395:
383:
31:
311:
265:
288:
163:
101:
before the cell is released into the bloodstream. The presence of circulating NRBCs in adults occurs in situations of hematopoietic stress such as severe infection, massive hemorrhage, marrow infiltration, or extramedullary hematopoiesis. That is, if NRBCs are identified on an adult's
577:
611:
594:
660:
1294:
705:
666:
490:
Greer, JP; Arber, DA; Glader, BE; List, AF; Means, RM; Rodgers, GM (19 November 2018). "Chapter 1: Examination of the Blood and Bone Marrow, sec. "Nucleated Red Blood Cell Counts"".
654:
648:
214:, there are two types of erythroblasts: normoblasts as cells that develop as expected, and megaloblasts as unusually large erythroblasts that are associated with illness.
1287:
698:
678:
1801:
1414:
1212:
825:
97:. After infancy, RBCs normally contain a nucleus only during the very early stages of the cell's life, and the nucleus is ejected as a normal part of
675: – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
545:
1280:
691:
297:
274:
255:
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501:
616:
599:
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241:
371:
elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.
190:
always refers to normal, healthy cells that are the immediate precursors of normal, healthy, mature (anucleate) RBCs. The name
546:"Clinical significance of nucleated red blood cell count in pediatric patients with transfusion-dependent beta thalassemia"
394:
1684:
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131:
103:
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1042:
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1777:
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351:). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called
336:
74:, all of these red blood cells are nucleated. In mammals, NRBCs occur in normal development as
1641:
1052:
524:
497:
491:
465:
332:
296:
461:
1718:
1621:
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837:
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416:
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79:
55:
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1813:
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1368:
1224:
1134:
779:
360:
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123:
1838:
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1358:
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1304:
1249:
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1152:
1012:
877:
769:
732:
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59:
30:
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518:
114:
to produce RBCs, and immature RBCs are being released into circulation. Possible
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325:
127:
111:
86:
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1007:
999:
961:
944:
934:
872:
764:
240:
211:
183:
67:
63:
324:
A megaloblast is an unusually large erythroblast that can be associated with
17:
1833:
1679:
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1244:
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151:
115:
469:
310:
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1806:
1700:
1579:
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1119:
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1336:
1207:
1083:
747:
344:
119:
94:
71:
1751:
1162:
222:
There are four stages in the normal development of a normoblast.:
161:
90:
29:
194:
always refers to abnormally developed precursors. Often the name
1276:
687:
443:"Blood cells and blood cell development in the animal kingdom"
364:
70:-containing cells in their blood, and with the exception of
355:. The cause of this cellular gigantism is an impairment in
82:, the process by which the body produces red blood cells.
110:, it suggests that there is a very high demand for the
38:; NRBCs are visible as larger cells with dark centers.
1826:
1786:
1760:
1732:
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1652:
1587:
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8:
517:Kottke-Marchant, K; Davis, B (6 June 2012).
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1332:
1317:
1295:
1281:
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995:
922:
830:
752:
743:
728:
706:
692:
684:
170:Several names are used for nucleated RBCs—
89:of humans of all ages and in the blood of
631:at the U.S. National Library of Medicine
496:(14th ed.). Wolters Kluwer Health.
462:10.1146/annurev.cellbio.22.010605.093317
224:
206:, but at other times it is considered a
1802:Megakaryocyte–erythroid progenitor cell
1213:Megakaryocyte–erythroid progenitor cell
669:Presented by the University of Virginia
663:Presented by the University of Virginia
657:Presented by the University of Virginia
651:Presented by the University of Virginia
433:
378:
523:. John Wiley & Sons. p. 294.
7:
359:that delays nuclear maturation and
567:Blood Smear: Details on RBCs, WBCs
544:Shehata, Amira M.F. (2020-09-30).
