40:
175:
152:
1 (PPARγ1), a nuclear hormone receptor contributing to terminal differentiation of cells. The PAX8-PPARγ1 fusion is present in approximately one-third of follicular thyroid carcinomas, specifically those cancers with a t(2;3)(q13;p25) translocation, permitting juxtaposition of portions of both genes.
314:
following two weeks of a low iodine diet (LID). Occasionally treatment must be repeated if annual scans indicate remaining cancerous tissue. Some physicians favor administering the maximum safe dose (calculated based on a number of factors), while others favor administering smaller doses, which may
188:
thyroid cancer is often considered a variant of follicular cell carcinoma. Hurthle cell forms are more likely than follicular carcinomas to be bilateral and multifocal and to metastasize to lymph nodes. Like follicular carcinoma, unilateral hemithyroidectomy is performed for non-invasive disease,
340:(WBS) using radioactive iodine. However, current protocol (in the USA) suggests a small number of clean annual WBS are required before relying on Tg testing plus neck ultrasound. When needed, whole body scans consist of withdrawal from thyroxine medication and/or injection of recombinant human
858:
843:
161:
tend to carry either a RAS mutation or a PAX8-PPARγ1 fusion, and only rarely are both genetic abnormalities present in the same case. Thus, follicular thyroid carcinomas seem to arise by two distinct and virtually nonoverlapping
221:
for the diagnosis of follicular carcinoma are capsular invasion and vascular invasion by tumor cells. Still, focuses of the capsular invasion should be carefully evaluated and discriminated from the capsular rupture due to
397:
Compared to other variants of
Follicular cell derived thyroid cancer, bone metastases are commonly associated with follicular carcinoma. In the present study a high rate of bone metastases of 34% was observed.
534:
Kushchayeva Y, Duh QY, Kebebew E, D'Avanzo A, Clark OH (2007). "Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with
Hurthle cell or follicular thyroid cancer".
344:(TSH). In both cases, a low iodine diet regimen must also be followed to optimize the takeup of the radioactive iodine dose. Low dose radioiodine of a few millicuries is administered. Full body
589:
Han, Kanghee; Ha, Hwa-Jeong; Kong, Joon Seog; Kim, Jung-Soon; Myung, Jae Kyung; Koh, Jae Soo; Park, Sunhoo; Shin, Myung-Soon; Song, Woo-Tack; Seol, Hye Sil; Lee, Seung-Sook (March 2018).
197:
It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions.
978:
149:
942:
930:
1081:
952:
Management
Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Taskforce (2015).
121:
971:
739:
433:
687:
Hegazy MA, Khater AA, Setit AE, et al. (2007). "Minimally invasive video-assisted thyroidectomy for small follicular thyroid nodules".
1312:
648:"Upregulation of HMGA2 in thyroid carcinomas: A novel molecular marker to distinguish between benign and malignant follicular neoplasias"
1307:
1302:
873:
964:
457:
422:
Mitchell, Richard
Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). "30". In Kumar, Vinay; Robbins, Stanley L. (eds.).
298:
and postoperative radioiodine ablation where carcinoma is confirmed. This way total thyroidectomy is not carried out unnecessarily.
571:
471:
Giordano, Thomas J.; Haugen, Bryan R.; Sherman, Steven I.; Shah, Manisha H.; Caoili, Elaine M.; Koenig, Ronald J. (2018-04-01).
1161:
1008:
210:
754:
1294:
318:
341:
249:
575:
1151:
939:
927:
141:
39:
1204:
1144:
1123:
987:
884:
1333:
1114:
92:
1199:
223:
1256:
50:
of follicular thyroid carcinoma showing a location where the cancer grows through the fibrous capsule.
1246:
1076:
391:
380:
315:
still be effective in ablating all thyroid tissue. I-131 is used for ablation of the thyroid tissue.
