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Fertility medication

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Folate in combination with zinc supplementation was shown to have a statistically significant effect on sperm concentration and morphology when compared to placebo. There is evidence suggesting a significant association between vitamin D serum concentrations and the quality of sperm in men, characterized by the sperm's motility and progress motility. Because the quality of men's sperm is influenced by genetics, results should be interpreted cautiously. There is little evidence that supplementation with antioxidants, such as
560:, fertility drugs have been used to combat this but the cancer risks are still not completely known. As of 2019, there have been studies that have shown the risk of developing ovarian cancer is higher when taking fertility medications. However, due to the low number of studies, lack of follow-up time and other contribution factors, the risk is unclear. Most studies conducted have shown that fertility drugs do not increase the risk of other gynecologic cancers ( 677:(VEGF). OHSS is characterized as cystic enlargement of the ovaries. Multiple birth is especially deleterious due to compounding risks including premature delivery and low birthweight, pre-eclampisa, and increased risk of neonatal mortality. While triplet births have been declining in ART, multiple births remain over 50% of births from IVF. However, there are limitations to measure, as 4% to 8% IVF clinics to do not report their data to the CDC. 3033: 3054: 605: 295: 36: 128: 530:
Combinations of vitamins and minerals, including selenium, co-enzyme Q10, L-carnitine, folic acid, zinc, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have been shown to improve male infertility, but due to the low amounts of studies and participants, more clinical studies are needed.
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in 2017. Its use to treat anovulatory infertility was based on an association of insulin resistance in non-obese women with PCOS. While metformin may increase ovulation in women with PCOS, there is no evidence of increased pregnancy rates or live-birth rates, and the combination therapy of metformin
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therapies have been associated with relatively low risk, time, and cost. There is evidence that chemotherapy cotreatment with gonadotropin-releasing hormone (GnRH) can increase the probability of spontaneous menses and ovulation resumption. However, this cotreatment has not shown an improvement in
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Human chorionic gonadotropin (hCG), also known as the “hormone of pregnancy” is a hormone that is normally produced during pregnancy and plays an integral role throughout reproduction. It is crucial in maintaining pregnancy, from the stages of placentation to early embryo development. It is also
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by inhibiting the negative feedback of estrogen at the hypothalamus. As the negative feedback of estrogen is inhibited, the hypothalamus secretes GnRh which in turn stimulates the anterior pituitary to secrete LH and FSH which help in ovulation. Between 60 and 85% of women, mostly with
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therapy for infertility has been studied in animals, but has not entered clinical trials. Stem cells collected from bone marrow and umbilical cord have shown the most ability to rehabilitate fertility in animals, but more studies are needed to determine efficacy.
425:. There has been some controversy over the efficacy between extracted and recombinant FSH for ovulation induction; however, a meta-analysis of 14 trials among 1726 women found that there were no differences in clinical pregnancy or live birth outcomes. 1585:
Irani M, Amirian M, Sadeghi R, Lez JL, Latifnejad Roudsari R (August 2017). "The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis".
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and clomiphene citrate did not provide a significant benefit compared to clomiphene citrate alone. First-line therapy for ovulation induction in women with PCOS remains the anti-estrogen clomiphene citrate or the aromatase inhibitor letrozole.
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stimulates the release of gonadotropins (LH and FSH) from the anterior pituitary in the body. This set of therapy is reserved for a subset of women with infertility and have produced ovulation rates of 90% and pregnancy rates of 80% or higher.
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Rudant J, Amigou A, Orsi L, Althaus T, Leverger G, Baruchel A, et al. (February 2013). "Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia: the ESCALE study (SFCE)".
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Main reasons for discontinuation across all types of fertility treatment and treatment stage, are "postponement of treatment, physical and psychological burden and relational and personal problems".
448:. First-line options for fertility preservation include embryo and oocyte preservation before starting chemotherapy, though these methods do not contribute to the preservation of gonadal function. 2985: 2065: 46: 1231:"Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists" 591:
Children born to mothers who use fertility medication to induce ovulation are more than twice as likely to develop leukemia during their childhoods than other children.
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Chemotherapy treatment in premenopausal women can compromise ovarian reserve and function, with gonadotoxic effects ranging from temporary to permanent infertility and
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Treatment decision-making involves four major factors: efficacy, burden of treatment (such as frequency of injections and office visits), safety, and financial costs.
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for women with PCOS treated with clomiphene compared to letrozole found that letrozole resulted in higher live birth rates. However, ovulation induction remains an
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in male infertility, it has been prescribed since the 1960s. As of 2013, there is not substantial evidence to suggest that clomiphene can treat male infertility.
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Fazeli Z, Abedindo A, Omrani MD, Ghaderian SM (February 2018). "Mesenchymal Stem Cells (MSCs) Therapy for Recovery of Fertility: a Systematic Review".
218:, and the aim is generally to develop multiple follicles (optimally between 11 and 14 antral follicles measuring 2–8 mm in diameter), followed by 2033: 449: 252: 3819: 3749: 2409: 744: 626: 322: 284: 294: 3324: 2696: 2689: 2796: 1991:"Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment" 3923: 3091: 418: 211: 2439: 3789: 2302: 674: 3824: 3689: 670: 652: 489: 107: 1459:"Aromatase inhibitors in the treatment of oligozoospermic or azoospermic men: a systematic review of randomized controlled trials" 3928: 3628: 3153: 1131:"The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis" 694: 513: 79: 3980: 3694: 2592: 2048: 3744: 630: 264: 248: 242: 160: 86: 3769: 3676: 3178: 333:, although both are not as effective as clomiphene and are thus less widely used for fertility purposes. They are used in 219: 2291: 3774: 3734: 3233: 2073: 462: 1033:"A decade's experience with an individualized clomiphene treatment regimen including its effect on the postcoital test" 54: 4036: 3603: 3414: 2902: 93: 3387: 615: 1375:"Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline" 3809: 3646: 3404: 3329: 3299: 2552: 2041: 469: 229: 1546:"Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review" 634: 619: 65: 50: 3859: 3471: 3211: 3135: 429: 393: 339: 75: 3221: 665:
Estrogen antagonists and gonadotropins may stimulate multiple follicles and other ovarian hormones leading to
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is centered around underlying causes, such as endocrine and systematic disorders that can cause hypogonadism.
