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Fitz-Hugh–Curtis syndrome

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With treatment, the prognosis of Fitz-Hugh–Curtis syndrome is excellent with vast majority of patients seeing complete resolution of symptoms. Complications of the disease include infertility, small bowel obstruction due to adhesions, chronic pelvic pain, recurrent salpingitis, and ectopic pregnancy.
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The signs and symptoms of Fitz-Hugh–Curtis syndrome greatly overlap with numerous other abdominal and pelvic pathologies. It is important for practitioners to perform a thorough history and physical as the differential for the symptoms of Fitz-Hugh–Curtis syndrome include cholecystitis, appendicitis,
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have also been found to cause Fitz-Hugh–Curtis syndrome on occasion. Fitz-Hugh–Curtis syndrome was originally studied solely as a complication of PID secondary to Gonorrhea, but studies have now shown that Chlamydia is the most common causal pathogen. Fitz-Hugh–Curtis syndrome occurs in 5-15% of
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Radiographic studies are often indicated to rule out other thoracic, abdominal, and pelvic pathologies. Chest and abdominal radiographs may be indicated to rule out pulmonary pathologies and to assess for free air under the diaphragm in the case of intestinal perforation. Abdominal and pelvic
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The mainstay of treatment of Fitz-Hugh–Curtis syndrome is antibiotics targeted at the causal organism. The CDC recommends a low threshold for treatment given the high risk of infertility and ectopic pregnancies with untreated disease. Antibiotic therapy should cover the most common pathogens
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with direct visualization of the characteristic "violin string adhesions" along with liver capsule scarring and inflammation. Antibody testing of 57-kDa chlamydial heat-shock protein can be done in cases where all other tests have been non-diagnostic and the clinical suspicion remains high.
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Patients are most often women of childbearing age. There are a number of risk factors for the development of Fitz-Hugh–Curtis syndrome, these include having multiple sexual partners, history of sexually transmitted disease, history of PID, use of an
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to the right shoulder. There is usually also tenderness on palpation of the right upper abdomen and tenderness to percussion of the lower ribs which protect the liver. Patients may also report fevers, malaise, back pain, pelvic pain,
203:(CT) scan should be obtained in the case that the clinical suspicion for appendicitis is high. In cases of Fitz-Hugh–Curtis syndrome, the CT scan may show increased blood flow to the liver capsule secondary to the inflammation. 194:
The workup for Fitz-Hugh–Curtis syndrome at presentation begins with ruling out pregnancy or an ectopic pregnancy with a pregnancy test, this can also help guide antibiotic therapy if indicated to prevent teratogens.
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Fitz-Hugh–Curtis syndrome, or perihepatitis, was first described by Carlos Stajano in 1920, who found adhesions between the liver capsule and the abdominal wall in patients suffering from gonococcal infections.
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are often obtained is these patients as part of the initial workup, since Fitz-Hugh–Curtis syndrome does not involve direct damage to the liver, LFTs will be normal or only slightly elevated.
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After ruling out other concerning pathologies if suspicion is high, the workup for Fitz-Hugh–Curtis syndrome involves testing for sexually transmitted diseases (Chlamydia and Gonorrhea) with
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Lopez-Zeno, J. A.; Keith, L. G.; Berger, G. S. (August 1985). "The Fitz-Hugh-Curtis syndrome revisited. Changing perspectives after half a century".
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Brun, J.-L.; Castan, B.; de Barbeyrac, B.; Cazanave, C.; Charvériat, A.; Faure, K.; Mignot, S.; Verdon, R.; Fritel, X.; Graesslin, O. (May 2019).
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Peter, N. G.; Clark, L. R.; Jaeger, J. R. (2004). "Fitz-Hugh-Curtis syndrome: a diagnosis to consider in women with right upper quadrant pain".
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You, Je Sung; Kim, Min Joung; Chung, Hyun Soo; Chung, Yong Eun; Park, Incheol; Chung, Sung Phil; Kim, Seungho; Lee, Hahn Shick (2012-07-01).
