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InChI=1S/C86H134N2O23/c1-47-33-49(3)37-71(104-13)79-73(106-15)41-53(7)78(108-79)75(95)82(97)87-31-21-19-25-61(87)84(99)109-76(51(5)39-57-27-29-63(89)69(43-57)102-11)55(9)65(91)45-67(93)59(35-47)23-17-18-24-60-36-48(2)34-50(4)38-72(105-14)80-74(107-16)42-54(8)86(101,111-80)81(96)83(98)88-32-22-20-26-62(88)85(100)110-77(56(10)66(92)46-68(60)94)52(6)40-58-28-30-64(90)70(44-58)103-12/h17-18,35-36,39-40,49-50,53-66,69-74,76-80,89-92,101H,19-34,37-38,41-46H2,1-16H3/b18-17+,47-35+,48-36+,51-39+,52-40+/t49-,50-,53+,54+,55+,56+,57-,58-,59+,60?,61?,62?,63+,64+,65-,66-,69+,70+,71-,72-,73+,74+,76+,77+,78?,79+,80+,86+/m0/s1
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344:(FKBPs) do not normally form dimers but can be caused to dimerize in the presence of FK1012. Genetically engineered proteins based on FKBPs can be used to manipulate protein localization, signaling pathways and protein activation.
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Keenan, Terence; Yaeger, David R.; Courage, Nancy L.; Rollins, Carl T.; Pavone, Mary Ellen; Rivera, Victor M.; Yang, Wu; Guo, Tao; Amara, Jane F.; Clackson, Tim; Gilman, Michael; Holt, Dennis A. (1998-08-01).
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C1C(2(C(C(O2)C(=O)C(=O)N3CCCCC3C(=O)O(((CC(=O)(/C=C(/C1)\C)C/C=C/CC4/C=C(/C(C(5(C((O5)(C(=O)C(=O)N6CCCCC6C(=O)O(((CC4=O)O)C)/C(=C/7CC((C7)OC)O)/C)O)C)OC)OC)C)\C)O)C)/C(=C/8CC((C8)OC)O)/C)C)OC)OC
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Steven T. Diver; Stuart L. Schreiber (1997). "Single-step syntheses of cell permeable protein dimerizers that activate signal transduction and gene expression".
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87:)-4--1-propen-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclooctacos-18-en-17-yl]-2-buten-1-yl}-12-{(1
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Fegan, A; White, B; Carlson, JC; Wagner, CR (Jun 9, 2010). "Chemically controlled protein assembly: techniques and applications".
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containing one or more FKBP12 domains. It is used in pharmacology to act as a mediator in the formation of FK506 dimer.
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91:)-1--1-propen-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclooctacos-18-ene-2,3,10,16-tetrone
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Blau, C. Anthony; Peterson, Kenneth R.; Drachman, Jonathan G.; Spencer, David M. (1997).
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Proceedings of the
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Except where otherwise noted, data are given for materials in their
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552:"Cell proliferation through forced engagement of c-Kit and Flt-3"
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Otto, K. G.; Jin, L; Spencer, D. M.; Blau, C. A. (2001).
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438:"A Proliferation Switch for Genetically Modified Cells"
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206:Key: IOISFHIZCFPBTB-HSZXOJBTSA-N
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608:. You can help Knowledge (XXG) by
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334:chemical inducer of dimerization
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330:chemically induced dimerization
320:consisting of two molecules of
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277:Molar mass
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103:3D model (
40:IUPAC name
472:0027-8424
415:0968-0896
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450:Bibcode
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168:PubChem
20:FK1012
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489:20324
480:41778
476:JSTOR
326:vinyl
318:dimer
316:is a
195:InChI
105:JSmol
606:stub
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468:ISSN
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