27:Red blood cell with a cell nucleus
25:
51:
393:
381:
309:
302:Orthochromatic normoblast (also
295:
286:
272:
263:
253:
239:
85:NRBCs are normally found in the
279:Polychromatic normoblast (also
661:Polychromatophilic Normoblasts
520:Laboratory Hematology Practice
493:Wintrobe's Clinical Hematology
1:
182:—with one minor variation in
78:to mature red blood cells in
1493:Extramedullary hematopoiesis
904:Extramedullary hematopoiesis
617:Dorland's Medical Dictionary
600:Dorland's Medical Dictionary
583:Dorland's Medical Dictionary
1893:
667:Orthochromatic Normoblasts
1659:Antigen-presenting cells
1447:
1422:
1384:
1344:
1070:Antigen-presenting cells
858:
833:
795:
755:
673:Histology image: 01804loa
1747:Nucleated red blood cell
1303:Myeloid blood cells and
1158:Nucleated red blood cell
714:Myeloid blood cells and
633:Medical Subject Headings
550:Menoufia Medical Journal
347:are collectively called
99:cellular differentiation
44:nucleated red blood cell
1849:Hematopoietic stem cell
1768:Leukocyte extravasation
1637:Foreign-body giant cell
1260:Hematopoietic stem cell
1179:Leukocyte extravasation
1048:Foreign-body giant cell
441:Hartenstein, V (2006).
422:Hematopoietic stem cell
166:Normocyte, Giemsa stain
138:involving bone marrow (
679:Histology at uiowa.edu
655:Basophilic Normoblasts
450:Annu Rev Cell Dev Biol
331:deficiency (caused by
167:
108:peripheral blood smear
39:
36:peripheral blood smear
349:megaloblastic anemias
341:folic acid deficiency
337:dietary insufficiency
260:Basophilic normoblast
165:
33:
1844:Hematopoietic system
1632:Langhans giant cells
1255:Hematopoietic system
1043:Langhans giant cells
132:miliary tuberculosis
104:complete blood count
1607:Alveolar macrophage
1018:Alveolar macrophage
304:orthochromatophilic
218:Healthy development
52:several other names
1778:Intrinsic immunity
1642:Touton giant cells
1189:Intrinsic immunity
1053:Touton giant cells
388:Blood cell lineage
281:polychromatophilic
168:
150:), and in chronic
40:
1859:
1858:
1822:
1821:
1695:
1694:
1622:Epithelioid cells
1501:
1500:
1481:
1480:
1477:
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1409:
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1033:Epithelioid cells
912:
911:
892:
891:
888:
887:
820:
819:
530:978-1-4443-9857-1
503:978-1-4963-6713-6
375:Additional images
333:pernicious anemia
317:
316:
50:), also known by
16:(Redirected from
1884:
1793:Precursor cells
1719:Promegakaryocyte
1585:
1512:
1437:Promegakaryocyte
1420:
1342:
1333:
1318:
1297:
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1204:Precursor cells
1130:Promegakaryocyte
996:
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848:Promegakaryocyte
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343:, or both (such
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210:. In the latter
58:that contains a
21:
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1861:
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1761:Immune response
1756:
1734:Red blood cells
1728:
1691:
1668:Langerhans cell
1663:Dendritic cells
1648:
1574:
1497:
1473:
1457:Proerythroblast
1443:
1405:
1389:Monocytopoiesis
1380:
1324:
1307:
1301:
1271:
1266:
1229:
1193:
1172:Immune response
1167:
1145:Red blood cells
1139:
1102:
1079:Langerhans cell
1074:Dendritic cells
1059:
985:
908:
884:
868:Proerythroblast
854:
816:
800:Monocytopoiesis
791:
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718:
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435:
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408:
401:
398:
389:
386:
377:
357:DNA replication
329:
322:
220:
160:
118:causes include
95:newborn infants