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hepatitis, pregnancy, pyelonephritis, renal colic, pleuritic causes such as pneumonia, pulmonary embolism, and pleurisy, among many others.
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as Chlamydia and Gonorrhea constitute the vast majority of cases, treatment for complicated PID involves the combination of ceftriaxone,
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ultrasounds are critical to rule out common causes of RUQ pain such as cholelithiasis, cholecystitis, and abdominal/pelvic abscesses.
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Fitz-Hugh–Curtis syndrome occurs almost exclusively in women, though it can be seen in males rarely. It is complication of
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from a cervical swab sample. If indicated, urethral, rectal, and/or pharyngeal swabs may be obtained as well.
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Wølner-Hanssen, P.; Weström, L.; Mårdh, P. A. (1980-04-26). "Perihepatitis and chlamydial salpingitis".
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including Chlamydia, Gonorrhea, other gram-negatives, and anaerobes. Current guidelines recommend
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Fitz-Hugh, Thomas (1934). "Acute gonococcic peritonitis of the right upper quadrant in women".
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The pathogens of PID spread either spontaneous secondary to an ascending infection through the
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The gold standard for diagnosis of Fitz-Hugh–Curtis syndrome, though rarely required, is
2135: 939:"Pelvic Inflammatory Diseases: Updated Guidelines for Clinical Practice – Short version" 28: 2284: 2082: 1944: 1836: 1796: 1774: 1610: 1473: 1458: 1402: 1253: 1249: 1026: 993: 635: 600: 525: 492: 149: 133: 77: 1051:"Fitz-Hugh-Curtis syndrome: An incidental diagnostic finding in an infertility workup" 561: 2518: 2357: 2352: 2090: 1615: 1600: 1563: 1498: 1416: 978: 376: 349: 249:. In cases of refractory pain, laparoscopy may be considered for lysis of adhesions. 246: 153: 124: 50: 1139: 923: 812: 757: 585: 303: 2475: 2441: 2377: 2009: 1862: 1741: 1649: 1627: 1568: 1503: 1431: 1346: 238: 53: 1299: 136:, lymphatically, or hematogenous. Inflammation then causes scar tissue to form on 1264: 2480: 2386: 2362: 2014: 1929: 1902: 1866: 1812: 1733: 1718: 1644: 1531: 1508: 1397: 242: 234: 220: 158: 112: 106: 954: 2499: 2456: 2427: 2422: 2309: 2301: 2115: 1999: 1949: 1871: 1779: 1710: 1595: 1421: 1275: 617: 508: 363:
Curtis, Arthur H. (1930). "A cause of adhesions in the right upper quadrant".
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aggravated by breathing, coughing or laughing, which may also present with
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The condition is named after the two physicians, Thomas Fitz-Hugh Jr. and
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presenting with the clinical syndrome of right upper quadrant (RUQ) pain.
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Onoh, R. C.; Mgbafuru, C. C.; Onubuogu, S. E.; Ugwuoke, I. (2016).
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Bailey & Love's Short Practice of Surgery - 28th Edition
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The major symptom and signs include an acute onset of RUQ
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Stajano, Carlos. "La reaccion frenica en ginecologia".
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Peter, N. G; Clark, L. R; Jaeger, J. R (2004-03-01).
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Peter, N. G; Clark, L. R; Jaeger, J. R (2004-03-01).
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Peter, N. G; Clark, L. R; Jaeger, J. R (2004-03-01).
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Peter, N. G; Clark, L. R; Jaeger, J. R (2004-03-01).