1615:"The association between serum vitamin D, fertility and semen quality: A systematic review and meta-analysis" 3794: 3659: 3397: 3158: 3125: 3084: 2607: 2285: 2136: 1074:"Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome" 410: 357: 206: 767:
Dancet EA, Fleur Dancet EA, D'Hooghe TM, d'Hooghe TM, van der Veen F, Bossuyt P, et al. (April 2014).
584:). The validity of these data may be affected by patient-reported biases, small subject numbers, and other 3913: 3729: 3294: 3173: 2644: 2399: 215: 516:
are used. Although there is no FDA indication for use of aromatase inhibitors improving spermatogenesis,
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Gorlitsky GA, Kase NG, Speroff L (March 1978). "Ovulation and pregnancy rates with clomiphene citrate".
539: 1326:"Gonadotropin therapy in assisted reproduction: an evolutionary perspective from biologics to biotech" 417:
and Gonal F, while Luveris is a recombinant LH. FSH and recombinant FSH analogues are mainly used for
342:(PCOS), ovulate successfully in response to clomiphene with a cumulative pregnancy rate of 30 to 40%. 4015: 3954: 3814: 3671: 3595: 3503: 3493: 3289: 3190: 2384: 2253: 3918: 3829: 3784: 3684: 3543: 3461: 3444: 3409: 3264: 3185: 3145: 3013: 2749: 2535: 2314: 2141: 422: 369: 361: 351: 334: 288: 260: 198: 194: 167: 3053: 1373:
Penzias A, Bendikson K, Butts S, Coutifaris C, Falcone T, Fossum G, et al. (September 2017).
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Conforti A, Esteves SC, Di Rella F, Strina I, De Rosa P, Fiorenza A, et al. (February 2019).
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Franik, Sebastian; Le, Quang-Khoi; Kremer, Jan Am; Kiesel, Ludwig; Farquhar, Cindy (2022-09-27).
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Fauser BC (December 2014). "Reproductive endocrinology: revisiting ovulation induction in PCOS".
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Willets AE, Corbo JM, Brown JN (July 2013). "Clomiphene for the treatment of male infertility".
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Bedaiwy MA, Abou-Setta AM, Desai N, Hurd W, Starks D, El-Nashar SA, et al. (March 2011).
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Ribeiro MA, Gameiro LF, Scarano WR, Briton-Jones C, Kapoor A, Rosa MB, El Dib R (May 2016).
1423: 1386: 1345: 1337: 1291: 1250: 1242: 1201: 1193: 1152: 1142: 1101: 1085: 1044: 1005: 968: 927: 880: 845: 831:"Selective estrogen receptor modulators (SERM)/Selektive Ostrogenrezeptormodulatoren (SERM)" 780: 149: 325:(SERM). It is the most widely used fertility drug. Other medications in this class include 3903: 3618: 3513: 3382: 3274: 3163: 3112: 3058: 3003: 2872: 2867: 2706: 2639: 2634: 2520: 2466: 2307: 2198: 2151: 813: 718:
Crowley F, Martin KA (2020). "Patient Education: Infertility in Women". In Post TW (ed.).
561: 377: 306: 223: 1795:"Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility" 492:
in women with PCOS, metformin is no longer recommended as infertility treatment per the
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Weiss NS, Kostova E, Nahuis M, Mol BW, van der Veen F, van Wely M (January 2019).
1862: 734: 3985: 3580: 3538: 3456: 2811: 2721: 2461: 2414: 2359: 2242: 2208: 1182:"Gonadotrophins for ovulation induction in women with polycystic ovary syndrome" 604: 585: 17: 1631: 1614: 1562: 1545: 1475: 1458: 818:. U.K. National Institute for Health and Care Excellence (NICE). February 2013. 3990: 3508: 3430: 3309: 3104: 2989: 2960: 2918: 2887: 2882: 2821: 2816: 2806: 2744: 2730: 2670: 2625: 2573: 2493: 2489: 2430: 2390: 2345: 2341: 2231: 2167: 2117: 2082: 2078: 1760: 1246: 1147: 849: 524: 330: 318: 1956: 1514: 1097: 973: 956: 932: 915: 3100: 2897: 2877: 2851: 2826: 2761: 2739: 2567: 2480: 2354: 2006: 1664:"Antioxidants in fertility: impact on male and female reproductive outcomes" 884: 481: 468:
used in assisted reproductive techniques as it can be used to replace LH in
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Smits RM, Mackenzie-Proctor R, Fleischer K, Showell MG (September 2018).
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if you can. Unsourced or poorly sourced material may be challenged and
1908: 432:. Proposed mechanisms for chemotherapy-induced ovarian damage include 3898: 3360: 3355: 2656: 2319: 1229:
Hickman LC, Llarena NC, Valentine LN, Liu X, Falcone T (April 2018).
916:"A pharmacological review of selective oestrogen receptor modulators" 402: 256: 156:. There are very few fertility medication options available for men. 1613:
Arab A, Hadi A, Moosavian SP, Askari G, Nasirian M (November 2019).
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The main techniques involving fertility medication in females are:
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Buhling K, Schumacher A, Eulenburg CZ, Laakmann E (August 2019).
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Agents that enhance ovarian activity can be classified as either
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of follicles, also triggering a predictable time of ovulation.
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Gameiro S, Boivin J, Peronace L, Verhaak CM (August 2012).
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Gysler M, March CM, Mishell DR, Bailey EJ (February 1982).
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Goldstein SR, Siddhanti S, Ciaccia AV, Plouffe L (2000).
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has been shown to be effective when compared to placebo.