253:
1251:
1139:
862:
1059:
712:
451:
1238:
1086:
1067:
1003:
806:
788:
735:
704:
669:
628:
610:
552:
510:
492:
439:
429:
272:
163:
154:
145:
59:
951:
1216:
1156:
1101:
796:
780:
696:
659:
618:
602:
544:
500:
484:
345:
213:(FNAC) suggests follicular neoplasm, thyroid lobectomy should be performed to establish the
96:
1279:
1211:
1169:
1035:
946:
934:
291:
137:
1194:
1109:
801:
768:
623:
590:
505:
387:
337:
214:
80:
174:
1327:
1228:
1221:
1186:
1174:
302:
286:
113:
84:
867:
757:
By the
American Cancer Society. In turn citing: AJCC Cancer Staging Manual (7th ed).
716:
591:"Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions"
1266:
1132:
1071:
349:
311:
185:
88:
913:
548:
51:
889:
321:
thyroidectomy has been used in recent years in cases where the nodules are small.
1284:
1091:
1017:
307:
284:
If follicular cells are found on cytological testing, it is common to carry out
64:
767:
Pal, Pooja; Singh, Bikramjit; Kane, Shubhada; Chaturvedi, Pankaj (March 2018).
1044:
1031:
1026:
1013:
956:
784:
700:
357:
353:
333:
235:
178:
112:
Approximately one-half of follicular thyroid carcinomas have mutations in the
47:
792:
614:
496:
423:
1274:
1022:
908:
852:
606:
443:
383:
for follicular thyroid cancer is 91%, and the 10-year survival rate is 85%.
206:
133:
810:
708:
673:
632:
556:
514:
472:
332:
Some studies have shown that thyroglobulin (Tg) testing combined with neck
488:
995:
364:
294:
and follicular carcinoma on histopathological examination, proceeding to
158:
68:
835:
148:(PAX-8), a gene important in thyroid development, and the gene encoding
368:
664:
647:
394:
of 100% for stages I and II, 71% for stage III, and 50% for stage IV.
95:
are the thyroid cells responsible for the production and secretion of
1049:
1040:
847:
473:"Pioglitazone Therapy of PAX8-PPARγ Fusion Protein Thyroid Carcinoma"
129:
16:
Malignant tumor made of hormone-producing cells in the thyroid gland
260:
173:
157:-class drug that potentiates PPARγ to boost insulin sensitivity.
878:
243:
239:
205:
It is impossible to distinguish between follicular adenoma and
125:
117:
960:
570:
Hu, MI; Vassilopoulou-Sellin, R; Lustig, R; Lamont, JP (2008).
336:
is more productive in finding disease recurrence than full- or
153:
This subtype may potentially be treated with pioglitazone, a
773:
Indian
Journal of Otolaryngology and Head & Neck Surgery
263:
has been proposed as a marker to identify malignant tumors.
940:
Cancer
Management Handbook: Thyroid and Parathyroid Cancers
367:, is produced in cell culture from genetically engineered
144:
specific for follicular thyroid carcinomas is one between
228:
worrisome histologic alterations following FNA of thyroid
140:
of which follicular thyroid cancer is a feature. Also, a
83:
and occurs more commonly in women over 50 years of age.
390:
into stages I to IV, follicular thyroid cancer has a
825:
769:"Bone Metastases in Follicular Carcinoma of Thyroid"
730:
F. Grünwald; Biersack, H. J.; Grںunwald, F. (2005).
477:
The
Journal of Clinical Endocrinology and Metabolism
1293:
1265:
1237:
1185:
1100:
1058:
994:
899:
829:
428:(8 ed.). Philadelphia, PA: Saunders/Elsevier.
91:for well-differentiated follicular thyroid cancer.
58:
29:
24:
132:have likewise been observed, as well as germline
646:Belge G, Meyer A, Klemke M, et al. (2008).
595:Journal of Pathology and Translational Medicine
189:and total thyroidectomy for invasive disease.
972:
8:
150:peroxisome proliferator-activated receptor γ
979:
965:
957:
826:
352:. Scan doses of radioactive iodine may be
38:
21:
800:
663:
622:
504:
417:
415:
413:
411:
407:
363:Recombinant human TSH, commercial name
449:
7:
310:treatment at levels from 50 to 200
14:
572:"Thyroid and Parathyroid Cancers"
226:penetration resulting in WHAFFT (
1077:ACTH-secreting pituitary adenoma
734:. Berlin: Springer. p. 10.