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Tarascon Emergency Department Quick Reference Guide
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Gynécologie, Obstétrique, Fertilité & Sénologie
599:Coremans, Laura; de Clerck, Frederik (2018-03-20). 21: 691:Wing, Edward J.; Schiffman, Fred J., eds. (2022). 466:Wing, Edward J.; Schiffman, Fred J., eds. (2022). 829:(21st ed.). New York: McGraw Hill. 2022. 695:(Tenth ed.). Philadelphia, PA: Elsevier. 670:(21st ed.). New York: McGraw Hill. 2022. 2151: 1327: 8: 992:Kazama, Itsuro; Nakajima, Toshiyuki (2013). 2158: 2144: 2136: 2078: 1855: 1536: 1527: 1370: 1361: 1334: 1320: 1312: 1223: 1154:Harrison's principles of internal medicine 827:Harrison's principles of internal medicine 668:Harrison's principles of internal medicine 443:Harrison's principles of internal medicine 104:(Gonorrhea) though other bacteria such as 27: 18: 1066: 1025: 634: 616: 524: 998:Clinical Medicine Insights: Case Reports 214:nucleic acid amplification tests (NAATs) 266: 1055:Nigerian Journal of Clinical Practice 7: 1184:(4th ed.). E.D. Insight Books. 1182:Quick Essentials: Emergency Medicine 1104:Cleveland Clinic Journal of Medicine 888:Cleveland Clinic Journal of Medicine 777:Cleveland Clinic Journal of Medicine 722:Cleveland Clinic Journal of Medicine 392:The Journal of Reproductive Medicine 276:Cleveland Clinic Journal of Medicine 2121:Persistent genital arousal disorder 14: 2462:Pelvic inflammatory disease (PID) 1935:Hypoactive sexual desire disorder 1454:Ovarian hyperstimulation syndrome 177:, and being under the age of 25. 377:10.1001/jama.1930.02710420033012 350:10.1001/jama.1934.02750250020010 2504:Non-gonococcal urethritis (NGU) 2167:Sexually transmitted infections 1549:Dysfunctional uterine bleeding 1: 562:10.1016/s0140-6736(80)90838-7 2236:Mycoplasma hominis infection 1645:Menorrhagia (hypermenorrhea) 1616:Polymenorrhea (epimenorrhea) 1199:Pregerson, D. Brady (2012). 693:Cecil essentials of medicine 468:Cecil essentials of medicine 56:leading to the formation of 2062:Pelvic inflammatory disease 426:Pelvic Inflammatory Disease 207:Liver function tests (LFTs) 90:pelvic inflammatory disease 47:pelvic inflammatory disease 2566: 2057:Pelvic congestion syndrome 1487:Fallopian tube obstruction 955:10.1016/j.gofs.2019.03.012 319:Semana Medica Buenes Aires 45:is a rare complication of 2106:Vestibular papillomatosis 2025: 1958: 1858: 1685: 1675:Metropathia haemorrhagica 1539: 1180:Pregerson, Brady (2010). 618:10.1186/s12876-018-0768-0 509:10.3349/ymj.2012.53.4.753 161:, vaginal discharge, and 43:Fitz-Hugh–Curtis syndrome 35: 26: 22:Fitz-Hugh–Curtis syndrome 2545:Rare infectious diseases 2200:lymphogranuloma venereum 1442:Follicular cyst of ovary 1203:. Jones & Bartlett. 1068:10.4103/1119-3077.181357 2217:Klebsiella granulomatis 1940:Sexual arousal disorder 1896:Candidal vulvovaginitis 1554:Endometrial hyperplasia 2530:Gynaecologic disorders 2265:Ureaplasma urealyticum 1383:Endometriosis of ovary 863:10.1037/e546742006-001 497:Yonsei Medical Journal 181:Differential diagnosis 2411:Molluscum contagiosum 2290:Trichomonas vaginalis 2229:Neisseria gonorrhoeae 2205:Chlamydia trachomatis 1827:Vesicouterine fistula 1770:Cervical incompetence 1695:Recurrent miscarriage 1633:Premenstrual syndrome 1494:Fallopian tube cancer 1116:10.3949/ccjm.71.3.233 900:10.3949/ccjm.71.3.233 