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Anatomical Therapeutic Chemical Classification System
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Human chorionic gonadotropin § Use as medication
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"Male infertility". 1845:Kroener L, Dumesic D, Al-Safi Z (August 2017). 1319: 1317: 1315: 1851:Current Opinion in Obstetrics & Gynecology 1703:Chehab M, Madala A, Trussell JC (March 2015). 1496: 1494: 809:"Fertility problems: assessment and treatment" 60:Please review the contents of the article and 3085: 2049: 1793:Rizzuto I, Behrens RF, Smith LA (June 2019). 1742: 1740: 1235:Journal of Assisted Reproduction and Genetics 144:, are medications which enhance reproductive 8: 2064:Major chemical drug groups – based upon the 1799:The Cochrane Database of Systematic Reviews 1186:The Cochrane Database of Systematic Reviews 1078:The Cochrane Database of Systematic Reviews 633:. Unsourced material may be challenged and 3888: 3560: 3314: 3092: 3078: 3070: 2056: 2042: 2034: 301:in females, with estrogen exerting mainly 2014: 1965: 1955: 1870: 1818: 1720: 1679: 1630: 1561: 1474: 1390: 1349: 1295: 1254: 1205: 1156: 1146: 1105: 1048: 972: 931: 784: 739:. Cham, Switzerland: Palgrave Macmillan. 653:Learn how and when to remove this message 736:Impacts of Medications on Male Fertility 556:Since infertility increases the risk of 490:ovarian hyperstimulation syndrome (OHSS) 401:are protein hormones that stimulate the 293: 710: 3043:Pharmacological classification systems 2410:Selective estrogen receptor modulators 1135:Reproductive Biology and Endocrinology 314:Selective estrogen receptor modulators 253:gonadotropin-releasing hormone agonist 226:of a maximum of two embryos at a time. 2690:Non-steroidal anti-inflammatory drugs 1840: 1838: 1788: 1786: 323:selective estrogen receptor modulator 7: 1938:Banker M, Garcia-Velasco JA (2015). 631:adding citations to reliable sources 409:or through genetic modification and 3924:Psychiatric disorders of childbirth 2303:Angiotensin II receptor antagonists 419:controlled ovarian hyperstimulation 299:Hypothalamic–pituitary–gonadal axis 212:Controlled ovarian hyperstimulation 27:Medical treatment for low fertility 675:vascular endothelial growth factor 514:assisted reproductive technologies 413:. Examples of recombinant FSH are 259:) may be used in combination with 25: 671:ovarian hyperstimulation syndrome 595:Ovarian hyperstimulation syndrome 484:has been used off-label to treat 3929:Postpartum physiological changes 3629:Postpartum physiological changes 3154:Assisted reproductive technology 3052: 3032: 3031: 1722:10.1016/j.fertnstert.2014.12.122 1681:10.1016/j.fertnstert.2018.05.028 1619:International Journal of Surgery 1392:10.1016/j.fertnstert.2017.06.026 1297:10.1016/j.fertnstert.2010.11.017 1010:10.1097/00006250-197803000-00002 786:10.1016/j.fertnstert.2013.12.045 695:Assisted reproductive technology 603: 440:of stromal cells, and injury to 126: 34: 3981:Adaptation to extrauterine life 2440:Hypothalamic–pituitary hormones 1550:Reproductive Biomedicine Online 955:Dickey RP, Holtkamp DE (1996). 430:premature ovarian failure (POF) 384:indication, which affects use. 3624:Maternal physiological changes 1811:10.1002/14651858.cd008215.pub3 1198:10.1002/14651858.CD010290.pub3 1090:10.1002/14651858.CD010287.pub4 829:Stute P, Birkhauser M (2015). 733:Drobnis EZ, Nangia AK (2017). 568:) or other malignant cancers ( 535:will increase male fertility. 249:gonadotropin-releasing hormone 243:Gonadotropin-releasing hormone 237:Gonadotropin-releasing hormone 161:gonadotropin releasing hormone 62:add the appropriate references 1: 3179:partner-assisted reproduction 2192:Thrombolytics / fibrinolytics 1749:Stem Cell Reviews and Reports 1428:10.1016/s0140-6736(96)08341-9 1050:10.1016/s0015-0282(16)46033-4 873:Nature Reviews. Endocrinology 838:Gynakologische Endokrinologie 222:, co-incubation, followed by 220:transvaginal oocyte retrieval 214:, which is generally part of 2903:Wakefulness-promoting agents 1897:Pediatric Blood & Cancer 1863:10.1097/GCO.0000000000000370 457:Human chorionic gonadotropin 3415:Traditional birth attendant 1324:LeĂŁo R, Esteves SC (2014). 