1009:Pancreatic neuroendocrine tumor
211:fine needle aspiration cytology
1082:GH-secreting pituitary adenoma
755:cancer.org > Thyroid Cancer
234:Follicular carcinoma tends to
1:
549:10.1016/j.amjsurg.2007.06.001
456:: CS1 maint: date and year (
33:Follicular thyroid carcinoma
988:Tumours of endocrine glands
342:Thyroid stimulating hormone
275:, followed by radioiodine.
250:Papillary thyroid carcinoma
209:on cytological grounds. If
181:of a Hurthle cell neoplasm.
116:of oncogenes, most notably
1350:
328:Finding disease recurrence
306:is invariably followed by
136:mutations responsible for
785:10.1007/s12070-017-1170-x
701:10.1007/s00268-007-9147-7
252:commonly metastasizes to
142:chromosomal translocation
77:Follicular thyroid cancer
46:
37:
25:Follicular thyroid cancer
1205:Adrenocortical carcinoma
652:Genes Chromosomes Cancer
296:completion thyroidectomy
93:Thyroid follicular cells
1162:Squamous-cell carcinoma
607:10.4132/jptm.2018.01.17
425:Robbins basic pathology
290:to distinguish between
1200:Adrenocortical adenoma
928:Thyroid cancer at DMOZ
182:
87:(Tg) can be used as a
489:10.1210/jc.2017-02533
348:scan follows using a
271:Treatment is usually
217:diagnosis. Features
177:
1247:Parathyroid neoplasm
392:5-year survival rate
381:5-year survival rate
254:cervical lymph nodes
246:via the bloodstream.
170:Hurthle cell variant
108:Associated mutations
79:accounts for 15% of
1140:Parafollicular cell
945:2017-05-17 at the
933:2017-03-14 at the
900:External resources
319:Minimally invasive
292:follicular adenoma
183:
1321:
1320:
1087:Craniopharyngioma
1068:Pituitary adenoma
1004:Pancreatic cancer
923:
922:
741:978-3-540-22309-2
665:10.1002/gcc.20505
435:978-1-4160-2973-1
287:hemithyroidectomy
279:Initial treatment
215:histopathological
155:thiazolidinedione
146:paired box gene 8
74:
73:
19:Medical condition
1341:
1217:Pheochromocytoma
981:
974:
967:
958:
827:
815:
814:
804:
764:
758:
752:
746:
745:
727:
721:
720:
684:
678:
677:
667:
643:
637:
636:
626:
586:
580:
579:
574:. Archived from
567:
561:
560:
531:
525:
524:
522:
521:
508:
483:(4): 1277–1281.
468:
462:
461:
455:
447:
419:
346:nuclear medicine
338:whole-body scans
97:thyroid hormones
42:
22:
1349:
1348:
1344:
1343:
1342:
1340:
1339:
1338:
1324:
1323:
1322:
1317:
1289:
1280:Pinealoblastoma
1261:
1233:
1181:
1170:Thyroid adenoma
1115:epithelial-cell
1096:
1054:
1036:Somatostatinoma
990:
985:
947:Wayback Machine
935:Wayback Machine
924:
919:
918:
895:
894:
838:
824:
819:
818:
766:
765:
761:
753:
749:
742:
729:
728:
724:
686:
685:
681:
645:
644:
640:
588:
587:
583:
569:
568:
564:
533:
532:
528:
519:
517:
470:
469:
465:
448:
436:
421:
420:
409:
404:
377:
330:
281:
269:
203:
195:
172:
138:Cowden syndrome
128:. Mutations in
110:
105:
20:
17:
12:
11:
5:
1347:
1345:
1337:
1336:
1334:Thyroid cancer
1326:
1325:
1319:
1318:
1316:
1315:
1310:
1305:
1299:
1297:
1291:
1290:
1288:
1287:
1282:
1277:
1271:
1269:
1263:
1262:
1260:
1259:
1254:
1249:
1243:
1241:
1235:
1234:
1232:
1231:
1226:
1225:
1224:
1219:
1209:
1208:
1207:
1202:
1191:
1189:
1183:
1182:
1180:
1179:
1178:
1177:
1172:
1164:
1159:
1154:
1149:
1148:
1147:
1137:
1136:
1135:
1126:
1110:Thyroid cancer
1106:
1104:
1098:
1097:
1095:
1094:
1089:
1084:
1079:
1074:
1064:
1062:
1056:
1055:
1053:
1052:
1047:
1038:
1029:
1020:
1011:
1006:
1000:
998:
992:
991:
986:
984:
983:
976:
969:
961:
955:
954:
949:
937:
921:
920:
917:
916:
904:
903:
901:
897:
896:
893:
892:
881:
870:
855:
839:
834:
833:
831:
830:Classification
823:
822:External links
820:
817:
816:
759:
747:
740:
732:Thyroid cancer
722:
695:(9): 1743–50.