66:organisms have
28:
23:
22:
15:
12:
11:
5:
1890:
1888:
1880:
1879:
1874:
1864:
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1764:
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1754:
1749:
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1738:
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1721:
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1714:Megakaryoblast
1711:
1705:
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1697:
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1634:
1624:
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1614:
1609:
1604:
1599:
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1591:
1582:
1576:
1575:
1573:
1572:
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1570:
1560:
1559:
1558:
1548:
1547:
1546:
1536:
1531:
1526:
1520:
1518:
1509:
1507:Myeloid tissue
1503:
1502:
1499:
1498:
1496:
1495:
1489:
1487:
1483:
1482:
1479:
1478:
1475:
1474:
1472:
1471:
1470:
1469:
1464:
1459:
1452:Erythropoiesis
1448:
1445:
1444:
1442:
1441:
1440:
1439:
1434:
1432:Megakaryoblast
1427:Thrombopoiesis
1423:
1417:
1411:
1410:
1407:
1406:
1404:
1403:
1402:
1401:
1396:
1385:
1382:
1381:
1379:
1378:
1377:
1376:
1371:
1366:
1361:
1356:
1349:Granulopoiesis
1345:
1339:
1330:
1315:
1309:
1308:
1302:
1300:
1299:
1292:
1285:
1277:
1268:
1267:
1265:
1264:
1263:
1262:
1252:
1247:
1241:
1239:
1235:
1234:
1231:
1230:
1228:
1227:
1222:
1221:
1220:
1215:
1210:
1201:
1199:
1195:
1194:
1192:
1191:
1186:
1181:
1175:
1173:
1169:
1168:
1166:
1165:
1160:
1155:
1149:
1147:
1141:
1140:
1138:
1137:
1132:
1127:
1125:Megakaryoblast
1122:
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1114:
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1107:
1104:
1103:
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1100:
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1098:
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1086:
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1076:
1067:
1065:
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1057:
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1055:
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1045:
1035:
1030:
1025:
1020:
1015:
1010:
1004:
1002:
993:
987:
986:
984:
983:
982:
981:
971:
970:
969:
959:
958:
957:
947:
942:
937:
931:
929:
920:
918:Myeloid tissue
914:
913:
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909:
907:
906:
900:
898:
894:
893:
890:
889:
886:
885:
883:
882:
881:
880:
875:
870:
863:Erythropoiesis
859:
856:
855:
853:
852:
851:
850:
845:
843:Megakaryoblast
838:Thrombopoiesis
834:
828:
822:
821:
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815:
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813:
812:
807:
796:
793:
792:
790:
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788:
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782:
777:
772:
767:
760:Granulopoiesis
756:
750:
741:
726:
720:
719:
713:
711:
710:
703:
696:
688:
682:
681:
676:
670:
664:
658:
652:
649:Pronormoblasts
644:
643:External links
641:
638:
637:
621:
604:
587:
578:"Erythroblast"
570:
559:
536:
529:
509:
502:
482:
432:
431:
429:
426:
425:
424:
419:
417:Haematopoiesis
414:
412:Erythropoiesis
407:
404:
403:
402:
399:
392:
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387:
380:
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373:
327:
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318:
315:
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307:
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277:
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261:
258:
250:
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236:
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229:
219:
216:
159:
156:
80:erythropoiesis
56:red blood cell
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1889:
1878:
1875:
1873:
1870:
1869:
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1850:
1847:
1846:
1845:
1842:
1840:
1837:
1835:
1832:
1831:
1829:
1825:
1815:
1814:Myelomonocyte
1812:
1808:
1805:
1803:
1800:
1798:
1795:
1794:
1792:
1791:
1789:
1785:
1779:
1776:
1774:
1771:
1769:
1766:
1765:
1763:
1759:
1753:
1750:
1748:
1745:
1743:
1740:
1739:
1737:
1735:
1731:
1725:
1724:Megakaryocyte
1722:
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1715:
1712:
1710:
1707:
1706:
1704:
1702:
1698:
1686:
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1678:
1674:
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1666:
1664:
1661:
1660:
1658:
1657:
1655:
1651:
1643:
1640:
1638:
1635:
1633:
1630:
1629:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1602:Kupffer cells
1600:
1598:
1595:
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1592:
1590:
1586:
1583:
1581:
1577:
1569:
1566:
1565:
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1561:
1557:
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1540:
1537:
1535:
1532:
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1522:
1521:
1519:
1517:
1513:
1510:
1508:
1504:
1494:
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1490:
1488:
1484:
1468:
1465:
1463:
1460:
1458:
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1454:
1453:
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1449:
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1438:
1435:
1433:
1430:
1429:
1428:
1425:
1424:
1421:
1418:
1416:
1412:
1400:
1397:
1395:
1392:
1391:
1390:
1387:
1386:
1383:
1375:
1372:
1370:
1369:Metamyelocyte
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1351:
1350:
1347:
1346:
1343:
1340:
1338:
1334:
1331:
1328:
1323:
1319:
1316:
1314:
1313:Hematopoiesis
1310:
1306:
1298:
1293:
1291:
1286:
1284:
1279:
1278:
1275:
1261:
1258:
1257:
1256:
1253:
1251:
1248:
1246:
1243:
1242:
1240:
1236:
1226:
1225:Myelomonocyte
1223:
1219:
1216:
1214:
1211:
1209:
1206:
1205:
1203:
1202:
1200:
1196:
1190:
1187:
1185:
1182:
1180:
1177:
1176:
1174:
1170:
1164:
1161:
1159:
1156:
1154:
1151:
1150:
1148:
1146:
1142:
1136:
1135:Megakaryocyte
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1117:
1115:
1113:
1109:
1097:
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1092:
1089:
1085:
1082:
1080:
1077:
1075:
1072:
1071:
1069:
1068:
1066:
1062:
1054:
1051:
1049:
1046:
1044:
1041:
1040:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1013:Kupffer cells
1011:
1009:
1006:
1005:
1003:
1001:
997:
994:
992:
988:
980:
977:
976:
975:
972:
968:
965:
964:
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960:
956:
953:
952:
951:
948:
946:
943:
941:
938:
936:
933:
932:
930:
928:
924:
921:
919:
915:
905:
902:
901:
899:
895:
879:
876:
874:
871:
869:
866:
865:
864:
861:
860:
857:
849:
846:
844:
841:
840:
839:
836:
835:
832:
829:
827:
823:
811:
808:
806:
803:
802:
801:
798:
797:
794:
786:
783:
781:
780:Metamyelocyte
778:
776:
773:
771:
768:
766:
763:
762:
761:
758:
757:
754:
751:
749:
745:
742:
739:
734:
730:
727:
725:
724:Hematopoiesis
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709:
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702:
697:
695:
690:
689:
686:
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668:
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634:
630:
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622:
619:
618:
613:
612:"Megaloblast"
608:
605:
602:
601:
596:
591:
588:
585:
584:
579:
574:
571:
568:
563:
560:
556:(3): 949–955.