356:Although primarily used in 47:reliable medical references 4053: 3647:Brain health and pollution 2553:Intravenous immunoglobulin 1632:10.1016/j.ijsu.2019.09.025 1563:10.1016/j.rbmo.2019.03.099 1476:10.5935/1518-0557.20160019 1463:JBRA Assisted Reproduction 1342:10.6061/clinics/2014(04)10 470:final maturation induction 460: 391: 349: 305:on FSH secretion from the 240: 230:Final maturation induction 3860:Chorionic villus sampling 3212:Obstetric ultrasonography 3136:Pre-conception counseling 3027: 1995:Human Reproduction Update 1761:10.1007/s12015-017-9765-x 1247:10.1007/s10815-018-1128-2 1148:10.1186/s12958-019-0460-4 998:Obstetrics and Gynecology 961:Human Reproduction Update 920:Human Reproduction Update 850:10.1007/s10304-015-0003-9 394:Gonadotropin preparations 340:polycystic ovary syndrome 53:or relies too heavily on 3750:Intrahepatic cholestasis 2608:Topoisomerase inhibitors 2292:renin–angiotensin system 2286:Calcium channel blockers 1957:10.4103/0974-1208.153120 1515:10.1177/1933719112466304 722:. Waltham, MA: UpToDate. 3820:Motor vehicle emissions 3681:Concomitant conditions 3655:environmental toxicants 3398:Auxiliary nurse midwife 3159:artificial insemination 3126:Natural family planning 1709:Fertility and Sterility 1668:Fertility and Sterility 1379:Fertility and Sterility 1284:Fertility and Sterility 1037:Fertility and Sterility 885:10.1038/nrendo.2014.156 814:NICE clinical guideline 773:Fertility and Sterility 411:bacterial recombination 358:breast cancer treatment 279:inhibit the effects of 207:artificial insemination 3914:Postpartum confinement 3174:in vitro fertilisation 2400:Hormonal contraception 2330:Bile acid sequestrants 2111:Proton-pump inhibitors 2074:gastrointestinal tract 974:10.1093/humupd/2.6.483 933:10.1093/humupd/6.3.212 538:As of September 2017, 436:of growing follicles, 364:(particularly generic 310: 216:in vitro fertilization 76:"Fertility medication" 3909:Postpartum depression 3790:Pruritic folliculitis 3534:Unassisted childbirth 2007:10.1093/humupd/dms031 1503:Reproductive Sciences 540:mesenchymal stem cell 297: 138:Fertility medications 4016:Gravidity and parity 3996:Congenital disorders 3955:Lactation consultant 3825:Pre-existing disease 3504:Childbirth positions 3494:Rupture of membranes 3191:Unintended pregnancy 3169:fertility medication 3009:Radiopharmaceuticals 2797:Antiparkinson agents 627:improve this section 407:postmenopausal women 362:aromatase inhibitors 346:Aromatase inhibitors 289:aromatase inhibitors 3919:Sex after pregnancy 3726:Endocrine diseases 3672:Prenatal depression 3544:Placental expulsion 3462:Uterine contraction 3445:cervical effacement 3186:Fertility awareness 2792:Antimigraine agents 2782:Antidementia agents 2685:Anti-inflammatories 2375:Medicated dressings 2315:Antihyperlipidemics 2142:Diabetes medication 423:ovulation induction 370:ovulation induction 368:) are also used in 352:Aromatase inhibitor 335:ovulation induction 261:luteinizing hormone 195:Ovulation induction 152:development of the 4037:Fertility medicine 3695:Hypercoagulability 3524:Natural childbirth 3373:Postterm pregnancy 3131:Male contraceptive 2645:Immunosuppressants 2515:Antimycobacterials 2471:Antithyroid agents 2455:Mineralocorticoids 2259:Cardiac stimulants 2249:Cardiac glycosides 2241:cardiac therapy / 2137:Anti-obesity drugs 1290:(3): 906–14.e1–4. 700:Diethylstilbestrol 311: 203:sexual intercourse 4024: 4023: 4009:Obstetric history 4004: 4003: 3965:Confinement nanny 3878: 3877: 3745:Acute fatty liver 3552: 3551: 3440:cervical dilation 3067: 3066: 2970:Ophthalmologicals 2680:Anabolic steroids 2583:Anticancer agents 2546:Ectoparasiticides 2266:Antihypertensives 2214:Antifibrinolytics 1909:10.1002/pbc.24192 746:978-3-319-69535-8 663: 662: 655: 512:Typically, other 476:Other medications 453:pregnancy rates. 303:negative feedback 135: 134: 111: 16:(Redirected from 4044: 3889: 3855:Cardiotocography 3561: 3467:Vaginal delivery 3340:Nesting instinct 3315: 3300:Rudimentary horn 3229:Prenatal testing 3094: 3087: 3080: 3071: 3056: 3035: 3034: 3019:Senotherapeutics 2873:Neuroprotectives 2868:Mood stabilizers 2767:Anti-ADHD agents 2707:Muscle relaxants 2640:Immunostimulants 2635:Immunomodulators 2467:Thyroid hormones 2405:Fertility agents 2308:Renin inhibitors 2199:Antihemorrhagics 2166:forming organs ( 2152:Dietary minerals 2058: 2051: 2044: 2035: 2029: 2028: 2018: 1986: 1980: 1979: 1969: 1959: 1944:J Hum Reprod Sci 1935: 1929: 1928: 1891: 1885: 1884: 1874: 1842: 1833: 1832: 1822: 1790: 1781: 1780: 1744: 1735: 1734: 1724: 1700: 1694: 1693: 1683: 1659: 1653: 1652: 1634: 1610: 1604: 1603: 1594:(5): 4069–4078. 