679:
638:
601:(2): 110–120.
581:
578:on 2013-10-04.
562:
526:
463:
434:
406:
405:
403:
400:
388:cancer staging
376:
373:
329:
326:
325:
324:
323:
322:
299:
280:
277:
268:
265:
258:
257:
247:
202:
201:Classification
199:
194:
191:
171:
168:
109:
106:
104:
101:
81:thyroid cancer
72:
71:
62:
56:
55:
44:
43:
35:
34:
31:
27:
26:
18:
15:
13:
10:
9:
6:
4:
3:
2:
1346:
1335:
1332:
1331:
1329:
1314:
1311:
1309:
1306:
1304:
1301:
1300:
1298:
1296:
1292:
1286:
1283:
1281:
1278:
1276:
1273:
1272:
1270:
1268:
1264:
1258:
1255:
1253:
1250:
1248:
1245:
1244:
1242:
1240:
1236:
1230:
1229:Paraganglioma
1227:
1223:
1222:Neuroblastoma
1220:
1218:
1215:
1214:
1213:
1210:
1206:
1203:
1201:
1198:
1197:
1196:
1193:
1192:
1190:
1188:
1187:Adrenal tumor
1184:
1176:
1175:Struma ovarii
1173:
1171:
1168:
1167:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1146:
1143:
1142:
1141:
1138:
1134:
1130:
1127:
1125:
1122:
1121:
1120:
1117:
1116:
1112:(malignant):
1111:
1108:
1107:
1105:
1103:
1099:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1069:
1066:
1065:
1063:
1061:
1057:
1051:
1048:
1046:
1042:
1039:
1037:
1033:
1030:
1028:
1024:
1021:
1019:
1015:
1012:
1010:
1007:
1005:
1002:
1001:
999:
997:
993:
989:
982:
977:
975:
970:
968:
963:
962:
959:
953:
950:
948:
944:
941:
938:
936:
932:
929:
926:
925:
915:
911:
910:
906:
905:
902:
898:
891:
887:
886:
882:
880:
876:
875:
871:
869:
865:
864:
860:
856:
854:
850:
849:
845:
841:
840:
837:
832:
828:
821:
812:
808:
803:
798:
794:
790:
786:
782:
778:
774:
770:
763:
760:
756:
751:
748:
743:
737:
733:
726:
723:
718:
714:
710:
706:
702:
698:
694:
690:
683:
680:
675:
671:
666:
661:
657:
653:
649:
642:
639:
634:
630:
625:
620:
616:
612:
608:
604:
600:
596:
592:
585:
582:
577:
573:
566:
563:
558:
554:
550:
546:
543:(4): 457–62.
