. (April 1991).
622:
579:
558:"Plasmodium falciparum products enhance human lymphocyte transformation by Epstein-Barr virus"
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472:
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357:
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in patients and animal models of autoimmune disease, and with his clinical collaborators,
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510:
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142:'s department of haematology (where Dacie was a senior lecturer) and in 1953 graduated
382:
861:
540:
184:
115:
63:
235:(London, Academic Press, 1977, 1983). Holborow was elected FRCP in 1978 and was the
108:
846:
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224:
458:
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287:
669:
626:
583:
548:
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361:
651:
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44:
772:
476:
297:"A serum factor in lupus erythematosus with affinity for tissue nuclei"
158:
233:
Immunology in
Medicine: A Comprehensive Guide to Clinical Immunology
118:, Eric John Holborow, known as "John" or "EJ", studied medicine at
130:. In 1942 immediately after qualifying MRCS, LRCP, he joined the
231:
and a co-editor with
William Gordon Reeves of two editions of
254:"Rheumatic Fever: Biochemical and Histopathological Aspects"
888:
Alumni of the
Medical College of St Bartholomew's Hospital
556:
Kataaha, P. K.; Facer, C. A.; Holborow, E. J. (May 1984).
486:"New immunofluorescent blood test for gluten sensitivity"
138:
from 1943 to 1946) in Egypt. Holborow in 1947 joined the
398:
Whitehouse, J. M.; Holborow, E. J. (27 November 1971).
295:
Holborow, E. J.; Weir, D. M.; Johnson, G. D. (1957).
806:
Munk's Roll, Volume XII, Royal
College of Physicians
149:
In 1953 Holborow joined the scientific staff of the
199:and in 1959 became the Society's second secretary.
86:
78:
70:
52:
30:
23:
828:Denman, Michael; Archer, Jim; Winrow, Viv (2009).
338:Holborow, E. J.; Denman, A. M. (December 1967).
747:"Smooth muscle autoantibodies and autoantigens"
219:set up the Bone and Joint Research Unit at the
201:
169:
163:
16:British physician and immunologist (1918–2009)
692:"Lasting Tribute page for Eric John Holborow"
400:"Smooth Muscle Antibody in Malignant Disease"
203:Together with Leonard Glynn ... he published
8:
908:Fellows of the Royal College of Physicians
20:
845:
762:
659:
616:
573:
509:
466:
423:
351:
320:
277:
683:
195:He was in 1956 a founder member of the
823:
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819:
817:
815:
796:
794:
792:
790:
788:
786:
784:
782:
727:
716:
830:"Obituary. John Holborow (1918–2009)"
7:
893:20th-century English medical doctors
229:The Journal of Immunological Methods
155:Canadian Red Cross Memorial Hospital
447:J Clin Pathol Suppl (R Coll Pathol)
340:"Autoimmune disease in inbred mice"
883:Alumni of Clare College, Cambridge
14:
913:Royal Army Medical Corps officers
217:Arthritis and Rheumatism Campaign
140:Royal Postgraduate Medical School
134:and served (under the command of
878:People educated at Epsom College
529:Journal of Immunological Methods
252:Holborow, E. J. (October 1953).
153:Rheumatism Research Unit at the
221:London Hospital Medical College
92:autoantibodies to smooth muscle
197:British Society for Immunology
1:
443:"Antinucleic acid antibodies"
383:10.1016/S0140-6736(71)90224-8
346:. 2(Suppl) (Suppl): 761–767.
239:in 1982. He retired in 1983.
541:10.1016/0022-1759(82)90035-7
847:10.1093/rheumatology/kep318
211:(London, Lancet Ltd, 1968).
209:An ABC of modern immunology
929:
82:Physician and immunologist
124:St Bartholomew's Hospital
441:Holborow, E. J. (1979).