1582: 1576: 1575: 1565: 1541: 1535: 1534: 1498: 1489: 1488: 1478: 1454: 1448: 1447: 1422:(9054): 787–90. 1411: 1405: 1404: 1394: 1370: 1364: 1363: 1353: 1321: 1310: 1309: 1299: 1275: 1269: 1268: 1258: 1226: 1220: 1219: 1209: 1177: 1171: 1170: 1160: 1150: 1126: 1120: 1119: 1109: 1069: 1063: 1062: 1052: 1028: 1022: 1021: 993: 987: 986: 976: 952: 946: 945: 935: 911: 905: 904: 868: 862: 861: 835: 826: 820: 819: 805: 799: 798: 788: 764: 758: 757: 755: 753: 730: 724: 723: 715: 658: 651: 647: 644: 638: 607: 599: 378:live birth rates 140:, also known as 130: 129: 121: 118: 112: 110: 69: 38: 37: 30: 21: 18:Fertility agents 4052: 4051: 4047: 4046: 4045: 4043: 4042: 4041: 4027: 4026: 4025: 4020: 4000: 3969: 3933: 3904:Postpartum care 3874: 3838: 3741:Liver diseases 3735:Thyroid disease 3633: 3619:Gestational age 3590: 3548: 3514:Labor induction 3419: 3410:Perinatal nurse 3383:Birth attendant 3344: 3304: 3238: 3234:Medical imaging 3195: 3164:fertility fraud 3140: 3107: 3098: 3068: 3063: 3059:Medicine portal 3023: 2979: 2951: 2946: 2938:Cough medicines 2933:Bronchodilators 2914: 2907: 2787:Antidepressants 2777:Anticonvulsants 2725: 2716: 2712:Bisphosphonates 2702:Corticosteroids 2664: 2651: 2623: 2614: 2598:Spindle poisons 2588:Antimetabolites 2571: 2562: 2484: 2475: 2450:Glucocorticoids 2445:Corticosteroids 2426: 2419: 2386: 2379: 2336: 2254:Antiarrhythmics 2227: 2220: 2177:Antithrombotics 2165: 2156: 2132:Antipropulsives 2128:Antidiarrhoeals 2105: 2076: 2068: 2062: 2032: 1988: 1987: 1983: 1937: 1936: 1932: 1893: 1892: 1888: 1844: 1843: 1836: 1805:(6): CD008215. 1792: 1791: 1784: 1746: 1745: 1738: 1702: 1701: 1697: 1661: 1660: 1656: 1612: 1611: 1607: 1588:Urology Journal 1584: 1583: 1579: 1543: 1542: 1538: 1500: 1499: 1492: 1456: 1455: 1451: 1413: 1412: 1408: 1372: 1371: 1367: 1323: 1322: 1313: 1277: 1276: 1272: 1228: 1227: 1223: 1192:(1): CD010290. 1179: 1178: 1174: 1128: 1127: 1123: 1084:(9): CD010287. 1071: 1070: 1066: 1030: 1029: 1025: 995: 994: 990: 954: 953: 949: 913: 912: 908: 870: 869: 865: 833: 828: 827: 823: 807: 806: 802: 766: 765: 761: 751: 749: 747: 732: 731: 727: 717: 716: 712: 708: 691: 683: 681:Discontinuation 659: 648: 642: 639: 624: 608: 597: 554: 549: 547:Adverse effects 503: 478: 465: 459: 396: 390: 354: 348: 316: 307:pituitary gland 274: 245: 239: 224:embryo transfer 188: 186:Main techniques 183: 142:fertility drugs 131: 127: 122: 116: 113: 70: 59: 55:primary sources 39: 35: 28: 23: 22: 15: 12: 11: 5: 4050: 4048: 4040: 4039: 4029: 4028: 4022: 4021: 4019: 4018: 4012: 4010: 4006: 4005: 4002: 4001: 3999: 3998: 3993: 3988: 3983: 3977: 3975: 3971: 3970: 3968: 3967: 3962: 3957: 3952: 3950:Health visitor 3947: 3941: 3939: 3935: 3934: 3932: 3931: 3926: 3921: 3916: 3911: 3906: 3901: 3895: 3893: 3886: 3880: 3879: 3876: 3875: 3873: 3872: 3867: 3865:Nonstress test 3862: 3857: 3852: 3846: 3844: 3840: 3839: 3837: 3836: 3835: 3834: 3833: 3832: 3827: 3822: 3817: 3812: 3807: 3799: 3798: 3797: 3792: 3787: 3781:Skin diseases 3779: 3778: 3777: 3772: 3767: 3762: 3754: 3753: 3752: 3747: 3739: 3738: 3737: 3732: 3724: 3723: 3722: 3717: 3712: 3707: 3697: 3692: 3687: 3679: 3674: 3669: 3668: 3667: 3662: 3657: 3649: 3643: 3641: 3635: 3634: 3632: 3631: 3626: 3621: 3616: 3611: 3606: 3600: 3598: 3592: 3591: 3589: 3588: 3583: 3578: 3573: 3571:Amniotic fluid 3567: 3565: 3558: 3554: 3553: 3550: 3549: 3547: 3546: 3541: 3536: 3531: 3526: 3521: 3519:Multiple birth 3516: 3511: 3506: 3501: 3496: 3491: 3490: 3489: 3484: 3479: 3469: 3464: 3459: 3454: 3453: 3452: 3447: 3442: 3427: 3425: 3421: 3420: 3418: 3417: 3412: 3407: 3402: 3401: 3400: 3390: 3385: 3380: 3375: 3370: 3369: 3368: 3358: 3352: 3350: 3346: 3345: 3343: 3342: 3337: 3332: 3327: 3325:Bradley method 3321: 3319: 3312: 3306: 3305: 3303: 3302: 3297: 3292: 3287: 3282: 3277: 3272: 3267: 3262: 3257: 3252: 3246: 3244: 3240: 3239: 3237: 3236: 3231: 3226: 3225: 3224: 3217:Pregnancy test 3214: 3209: 3203: 3201: 3197: 3196: 3194: 3193: 3188: 3183: 3182: 3181: 3176: 3171: 3166: 3161: 3150: 3148: 3142: 3141: 3139: 3138: 3133: 3128: 3123: 3117: 3115: 3109: 3108: 3099: 3097: 3096: 3089: 3082: 3074: 3065: 3064: 3062: 3061: 3050: 3045: 3040: 3028: 3025: 3024: 3022: 3021: 3016: 3011: 3006: 3004:Contrast media 3001: 2995: 2993: 2981: 2980: 2978: 2977: 2972: 2966: 2964: 2957:sensory organs 2953: 2952: 2950: 2949: 2944: 2940: 2935: 2930: 2924: 2922: 2909: 