555:
551:
547:
540:
537:
532:
526:
522:
521:
513:
510:
505:
499:
495:
494:
486:
483:
471:
467:
463:
459:
455:
451:
444:
437:
434:
427:
423:
420:
418:
415:
413:
410:
409:
405:
400:Hematopoiesis
396:
391:
384:
379:
374:
372:
370:
366:
362:
361:cell division
358:
354:
350:
346:
342:
338:
334:
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319:
312:
308:
305:
301:
298:
294:
293:
289:
285:
282:
278:
275:
271:
270:
266:
262:
259:
256:
252:
251:
248:
247:Pronormoblast
245:
242:
238:
237:
233:
230:
227:
226:
223:
217:
215:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
164:
157:
155:
153:
149:
145:
141:
137:
133:
129:
125:
124:myelofibrosis
121:
117:
113:
109:
105:
100:
96:
92:
88:
83:
81:
77:
73:
69:
65:
62:. Almost all
61:
57:
53:
49:
45:
37:
32:
19:
18:Erythroblasts
1773:Phagocytosis
1746:
1742:Reticulocyte
1516:Granulocytes
1467:Reticulocyte
1359:Promyelocyte
1322:Myelopoiesis
1184:Phagocytosis
1157:
1153:Reticulocyte
927:Granulocytes
878:Reticulocyte
770:Promyelocyte
733:Myelopoiesis
624:
615:
607:
598:
595:"Normoblast"
590:
581:
573:
562:
553:
549:
539:
519:
512:
492:
485:
473:. Retrieved
453:
449:
436:
353:macrocytosis
323:
320:Pathogenesis
303:
280:
228:Illustration
221:
203:
200:synonymously
196:erythroblast
195:
191:
187:
186:. The name
179:
175:
172:erythroblast
171:
169:
158:Nomenclature
84:
60:cell nucleus
47:
43:
41:
1877:Blood cells
1872:Human cells
1627:giant cells
1617:Osteoclasts
1597:Histiocytes
1589:Macrophages
1399:Promonocyte
1038:giant cells
1028:Osteoclasts
1008:Histiocytes
1000:Macrophages
810:Promonocyte
629:Normoblasts
475:October 28,
456:: 677–712.
369:cytoplasmic
231:Description
192:megaloblast
180:megaloblast
128:thalassemia
112:bone marrow
87:bone marrow
1866:Categories
1551:Eosinophil
1534:Neutrophil
1524:Myeloblast
1462:Normoblast
1354:Myeloblast
962:Eosinophil
945:Neutrophil
935:Myeloblast
873:Normoblast
765:Myeloblast
428:References
363:. Because
204:normoblast
188:normoblast
184:word sense
176:normoblast
116:pathologic
76:precursors
68:hemoglobin
64:vertebrate
1834:Phagocyte
1701:Platelets
1680:Monoblast
1612:Microglia
1580:Monocytes
1563:Mast cell
1529:Band cell
1394:Monoblast
1374:Band cell
1364:Myelocyte
1245:Phagocyte
1112:Platelets
1091:Monoblast
1023:Microglia
991:Monocytes
974:Mast cell
940:Band cell
805:Monoblast
785:Band cell
775:Myelocyte
326:vitamin B
152:hypoxemia
148:lymphomas
144:leukemias
1807:CFU-GEMM
1568:CFU-Mast
1544:CFU-Baso
1539:Basophil
1327:CFU-GEMM
1218:CFU-GEMM
979:CFU-Mast
955:CFU-Baso
950:Basophil
738:CFU-GEMM
470:16824014
406:See also
208:hypernym
198:is used
140:myelomas
34:A human
1709:CFU-Meg
1556:CFU-Eos
1486:General
1120:CFU-Meg
967:CFU-Eos
897:General
345:anemias
136:cancers
91:fetuses
72:mammals
54:, is a
1839:Plasma
1797:CFU-GM
1673:CFU-DL
1337:CFU-GM
1305:plasma
1250:Plasma
1208:CFU-GM
1084:CFU-DL
748:CFU-GM
716:plasma
635:(MeSH)
527:
500:
468:
234:Image
178:, and
120:anemia
1827:Other
1787:Other
1752:CFU-E
1653:Other
1238:Other
1198:Other
1163:CFU-E
1064:Other
446:(PDF)
212:sense
202:with
525:ISBN
498:ISBN
477:2016
466:PMID
367:and
93:and
48:NRBC
1685:MPS
1415:MEP
1096:MPS
826:MEP
614:at
597:at
580:at
458:doi
365:RNA
339:),
335:or
106:or
1868::
554:33
552:.
548:.
464:.
454:22
452:.
448:.
328:12
174:,
154:.
146:,
142:,
134:,
130:,
126:,
122:,
42:A
1329:)
1325:(
1296:e
1289:t
1282:v
740:)
736:(
707:e
700:t
693:v
533:.
506:.
479:.
460::
306:)
283:)
46:(
20:)
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