789:10.3949/ccjm.71.3.233 734:10.3949/ccjm.71.3.233 288:10.3949/ccjm.71.3.233 101:Neisseria gonorrhoeae 95:Chlamydia trachomatis 36:Perihepatic adhesions 2535:Syndromes in females 2525:Chlamydia infections 2371:Human papillomavirus 2260:Ureaplasma infection 1985:Rectovaginal fistula 1410:Poor ovarian reserve 1010:10.4137/CCRep.S11522 605:BMC Gastroenterology 190:Diagnosis and workup 2189:Haemophilus ducreyi 2035:Postcoital bleeding 1963:Urogenital fistulas 1891:Bacterial vaginosis 1544:Asherman's syndrome 201:Computed tomography 173:, use of a vaginal 171:intrauterine device 129:patients with PID. 2253:Treponema pallidum 2241:Mycoplasma hominis 1920:Sexual dysfunction 1886:Atrophic vaginitis 1822:Retroverted uterus 1785:Female infertility 1765:Cervical dysplasia 1690:Female infertility 1482:Female infertility 1437:Corpus luteum cyst 1393:Ovulatory disorder 1388:Female infertility 1286:External resources 74:Arthur Hale Curtis 2512: 2511: 2404:HSV-1 & HSV-2 2392:Hepatitis B virus 2133: 2132: 2129: 2128: 2070: 2069: 2045: 2044: 1978:Obstetric fistula 1876:Vaginal discharge 1845: 1844: 1790:Cervical stenosis 1705: 1704: 1559:Endometrial polyp 1517: 1516: 1447:Theca lutein cyst 1309: 1308: 1210:978-0-7637-8789-9 1191:978-0-9761552-3-2 1163:978-1-264-26850-4 855:PsycEXTRA Dataset 836:978-1-264-26850-4 702:978-0-323-72271-1 677:978-1-264-26850-4 556:(8174): 901–903. 477:978-0-323-72271-1 452:978-1-264-26850-4 138:Glisson's capsule 40: 39: 16:Medical condition 2557: 2491: 2472: 2453: 2160: 2153: 2146: 2137: 2101:Kraurosis vulvae 2096:Bartholin's cyst 2079: 2030:Vaginal bleeding 1923: 1856: 1832:Uterine prolapse 1660:Menometrorrhagia 1584: 1537: 1528: 1427:Ovarian apoplexy 1371: 1362: 1336: 1329: 1322: 1313: 1224: 1214: 1195: 1168: 1167: 1150: 1144: 1143: 1095: 1089: 1088: 1070: 1046: 1040: 1039: 1029: 989: 983: 982: 934: 928: 927: 879: 873: 872: 870: 869: 847: 841: 840: 823: 817: 816: 768: 762: 761: 713: 707: 706: 688: 682: 681: 664: 658: 655: 649: 648: 638: 620: 596: 590: 589: 545: 539: 538: 528: 488: 482: 481: 463: 457: 456: 439: 433: 422: 416: 415: 387: 381: 380: 360: 354: 353: 333: 327: 326: 314: 308: 307: 271: 92:(PID) caused by 49:(PID) involving 31: 19: 2565: 2564: 2560: 2559: 2558: 2556: 2555: 2554: 2515: 2514: 2513: 2508: 2487: 2468: 2449: 2440: 2434: 2378:Genital warts ( 2319: 2296: 2271: 2170: 2164: 2134: 2125: 2066: 2041: 2021: 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2227: 2215: 2203: 2187: 2010:Sigmoidocele 1918: 1863:Hematocolpos 1742:Parametritis 1650:Metrorrhagia 1628:Dysmenorrhea 1581:Menstruation 1579: 1569:Endometritis 1504:Hydrosalpinx 1432:Ovarian cyst 1293: 1269: 1258: 1239: 1200: 1181: 1153: 1148: 1107: 1103: 1093: 1058: 1054: 1044: 1001: 997: 987: 946: 942: 932: 891: 887: 877: 866:. 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Index


pelvic inflammatory disease
liver capsule
inflammation
adhesions
Arthur Hale Curtis
abdominal pain
pelvic inflammatory disease
Chlamydia trachomatis
Neisseria gonorrhoeae
Bacteroides
Gardnerella
E. coli
Streptococcus
fallopian tubes
Glisson's capsule
abdominal pain
referred pain
dyspareunia
dysuria
intrauterine device
douche
Computed tomography
Liver function tests (LFTs)
nucleic acid amplification tests (NAATs)
laparoscopy
ceftriaxone
azithromycin
doxycycline
metronidazole

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