2908: 2906: 2905: 2900: 2895: 2890: 2885: 2880: 2875: 2870: 2865: 2856: 2855: 2854: 2849: 2844: 2834: 2829: 2824: 2819: 2814: 2809: 2804: 2802:Antipsychotics 2799: 2794: 2789: 2784: 2779: 2774: 2772:Antiaddictives 2769: 2764: 2759: 2758: 2757: 2752: 2742: 2736: 2734: 2727:nervous system 2718: 2717: 2715: 2714: 2709: 2704: 2699: 2697:Antirheumatics 2694: 2693: 2692: 2682: 2676: 2674: 2653: 2652: 2650: 2649: 2648: 2647: 2642: 2631: 2629: 2616: 2615: 2613: 2612: 2611: 2610: 2605: 2603:Antineoplastic 2600: 2595: 2590: 2579: 2577: 2564: 2563: 2561: 2560: 2555: 2550: 2549: 2548: 2543: 2538: 2536:Antiprotozoals 2531:Antiparasitics 2528: 2523: 2518: 2511:Antibacterials 2507:Antimicrobials 2503: 2501: 2477: 2476: 2474: 2473: 2464: 2459: 2458: 2457: 2452: 2442: 2436: 2434: 2421: 2420: 2418: 2417: 2412: 2407: 2402: 2396: 2394: 2381: 2380: 2378: 2377: 2372: 2370:Antipsoriatics 2367: 2362: 2357: 2351: 2349: 2338: 2337: 2335: 2334: 2333: 2332: 2327: 2322: 2312: 2311: 2310: 2305: 2300: 2298:ACE inhibitors 2288: 2283: 2278: 2273: 2268: 2263: 2262: 2261: 2256: 2251: 2237: 2235: 2226:cardiovascular 2222: 2221: 2219: 2218: 2217: 2216: 2211: 2206: 2196: 2195: 2194: 2189: 2187:Anticoagulants 2184: 2173: 2171: 2158: 2157: 2155: 2154: 2149: 2144: 2139: 2134: 2125: 2120: 2115: 2114: 2113: 2108: 2103: 2099: 2088: 2086: 2070: 2069: 2063: 2061: 2060: 2053: 2046: 2038: 2031: 2030: 1981: 1930: 1903:(2): 301–308. 1886: 1857:(4): 195–201. 1834: 1782: 1736: 1715:(3): 595–604. 1695: 1674:(4): 578–580. 1654: 1605: 1577: 1556:(2): 269–279. 1536: 1490: 1449: 1406: 1385:(3): 426–441. 1365: 1311: 1270: 1241:(4): 571–581. 1221: 1172: 1121: 1064: 1023: 988: 967:(6): 483–506. 947: 906: 863: 821: 800: 759: 745: 725: 709: 707: 704: 703: 702: 697: 690: 687: 682: 679: 667:multiple birth 661: 660: 611: 609: 602: 596: 593: 558:ovarian cancer 553: 550: 548: 545: 533:pentoxifylline 505:Treatment for 502: 499: 486:oligomenorrhea 477: 474: 461:Main article: 458: 455: 392:Main article: 389: 386: 350:Main article: 347: 344: 315: 312: 273: 270: 251:(GnRH) or any 241:Main article: 238: 235: 234: 233: 227: 209: 187: 184: 182: 179: 133: 132: 125: 123: 42: 40: 33: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4049: 4038: 4035: 4034: 4032: 4017: 4014: 4013: 4011: 4007: 3997: 3994: 3992: 3989: 3987: 3984: 3982: 3979: 3978: 3976: 3972: 3966: 3963: 3961: 3960:Monthly nurse 3958: 3956: 3953: 3951: 3948: 3946: 3943: 3942: 3940: 3936: 3930: 3927: 3925: 3922: 3920: 3917: 3915: 3912: 3910: 3907: 3905: 3902: 3900: 3897: 3896: 3894: 3890: 3887: 3885: 3881: 3871: 3868: 3866: 3863: 3861: 3858: 3856: 3853: 3851: 3850:Amniocentesis 3848: 3847: 3845: 3841: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3813: 3811: 3810:Vaginal flora 3808: 3806: 3803: 3802: 3800: 3796: 3793: 3791: 3788: 3786: 3783: 3782: 3780: 3776: 3773: 3771: 3768: 3766: 3763: 3761: 3758: 3757: 3755: 3751: 3748: 3746: 3743: 3742: 3740: 3736: 3733: 3731: 3728: 3727: 3725: 3721: 3718: 3716: 3713: 3711: 3708: 3706: 3703: 3702: 3701: 3700:Substance use 3698: 3696: 3693: 3691: 3688: 3686: 3683: 3682: 3680: 3678: 3675: 3673: 3670: 3666: 3663: 3661: 3658: 3656: 3653: 3652: 3650: 3648: 3645: 3644: 3642: 3640: 3636: 3630: 3627: 3625: 3622: 3620: 3617: 3615: 3614:Fundal height 3612: 3610: 3607: 3605: 3602: 3601: 3599: 3597: 3593: 3587: 3584: 3582: 3579: 3577: 3574: 3572: 3569: 3568: 3566: 3562: 3559: 3555: 3545: 3542: 3540: 3537: 3535: 3532: 3530: 3527: 3525: 3522: 3520: 3517: 3515: 3512: 3510: 3507: 3505: 3502: 3500: 3497: 3495: 3492: 3488: 3485: 3483: 3480: 3478: 3475: 3474: 3473: 3470: 3468: 3465: 3463: 3460: 3458: 3455: 3451: 3448: 3446: 3443: 3441: 3438: 3437: 3436: 3432: 3429: 3428: 3426: 3422: 3416: 3413: 3411: 3408: 3406: 3403: 3399: 3396: 3395: 3394: 3391: 3389: 3386: 3384: 3381: 3379: 3376: 3374: 3371: 3367: 3366:Preterm birth 3364: 3363: 3362: 3359: 3357: 3354: 3353: 3351: 3347: 3341: 3338: 3336: 3333: 3331: 3330:Hypnobirthing 3328: 3326: 3323: 3322: 3320: 3316: 3313: 3311: 3307: 3301: 3298: 3296: 3293: 3291: 3288: 3286: 3283: 3281: 3278: 3276: 3273: 3271: 3268: 3266: 3263: 3261: 3258: 3256: 3253: 3251: 3248: 3247: 3245: 3241: 3235: 3232: 3230: 3227: 3223: 3220: 3219: 3218: 3215: 3213: 3210: 3208: 3207:3D ultrasound 3205: 3204: 3202: 3198: 3192: 3189: 3187: 3184: 3180: 3177: 3175: 3172: 3170: 3167: 3165: 3162: 3160: 3157: 3156: 3155: 3152: 3151: 3149: 3147: 3143: 3137: 3134: 3132: 3129: 3127: 