542:
538:
530:
527:
516:
512:
507:
502:
498:
494:
490:
486:
482:
478:
474:
467:
464:
459:
453:
445:
441:
437:
431:
427:
426:
418:
416:
414:
412:
408:
401:
399:
395:
393:
389:
384:
382:
374:
372:
370:
366:
361:
359:
355:
351:
347:
343:
339:
335:
327:
320:
317:
316:
313:
309:
305:
304:
303:Thyroidectomy
300:
297:
293:
289:
288:
283:
282:
278:
276:
274:
266:
264:
262:
255:
251:
248:
245:
241:
237:
233:
232:
231:
229:
225:
220:
216:
212:
208:
200:
198:
192:
190:
187:
180:
176:
169:
167:
165:
160:
156:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
114:Ras subfamily
107:
102:
100:
98:
94:
90:
86:
85:Thyroglobulin
82:
78:
70:
66:
63:
61:
57:
53:
52:H&E stain
49:
45:
41:
36:
32:
28:
23:
1267:Pineal gland
1133:Hurthle cell
1128:
1118:
1113:
1072:Prolactinoma
907:
883:
872:
857:
842:
779:(1): 10–14.
776:
772:
762:
750:
731:
725:
692:
689:World J Surg
688:
682:
658:(1): 56–63.
655:
651:
641:
598:
594:
584:
576:the original
565:
540:
536:
529:
518:. Retrieved
480:
476:
466:
424:
396:
385:
379:The overall
378:
362:
350:gamma camera
331:
301:
295:
285:
270:
259:
227:
219:sine qua non
218:
204:
196:
186:Hurthle cell
184:
111:
89:tumor marker
76:
75:
1285:Pineocytoma
1239:Parathyroid
1092:Pituicytoma
1018:Glucagonoma
386:By overall
312:millicuries
308:radioiodine
236:metastasize
65:ENT surgery
30:Other names
1152:Anaplastic
1129:Follicular
1045:Gastrinoma
1027:Insulinoma
520:2023-06-11
402:References
334:ultrasound
179:Micrograph
166:pathways.
48:Micrograph
1275:Pinealoma
1257:Carcinoma
1145:Medullary
1124:Papillary
1119:carcinoma
1060:Pituitary
909:eMedicine
793:2231-3796
615:2383-7837
537:Am J Surg
497:1945-7197
452:cite book
375:Prognosis
267:Treatment
207:carcinoma
193:Diagnosis
164:molecular
134:PTEN gene
60:Specialty
1328:Category
1157:Lymphoma
996:Pancreas
943:Archived
931:Archived
811:29456936
717:19818345
709:17653588
674:17943974
633:29374960
557:18070728
515:29373711
444:69672074
365:Thyrogen
273:surgical
69:oncology
1252:Adenoma
1212:Medulla
1166:Benign
1102:Thyroid
914:med/804
890:D013964
802:5807283
624:5859246
506:6456920
371:cells.
369:hamster
1195:Cortex
1050:VIPoma
879:188470
809:
799:
791:
738:
715:
707:
672:
631:
621:
613:
555:
513:
503:
495:
442:
432:
159:Tumors
130:MINPP1
124:, and
713:S2CID
261:HMGA2
103:Cause
885:MeSH
874:OMIM
863:9-CM
807:PMID
789:ISSN
736:ISBN
705:PMID
670:PMID
629:PMID
611:ISSN
553:PMID
511:PMID
493:ISSN
458:link
440:OCLC
430:ISBN
244:bone
242:and
240:lung
126:KRAS
122:NRAS
118:HRAS
1295:MEN
868:193
859:ICD
853:C73
844:ICD
797:PMC
781:doi
697:doi
660:doi
619:PMC
603:doi
545:doi
541:195
501:PMC
485:doi
481:103
356:or
238:to
230:).
224:FNA
1330::
1313:2B
1308:2A
1070::
1043::
1034::
1025::
1016::
912::
888::
877::
866::
851::
848:10
805:.
795:.
787:.
777:70
775:.
771:.
711:.
703:.
693:31
691:.
668:.
656:47
654:.
650:.
627:.
617:.
609:.
599:52
597:.
593:.
551:.
539:.
509:.
499:.
491:.
479:.
475:.
454:}}
450:{{
438:.
410:^
360:.
120:,
99:.
67:,
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1041:G
1032:δ
1023:β
1014:α
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