205:Autoimmunity and disease
120:Clare College, Cambridge
903:British rheumatologists
459:10.1136/jcp.s3-13.1.107
301:British Medical Journal
270:10.1136/pgmj.29.336.482
726:Cite journal requires
416:10.1136/bmj.4.5786.511
313:10.1136/bmj.2.5047.732
213:
193:
177:inflammatory arthritis
168:
898:British immunologists
696:funeral-notices.co.uk
502:10.1136/adc.56.11.864
246:Selected publications
126:, graduating in 1942
90:first description of
802:"Eric John Holborow"
652:10.1136/ard.50.4.231
609:10.1136/ard.47.4.280
114:After education at
128:MB BChir (Cantab.)
100:Eric John Holborow
25:Eric John Holborow
840:(12): 1622–1623.
410:(5786): 511–513.
377:(7729): 850–852.
307:(5047): 732–734.
237:Bradshaw Lecturer
136:John Vivian Dacie
97:
96:
920:
852:
851:
849:
825:
810:
809:
798:
777:
776:
766:
751:Clin Exp Immunol
742:
736:
735:
729:
724:
722:
714:
713:(7418): 818–819.
706:
700:
699:
688:
673:
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630:
620:
587:
577:
562:Clin Exp Immunol
552:
523:
513:
480:
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427:
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355:
344:Clin Exp Immunol
334:
324:
291:
281:
264:(336): 482–486.
106:
59:
40:
38:
21:
928:
927:
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918:
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858:
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856:
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827:
826:
813:
800:
799:
780:
745:Toh BH (1979).
744:
743:
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715:
708:
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690:
689:
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633:
590:
555:
526:
496:(11): 864–868.
483:
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173:rheumatic fever
102:
66:
61:
57:
56:3 February 2009
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757:(3): 621–628.
737:
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682:
681:
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676:
675:
674:
646:(4): 231–236.
631:
603:(4): 280–285.
588:
568:(2): 371–376.
553:
535:(2): 231–242.
524:
490:Arch Dis Child
481:
438:
395:
366:
335:
292:
258:Postgrad Med J
247:
244:
189:Barbara Ansell
95:
94:
88:
87:Known for
84:
83:
80:
76:
75:
72:
68:
67:
62:
60:(aged 90)
54:
50:
49:
43:
32:
28:
27:
24:
15:
13:
10:
9:
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4:
3:
2:
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657:
653:
649:
645:
641:
640:Ann Rheum Dis
637:
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597:Ann Rheum Dis
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206:
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192:
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186:
185:Eric Bywaters
182:
179:and systemic
178:
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167:
162:
160:
156:
152:
147:
145:
141:
137:
133:
129:
125:
121:
117:
116:Epsom College
112:
110:
105:
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93:
89:
85:
81:
79:Occupation(s)
77:
73:
69:
65:
64:Ashford, Kent
55:
51:
46:
41:20 March 1918
33:
29:
22:
19:
837:
834:Rheumatology
833:
805:
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719:cite journal
710:
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450:
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261:
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241:
232:
228:
215:In 1976 the
214:
208:
204:
202:
194:
170:
164:
148:
113:
109:autoimmunity
99:
98:
58:(2009-02-03)
18:
873:2009 deaths
868:1918 births
453:: 107–111.
225:Whitechapel
71:Nationality
47:, Wiltshire
862:Categories
678:References
371:The Lancet
223:(LHMC) in
37:1918-03-20
404:Br Med J
331:13460368
288:13100127
45:Amesbury
764:1537904
670:2029205
661:1004392
627:2835019
618:1003507
584:6329564
575:1536217
549:6819318
520:7030226
511:1627382
468:1521600
434:4942740
425:1799774
391:4106875
362:5590109
353:1579518
322:1962253
279:2500480
74:British
771:
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159:Taplow
773:93995
477:93113
769:PMID
732:help
666:PMID
623:PMID
580:PMID
545:PMID
516:PMID
473:PMID
430:PMID
387:PMID
358:PMID
327:PMID
284:PMID
187:and
181:CTDs
132:RAMC
122:and
104:FRCP
53:Died
31:Born
842:doi
759:PMC
711:286
656:PMC
648:doi
613:PMC
605:doi
570:PMC
537:doi
506:PMC
498:doi
463:PMC
455:doi
420:PMC
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266:doi
157:in
151:MRC
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