3124: 3122: 3121:Birth control 3119: 3118: 3116: 3114: 3110: 3106: 3102: 3095: 3090: 3088: 3083: 3081: 3076: 3075: 3072: 3060: 3055: 3051: 3049: 3046: 3044: 3041: 3039: 3030: 3029: 3026: 3020: 3017: 3015: 3012: 3010: 3007: 3005: 3002: 3000: 2997: 2996: 2994: 2991: 2987: 2982: 2976: 2973: 2971: 2968: 2967: 2965: 2962: 2958: 2954: 2948: 2941: 2939: 2936: 2934: 2931: 2929: 2928:Decongestants 2926: 2925: 2923: 2920: 2916: 2910: 2904: 2901: 2899: 2896: 2894: 2891: 2889: 2886: 2884: 2881: 2879: 2876: 2874: 2871: 2869: 2866: 2864: 2860: 2857: 2853: 2850: 2848: 2847:Dissociatives 2845: 2843: 2840: 2839: 2838: 2837:Hallucinogens 2835: 2833: 2830: 2828: 2825: 2823: 2820: 2818: 2815: 2813: 2810: 2808: 2805: 2803: 2800: 2798: 2795: 2793: 2790: 2788: 2785: 2783: 2780: 2778: 2775: 2773: 2770: 2768: 2765: 2763: 2760: 2756: 2753: 2751: 2748: 2747: 2746: 2743: 2741: 2738: 2737: 2735: 2732: 2728: 2723: 2719: 2713: 2710: 2708: 2705: 2703: 2700: 2698: 2695: 2691: 2688: 2687: 2686: 2683: 2681: 2678: 2677: 2675: 2672: 2668: 2662: 2658: 2654: 2646: 2643: 2641: 2638: 2637: 2636: 2633: 2632: 2630: 2627: 2621: 2617: 2609: 2606: 2604: 2601: 2599: 2596: 2594: 2591: 2589: 2586: 2585: 2584: 2581: 2580: 2578: 2575: 2569: 2565: 2559: 2556: 2554: 2551: 2547: 2544: 2542: 2541:Anthelmintics 2539: 2537: 2534: 2533: 2532: 2529: 2527: 2524: 2522: 2519: 2516: 2512: 2508: 2505: 2504: 2502: 2499: 2495: 2491: 2487: 2482: 2478: 2472: 2468: 2465: 2463: 2460: 2456: 2453: 2451: 2448: 2447: 2446: 2443: 2441: 2438: 2437: 2435: 2432: 2428: 2422: 2416: 2413: 2411: 2408: 2406: 2403: 2401: 2398: 2397: 2395: 2392: 2388: 2385:genitourinary 2382: 2376: 2373: 2371: 2368: 2366: 2365:Antipruritics 2363: 2361: 2358: 2356: 2353: 2352: 2350: 2347: 2343: 2339: 2331: 2328: 2326: 2323: 2321: 2318: 2317: 2316: 2313: 2309: 2306: 2304: 2301: 2299: 2296: 2295: 2294: 2293: 2289: 2287: 2284: 2282: 2281:Beta blockers 2279: 2277: 2274: 2272: 2269: 2267: 2264: 2260: 2257: 2255: 2252: 2250: 2247: 2246: 2245: 2244: 2239: 2238: 2236: 2233: 2229: 2223: 2215: 2212: 2210: 2207: 2205: 2202: 2201: 2200: 2197: 2193: 2190: 2188: 2185: 2183: 2182:Antiplatelets 2180: 2179: 2178: 2175: 2174: 2172: 2169: 2163: 2159: 2153: 2150: 2148: 2145: 2143: 2140: 2138: 2135: 2133: 2129: 2126: 2124: 2121: 2119: 2116: 2112: 2109: 2107: 2100: 2098: 2095: 2094: 2093: 2090: 2089: 2087: 2084: 2080: 2075: 2071: 2067: 2059: 2054: 2052: 2047: 2045: 2040: 2039: 2036: 2026: 2022: 2017: 2012: 2008: 2004: 2001:(6): 652–69. 2000: 1996: 1992: 1985: 1982: 1977: 1973: 1968: 1963: 1958: 1953: 1949: 1945: 1941: 1934: 1931: 1926: 1922: 1918: 1914: 1910: 1906: 1902: 1898: 1890: 1887: 1882: 1878: 1873: 1868: 1864: 1860: 1856: 1852: 1848: 1841: 1839: 1835: 1830: 1826: 1821: 1816: 1812: 1808: 1804: 1800: 1796: 1789: 1787: 1783: 1778: 1774: 1770: 1766: 1762: 1758: 1754: 1750: 1743: 1741: 1737: 1732: 1728: 1723: 1718: 1714: 1710: 1706: 1699: 1696: 1691: 1687: 1682: 1677: 1673: 1669: 1665: 1658: 1655: 1650: 1646: 1642: 1638: 1633: 1628: 1624: 1620: 1616: 1609: 1606: 1601: 1597: 1593: 1589: 1581: 1578: 1573: 1569: 1564: 1559: 1555: 1551: 1547: 1540: 1537: 1532: 1528: 1524: 1520: 1516: 1512: 1509:(7): 739–44. 1508: 1504: 1497: 1495: 1491: 1486: 1482: 1477: 1472: 1468: 1464: 1460: 1453: 1450: 1445: 1441: 1437: 1433: 1429: 1425: 1421: 1417: 1410: 1407: 1402: 1398: 1393: 1388: 1384: 1380: 1376: 1369: 1366: 1361: 1357: 1352: 1347: 1343: 1339: 1336:(4): 279–93. 1335: 1331: 1327: 1320: 1318: 1316: 1312: 1307: 1303: 1298: 1293: 1289: 1285: 1281: 1274: 1271: 1266: 1262: 1257: 1252: 1248: 1244: 1240: 1236: 1232: 1225: 1222: 1217: 1213: 1208: 1203: 1199: 1195: 1191: 1187: 1183: 1176: 1173: 1168: 1164: 1159: 1154: 1149: 1144: 1140: 1136: 1132: 1125: 1122: 1117: 1113: 1108: 1103: 1099: 1095: 1091: 1087: 1083: 1079: 1075: 1068: 1065: 1060: 1056: 1051: 1046: 1042: 1038: 1034: 1027: 1024: 1019: 1015: 1011: 1007: 1003: 999: 992: 989: 984: 980: 975: 970: 966: 962: 958: 951: 948: 943: 939: 934: 929: 926:(3): 212–24. 925: 921: 917: 910: 907: 902: 898: 894: 890: 886: 882: 879:(12): 704–5. 878: 874: 867: 864: 859: 855: 851: 847: 843: 839: 832: 825: 822: 817: 815: 810: 804: 801: 796: 792: 787: 782: 778: 774: 770: 763: 760: 748: 742: 738: 737: 729: 726: 721: 714: 711: 705: 701: 698: 696: 693: 692: 688: 686: 680: 678: 676: 672: 669:and possible 668: 657: 654: 646: 636: 632: 628: 622: 621: 617: 612:This section 610: 606: 601: 600: 594: 592: 589: 587: 583: 579: 575: 571: 567: 563: 559: 551: 546: 544: 541: 536: 534: 528: 526: 521: 519: 515: 510: 508: 500: 498: 495: 491: 487: 483: 475: 473: 471: 464: 456: 454: 451: 447: 444:resulting in 443: 442:blood vessels 439: 435: 431: 426: 424: 420: 416: 412: 408: 404: 400: 399:Gonadotropins 395: 388:Gonadotropins 387: 385: 383: 379: 375: 374:meta-analysis 371: 367: 363: 359: 353: 345: 343: 341: 336: 332: 328: 324: 320: 313: 308: 304: 300: 296: 292: 290: 286: 282: 278: 277:Antiestrogens 272:Antiestrogens 271: 269: 266: 262: 258: 254: 250: 244: 236: 231: 228: 225: 221: 217: 213: 210: 208: 204: 200: 199:fertilization 196: 193: 192: 191: 185: 180: 178: 175: 173: 172:gonadotropins 169: 166: 162: 157: 155: 151: 147: 143: 139: 124: 120: 109: 106: 102: 99: 95: 92: 88: 85: 81: 78: â€“  77: 73: 72:Find sources: 67: 63: 57: 56: 52: 48: 43:This article 41: 32: 31: 19: 3690:Hypertension 3677:Immunization 3660:in pregnancy 3576:Amniotic sac 3529:Silent birth 3472:Presentation 3435:Bishop score 3405:Obstetrician 3295:Interstitial 3222:home testing 3168: 2842:Psychedelics 2812:Aphrodisiacs 2486:infestations 2462:Sex hormones 2415:Sex hormones 2404: 2360:Cicatrizants 2290: 2276:Vasodilators 2243:antianginals 2240: 2092:stomach acid 2091: 1998: 1994: 1984: 1947: 1943: 1933: 1900: 1896: 1889: 1854: 1850: 1802: 1798: 1752: 1748: 1712: 1708: 1698: 1671: 1667: 1657: 1622: 1618: 1608: 1591: 1587: 1580: 1553: 1549: 1539: 1506: 1502: 1466: 1462: 1452: 1419: 1415: 1409: 1382: 1378: 1368: 1333: 1329: 1287: 1283: 1273: 1238: 1234: 1224: 1189: 1185: 1175: 1138: 1134: 1124: 1081: 1077: 1067: 1043:(2): 161–7. 1040: 1036: 1026: 1004:(3): 265–9. 1001: 997: 991: 964: 960: 950: 923: 919: 909: 876: 872: 866: 841: 837: 824: 812: 803: 779:(4): 924–6. 776: 772: 762: 750:. Retrieved 735: 728: 719: 713: 684: 664: 649: 640: 625:Please help 613: 590: 555: 537: 529: 522: 518:testolactone 511: 507:oligospermia 504: 479: 466: 450:GnRH agonist 427: 397: 355: 317: 275: 246: 189: 176: 158: 141: 137: 136: 114: 104: 97: 90: 83: 71: 51:verification 44: 3986:Apgar score 3770:Hepatitis C 3756:Infections 3596:Development 3581:Endometrium 3539:Water birth 3457:Bloody show 3388:Men's roles 3318:Preparation 3270:Heterotopic 2975:Otologicals 2947:antagonists 2913:respiratory 2888:Orexigenics 2883:Neurotoxins 2832:Euphoriants 2822:Entactogens 2817:Depressants 2807:Anxiolytics 2745:Anesthetics 2521:Antifungals 2118:Antiemetics 2106:antagonists 1950:(1): 13–7. 1755:(1): 1–12. 1625:: 101–109. 1469:(2): 82–8. 752:23 February 643:August 2020 588:variables. 586:confounding 566:endometrial 421:as well as 168:antagonists 117:August 2020 45:needs more 3991:Child care 3884:Postpartum 3843:Procedures 3795:Dermatoses 3651:Nutrition 3509:Home birth 3431:Pelvimetry 3310:Childbirth 3290:Unintended 3146:Conception 3105:childbirth 2898:Stimulants 2878:Nootropics 2852:Deliriants 2827:Entheogens 2762:Anorectics 2740:Analgesics 2593:Alkylating 2526:Antivirals 2481:infections 2355:Emollients 2209:Coagulants 2079:metabolism 1711:(Review). 1505:(Review). 1465:(Review). 1418:(Review). 1332:(Review). 844:(2): 126. 706:References 525:clomiphene 376:analyzing 331:raloxifene 319:Clomiphene 87:newspapers 3499:Caesarean 3265:Abdominal 3101:Pregnancy 3048:ATC codes 3014:Dressings 2999:Antidotes 2863:Sedatives 2859:Hypnotics 2568:malignant 2425:endocrine 2271:Diuretics 2204:Platelets 2164:and blood 2123:Laxatives 1649:203580672 1531:206804686 1141:(1): 18. 1098:1469-493X 614:does not 482:metformin 480:Although 434:apoptosis 415:Follistim 382:off-label 366:letrozole 327:tamoxifen 255:(such as 146:fertility 4031:Category 3892:Maternal 3870:Abortion 3815:Bleeding 3765:COVID-19 3730:Diabetes 3715:Cannabis 3665:prenatal 3586:Placenta 3557:Prenatal 3487:shoulder 3482:cephalic 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Index

Fertility agents
reliable medical references
verification
primary sources
add the appropriate references
removed
"Fertility medication"
news
newspapers
books
scholar
JSTOR
fertility
follicle
ovary
gonadotropin releasing hormone
estrogen
antagonists
gonadotropins
Ovulation induction
fertilization
sexual intercourse
artificial insemination
Controlled ovarian hyperstimulation
in vitro fertilization
transvaginal oocyte retrieval
embryo transfer
Final maturation induction
Gonadotropin-releasing hormone
gonadotropin-releasing hormone

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